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ONTOLOGY REPORT - ANNOTATIONS

Term:endoplasmic reticulum calcium ion homeostasis
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Accession:GO:0032469 term browser browse the term
Definition:Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
Synonyms:exact_synonym: ER calcium ion concentration regulation;   ER calcium ion homeostasis;   calcium ion homeostasis in ER;   calcium ion homeostasis in endoplasmic reticulum;   endoplasmic reticulum calcium ion concentration regulation;   regulation of ER calcium ion concentration;   regulation of calcium ion concentration in ER;   regulation of calcium ion concentration in endoplasmic reticulum;   regulation of endoplasmic reticulum calcium ion concentration
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


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endoplasmic reticulum calcium ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 involved_in ISO (PMID:10587333)
(PMID:16402920)		 RGD PMID:10587333 PMID:16402920 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 IDA RGD PMID:11956212 RGD:631751 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:1097161|MGI:88138 (MGI:3527292|PMID:15613488) RGD PMID:15613488 MGI:3527292 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta involved_in IDA PMID:12676813 BHF-UCL PMID:12676813 RGD:10047271 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 involved_in ISO
ISS		 (PMID:30401460)
GO_REF:0000024		 RGD
UniProt		 PMID:30401460 GO_REF:0000024 NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881 		JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 acts_upstream_of_or_within ISO (MGI:5525071|PMID:22240901) RGD PMID:22240901 MGI:5525071 NCBI chr 7:107,962,194...107,965,368
Ensembl chr 7:107,962,207...107,965,366 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO
IBA		 (PMID:15102845), (PMID:22045699)
PMID:21873635		 RGD PMID:15102845 PMID:22045699 PMID:21873635 RGD:13792537 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 acts_upstream_of_or_within ISO MGI:1097161|MGI:88138|MGI:99702 (MGI:3527292|PMID:15613488) RGD PMID:15613488 MGI:3527292 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Kctd17 potassium channel tetramerization domain containing 17 involved_in ISO (PMID:25983243) RGD PMID:25983243 NCBI chr 7:109,979,060...110,009,091
Ensembl chr 7:109,979,060...110,008,927 		JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 involved_in ISO (PMID:15692567) RGD PMID:15692567 NCBI chr 6:132,096,992...132,156,702
Ensembl chr 6:132,096,901...132,154,583 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (MGI:4849347|PMID:21030605) RGD PMID:21030605 MGI:4849347 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:17431506)
UniProtKB:P49769 (PMID:16959576), (PMID:25394380)
MGI:109284|MGI:1857974|MGI:1930934|MGI:1930937 (MGI:1353133|PMID:10662826), (MGI:3044229|PMID:15123735), (MGI:3622834|PMID:15009636), (MGI:3713016|PMID:17431506), (MGI:3758537|PMID:12460542)		 UniProt
RGD		 PMID:10662826 PMID:12460542 PMID:15009636 PMID:15123735 PMID:16959576 More... GO_REF:0000024 MGI:1353133 MGI:3044229 MGI:3622834 MGI:3713016 MGI:3758537 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:1202717 (MGI:3758537|PMID:12460542) RGD PMID:12460542 MGI:3758537 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Selenok selenoprotein K involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:5,152,066...5,160,648
Ensembl chr16:5,152,066...5,159,188 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 acts_upstream_of_or_within ISO (MGI:3050914|PMID:15304216), (MGI:5525071|PMID:22240901) RGD PMID:15304216 PMID:22240901 MGI:3050914 MGI:5525071 NCBI chr 7:130,512,428...130,543,637
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000002
GO_REF:0000104
(MGI:5787843|PMID:27212239)
PMID:21873635
(PMID:27212239)		 UniProt
InterPro
RGD		 PMID:27212239 PMID:21873635 GO_REF:0000002 GO_REF:0000024 GO_REF:0000104 MGI:5787843, RGD:13792537 NCBI chr13:79,460,229...79,483,557
Ensembl chr13:79,460,135...79,483,555 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:16989814) RGD PMID:16989814 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
negative regulation of endoplasmic reticulum calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO (PMID:11402072), (PMID:19061639) RGD PMID:11402072 PMID:19061639 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 acts_upstream_of_or_within ISO MGI:88138|MGI:99702 (MGI:3527292|PMID:15613488) RGD PMID:15613488 MGI:3527292 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO MGI:1097161 (MGI:3527292|PMID:15613488) RGD PMID:15613488 MGI:3527292 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in ISO (PMID:17024184) RGD PMID:17024184 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO (PMID:21183955) RGD PMID:21183955 NCBI chr  X:151,397,567...151,429,666
Ensembl chr  X:151,397,576...151,428,506 		JBrowse link
G Fis1 fission, mitochondrial 1 involved_in ISO (PMID:21183955) RGD PMID:21183955 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 involved_in ISO (PMID:24349085) RGD PMID:24349085 NCBI chr 2:227,500,366...227,645,243
Ensembl chr 2:227,500,367...227,645,169 		JBrowse link
G Tgm2 transglutaminase 2 involved_in ISO (PMID:24349085)
(MGI:5574435|PMID:24349085)		 RGD PMID:24349085 MGI:5574435 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Thada THADA, armadillo repeat containing involved_in ISO (PMID:28399403) RGD PMID:28399403 NCBI chr 6:10,183,942...10,488,007
Ensembl chr 6:10,183,982...10,487,159 		JBrowse link
positive regulation of endoplasmic reticulum calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO (PMID:11402072) RGD PMID:11402072 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within
involved_in		 ISO (MGI:6270315|PMID:30188326)
(PMID:16402920)		 RGD PMID:16402920 PMID:30188326 MGI:6270315 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Tmtc4 transmembrane O-mannosyltransferase targeting cadherins 4 acts_upstream_of_or_within ISO MGI:5008116 (MGI:6270315|PMID:30188326) RGD PMID:30188326 MGI:6270315 NCBI chr15:100,000,157...100,056,573
Ensembl chr15:100,000,152...100,056,543 		JBrowse link
smooth endoplasmic reticulum calcium ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein acts_upstream_of_or_within ISO MGI:1202717 (MGI:2449878|PMID:12431992) RGD PMID:12431992 MGI:2449878 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:88059 (MGI:2449878|PMID:12431992)		 RGD PMID:12431992 PMID:21873635 MGI:2449878, RGD:13792537 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19748
    homeostatic process 1915
      chemical homeostasis 1172
        inorganic ion homeostasis 579
          calcium ion homeostasis 361
            intracellular calcium ion homeostasis 334
              endoplasmic reticulum calcium ion homeostasis 28
                negative regulation of endoplasmic reticulum calcium ion concentration + 9
                positive regulation of endoplasmic reticulum calcium ion concentration + 3
                smooth endoplasmic reticulum calcium ion homeostasis + 2
Path 2
Term Annotations click to browse term
  biological_process 19748
    homeostatic process 1915
      chemical homeostasis 1172
        monoatomic ion homeostasis 656
          intracellular monoatomic ion homeostasis 577
            intracellular monoatomic cation homeostasis 566
              intracellular calcium ion homeostasis 334
                endoplasmic reticulum calcium ion homeostasis 28
                  negative regulation of endoplasmic reticulum calcium ion concentration + 9
                  positive regulation of endoplasmic reticulum calcium ion concentration + 3
                  smooth endoplasmic reticulum calcium ion homeostasis + 2
paths to the root