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ONTOLOGY REPORT - ANNOTATIONS


Term:icosanoid secretion
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Accession:GO:0032309 term browser browse the term
Definition:The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue.
Synonyms:exact_synonym: eicosanoid secretion



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arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,639
JBrowse link
G ANXA1 annexin A1 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:2661244|PMID:12553880)
GO_Central
Ensembl
GO_Central
MGI
PMID:12553880 PMID:21873635 GO_REF:0000107 MGI:2661244 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,307...226,432,287
JBrowse link
G BDKRB2 bradykinin receptor B2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:117,438,622...117,472,005
Ensembl chr 7:117,438,543...117,472,003
JBrowse link
G DRD2 dopamine receptor D2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G DRD3 dopamine receptor D3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,510...145,819,173
JBrowse link
G DRD4 dopamine receptor D4 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 2:398,766...401,539
Ensembl chr 2:398,766...401,432
JBrowse link
G KISS1R KISS1 receptor ISO RGD PMID:11457843 RGD:1357971 NCBI chr 2:77,472,361...77,479,204
Ensembl chr 2:77,472,362...77,479,204
JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor ISO RGD PMID:9291830 RGD:1600299 NCBI chr 3:91,964,415...92,023,821 JBrowse link
G LOC110259864 group 10 secretory phospholipase A2-like involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 3:7,623,326...7,641,061
Ensembl chr 3:7,623,311...7,641,082
JBrowse link
G NMB neuromedin B ISO stimulates RGD PMID:8532598 RGD:1642335 NCBI chr 7:52,880,817...52,886,651 JBrowse link
G NMUR2 neuromedin U receptor 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr16:70,659,732...70,672,346
Ensembl chr16:70,659,521...70,676,316
JBrowse link
G OC90 otoconin 90 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 4:9,028,483...9,054,503 JBrowse link
G PLA2G12A phospholipase A2 group XIIA involved_in IEA InterPro GO_REF:0000002 NCBI chr 8:112,483,322...112,512,520 JBrowse link
G PLA2G12B phospholipase A2 group XIIB involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr14:75,754,525...75,778,933
Ensembl chr14:75,753,714...75,778,802
JBrowse link
G PLA2G1B phospholipase A2 group IB involved_in
NOT|involved_in
IEA
IDA
(PMID:15528384) InterPro
InterPro
BHF-UCL
BHF-UCL
PMID:15528384 GO_REF:0000002 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319
JBrowse link
G PLA2G2A phospholipase A2 group IIA involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 6:78,327,728...78,339,546
Ensembl chr 6:78,327,319...78,330,699
JBrowse link
G PLA2G2D phospholipase A2 group IID involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 6:78,391,063...78,397,394
Ensembl chr 6:78,391,062...78,397,514
JBrowse link
G PLA2G2E phospholipase A2 group IIE involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 6:78,278,080...78,282,253
Ensembl chr 6:78,278,990...78,282,259
JBrowse link
G PLA2G2F phospholipase A2 group IIF involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 6:78,413,459...78,423,311
Ensembl chr 6:78,413,284...78,423,309
JBrowse link
G PLA2G3 phospholipase A2 group III involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr14:47,923,005...47,928,762
Ensembl chr14:47,923,787...47,928,810
JBrowse link
G PLA2G4A phospholipase A2 group IVA acts_upstream_of_or_within
involved_in
ISO (MGI:3709446|PMID:17293613)
(MGI:5297793|PMID:10946309)
MGI
UniProt
PMID:10946309 PMID:17293613 MGI:3709446 MGI:5297793 NCBI chr 9:127,853,581...128,164,825
Ensembl chr 9:127,859,051...128,162,636
JBrowse link
G PLA2G4F phospholipase A2 group IVF involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3709446|PMID:17293613) Ensembl
Ensembl
MGI
PMID:17293613 GO_REF:0000107 MGI:3709446 NCBI chr 1:129,200,568...129,218,417
Ensembl chr 1:129,201,069...129,217,008
JBrowse link
G PLA2G5 phospholipase A2 group V involved_in IBA
IEA
ISO
(PMID:21873635) GO_Central
GO_Central
InterPro
RGD
InterPro
PMID:11106649 PMID:21873635 GO_REF:0000002 RGD:2303037 NCBI chr 6:78,365,697...78,376,383
