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ONTOLOGY REPORT - ANNOTATIONS

Term:purine-rich negative regulatory element binding
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Accession:GO:0032422 term browser browse the term
Definition:Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.
Synonyms:broad_synonym: PNR element binding


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purine-rich negative regulatory element binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elk3 ETS transcription factor ELK3 enables ISO (PMID:12933792) RGD PMID:12933792 NCBI chr 7:27,768,582...27,831,088
Ensembl chr 7:27,768,599...27,804,084 		JBrowse link
G Pura purine rich element binding protein A enables ISO
IEA		 (MGI:3688338|PMID:12933792)
GO_REF:0000002
(PMID:12933792)		 RGD
InterPro		 PMID:12933792 GO_REF:0000002 MGI:3688338 NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513 		JBrowse link
G Purb purine rich element binding protein B enables IDA
IEA
IBA		 PMID:12933792
GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 PMID:12933792 GO_REF:0000002 GO_REF:0000033, RGD:1581942 NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432 		JBrowse link
G Purg purine-rich element binding protein G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:58,732,327...58,763,356
Ensembl chr16:58,720,335...58,763,359 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20732
    binding 17791
      organic cyclic compound binding 6221
        nucleic acid binding 3870
          transcription regulatory region nucleic acid binding 1302
            transcription cis-regulatory region binding 1297
              purine-rich negative regulatory element binding 4
Path 2
Term Annotations click to browse term
  molecular_function 20732
    binding 17791
      organic cyclic compound binding 6221
        nucleic acid binding 3870
          DNA binding 2302
            double-stranded DNA binding 1456
              sequence-specific double-stranded DNA binding 1361
                transcription cis-regulatory region binding 1297
                  purine-rich negative regulatory element binding 4
paths to the root