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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA duplex unwinding
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Accession:GO:0032508 term browser browse the term
Definition:The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
Comment:Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
Synonyms:exact_synonym: DNA unwinding;   duplex DNA melting


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DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:20655937 GO_REF:0000118 RGD:7421590 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G ASCC3 activating signal cointegrator 1 complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:98,345,023...98,720,332
Ensembl chr 6:102,224,820...102,599,521 		JBrowse link
G BLM BLM RecQ like helicase involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr15:69,407,248...69,508,070
Ensembl chr15:88,607,157...88,707,864 		JBrowse link
G BRIP1 BRCA1 interacting helicase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr17:55,786,568...55,973,366
Ensembl chr17:60,901,073...61,083,462 		JBrowse link
G CHD1L chromodomain helicase DNA binding protein 1 like involved_in IEA GOC GO_REF:0000108 NCBI chr 1:122,595,246...122,720,788
Ensembl chr 1:112,809,274...112,862,219 		JBrowse link
G CHD8 chromodomain helicase DNA binding protein 8 involved_in IEA GOC GO_REF:0000108 NCBI chr14:2,202,847...2,274,012
Ensembl chr14:20,281,422...20,326,361 		JBrowse link
G CHTF18 chromosome transmission fidelity factor 18 involved_in IEA GOC GO_REF:0000108 Ensembl chr16:803,340...813,170 JBrowse link
G CHTF8 chromosome transmission fidelity factor 8 involved_in IEA GOC GO_REF:0000108 NCBI chr16:49,489,176...49,503,736
Ensembl chr16:68,877,028...68,891,513 		JBrowse link
G DDX1 DEAD-box helicase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:15,582,499...15,619,751
Ensembl chr2A:15,716,044...15,753,623 		JBrowse link
G DDX11 DEAD/H-box helicase 11 involved_in ISO (PMID:10648783), (PMID:18499658), (PMID:26503245) UniProt PMID:10648783 PMID:18499658 PMID:26503245 NCBI chr12:55,176,165...55,207,123 JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in IEA GOC GO_REF:0000108 NCBI chr  X:33,780,381...33,796,829
Ensembl chr  X:41,475,116...41,505,837 		JBrowse link
G DHX36 DEAH-box helicase 36 involved_in IEA GOC GO_REF:0000108 NCBI chr 3:151,331,468...151,382,406
Ensembl chr 3:158,885,541...158,935,871 		JBrowse link
G DHX9 DExH-box helicase 9 involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr 1:158,355,472...158,404,178
Ensembl chr 1:162,006,822...162,055,833 		JBrowse link
G DSCC1 DNA replication and sister chromatid cohesion 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 8:116,524,249...116,546,178
Ensembl chr 8:119,272,490...119,294,342 		JBrowse link
G DTD1 D-aminoacyl-tRNA deacylase 1 involved_in ISO (PMID:17264083) DisProt PMID:17264083 NCBI chr20:18,549,512...18,720,272
Ensembl chr20:18,499,564...18,670,699 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit involved_in IEA GOC GO_REF:0000108 NCBI chr19:42,298,927...42,319,816
Ensembl chr19:50,897,004...50,915,819 		JBrowse link
G FANCM FA complementation group M involved_in IEA GOC GO_REF:0000108 NCBI chr14:25,752,295...25,817,001
Ensembl chr14:44,080,146...44,143,958 		JBrowse link
G FBH1 F-box DNA helicase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr10:5,931,389...5,978,844
Ensembl chr10:5,915,713...5,962,778 		JBrowse link
G G3BP1 G3BP stress granule assembly factor 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 5:147,195,100...147,234,576
Ensembl chr 5:153,197,813...153,230,414 		JBrowse link
G HELB DNA helicase B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2152689|PMID:11557815) GOC
GOC		 PMID:11557815 GO_REF:0000108 MGI:2152689 NCBI chr12:22,571,448...22,607,417
Ensembl chr12:23,078,732...23,114,134 		JBrowse link
G HELQ helicase, POLQ like involved_in IEA GOC GO_REF:0000108 NCBI chr 4:40,740,392...40,788,907
Ensembl chr 4:46,586,882...46,635,108 		JBrowse link
G HELZ2 helicase with zinc finger 2 involved_in IEA GOC GO_REF:0000108 Ensembl chr20:61,483,623...61,498,083 JBrowse link
G IGHMBP2 immunoglobulin mu DNA binding protein 2 involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr11:63,991,285...64,028,430
Ensembl chr11:67,294,195...67,331,659 		JBrowse link
G LOC100970335 X-ray repair cross-complementing protein 6-like involved_in IEA GOC GO_REF:0000108 NCBI chr  X:139,876,341...139,878,314 JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 3:124,643,362...124,667,121
Ensembl chr 3:131,950,887...131,974,641 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 NCBI chr 6:51,816,615...51,837,404
Ensembl chr 6:53,085,231...53,105,344 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 8:44,387,529...44,404,773
