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ONTOLOGY REPORT - ANNOTATIONS


Term:icosanoid secretion
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Accession:GO:0032309 term browser browse the term
Definition:The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue.
Synonyms:exact_synonym: eicosanoid secretion



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arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in IEA
ISO
GO_REF:0000107
(PMID:17077303)
Ensembl
RGD
PMID:17077303 GO_REF:0000107 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Anxa1 annexin A1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2449710 (MGI:2661244|PMID:12553880)
RGD PMID:12553880 PMID:21873635 MGI:2661244, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Bdkrb2 bradykinin receptor B2 involved_in ISO
IEA
(PMID:17077303)
GO_REF:0000107
RGD
Ensembl
PMID:17077303 GO_REF:0000107 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO (PMID:8301582) RGD PMID:8301582 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO (PMID:8301582) RGD PMID:8301582 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd4 dopamine receptor D4 involved_in ISO
IEA
(PMID:7512953)
GO_REF:0000107
RGD
Ensembl
PMID:7512953 GO_REF:0000107 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Kiss1r KISS1 receptor IDA RGD PMID:11457843 RGD:1357971 NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor IDA RGD PMID:9291830 RGD:1600299 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Nmb neuromedin B IDA stimulates RGD PMID:8532598 RGD:1642335 NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
JBrowse link
G Nmur2 neuromedin U receptor 2 involved_in ISO (PMID:10887190) RGD PMID:10887190 NCBI chr10:40,166,223...40,182,078
Ensembl chr10:40,166,226...40,182,078
JBrowse link
G Oc90 otoconin 90 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:97,635,890...97,669,416
Ensembl chr 7:97,635,890...97,669,416
JBrowse link
G Pla2g10 phospholipase A2, group X involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000
JBrowse link
G Pla2g12a phospholipase A2, group XIIA involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:218,436,450...218,452,760
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Pla2g12b phospholipase A2, group XIIB involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:27,369,196...27,389,517
Ensembl chr20:27,370,266...27,388,743
JBrowse link
G Pla2g1b phospholipase A2 group IB NOT|involved_in ISO
IEA
(PMID:15528384)
GO_REF:0000002
RGD
InterPro
PMID:15528384 GO_REF:0000002 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
JBrowse link
G Pla2g2a phospholipase A2 group IIA involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pla2g2c phospholipase A2, group IIC involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:150,959,365...150,981,388
Ensembl chr 5:150,959,182...150,981,377
JBrowse link
G Pla2g2f phospholipase A2, group IIF involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:150,986,788...150,993,175
Ensembl chr 5:150,986,788...150,993,175
JBrowse link
G Pla2g3 phospholipase A2, group III involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in
acts_upstream_of_or_within
ISO (MGI:5297793|PMID:10946309)
(MGI:3709446|PMID:17293613)
RGD PMID:10946309 PMID:17293613 MGI:3709446 MGI:5297793 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pla2g4f phospholipase A2, group IVF acts_upstream_of_or_within ISO (MGI:3709446|PMID:17293613) RGD PMID:17293613 MGI:3709446 NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
ISO
IBA
(MGI:5297792|PMID:11830583)
PMID:21873635
RGD PMID:11830583 PMID:11106649 PMID:21873635 MGI:5297792, RGD:2303037, RGD:13792537 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 involved_in ISO (PMID:10833412), (PMID:15695510) RGD PMID:10833412 PMID:15695510 NCBI chr 6:61,329,810...61,391,736
Ensembl chr 6:61,329,810...61,391,734
JBrowse link
G Proca1 protein interacting with cyclin A1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:63,090,018...63,102,941
Ensembl chr10:63,090,018...63,102,940
JBrowse link
negative regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5pf ATP synthase peripheral stalk subunit F6 IDA RGD PMID:9822642 RGD:13800919 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Hrh2 histamine receptor H 2 IDA RGD PMID:1313563 RGD:9685527 NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 involved_in ISO (MGI:5297792|PMID:11830583) RGD PMID:11830583 MGI:5297792 NCBI chr 3:44,883,943...45,013,793
Ensembl chr 3:44,883,943...45,013,660
JBrowse link
negative regulation of icosanoid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:18799632 RGD:2313549 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
negative regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 involved_in ISO (PMID:21242590) RGD PMID:21242590 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 IMP
IDA
RGD PMID:19474762 PMID:11581303 RGD:13800898, RGD:13800911 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
positive regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1b arginine vasopressin receptor 1B involved_in ISO (PMID:9322919) RGD PMID:9322919 NCBI chr13:43,046,960...43,057,110
Ensembl chr13:43,046,267...43,057,792
JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:11130725 RGD:151708734 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (MGI:4437204|PMID:10364264) RGD PMID:10364264 MGI:4437204 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Ntsr1 neurotensin receptor 1 IMP RGD PMID:11852105 RGD:9743869 NCBI chr 3:167,606,215...167,656,377
