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ONTOLOGY REPORT - ANNOTATIONS

Term:icosanoid secretion
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Accession:GO:0032309 term browser browse the term
Definition:The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue.
Synonyms:exact_synonym: eicosanoid secretion

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arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 acts_upstream_of_or_within ISO (MGI:2661244|PMID:12553880) MGI PMID:12553880 MGI:2661244 NCBI chrNW_004955512:5,686,508...5,703,645 JBrowse link
G Bdkrb2 bradykinin receptor B2 involved_in ISO (PMID:17077303) BHF-UCL PMID:17077303 NCBI chrNW_004955438:16,514,300...16,537,160
Ensembl chrNW_004955438:16,511,759...16,537,172 		JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO (PMID:8301582) BHF-UCL PMID:8301582 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573 		JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO (PMID:8301582) BHF-UCL PMID:8301582 NCBI chrNW_004955427:14,219,519...14,252,178
Ensembl chrNW_004955427:14,219,594...14,252,178 		JBrowse link
G Drd4 dopamine receptor D4 involved_in ISO (PMID:7512953) BHF-UCL PMID:7512953 NCBI chrNW_004955476:11,424,347...11,426,962
Ensembl chrNW_004955476:11,424,411...11,426,960 		JBrowse link
G Kiss1r KISS1 receptor ISO RGD PMID:11457843 RGD:1357971 NCBI chrNW_004955495:6,918,632...6,921,891 JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor ISO RGD PMID:9291830 RGD:1600299 NCBI chrNW_004955441:15,205,883...15,263,617 JBrowse link
G Nmb neuromedin B ISO stimulates RGD PMID:8532598 RGD:1642335 NCBI chrNW_004955416:14,467,648...14,470,645
Ensembl chrNW_004955416:14,467,650...14,470,515 		JBrowse link
G Nmur2 neuromedin U receptor 2 involved_in ISO (PMID:10887190) UniProt PMID:10887190 NCBI chrNW_004955408:6,862,243...6,872,805 JBrowse link
G Pla2g1b phospholipase A2 group IB NOT|involved_in ISO (PMID:15528384) BHF-UCL PMID:15528384 NCBI chrNW_004955455:11,308,848...11,316,245
Ensembl chrNW_004955455:11,308,643...11,316,254 		JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in
acts_upstream_of_or_within		 ISO (MGI:5297793|PMID:10946309)
(MGI:3709446|PMID:17293613)		 UniProt
MGI		 PMID:10946309 PMID:17293613 MGI:3709446 MGI:5297793 NCBI chrNW_004955406:25,257,361...25,392,079
Ensembl chrNW_004955406:25,257,355...25,394,206 		JBrowse link
G Pla2g4f phospholipase A2 group IVF acts_upstream_of_or_within ISO (MGI:3709446|PMID:17293613) MGI PMID:17293613 MGI:3709446 NCBI chrNW_004955416:8,876,560...8,889,764
Ensembl chrNW_004955416:8,873,356...8,889,940 		JBrowse link
G Pla2g5 phospholipase A2 group V involved_in ISO (MGI:5297792|PMID:11830583) RGD
UniProt		 PMID:11106649 PMID:11830583 MGI:5297792 RGD:2303037 NCBI chrNW_004955452:662,281...721,507
Ensembl chrNW_004955452:710,271...723,142 		JBrowse link
G Pnpla8 patatin like phospholipase domain containing 8 involved_in ISO (PMID:10833412), (PMID:15695510) UniProt PMID:10833412 PMID:15695510 NCBI chrNW_004955410:12,715,072...12,753,433
Ensembl chrNW_004955410:12,711,082...12,753,433 		JBrowse link
negative regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5pf ATP synthase peripheral stalk subunit F6 ISO RGD PMID:9822642 RGD:13800919 NCBI chrNW_004955407:25,601,253...25,609,933
Ensembl chrNW_004955407:25,601,083...25,609,888 		JBrowse link
G Hrh2 histamine receptor H2 ISO RGD PMID:1313563 RGD:9685527 NCBI chrNW_004955408:28,186,316...28,225,146
Ensembl chrNW_004955408:28,186,249...28,229,411 		JBrowse link
G Pla2r1 phospholipase A2 receptor 1 involved_in ISO (MGI:5297792|PMID:11830583) UniProt PMID:11830583 MGI:5297792 NCBI chrNW_004955449:13,542,458...13,653,907
Ensembl chrNW_004955449:13,542,458...13,653,901 		JBrowse link