Ensembl chr 8:41,778,247...41,794,783 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 NCBI chr22:16,407,145...16,431,822
Ensembl chr22:34,249,831...34,274,423 		JBrowse link
G MCM6 minichromosome maintenance complex component 6 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr2B:23,986,278...24,023,045
Ensembl chr2B:139,911,909...139,947,687 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 7:92,128,037...92,136,976
Ensembl chr 7:105,561,591...105,570,720 		JBrowse link
G MCM8 minichromosome maintenance 8 homologous recombination repair factor involved_in IEA InterPro
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr20:5,945,034...5,993,725
Ensembl chr20:5,729,174...5,775,133 		JBrowse link
G MCM9 minichromosome maintenance 9 homologous recombination repair factor involved_in IEA InterPro
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr 6:116,620,188...116,743,435
Ensembl chr 6:120,763,329...120,881,865 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966 		JBrowse link
G NAV2 neuron navigator 2 involved_in IEA GOC GO_REF:0000108 NCBI chr11:19,370,095...20,143,255
Ensembl chr11:19,288,598...20,055,758 		JBrowse link
G NBN nibrin involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307 		JBrowse link
G PIF1 PIF1 5'-to-3' DNA helicase involved_in IEA GOC GO_REF:0000108 NCBI chr15:43,756,605...43,766,631
Ensembl chr15:62,041,461...62,052,311 		JBrowse link
G POLQ DNA polymerase theta involved_in IEA GOC GO_REF:0000108 NCBI chr 3:118,535,968...118,648,275
Ensembl chr 3:125,446,829...125,559,283 		JBrowse link
G POT1 protection of telomeres 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:116,807,913...116,926,998
Ensembl chr 7:129,487,571...129,605,558 		JBrowse link
G RAD50 RAD50 double strand break repair protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:127,972,630...128,059,911
Ensembl chr 5:134,134,495...134,222,261 		JBrowse link
G RECQL4 RecQ like helicase 4 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 8:144,267,101...144,276,985 JBrowse link
G RFC2 replication factor C subunit 2 involved_in IEA GOC GO_REF:0000108 Ensembl chr 7:81,378,937...81,401,937 JBrowse link
G RFC3 replication factor C subunit 3 involved_in IEA GOC GO_REF:0000108 NCBI chr13:15,073,464...15,220,646
Ensembl chr13:33,503,439...33,523,403 		JBrowse link
G RFC4 replication factor C subunit 4 involved_in IEA GOC GO_REF:0000108 NCBI chr 3:183,824,865...183,841,895
Ensembl chr 3:192,290,639...192,307,839 		JBrowse link
G RFC5 replication factor C subunit 5 involved_in IEA GOC GO_REF:0000108 NCBI chr12:115,595,398...115,611,442
Ensembl chr12:118,973,560...118,990,308 		JBrowse link
G RTEL1 regulator of telomere elongation helicase 1 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr20:61,581,331...61,618,718 JBrowse link
G RUVBL1 RuvB like AAA ATPase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 3:125,120,524...125,200,859
Ensembl chr 3:132,486,229...132,528,918 		JBrowse link
G RUVBL2 RuvB like AAA ATPase 2 involved_in IEA GOC GO_REF:0000108 NCBI chr19:45,995,394...46,017,835
Ensembl chr19:54,739,474...54,761,407 		JBrowse link
G SLC25A16 solute carrier family 25 member 16 involved_in IEA GOC GO_REF:0000108 NCBI chr10:64,898,024...64,956,541
Ensembl chr10:67,506,006...67,549,308
Ensembl chr10:67,506,006...67,549,308 		JBrowse link
G SUB1 SUB1 regulator of transcription involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:77,728,309...77,800,534
Ensembl chr 5:83,112,131...83,130,755 		JBrowse link
G SUPV3L1 Suv3 like RNA helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:65,647,273...65,676,179
Ensembl chr10:68,180,671...68,209,538 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25848017) Ensembl
MGI		 PMID:25848017 GO_REF:0000107 NCBI chr 3:48,387,762...48,389,693
Ensembl chr 3:49,470,222...49,471,331 		JBrowse link
G UPF1 UPF1 RNA helicase and ATPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:18,269,878...18,306,199
Ensembl chr19:19,292,725...19,313,224 		JBrowse link
G WRN WRN RecQ like helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:30,353,643...30,492,978
Ensembl chr 8:27,541,145...27,679,855 		JBrowse link
G WRNIP1 WRN helicase interacting protein 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:2,587,170...2,608,179
Ensembl chr 6:2,691,235...2,711,062 		JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in IEA GOC GO_REF:0000108 NCBI chr2B:103,371,459...103,468,419
Ensembl chr2B:221,972,742...222,071,235 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 involved_in IEA GOC GO_REF:0000108 NCBI chr22:22,516,281...22,557,379
Ensembl chr22:40,603,038...40,643,314 		JBrowse link
G ZGRF1 zinc finger GRF-type containing 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 4:105,026,069...105,128,226
Ensembl chr 4:115,590,311...115,686,089 		JBrowse link