Ensembl chr 6:78,365,700...78,406,457
JBrowse link
G PNPLA8 patatin like phospholipase domain containing 8 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:108,271,343...108,320,574
Ensembl chr 9:108,255,083...108,320,264
JBrowse link
G PROCA1 protein interacting with cyclin A1 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr12:44,942,146...44,950,899
Ensembl chr12:44,942,147...44,949,129
JBrowse link
negative regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5PF ATP synthase peripheral stalk subunit F6 ISO RGD PMID:9822642 RGD:13800919 NCBI chr13:189,281,429...189,290,234
Ensembl chr13:189,278,945...189,290,229
JBrowse link
G HRH2 histamine receptor H2 ISO RGD PMID:1313563 RGD:9685527 NCBI chr 2:81,883,670...81,932,464
Ensembl chr 2:81,883,670...81,932,275
JBrowse link
G PLA2R1 phospholipase A2 receptor 1 involved_in ISO (MGI:5297792|PMID:11830583) UniProt PMID:11830583 MGI:5297792 NCBI chr15:66,899,783...67,018,608
Ensembl chr15:66,898,508...67,001,163
JBrowse link
negative regulation of icosanoid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:18799632 RGD:2313549 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388
JBrowse link
G CYP4F52 cytochrome P450 family 4 subfamily F member 52 involved_in ISO (PMID:18391101) UniProt PMID:18391101 NCBI chr 2:61,745,069...61,759,971 JBrowse link
negative regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL4 acyl-CoA synthetase long chain family member 4 involved_in ISO (PMID:21242590) UniProt PMID:21242590 NCBI chr  X:89,760,863...89,838,103
Ensembl chr  X:89,760,865...89,837,678
JBrowse link
G ATP5PF ATP synthase peripheral stalk subunit F6 ISO RGD PMID:11581303 PMID:19474762 RGD:13800898 RGD:13800911 NCBI chr13:189,281,429...189,290,234
Ensembl chr13:189,278,945...189,290,229
JBrowse link
positive regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVPR1B vasopressin receptor 1B involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:66,769,472...66,776,916
Ensembl chr 9:66,772,591...66,776,931
JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:11130725 RGD:151708734 NCBI chr17:61,622,865...61,627,278
Ensembl chr17:61,622,703...61,627,633
JBrowse link
G LOC110259864 group 10 secretory phospholipase A2-like involved_in ISO (MGI:5051938|PMID:20844270) BHF-UCL PMID:20844270 MGI:5051938 NCBI chr 3:7,623,326...7,641,061
Ensembl chr 3:7,623,311...7,641,082
JBrowse link
G MIF macrophage migration inhibitory factor involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,862,317
JBrowse link
G NTSR1 neurotensin receptor 1 ISO RGD PMID:11852105 RGD:9743869 NCBI chr17:61,989,601...62,038,299
Ensembl chr17:61,989,112...62,035,345
JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:15576376 PMID:20732873 RGD:6482749 RGD:6482753 NCBI chr 5:9,713,809...9,777,921
Ensembl chr 5:9,685,214...9,777,922
JBrowse link
G PLA2R1 phospholipase A2 receptor 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr15:66,899,783...67,018,608
Ensembl chr15:66,898,508...67,001,163
JBrowse link
positive regulation of fever generation by positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFRSF11A TNF receptor superfamily member 11a involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:159,128,039...159,187,476
Ensembl chr 1:159,128,038...159,187,481
JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr11:24,468,011...24,505,421
Ensembl chr11:24,466,586...24,505,422
JBrowse link
positive regulation of icosanoid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP4F52 cytochrome P450 family 4 subfamily F member 52 involved_in ISO (PMID:17341693) UniProt PMID:17341693 NCBI chr 2:61,745,069...61,759,971 JBrowse link
positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 ISO RGD PMID:1324048 RGD:8662308 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G IL1A interleukin 1 alpha ISO RGD PMID:8612624 RGD:7800677 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G LOC110258578 interleukin-1 beta-like involved_in ISO (MGI:4413614|PMID:19940926) BHF-UCL PMID:19940926 MGI:4413614
G LOC110259864 group 10 secretory phospholipase A2-like involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 3:7,623,326...7,641,061
Ensembl chr 3:7,623,311...7,641,082
JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 ISO RGD PMID:12649265 RGD:7495834 NCBI chr12:10,891,445...11,018,617
Ensembl chr12:10,894,932...11,018,641
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 ISO RGD PMID:9786861 RGD:2304243 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G OXT oxytocin/neurophysin I prepropeptide ISO RGD PMID:9575824 RGD:2304227 NCBI chr17:32,605,586...32,606,449
Ensembl chr17:32,605,588...32,606,483
JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3616954|PMID:16269410) Ensembl
Ensembl
MGI
PMID:16269410 GO_REF:0000107 MGI:3616954 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,192...31,476,472
JBrowse link
G P2RY2 purinergic receptor P2Y2 ISO RGD PMID:15840771 RGD:2316683 NCBI chr 9:7,672,294...7,695,085
Ensembl chr 9:7,672,401...7,695,163
JBrowse link
G PLA2G3 phospholipase A2 group III involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:6108995|PMID:28947740) Ensembl
Ensembl
MGI
PMID:28947740 GO_REF:0000107 MGI:6108995 NCBI chr14:47,923,005...47,928,762
Ensembl chr14:47,923,787...47,928,810
JBrowse link
G PLA2G4A phospholipase A2 group IVA acts_upstream_of_or_within ISO (MGI:5779244|PMID:26828067) MGI PMID:26828067 MGI:5779244 NCBI chr 9:127,853,581...128,164,825
Ensembl chr 9:127,859,051...128,162,636
JBrowse link
G PTGES prostaglandin E synthase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5779244|PMID:26828067) Ensembl
Ensembl
MGI
PMID:26828067 GO_REF:0000107 MGI:5779244 NCBI chr 1:269,911,785...269,924,481
Ensembl chr 1:269,911,789...269,924,462
JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 involved_in IMP (PMID:19790068) AgBase
AgBase
PMID:19790068 NCBI chr14:41,125,819...41,169,582
Ensembl chr14:41,125,869...41,169,582
JBrowse link
positive regulation of prostaglandin secretion involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIF macrophage migration inhibitory factor involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,862,317
JBrowse link
prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 acts_upstream_of_or_within ISO (PMID:25173977) MGI PMID:25173977 NCBI chr11:64,089,149...64,309,831 JBrowse link
G LEP leptin involved_in IEA
ISS
Ensembl
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
JBrowse link
G NOS2 nitric oxide synthase 2 involved_in IEA
ISS
Ensembl
Ensembl
UniProt
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of
involved_in
ISO
IEA
(MGI:3616954|PMID:16269410) MGI
Ensembl
PMID:16269410 GO_REF:0000107 MGI:3616954 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,192...31,476,472
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 acts_upstream_of_or_within ISO (MGI:6501918|PMID:32484881) MGI PMID:32484881 MGI:6501918 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYK spleen associated tyrosine kinase involved_in IEA
ISS
Ensembl
UniProt
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,712...2,161,172
JBrowse link
regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 involved_in IMP (PMID:18703674) AgBase
AgBase
PMID:18703674 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17268
    localization 5284
      establishment of localization 4649
        transport 4485
          secretion 1112
            icosanoid secretion 54
              arachidonic acid secretion + 34
              negative regulation of icosanoid secretion + 6
              positive regulation of icosanoid secretion + 22
              prostaglandin secretion + 23
              regulation of icosanoid secretion + 28
Path 2
Term Annotations click to browse term
  biological_process 17268
    localization 5284
      establishment of localization 4649
        transport 4485
          ion transport 1612
            anion transport 550
              organic anion transport 390
                carboxylic acid transport 312
                  icosanoid transport 63
                    icosanoid secretion 54
                      arachidonic acid secretion + 34
                      negative regulation of icosanoid secretion + 6
                      positive regulation of icosanoid secretion + 22
                      prostaglandin secretion + 23
                      regulation of icosanoid secretion + 28
paths to the root