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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of telomere maintenance
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Accession:GO:0032205 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
Synonyms:exact_synonym: down regulation of telomere maintenance;   downregulation of telomere maintenance
 narrow_synonym: inhibition of telomere maintenance


show annotations for term's descendants           Sort by:
negative regulation of telomere maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (PMID:17055345) RGD PMID:17055345 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:17055345) RGD PMID:17055345 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase acts_upstream_of ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:11971978) RGD PMID:11971978 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
G Terf2ip TERF2 interacting protein involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr19:39,976,965...39,984,055
Ensembl chr19:39,976,906...39,984,064 		JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 acts_upstream_of_or_within ISO (PMID:12676566) RGD PMID:12676566 NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984 		JBrowse link
negative regulation of protection from non-homologous end joining at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 involved_in ISO (MGI:3758502|PMID:14690602)
(PMID:14690602)		 RGD PMID:14690602 MGI:3758502 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in ISO (MGI:3758502|PMID:14690602)
(PMID:14690602)		 RGD PMID:14690602 MGI:3758502 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
negative regulation of telomere capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:17694070) RGD PMID:17694070 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Nbn nibrin involved_in IEA
ISO		 GO_REF:0000107
(PMID:17694070)		 Ensembl
RGD		 PMID:17694070 GO_REF:0000107 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in ISO
IEA		 (PMID:17694070)
GO_REF:0000107		 RGD
Ensembl		 PMID:17694070 GO_REF:0000107 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor involved_in ISO (PMID:12676087) RGD PMID:12676087 NCBI chr10:59,786,258...60,014,395
Ensembl chr10:59,786,258...60,014,395 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:24270157) RGD PMID:24270157 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
negative regulation of telomere maintenance in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (MGI:5645200|PMID:22579284)
(PMID:22579284)		 RGD PMID:22579284 MGI:5645200 NCBI chr 3:168,427,247...168,465,349
Ensembl chr 3:168,419,579...168,465,348 		JBrowse link
negative regulation of telomere maintenance via recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf2 telomeric repeat binding factor 2 involved_in ISO
IBA		 (PMID:15507207)
(PMID:24120135)
GO_REF:0000033
(MGI:5883205|PMID:24120135)		 RGD
GO_Central		 PMID:15507207 PMID:24120135 GO_REF:0000033 MGI:5883205 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
negative regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor involved_in IEA
ISO
IBA		 GO_REF:0000107
UniProtKB:Q9NUX5 (PMID:15181449), (PMID:15380063), (PMID:25172512)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:15181449 PMID:15380063 PMID:25172512 GO_REF:0000033 GO_REF:0000107 NCBI chr19:33,586,739...33,589,481
Ensembl chr19:33,586,745...33,589,461 		JBrowse link
G Ctc1 CST telomere replication complex component 1 involved_in ISO (PMID:22763445) RGD PMID:22763445 NCBI chr10:53,714,614...53,735,298
Ensembl chr10:53,714,644...53,735,298 		JBrowse link
G Dcp2 decapping mRNA 2 involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557 		JBrowse link
G Exosc10 exosome component 10 involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940 		JBrowse link
G Gnl3l G protein nucleolar 3 like involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr  X:19,961,277...19,994,454
Ensembl chr  X:19,958,603...19,994,508 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 involved_in ISO (PMID:23935072) RGD PMID:23935072 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183 		JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in IEA
ISO		 GO_REF:0000107
(PMID:18082603)		 Ensembl
RGD		 PMID:18082603 GO_REF:0000107 NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588 		JBrowse link
G Nat10 N-acetyltransferase 10 involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr 3:90,111,643...90,149,891
Ensembl chr 3:90,111,645...90,149,927 		JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase involved_in ISO (PMID:16522649), (PMID:23657261) RGD PMID:16522649 PMID:23657261 NCBI chr 8:66,110,641...66,120,202
Ensembl chr 8:66,111,072...66,120,200 		JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 involved_in ISO
IEA		 (PMID:11701125), (PMID:21119197)
GO_REF:0000107		 RGD
Ensembl		 PMID:11701125 PMID:21119197 GO_REF:0000107 NCBI chr15:38,097,896...38,157,143
