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ONTOLOGY REPORT - ANNOTATIONS


Term:icosanoid secretion
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Accession:GO:0032309 term browser browse the term
Definition:The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue.
Synonyms:exact_synonym: eicosanoid secretion



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arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G ANXA1 annexin A1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2661244|PMID:12553880) MGI
Ensembl
PMID:12553880 GO_REF:0000107 MGI:2661244 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779
JBrowse link
G BDKRB2 bradykinin receptor B2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253
JBrowse link
G DRD2 dopamine receptor D2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935
JBrowse link
G DRD3 dopamine receptor D3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:111,265,834...111,317,176
Ensembl chr 3:118,187,636...118,237,403
JBrowse link
G DRD4 dopamine receptor D4 involved_in ISO (PMID:7512953) BHF-UCL PMID:7512953 NCBI chr11:640,401...646,775 JBrowse link
G KISS1R KISS1 receptor ISO RGD PMID:11457843 RGD:1357971 NCBI chr19:211,563...215,332 JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor ISO RGD PMID:9291830 RGD:1600299 NCBI chr2A:48,808,822...48,879,021 JBrowse link
G NMB neuromedin B ISO stimulates RGD PMID:8532598 RGD:1642335 NCBI chr15:63,322,869...63,326,989 JBrowse link
G NMUR2 neuromedin U receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:147,811,260...147,825,659
Ensembl chr 5:153,811,055...153,827,176
JBrowse link
G PLA2G12A phospholipase A2 group XIIA involved_in IEA InterPro GO_REF:0000002 NCBI chr 4:102,207,312...102,226,307
Ensembl chr 4:112,773,886...112,794,063
JBrowse link
G PLA2G12B phospholipase A2 group XIIB involved_in IEA InterPro GO_REF:0000002 NCBI chr10:69,482,065...69,502,398
Ensembl chr10:71,946,506...71,965,482
JBrowse link
G PLA2G1B phospholipase A2 group IB NOT|involved_in ISO
IEA
(PMID:15528384) BHF-UCL
InterPro
PMID:15528384 GO_REF:0000002 NCBI chr12:117,896,729...117,900,946
Ensembl chr12:121,270,082...121,275,740
JBrowse link
G PLA2G2A phospholipase A2 group IIA involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:18,930,294...18,934,563
Ensembl chr 1:19,971,084...19,977,627
JBrowse link
G PLA2G2C phospholipase A2 group IIC involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:19,118,341...19,142,668
Ensembl chr 1:20,161,553...20,176,092
JBrowse link
G PLA2G2D phospholipase A2 group IID involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:19,066,890...19,074,711
Ensembl chr 1:20,110,323...20,117,618
JBrowse link
G PLA2G2E phospholipase A2 group IIE involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:18,874,301...18,878,218
Ensembl chr 1:19,918,391...19,921,639
JBrowse link
G PLA2G2F phospholipase A2 group IIF involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:19,094,401...19,105,920
Ensembl chr 1:20,138,042...20,149,099
JBrowse link
G PLA2G3 phospholipase A2 group III involved_in IEA InterPro GO_REF:0000002 NCBI chr22:12,158,589...12,164,441
Ensembl chr22:29,995,364...30,001,160
JBrowse link
G PLA2G4A phospholipase A2 group IVA acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3709446|PMID:17293613) MGI
Ensembl
PMID:17293613 GO_REF:0000107 MGI:3709446 NCBI chr 1:162,362,600...162,521,974
Ensembl chr 1:166,512,870...166,672,101
JBrowse link
G PLA2G4F phospholipase A2 group IVF acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3709446|PMID:17293613) MGI
Ensembl
PMID:17293613 GO_REF:0000107 MGI:3709446 NCBI chr15:21,095,474...21,110,983
Ensembl chr15:39,253,819...39,271,482
JBrowse link
G PLA2G5 phospholipase A2 group V involved_in ISO
IEA
RGD
InterPro
PMID:11106649 GO_REF:0000002 RGD:2303037 NCBI chr 1:18,983,104...19,046,834
Ensembl chr 1:20,068,110...20,089,840
JBrowse link
G PNPLA8 patatin like phospholipase domain containing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:100,456,096...100,511,836
