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ONTOLOGY REPORT - ANNOTATIONS


Term:molybdopterin cofactor biosynthetic process
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Accession:GO:0032324 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
Synonyms:exact_synonym: molybdopterin cofactor anabolism;   molybdopterin cofactor synthesis
 related_synonym: molybdopterin cofactor biosynthesis;   molybdopterin cofactor formation
 xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis



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molybdopterin cofactor biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gphn gephyrin involved_in ISO (PMID:26613940), (PMID:9990024)
MGI:2182559 (MGI:2451208|PMID:12565882), (MGI:7493899|PMID:18411266)
RGD PMID:9990024 PMID:12565882 PMID:18411266 PMID:26613940 MGI:2451208 MGI:7493899 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
JBrowse link
G Mocos molybdenum cofactor sulfurase involved_in ISO (MGI:7490422|PMID:35372998) RGD PMID:35372998 MGI:7490422 NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
JBrowse link
G Mocs1 molybdenum cofactor synthesis 1 acts_upstream_of_or_within
involved_in
ISO MGI:2659140 (MGI:2447229|PMID:12471057), (MGI:3576970|PMID:15862276), (MGI:3757917|PMID:17236133)
(MGI:3757917|PMID:17236133)
RGD PMID:12471057 PMID:15862276 PMID:17236133 MGI:2447229 MGI:3576970 MGI:3757917 NCBI chr 9:11,547,533...11,573,935
Ensembl chr 9:11,547,531...11,567,790
JBrowse link
G Mocs2 molybdenum cofactor synthesis 2 involved_in ISO MGI:4881158 (MGI:5904641|PMID:27138983) RGD PMID:27138983 MGI:5904641 NCBI chr 2:46,504,588...46,516,327
Ensembl chr 2:46,504,588...46,516,324
JBrowse link
Mo-molybdopterin cofactor biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gphn gephyrin involved_in
acts_upstream_of_or_within
IEA
IBA
IDA
ISO
GO_REF:0000104
GO_REF:0000033
PMID:23163752
MGI:2182559 (MGI:2182545|PMID:9812897)
UniProt
GO_Central
RGD
PMID:9812897 PMID:23163752 GO_REF:0000033 GO_REF:0000104 MGI:2182545, RGD:8554131 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
JBrowse link
G Mocos molybdenum cofactor sulfurase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
JBrowse link
G Mocs1 molybdenum cofactor synthesis 1 involved_in ISO
IBA
(PMID:15180982)
GO_REF:0000033
(PMID:16021469), (PMID:9731530), (PMID:9921896)
RGD
GO_Central
PMID:9731530 PMID:9921896 PMID:15180982 PMID:16021469 GO_REF:0000033 NCBI chr 9:11,547,533...11,573,935
Ensembl chr 9:11,547,531...11,567,790
JBrowse link
G Mocs2 molybdenum cofactor synthesis 2 involved_in ISO
ISS
(PMID:10053004), (PMID:12732628), (PMID:15073332), (PMID:16021469)
GO_REF:0000024
RGD
UniProt
PMID:10053004 PMID:12732628 PMID:15073332 PMID:16021469 GO_REF:0000024 NCBI chr 2:46,504,588...46,516,327
Ensembl chr 2:46,504,588...46,516,324
JBrowse link
G Mocs3 molybdenum cofactor synthesis 3 involved_in ISO (PMID:15073332), (PMID:30817134) RGD PMID:15073332 PMID:30817134 NCBI chr 3:156,939,763...156,941,723
Ensembl chr 3:156,939,809...156,941,890
JBrowse link
G Nfs1 NFS1 cysteine desulfurase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:144,637,309...144,659,660
Ensembl chr 3:144,637,309...144,659,666
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20325
    metabolic process 11737
      prosthetic group metabolic process 6
        molybdopterin cofactor metabolic process 6
          molybdopterin cofactor biosynthetic process 6
            Mo-molybdopterin cofactor biosynthetic process + 6
            W-molybdopterin cofactor biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 20325
    metabolic process 11737
      organic substance metabolic process 11231
        organonitrogen compound metabolic process 5810
          protein metabolic process 4706
            prosthetic group metabolic process 6
              molybdopterin cofactor metabolic process 6
                molybdopterin cofactor biosynthetic process 6
                  Mo-molybdopterin cofactor biosynthetic process + 6
                  W-molybdopterin cofactor biosynthetic process 0
paths to the root