Ensembl chr15:38,097,886...38,157,140 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:19567472) RGD PMID:19567472 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO UniProtKB:Q96AP0 (PMID:15181449), (PMID:15632080) RGD PMID:15181449 PMID:15632080 NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042 		JBrowse link
G Stn1 STN1 subunit of CST complex involved_in ISO
IEA		 (PMID:22763445)
GO_REF:0000107		 RGD
Ensembl		 PMID:22763445 GO_REF:0000107 NCBI chr 1:246,391,311...246,429,844
Ensembl chr 1:246,395,613...246,429,531 		JBrowse link
G Ten1 TEN1 subunit of CST complex involved_in ISO
IBA		 (PMID:22763445)
GO_REF:0000033		 RGD
GO_Central		 PMID:22763445 GO_REF:0000033 NCBI chr10:101,431,328...101,455,105
Ensembl chr10:101,431,328...101,453,052 		JBrowse link
G Tent4b terminal nucleotidyltransferase 4B involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr19:18,807,616...18,868,969
Ensembl chr19:18,807,525...18,869,537 		JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO UniProtKB:O14746 (PMID:11971978) RGD PMID:11971978 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:17055345) RGD PMID:17055345 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 involved_in ISO (PMID:10581025), (PMID:15133513) RGD PMID:10581025 PMID:15133513 NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984 		JBrowse link
G Tp53 tumor protein p53 involved_in IEA
ISO		 GO_REF:0000107
(PMID:10597287)		 Ensembl
RGD		 PMID:10597287 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
negative regulation of telomere maintenance via telomere lengthening term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:18812185) RGD PMID:18812185 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Mcrs1 microspherule protein 1 involved_in ISO (PMID:15044100) RGD PMID:15044100 NCBI chr 7:130,383,853...130,392,667
Ensembl chr 7:130,383,853...130,392,685 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in ISO (MGI:5705431|PMID:26586427) RGD PMID:26586427 MGI:5705431 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit involved_in ISO (PMID:24012755) RGD PMID:24012755 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit involved_in ISO (PMID:24012755) RGD PMID:24012755 NCBI chr10:11,526,623...11,549,313
Ensembl chr10:11,528,424...11,549,295 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:24012755) RGD PMID:24012755 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
G Tnks tankyrase involved_in ISO (PMID:25939383) RGD PMID:25939383 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260 		JBrowse link
G Tnks2 tankyrase 2 involved_in ISO (PMID:25939383) RGD PMID:25939383 NCBI chr 1:234,567,888...234,621,079
Ensembl chr 1:234,567,858...234,621,079 		JBrowse link
negative regulation of telomeric D-loop disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf1 telomeric repeat binding factor 1 involved_in ISO
IBA		 (PMID:15200954)
GO_REF:0000033		 RGD
GO_Central		 PMID:15200954 GO_REF:0000033 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO
IBA		 (PMID:15200954)
GO_REF:0000033		 RGD
GO_Central		 PMID:15200954 GO_REF:0000033 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20133
    cellular process 19325
      metabolic process 12307
        negative regulation of metabolic process 3254
          negative regulation of macromolecule metabolic process 3004
            negative regulation of DNA metabolic process 144
              negative regulation of telomere maintenance 37
                negative regulation of telomere capping + 9
                negative regulation of telomere maintenance in response to DNA damage + 5
                negative regulation of telomere maintenance via recombination 1
                negative regulation of telomere maintenance via semi-conservative replication 0
                negative regulation of telomere maintenance via telomere lengthening + 27
                negative regulation of telomeric loop disassembly + 2
                negative regulation of telomeric loop formation 0
Path 2
Term Annotations click to browse term
  biological_process 20133
    biological regulation 13561
      regulation of biological process 13134
        regulation of cellular process 12758
          regulation of metabolic process 6822
            regulation of primary metabolic process 5712
              regulation of nucleobase-containing compound metabolic process 3981
                negative regulation of nucleobase-containing compound metabolic process 1543
                  negative regulation of DNA metabolic process 144
                    negative regulation of telomere maintenance 37
                      negative regulation of telomere capping + 9
                      negative regulation of telomere maintenance in response to DNA damage + 5
                      negative regulation of telomere maintenance via recombination 1
                      negative regulation of telomere maintenance via semi-conservative replication 0
                      negative regulation of telomere maintenance via telomere lengthening + 27
                      negative regulation of telomeric loop disassembly + 2
                      negative regulation of telomeric loop formation 0
paths to the root