DNA unwinding involved in DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLM BLM RecQ like helicase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:69,407,248...69,508,070
Ensembl chr15:88,607,157...88,707,864 		JBrowse link
G CDC45 cell division cycle 45 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:2,239,040...2,279,807
Ensembl chr22:17,913,729...17,955,195 		JBrowse link
G GINS1 GINS complex subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:25,352,711...25,393,926
Ensembl chr20:25,757,555...25,797,829 		JBrowse link
G GINS2 GINS complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,344,706...66,356,079
Ensembl chr16:85,681,716...85,691,626 		JBrowse link
G GINS3 GINS complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:38,653,876...38,672,154
Ensembl chr16:57,790,392...57,801,904 		JBrowse link
G GINS4 GINS complex subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:40,774,253...40,790,609
Ensembl chr 8:38,224,907...38,240,562 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10531422) Ensembl
MGI
TreeGrafter		 PMID:10531422 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:124,643,362...124,667,121
Ensembl chr 3:131,950,887...131,974,641 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,816,615...51,837,404
Ensembl chr 6:53,085,231...53,105,344 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15917436) Ensembl
MGI
TreeGrafter		 PMID:15917436 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:44,387,529...44,404,773
Ensembl chr 8:41,778,247...41,794,783 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:16,407,145...16,431,822
Ensembl chr22:34,249,831...34,274,423 		JBrowse link
G MCM6 minichromosome maintenance complex component 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15917436) Ensembl
MGI
TreeGrafter		 PMID:15917436 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:23,986,278...24,023,045
Ensembl chr2B:139,911,909...139,947,687 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15917436) Ensembl
MGI
TreeGrafter		 PMID:15917436 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:92,128,037...92,136,976
Ensembl chr 7:105,561,591...105,570,720 		JBrowse link
G PURA purine rich element binding protein A involved_in ISO (PMID:15777841) UniProt PMID:15777841 NCBI chr 5:135,541,865...135,610,526
Ensembl chr 5:141,659,224...141,727,870
Ensembl chr 5:141,659,224...141,727,870 		JBrowse link
G RAD51 RAD51 recombinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:19,638,310...19,672,474
Ensembl chr15:37,891,056...37,925,207 		JBrowse link
G RECQL RecQ like helicase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:64,796,383...64,829,165
Ensembl chr12:67,400,315...67,432,724 		JBrowse link
G RECQL4 RecQ like helicase 4 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr 8:144,267,101...144,276,985 JBrowse link
G RECQL5 RecQ like helicase 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:69,577,778...69,618,068
Ensembl chr17:75,128,325...75,168,254 		JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:133,670,085...133,682,228
Ensembl chr 7:146,139,837...146,151,495 		JBrowse link
G TWNK twinkle mtDNA helicase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11431692) Ensembl
MGI		 PMID:11431692 GO_REF:0000107 NCBI chr10:97,588,811...97,595,663
Ensembl chr10:101,065,096...101,071,407 		JBrowse link
G WRN WRN RecQ like helicase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:30,353,643...30,492,978
Ensembl chr 8:27,541,145...27,679,855 		JBrowse link
negative regulation of DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SUB1 SUB1 regulator of transcription involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:77,728,309...77,800,534
Ensembl chr 5:83,112,131...83,130,755 		JBrowse link
G TOP2A DNA topoisomerase II alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:16,872,169...16,901,605
Ensembl chr17:17,097,778...17,126,207 		JBrowse link
nucleotide-excision repair, DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:32,983,492...33,020,492
Ensembl chr2B:127,922,483...127,959,372 		JBrowse link
Term paths to the root
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  biological_process 16440
    cellular process 15499
      cellular component organization or biogenesis 6620
        cellular component organization 6401
          organelle organization 3612
            chromosome organization 568
              DNA conformation change 82
                DNA geometric change 74
                  DNA duplex unwinding 70
                    DNA unwinding involved in DNA replication + 20
                    negative regulation of DNA duplex unwinding + 2
                    nucleotide-excision repair, DNA duplex unwinding 1
                    positive regulation of DNA duplex unwinding + 0
                    regulation of DNA duplex unwinding + 2
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