negative regulation of icosanoid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:18799632 RGD:2313549 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
negative regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long chain family member 4 involved_in ISO (PMID:21242590) UniProt PMID:21242590 NCBI chrNW_004955490:6,143,833...6,228,395
Ensembl chrNW_004955490:6,143,833...6,228,452 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 ISO RGD PMID:11581303 PMID:19474762 RGD:13800898 RGD:13800911 NCBI chrNW_004955407:25,601,253...25,609,933
Ensembl chrNW_004955407:25,601,083...25,609,888 		JBrowse link
positive regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1b arginine vasopressin receptor 1B involved_in ISO (PMID:9322919) ARUK-UCL PMID:9322919 NCBI chrNW_004955406:41,706,088...41,716,173
Ensembl chrNW_004955406:41,705,305...41,716,173 		JBrowse link
G Hrh3 histamine receptor H3 ISO RGD PMID:11130725 RGD:151708734 NCBI chrNW_004955528:1,819,247...1,826,707
Ensembl chrNW_004955528:1,819,247...1,826,707 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (MGI:4437204|PMID:10364264) BHF-UCL PMID:10364264 MGI:4437204 NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460 		JBrowse link
G Ntsr1 neurotensin receptor 1 ISO RGD PMID:11852105 RGD:9743869 NCBI chrNW_004955528:1,348,616...1,394,798
Ensembl chrNW_004955528:1,348,555...1,394,868 		JBrowse link
G Pla2g10 phospholipase A2 group X involved_in ISO (MGI:5051938|PMID:20844270) BHF-UCL PMID:20844270 MGI:5051938 NCBI chrNW_004955442:4,208,497...4,225,893
Ensembl chrNW_004955442:4,208,575...4,225,834 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:15576376 PMID:20732873 RGD:6482749 RGD:6482753 NCBI chrNW_004955413:24,431,592...24,482,229
Ensembl chrNW_004955413:24,429,589...24,482,537 		JBrowse link
G Pla2r1 phospholipase A2 receptor 1 involved_in ISO (MGI:5297793|PMID:10946309) UniProt PMID:10946309 MGI:5297793 NCBI chrNW_004955449:13,542,458...13,653,907
Ensembl chrNW_004955449:13,542,458...13,653,901 		JBrowse link
positive regulation of fever generation by positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf11a TNF receptor superfamily member 11a involved_in ISO (MGI:4413614|PMID:19940926) BHF-UCL PMID:19940926 MGI:4413614 NCBI chrNW_004955402:46,242,329...46,298,157
Ensembl chrNW_004955402:46,264,164...46,296,368 		JBrowse link
G Tnfsf11 TNF superfamily member 11 involved_in ISO (MGI:4413614|PMID:19940926) BHF-UCL PMID:19940926 MGI:4413614 NCBI chrNW_004955518:431,401...462,063
Ensembl chrNW_004955518:430,642...462,705 		JBrowse link
positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 ISO RGD PMID:1324048 RGD:8662308 NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753 		JBrowse link
G Il1a interleukin 1 alpha ISO RGD PMID:8612624 RGD:7800677 NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (MGI:4413614|PMID:19940926) BHF-UCL PMID:19940926 MGI:4413614 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO RGD PMID:12649265 RGD:7495834 NCBI chrNW_004955478:3,331,607...3,448,840
Ensembl chrNW_004955478:3,331,607...3,448,842 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO RGD PMID:9786861 RGD:2304243 NCBI chrNW_004955408:391,094...430,638
Ensembl chrNW_004955408:391,094...430,981 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (MGI:3616954|PMID:16269410) MGI PMID:16269410 MGI:3616954 NCBI chrNW_004955482:7,048,674...7,087,525
Ensembl chrNW_004955482:7,048,776...7,086,926 		JBrowse link
G P2ry2 purinergic receptor P2Y2 ISO RGD PMID:15840771 RGD:2316683 NCBI chrNW_004955414:18,248,082...18,271,047
Ensembl chrNW_004955414:18,248,082...18,260,450 		JBrowse link
G Pla2g10 phospholipase A2 group X involved_in ISO (PMID:18511424) BHF-UCL PMID:18511424 NCBI chrNW_004955442:4,208,497...4,225,893
