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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular cholesterol transport
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Accession:GO:0032367 term browser browse the term
Definition:The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.

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intracellular cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 involved_in ISO (PMID:10431236) BHF-UCL PMID:10431236 NCBI chrNW_004955419:21,553,863...21,681,626
Ensembl chrNW_004955419:21,553,835...21,681,619 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:15994327) BHF-UCL PMID:15994327 NCBI chrNW_004955407:39,410,262...39,459,383
Ensembl chrNW_004955407:39,410,262...39,459,383 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 involved_in ISO (PMID:27238017), (PMID:28784760), (PMID:9211849) UniProt PMID:9211849 PMID:27238017 PMID:28784760 NCBI chrNW_004955402:11,699,434...11,742,899
Ensembl chrNW_004955402:11,699,434...11,742,899 		JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:15937921), (PMID:27238017)
(PMID:19723497)
(MGI:3763329|PMID:17018531)
(PMID:17018531), (PMID:18823126)		 UniProt
MGI
HGNC-UCL		 PMID:15937921 PMID:17018531 PMID:18823126 PMID:19723497 PMID:27238017 MGI:3763329 NCBI chrNW_004955523:1,010,976...1,021,048
Ensembl chrNW_004955523:1,010,976...1,021,144 		JBrowse link
G Osbp oxysterol binding protein involved_in ISO (PMID:29514919) UniProt PMID:29514919 NCBI chrNW_004955511:4,057,514...4,076,039
Ensembl chrNW_004955511:4,057,514...4,076,046 		JBrowse link
G Relch RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing involved_in ISO (PMID:29514919) UniProt PMID:29514919 NCBI chrNW_004955402:46,114,835...46,226,330
Ensembl chrNW_004955402:46,115,066...46,224,752 		JBrowse link
G Scp2 sterol carrier protein 2 involved_in ISO (PMID:7642518) UniProt PMID:7642518 NCBI chrNW_004955464:6,097,241...6,224,287
Ensembl chrNW_004955464:6,094,758...6,224,287 		JBrowse link
G Serac1 serine active site containing 1 involved_in ISO (PMID:22683713) UniProt PMID:22683713 NCBI chrNW_004955439:4,234,440...4,291,947
Ensembl chrNW_004955439:4,234,382...4,291,941 		JBrowse link
G Star steroidogenic acute regulatory protein ISO RGD PMID:14617579 RGD:4145640 NCBI chrNW_004955463:13,760,089...13,765,245
Ensembl chrNW_004955463:13,760,089...13,765,244 		JBrowse link
G Stard4 StAR related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) BHF-UCL PMID:18403318 NCBI chrNW_004955418:3,637,390...3,652,054
Ensembl chrNW_004955418:3,638,399...3,648,402 		JBrowse link
G Tspo2 translocator protein 2 involved_in ISO (PMID:32358067)
(MGI:6450299|PMID:32358067)		 UniProt PMID:32358067 MGI:6450299 NCBI chrNW_004955437:7,714,107...7,715,796
Ensembl chrNW_004955437:7,714,107...7,715,796 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISO (PMID:10637304) UniProt PMID:10637304 NCBI chrNW_004955484:7,368,938...7,375,964 JBrowse link
endosome to lysosome transport of low-density lipoprotein particle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl8b ADP ribosylation factor like GTPase 8B involved_in ISO (PMID:21802320) UniProt PMID:21802320 NCBI chrNW_004955421:8,231,337...8,276,907
Ensembl chrNW_004955421:8,231,582...8,276,907 		JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO (MGI:5691857|PMID:25144390) UniProt PMID:25144390 MGI:5691857 NCBI chrNW_004955422:16,899,730...16,923,962 JBrowse link
negative regulation of intracellular cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200 		JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chrNW_004955464:4,424,583...4,439,805
Ensembl chrNW_004955464:4,425,435...4,439,842 		JBrowse link
positive regulation of intracellular cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scp2 sterol carrier protein 2 involved_in ISO (PMID:15449949) UniProt PMID:15449949 NCBI chrNW_004955464:6,097,241...6,224,287
Ensembl chrNW_004955464:6,094,758...6,224,287 		JBrowse link
positive regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:22848640)
(MGI:5446858|PMID:22848640)		 BHF-UCL PMID:22848640 MGI:5446858 NCBI chrNW_004955450:14,545,586...14,574,161
Ensembl chrNW_004955450:14,512,381...14,574,696 		JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:12417523), (PMID:12464675), (PMID:15166224) BHF-UCL PMID:12417523 PMID:12464675 PMID:15166224 NCBI chrNW_004955452:5,081,919...5,102,349
Ensembl chrNW_004955452:5,081,556...5,095,182 		JBrowse link
receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldlr low density lipoprotein receptor involved_in ISO (PMID:6299582) BHF-UCL PMID:6299582 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056 		JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:12417523), (PMID:12464675), (PMID:15166224) BHF-UCL PMID:12417523 PMID:12464675 PMID:15166224 NCBI chrNW_004955452:5,081,919...5,102,349
Ensembl chrNW_004955452:5,081,556...5,095,182 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (MGI:4413421|PMID:18948618) MGI PMID:18948618 MGI:4413421 NCBI chrNW_004955413:9,080,901...9,237,644
Ensembl chrNW_004955413:9,080,914...9,237,650 		JBrowse link
regulation of intracellular cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO (PMID:15238223)
(MGI:6478054|PMID:22748276)		 UniProt PMID:15238223 PMID:22748276 MGI:6478054 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200 		JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator involved_in ISO (PMID:20663892) UniProt PMID:20663892 NCBI chrNW_004955492:7,669,956...7,683,293
Ensembl chrNW_004955492:7,672,746...7,683,728 		JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit acts_upstream_of_or_within ISO (MGI:4358633|PMID:19723497)
(PMID:19723497)		 MGI PMID:19723497 MGI:4358633 NCBI chrNW_004955436:825,387...850,558
Ensembl chrNW_004955436:825,387...850,558 		JBrowse link
vesicle-mediated cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in ISO (PMID:29353240) UniProt PMID:29353240 NCBI chrNW_004955429:6,231,135...6,399,672
Ensembl chrNW_004955429:6,336,355...6,399,672 		JBrowse link
G Syt7 synaptotagmin 7 involved_in ISO (MGI:5645834|PMID:25860611) UniProt PMID:25860611 MGI:5645834 NCBI chrNW_004955511:6,051,392...6,093,651
Ensembl chrNW_004955511:6,051,386...6,093,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12096
    localization 4894
      cellular localization 2422
        intracellular transport 1148
          intracellular lipid transport 32
            intracellular sterol transport 24
              intracellular cholesterol transport 24
                negative regulation of intracellular cholesterol transport + 2
                positive regulation of intracellular cholesterol transport + 3
                receptor-mediated endocytosis involved in cholesterol transport + 6
                regulation of intracellular cholesterol transport + 7
                vesicle-mediated cholesterol transport + 4
Path 2
Term Annotations click to browse term
  biological_process 12096
    localization 4894
      establishment of localization 3490
        transport 3332
          organic substance transport 1681
            lipid transport 288
              sterol transport 94
                cholesterol transport 93
                  intracellular cholesterol transport 24
                    negative regulation of intracellular cholesterol transport + 2
                    positive regulation of intracellular cholesterol transport + 3
                    receptor-mediated endocytosis involved in cholesterol transport + 6
                    regulation of intracellular cholesterol transport + 7
                    vesicle-mediated cholesterol transport + 4
paths to the root