Ensembl chr 7:113,177,202...113,230,799
JBrowse link
G PROCA1 protein interacting with cyclin A1 involved_in IEA InterPro GO_REF:0000002 NCBI chr17:28,063,498...28,072,327
Ensembl chr17:28,568,429...28,577,232
JBrowse link
negative regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5PF ATP synthase peripheral stalk subunit F6 ISO RGD PMID:9822642 RGD:13800919 NCBI chr21:12,169,567...12,180,717
Ensembl chr21:25,519,441...25,537,363
JBrowse link
G HRH2 histamine receptor H2 ISO RGD PMID:1313563 RGD:9685527 NCBI chr 5:171,004,893...171,057,539
Ensembl chr 5:177,928,039...177,931,566
JBrowse link
G PLA2R1 phospholipase A2 receptor 1 involved_in ISO (MGI:5297792|PMID:11830583) UniProt PMID:11830583 MGI:5297792 NCBI chr2B:47,226,791...47,355,831
Ensembl chr2B:164,605,440...164,726,017
JBrowse link
negative regulation of icosanoid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:18799632 RGD:2313549 NCBI chr  X:105,252,903...105,257,171
Ensembl chr  X:115,671,594...115,672,685
JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:15,367,328...15,388,139
Ensembl chr19:16,349,577...16,368,520
JBrowse link
negative regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL4 acyl-CoA synthetase long chain family member 4 involved_in ISO (PMID:21242590) UniProt PMID:21242590 NCBI chr  X:98,731,109...98,841,067
Ensembl chr  X:109,206,964...109,310,914
JBrowse link
G ATP5PF ATP synthase peripheral stalk subunit F6 ISO RGD PMID:11581303 PMID:19474762 RGD:13800898 RGD:13800911 NCBI chr21:12,169,567...12,180,717
Ensembl chr21:25,519,441...25,537,363
JBrowse link
positive regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVPR1B arginine vasopressin receptor 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:181,713,548...181,723,645
Ensembl chr 1:185,999,627...186,007,043
JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:11130725 RGD:151708734 NCBI chr20:58,581,228...58,586,585
Ensembl chr20:59,901,327...59,909,901
JBrowse link
G MIF macrophage migration inhibitory factor involved_in ISO (MGI:4437204|PMID:10364264) BHF-UCL PMID:10364264 MGI:4437204 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link
G NTSR1 neurotensin receptor 1 ISO RGD PMID:11852105 RGD:9743869 NCBI chr20:59,100,110...59,151,563
Ensembl chr20:60,392,736...60,446,056
JBrowse link
G PLA2G10 phospholipase A2 group X involved_in ISO (MGI:5051938|PMID:20844270) BHF-UCL PMID:20844270 MGI:5051938 NCBI chr16:13,600,152...13,622,629 JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:15576376 PMID:20732873 RGD:6482749 RGD:6482753 NCBI chr22:18,998,060...19,094,507
Ensembl chr22:36,849,794...36,919,509
Ensembl chr22:36,849,794...36,919,509
JBrowse link
G PLA2R1 phospholipase A2 receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:47,226,791...47,355,831
Ensembl chr2B:164,605,440...164,726,017
JBrowse link
G SSTR4 somatostatin receptor 4 ISO RGD PMID:8175684 RGD:2325010 NCBI chr20:22,982,009...22,986,058
Ensembl chr20:23,333,320...23,334,766
JBrowse link
positive regulation of fever generation by positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFRSF11A TNF receptor superfamily member 11a involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:55,695,394...55,761,307
Ensembl chr18:59,034,770...59,075,044
JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,750,835...23,784,740 JBrowse link
positive regulation of icosanoid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:46,228,434...46,240,736
Ensembl chr 1:47,583,564...47,594,870
JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:15,367,328...15,388,139
Ensembl chr19:16,349,577...16,368,520
JBrowse link
positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 ISO RGD PMID:1324048 RGD:8662308 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
JBrowse link
G IL1A interleukin 1 alpha ISO RGD PMID:8612624 RGD:7800677 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801
JBrowse link
G IL1B interleukin 1 beta involved_in ISO (MGI:4413614|PMID:19940926) BHF-UCL PMID:19940926 MGI:4413614 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 ISO RGD PMID:12649265 RGD:7495834 NCBI chr17:63,342,720...63,483,926
