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ONTOLOGY REPORT - ANNOTATIONS


Term:molybdopterin cofactor biosynthetic process
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Accession:GO:0032324 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
Synonyms:exact_synonym: molybdopterin cofactor anabolism;   molybdopterin cofactor synthesis
 related_synonym: molybdopterin cofactor biosynthesis;   molybdopterin cofactor formation
 xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis


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molybdopterin cofactor biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPHN gephyrin involved_in IEA
IDA
IBA
IMP
(PMID:26613940)
(PMID:21873635)
(PMID:9990024)
UniProt
GO_Central
CAFA
PMID:9990024 PMID:21873635 PMID:26613940 GO_REF:0000104 NCBI chr14:66,507,934...67,181,805
Ensembl chr14:66,507,407...67,181,803
JBrowse link
G MOCOS molybdenum cofactor sulfurase involved_in TAS Reactome Reactome:R-HSA-947581 NCBI chr18:36,187,497...36,272,157
Ensembl chr18:36,187,497...36,272,157
JBrowse link
G MOCS1 molybdenum cofactor synthesis 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2447229|PMID:12471057), (MGI:3576970|PMID:15862276), (MGI:3757917|PMID:17236133) MGI
Ensembl
PMID:12471057 PMID:15862276 PMID:17236133 GO_REF:0000107 MGI:2447229 MGI:3576970 MGI:3757917 NCBI chr 6:39,904,170...39,934,462
Ensembl chr 6:39,899,578...39,934,551
JBrowse link
G MOCS2 molybdenum cofactor synthesis 2 involved_in TAS Reactome Reactome:R-HSA-947581 NCBI chr 5:53,095,679...53,109,757
Ensembl chr 5:53,095,679...53,110,063
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18536
    metabolic process 11863
      prosthetic group metabolic process 6
        molybdopterin cofactor metabolic process 6
          molybdopterin cofactor biosynthetic process 4
Path 2
Term Annotations click to browse term
  biological_process 18536
    metabolic process 11863
      organic substance metabolic process 11369
        macromolecule metabolic process 9816
          cellular macromolecule metabolic process 8299
            cellular protein metabolic process 5022
              prosthetic group metabolic process 6
                molybdopterin cofactor metabolic process 6
                  molybdopterin cofactor biosynthetic process 4
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