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Pla2g10 phospholipase A2, group X involved_in IEA
ISO
GO_REF:0000107
(MGI:5051938|PMID:20844270)
Ensembl
RGD
PMID:20844270 GO_REF:0000107 MGI:5051938 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000
JBrowse link
G Pla2g6 phospholipase A2 group VI IMP
IDA
RGD PMID:20732873 PMID:15576376 RGD:6482749, RGD:6482753 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5297793|PMID:10946309)
UniProt
RGD
PMID:10946309 GO_REF:0000024 MGI:5297793 NCBI chr 3:44,883,943...45,013,793
Ensembl chr 3:44,883,943...45,013,660
JBrowse link
G Sstr4 somatostatin receptor 4 IDA RGD PMID:8175684 RGD:2325010 NCBI chr 3:135,854,826...135,856,689
Ensembl chr 3:135,854,826...135,856,689
JBrowse link
positive regulation of fever generation by positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf11a TNF receptor superfamily member 11A involved_in ISO (MGI:4413614|PMID:19940926) RGD PMID:19940926 MGI:4413614 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tnfsf11 TNF superfamily member 11 involved_in ISO
IEA
(MGI:4413614|PMID:19940926)
GO_REF:0000107
RGD
Ensembl
PMID:19940926 GO_REF:0000107 MGI:4413614 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 IDA RGD PMID:1324048 RGD:8662308 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Il1a interleukin 1 alpha IDA RGD PMID:8612624 RGD:7800677 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta involved_in ISO (MGI:4413614|PMID:19940926) RGD PMID:19940926 MGI:4413614 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IMP RGD PMID:12649265 RGD:7495834 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:9786861 RGD:2304243 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:9575824 RGD:2304227 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (MGI:3616954|PMID:16269410) RGD PMID:16269410 MGI:3616954 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G P2ry2 purinergic receptor P2Y2 IDA RGD PMID:15840771 RGD:2316683 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G Pla2g10 phospholipase A2, group X involved_in ISO (PMID:18511424) RGD PMID:18511424 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000
JBrowse link
G Pla2g3 phospholipase A2, group III acts_upstream_of_or_within ISO MGI:4461174 (MGI:6108995|PMID:28947740) RGD PMID:28947740 MGI:6108995 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Pla2g4a phospholipase A2 group IVA acts_upstream_of_or_within ISO MGI:2385582 (MGI:5779244|PMID:26828067) RGD PMID:26828067 MGI:5779244 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Ptges prostaglandin E synthase acts_upstream_of_or_within ISO MGI:3051640 (MGI:5779244|PMID:26828067) RGD PMID:26828067 MGI:5779244 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 involved_in ISO (PMID:19790068) RGD PMID:19790068 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
positive regulation of prostaglandin secretion involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mif macrophage migration inhibitory factor involved_in ISO (MGI:2156302|PMID:11756671) RGD PMID:11756671 MGI:2156302 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 acts_upstream_of_or_within ISO (PMID:25173977) RGD PMID:25173977 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Lep leptin involved_in ISS
ISO
GO_REF:0000024
(PMID:19688109)
UniProt
RGD
PMID:19688109 GO_REF:0000024 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nos2 nitric oxide synthase 2 involved_in ISO
IEA
ISS
(PMID:19688109)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19688109 GO_REF:0000024 GO_REF:0000107 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of ISO MGI:2386080 (MGI:3616954|PMID:16269410) RGD PMID:16269410 MGI:3616954 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 acts_upstream_of_or_within ISO (MGI:6501918|PMID:32484881) RGD PMID:32484881 MGI:6501918 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syk spleen associated tyrosine kinase involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:87668|PMID:9171347)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9171347 GO_REF:0000024 GO_REF:0000107 MGI:87668 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 involved_in ISO (PMID:18703674) RGD PMID:18703674 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    localization 5475
      establishment of localization 4825
        transport 4663
          secretion 1176
            icosanoid secretion 53
              arachidonic acid secretion + 34
              negative regulation of icosanoid secretion + 5
              positive regulation of icosanoid secretion + 22
              prostaglandin secretion + 23
              regulation of icosanoid secretion + 28
Path 2
Term Annotations click to browse term
  biological_process 18737
    localization 5475
      establishment of localization 4825
        transport 4663
          ion transport 1667
            anion transport 533
              organic anion transport 388
                carboxylic acid transport 315
                  icosanoid transport 62
                    icosanoid secretion 53
                      arachidonic acid secretion + 34
                      negative regulation of icosanoid secretion + 5
                      positive regulation of icosanoid secretion + 22
                      prostaglandin secretion + 23
                      regulation of icosanoid secretion + 28
paths to the root