Ensembl chrNW_004955442:4,208,575...4,225,834 		JBrowse link
G Pla2g3 phospholipase A2 group III acts_upstream_of_or_within ISO (MGI:6108995|PMID:28947740) MGI PMID:28947740 MGI:6108995 NCBI chrNW_004955455:5,314,520...5,320,151
Ensembl chrNW_004955455:5,315,450...5,320,053 		JBrowse link
G Pla2g4a phospholipase A2 group IVA acts_upstream_of_or_within ISO (MGI:5779244|PMID:26828067) MGI PMID:26828067 MGI:5779244 NCBI chrNW_004955406:25,257,361...25,392,079
Ensembl chrNW_004955406:25,257,355...25,394,206 		JBrowse link
G Ptges prostaglandin E synthase acts_upstream_of_or_within ISO (MGI:5779244|PMID:26828067) MGI PMID:26828067 MGI:5779244 NCBI chrNW_004955445:10,053,745...10,056,981 JBrowse link
G Trpv4 transient receptor potential cation channel subfamily V member 4 involved_in ISO (PMID:19790068) AgBase PMID:19790068 NCBI chrNW_004955455:8,744,865...8,781,644
Ensembl chrNW_004955455:8,744,176...8,783,741 		JBrowse link
positive regulation of prostaglandin secretion involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mif macrophage migration inhibitory factor involved_in ISO (MGI:2156302|PMID:11756671) BHF-UCL PMID:11756671 MGI:2156302 NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460 		JBrowse link
prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 acts_upstream_of_or_within ISO (PMID:25173977) MGI PMID:25173977 NCBI chrNW_004955404:14,700,808...14,927,944
Ensembl chrNW_004955404:14,700,808...14,928,617 		JBrowse link
G Lep leptin involved_in ISO (PMID:19688109) UniProt PMID:19688109 NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472 		JBrowse link
G Nos2 nitric oxide synthase 2 involved_in ISO (PMID:19688109) UniProt PMID:19688109 NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of ISO (MGI:3616954|PMID:16269410) MGI PMID:16269410 MGI:3616954 NCBI chrNW_004955482:7,048,674...7,087,525
Ensembl chrNW_004955482:7,048,776...7,086,926 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 acts_upstream_of_or_within ISO (MGI:6501918|PMID:32484881) MGI PMID:32484881 MGI:6501918 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171 		JBrowse link
regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syk spleen associated tyrosine kinase involved_in ISO (MGI:87668|PMID:9171347) UniProt PMID:9171347 MGI:87668 NCBI chrNW_004955515:1,328,793...1,400,206
Ensembl chrNW_004955515:1,328,630...1,380,581 		JBrowse link
regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 involved_in ISO (PMID:18703674) AgBase PMID:18703674 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12182
    localization 4081
      establishment of localization 3485
        transport 3323
          secretion 946
            icosanoid secretion 43
              arachidonic acid secretion + 24
              negative regulation of icosanoid secretion + 5
              positive regulation of icosanoid secretion + 20
              prostaglandin secretion + 22
              regulation of icosanoid secretion + 26
Path 2
Term Annotations click to browse term
  biological_process 12182
    localization 4081
      establishment of localization 3485
        transport 3323
          ion transport 1196
            anion transport 399
              organic anion transport 287
                carboxylic acid transport 241
                  icosanoid transport 51
                    icosanoid secretion 43
                      arachidonic acid secretion + 24
                      negative regulation of icosanoid secretion + 5
                      positive regulation of icosanoid secretion + 20
                      prostaglandin secretion + 22
                      regulation of icosanoid secretion + 26
paths to the root