Ensembl chr17:68,730,011...68,870,454
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 ISO RGD PMID:9786861 RGD:2304243 NCBI chr 5:175,437,167...175,495,469
Ensembl chr 5:182,748,381...182,795,135
JBrowse link
G OXT oxytocin/neurophysin I prepropeptide ISO RGD PMID:9575824 RGD:2304227 NCBI chr20:3,157,246...3,159,013 JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (MGI:3616954|PMID:16269410) MGI PMID:16269410 MGI:3616954 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068
JBrowse link
G P2RY2 purinergic receptor P2Y2 ISO RGD PMID:15840771 RGD:2316683 NCBI chr11:68,294,366...68,319,118
Ensembl chr11:71,532,958...71,534,091
JBrowse link
G PLA2G10 phospholipase A2 group X involved_in ISO (PMID:18511424) BHF-UCL PMID:18511424 NCBI chr16:13,600,152...13,622,629 JBrowse link
G PLA2G3 phospholipase A2 group III acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:6108995|PMID:28947740) MGI
Ensembl
PMID:28947740 GO_REF:0000107 MGI:6108995 NCBI chr22:12,158,589...12,164,441
Ensembl chr22:29,995,364...30,001,160
JBrowse link
G PLA2G4A phospholipase A2 group IVA acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5779244|PMID:26828067) MGI
Ensembl
PMID:26828067 GO_REF:0000107 MGI:5779244 NCBI chr 1:162,362,600...162,521,974
Ensembl chr 1:166,512,870...166,672,101
JBrowse link
G PTGES prostaglandin E synthase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5779244|PMID:26828067) MGI
Ensembl
PMID:26828067 GO_REF:0000107 MGI:5779244 NCBI chr 9:100,865,702...100,880,408
Ensembl chr 9:129,522,547...129,537,020
JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 involved_in ISO (PMID:19790068) AgBase PMID:19790068 NCBI chr12:107,359,005...107,409,359
Ensembl chr12:110,754,238...110,786,182
JBrowse link
positive regulation of prostaglandin secretion involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIF macrophage migration inhibitory factor involved_in ISO (MGI:2156302|PMID:11756671) BHF-UCL PMID:11756671 MGI:2156302 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link
prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:25173977) MGI
Ensembl
PMID:25173977 GO_REF:0000107 NCBI chr13:76,193,929...76,476,119
Ensembl chr13:95,349,915...95,582,058
JBrowse link
G LEP leptin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
JBrowse link
G NOS2 nitric oxide synthase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of ISO (MGI:3616954|PMID:16269410) MGI PMID:16269410 MGI:3616954 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:6501918|PMID:32484881) MGI
Ensembl
PMID:32484881 GO_REF:0000107 MGI:6501918 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101
JBrowse link
regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 involved_in ISO (PMID:18703674) AgBase PMID:18703674 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15332
    localization 4784
      establishment of localization 4187
        transport 4022
          secretion 1031
            icosanoid secretion 56
              arachidonic acid secretion + 35
              negative regulation of icosanoid secretion + 6
              positive regulation of icosanoid secretion + 24
              prostaglandin secretion + 23
              regulation of icosanoid secretion + 30
Path 2
Term Annotations click to browse term
  biological_process 15332
    localization 4784
      establishment of localization 4187
        transport 4022
          ion transport 1474
            anion transport 479
              organic anion transport 333
                carboxylic acid transport 275
                  icosanoid transport 65
                    icosanoid secretion 56
                      arachidonic acid secretion + 35
                      negative regulation of icosanoid secretion + 6
                      positive regulation of icosanoid secretion + 24
                      prostaglandin secretion + 23
                      regulation of icosanoid secretion + 30
paths to the root