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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular cholesterol transport
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Accession:GO:0032367 term browser browse the term
Definition:The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.


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intracellular cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 involved_in ISO (PMID:10431236) BHF-UCL PMID:10431236 NCBI chr11:60,761,669...60,869,753
Ensembl chr11:60,761,655...60,890,496 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:15994327) BHF-UCL PMID:15994327 NCBI chr31:36,574,406...36,627,598
Ensembl chr31:36,553,380...36,620,043 		JBrowse link
G NPC1 NPC intracellular cholesterol transporter 1 involved_in ISO (PMID:27238017), (PMID:28784760), (PMID:9211849) UniProt PMID:9211849 PMID:27238017 PMID:28784760 NCBI chr 7:64,764,941...64,802,507
Ensembl chr 7:64,760,121...64,802,902 		JBrowse link
G NPC2 NPC intracellular cholesterol transporter 2 involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA		 (PMID:19723497)
(PMID:21873635)		 UniProt
MGI
GO_Central		 PMID:19723497 PMID:21873635 GO_REF:0000024 NCBI chr 8:47,641,185...47,650,543
Ensembl chr 8:47,628,077...47,650,576 		JBrowse link
G OSBP oxysterol binding protein involved_in ISO (PMID:29514919) UniProt PMID:29514919 NCBI chr18:37,159,511...37,191,720
Ensembl chr18:37,159,576...37,189,731 		JBrowse link
G RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:14,573,377...14,683,795
Ensembl chr 1:14,579,381...14,683,555 		JBrowse link
G SCP2 sterol carrier protein 2 involved_in ISO (PMID:7642518) UniProt PMID:7642518 NCBI chr 5:55,860,053...55,971,657
Ensembl chr 5:55,860,549...55,964,014 		JBrowse link
G SERAC1 serine active site containing 1 involved_in ISO (PMID:22683713) UniProt PMID:22683713 NCBI chr 1:47,599,802...47,651,034
Ensembl chr 1:47,578,472...47,669,494 		JBrowse link
G STAR steroidogenic acute regulatory protein ISO RGD PMID:14617579 RGD:4145640 NCBI chr16:27,326,355...27,331,025
Ensembl chr16:27,326,355...27,331,025 		JBrowse link
G STARD4 StAR related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) BHF-UCL PMID:18403318 NCBI chr 3:1,154,358...1,171,248
Ensembl chr 3:1,154,358...1,170,469 		JBrowse link
G TSPO2 translocator protein 2 involved_in IMP (PMID:32358067) UniProt PMID:32358067 NCBI chr12:9,796,421...9,799,181
Ensembl chr12:9,795,739...9,799,178 		JBrowse link
G VPS4A vacuolar protein sorting 4 homolog A involved_in ISO (PMID:10637304) UniProt PMID:10637304 NCBI chr 5:80,327,059...80,340,380 JBrowse link
endosome to lysosome transport of low-density lipoprotein particle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL8B ADP ribosylation factor like GTPase 8B involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:12,479,680...12,525,330
Ensembl chr20:12,481,860...12,525,499 		JBrowse link
G TPCN2 two pore segment channel 2 involved_in ISO (MGI:5691857|PMID:25144390) UniProt PMID:25144390 MGI:5691857 NCBI chr18:48,956,833...48,984,499
Ensembl chr18:48,957,249...48,984,564 		JBrowse link
negative regulation of intracellular cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 5:54,197,211...54,210,724 JBrowse link
positive regulation of intracellular cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCP2 sterol carrier protein 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:55,860,053...55,971,657
Ensembl chr 5:55,860,549...55,964,014 		JBrowse link
positive regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA2 annexin A2 involved_in ISO (PMID:22848640)
(MGI:5446858|PMID:22848640)		 BHF-UCL PMID:22848640 MGI:5446858 NCBI chr30:25,176,845...25,210,244
Ensembl chr30:25,115,842...25,218,281 		JBrowse link
G LDLRAP1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:12417523), (PMID:12464675), (PMID:15166224) BHF-UCL PMID:12417523 PMID:12464675 PMID:15166224 NCBI chr 2:74,340,272...74,363,929
Ensembl chr 2:74,341,036...74,364,162 		JBrowse link
receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LDLR low density lipoprotein receptor involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:50,115,175...50,152,443
Ensembl chr20:50,048,736...50,152,355 		JBrowse link
G LDLRAP1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:12417523), (PMID:12464675), (PMID:15166224) BHF-UCL PMID:12417523 PMID:12464675 PMID:15166224 NCBI chr 2:74,340,272...74,363,929
Ensembl chr 2:74,341,036...74,364,162 		JBrowse link
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (MGI:4413421|PMID:18948618)
(PMID:21873635)		 MGI
GO_Central		 PMID:18948618 PMID:21873635 MGI:4413421 NCBI chr27:34,003,334...34,166,334
Ensembl chr27:34,003,539...34,161,437 		JBrowse link
regulation of intracellular cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 involved_in ISO (PMID:15238223)
(MGI:6478054|PMID:22748276)		 UniProt PMID:15238223 PMID:22748276 MGI:6478054 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
G ARV1 ARV1 homolog, fatty acid homeostasis modulator involved_in ISO (PMID:20663892) UniProt PMID:20663892 NCBI chr 4:8,409,039...8,424,776
Ensembl chr 4:8,409,484...8,424,644 		JBrowse link
G NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19723497)
(MGI:4358633|PMID:19723497)		 Ensembl
MGI		 PMID:19723497 GO_REF:0000107 MGI:4358633 NCBI chr 1:57,866,760...57,895,505
Ensembl chr 1:57,866,879...57,893,077 		JBrowse link
vesicle-mediated cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:10,464,019...10,642,365
Ensembl chr 2:10,463,010...10,640,327 		JBrowse link
G SYT7 synaptotagmin 7 involved_in ISO (MGI:5645834|PMID:25860611) UniProt PMID:25860611 MGI:5645834 NCBI chr18:54,863,072...54,926,121
Ensembl chr18:54,861,754...54,921,367 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13969
    localization 5461
      cellular localization 2657
        intracellular transport 1332
          intracellular lipid transport 34
            intracellular sterol transport 24
              intracellular cholesterol transport 24
                negative regulation of intracellular cholesterol transport + 2
                positive regulation of intracellular cholesterol transport + 3
                receptor-mediated endocytosis involved in cholesterol transport + 6
                regulation of intracellular cholesterol transport + 7
                vesicle-mediated cholesterol transport + 4
Path 2
Term Annotations click to browse term
  biological_process 13969
    localization 5461
      establishment of localization 3975
        transport 3816
          organic substance transport 2013
            lipid transport 343
              sterol transport 105
                cholesterol transport 97
                  intracellular cholesterol transport 24
                    negative regulation of intracellular cholesterol transport + 2
                    positive regulation of intracellular cholesterol transport + 3
                    receptor-mediated endocytosis involved in cholesterol transport + 6
                    regulation of intracellular cholesterol transport + 7
                    vesicle-mediated cholesterol transport + 4
paths to the root