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ONTOLOGY REPORT - ANNOTATIONS


Term:aldosterone metabolic process
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Accession:GO:0032341 term browser browse the term
Definition:The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.
Synonyms:exact_synonym: aldosterone metabolism


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aldosterone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scnn1b sodium channel epithelial 1 subunit beta involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:6478095|PMID:28567665)
Ensembl
RGD
PMID:28567665 GO_REF:0000107 MGI:6478095 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IMP
IEA
ISO
PMID:19342457
GO_REF:0000107
(PMID:19342457)
Ensembl
RGD
PMID:19342457, PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IMP
IBA
PMID:19342457
PMID:21873635
UniProt
GO_Central
PMID:19342457, PMID:21873635 RGD:4891166, RGD:13792537 NCBI chr 7:116,195,976...116,201,829 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IDA
ISO
IBA
(PMID:19342457), (PMID:2256920)
PMID:21873635
RGD PMID:2256920 PMID:19342457, PMID:11832364, PMID:21873635 RGD:727991, RGD:13792537 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 involved_in ISO (PMID:1741400), (PMID:19342457), (PMID:2256920), (PMID:23322723) RGD PMID:1741400 PMID:2256920 PMID:19342457 PMID:23322723 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:19584291)
Ensembl
RGD
PMID:19584291 GO_REF:0000107 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IEA
IMP
(PMID:19342457)
GO_REF:0000107
RGD
Ensembl
PMID:19342457, PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:16527843) RGD PMID:16527843 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Dab2 DAB adaptor protein 2 IDA RGD PMID:17303656 RGD:7243836 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO
IEA
(PMID:16981135)
GO_REF:0000107
RGD
Ensembl
PMID:16981135 GO_REF:0000107 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO
ISS
(PMID:29403011)
GO_REF:0000024
RGD
UniProt
PMID:29403011 GO_REF:0000024 NCBI chr11:82,862,664...82,876,165
Ensembl chr11:83,883,879...83,897,394
JBrowse link
regulation of aldosterone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 acts_upstream_of_or_within ISO MGI:3050114 (MGI:3693138|PMID:17122062) RGD PMID:17122062 MGI:3693138 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11881
      cellular metabolic process 10838
        cellular aldehyde metabolic process 66
          aldosterone metabolic process 14
            aldosterone biosynthetic process + 12
            aldosterone catabolic process 0
            negative regulation of aldosterone metabolic process + 4
            positive regulation of aldosterone metabolic process + 3
            regulation of aldosterone metabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 19612
    biological regulation 13584
      regulation of biological quality 4255
        regulation of hormone levels 607
          hormone metabolic process 233
            cellular hormone metabolic process 143
              C21-steroid hormone metabolic process 44
                aldosterone metabolic process 14
                  aldosterone biosynthetic process + 12
                  aldosterone catabolic process 0
                  negative regulation of aldosterone metabolic process + 4
                  positive regulation of aldosterone metabolic process + 3
                  regulation of aldosterone metabolic process + 9
paths to the root