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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial DNA metabolic process
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Accession:GO:0032042 term browser browse the term
Definition:The chemical reactions and pathways involving mitochondrial DNA.
Synonyms:exact_synonym: mitochondrial DNA metabolism;   mtDNA metabolic process;   mtDNA metabolism
 only_in_taxon: NCBITaxon:2759 ! Eukaryota



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mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H acts_upstream_of_or_within ISO (PMID:30705315) MGI PMID:30705315
G MTNAP1 mitochondrial nucleoid associated protein 1 involved_in ISO (PMID:37676315) UniProt PMID:37676315 NCBI chr12:7,710,264...7,727,672
Ensembl chr12:7,710,279...7,725,080
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:25378300) MGI
Ensembl
PMID:25378300 GO_REF:0000107 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
JBrowse link
G POLG2 DNA polymerase gamma 2, accessory subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23197651) Ensembl
MGI
PMID:23197651 GO_REF:0000107 NCBI chr12:14,582,075...14,601,576
Ensembl chr12:14,582,544...14,601,570
JBrowse link
G SESN2 sestrin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22958918) Ensembl
MGI
PMID:22958918 GO_REF:0000107 NCBI chr 6:85,321,982...85,348,044
Ensembl chr 6:85,324,228...85,348,032
JBrowse link
G TK2 thymidine kinase 2 acts_upstream_of_or_within ISO (PMID:18467430) MGI PMID:18467430 NCBI chr 6:27,226,421...27,255,645
Ensembl chr 6:27,226,425...27,255,574
JBrowse link
G TOP3A DNA topoisomerase III alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:60,443,592...60,468,968
Ensembl chr12:60,443,677...60,468,964
JBrowse link
mitochondrial DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENDOG endonuclease G involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:269,153,955...269,157,789
Ensembl chr 1:269,154,090...269,157,788
JBrowse link
mitochondrial DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 acts_upstream_of_or_within ISO (PMID:24101517) MGI PMID:24101517 NCBI chr13:70,417,326...70,428,923
Ensembl chr13:70,417,326...70,428,922
JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:71,550,405...71,607,067
Ensembl chr14:71,552,121...71,610,740
JBrowse link
G LIG3 DNA ligase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:21390132)
(PMID:21390131), (PMID:21390132)
BHF-UCL
MGI
PMID:21390131 PMID:21390132 NCBI chr12:40,153,105...40,205,077
Ensembl chr12:40,153,397...40,183,622
JBrowse link
G MGME1 mitochondrial genome maintenance exonuclease 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr17:26,381,561...26,395,201
Ensembl chr17:26,369,875...26,395,192
JBrowse link
G NEURL4 neuralized E3 ubiquitin protein ligase 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:35157000) MGI
Ensembl
PMID:35157000 GO_REF:0000107 NCBI chr12:52,667,826...52,680,158
Ensembl chr12:52,667,831...52,680,189
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:25378300) MGI
Ensembl
PMID:25378300 GO_REF:0000107 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
JBrowse link
G PRIMPOL primase and DNA directed polymerase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:45,764,261...45,851,052
Ensembl chr15:45,709,710...45,819,919
JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24101517) Ensembl
MGI
PMID:24101517 GO_REF:0000107 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:71,550,405...71,607,067
Ensembl chr14:71,552,121...71,610,740
JBrowse link
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16327803) Ensembl
MGI
PMID:16327803 GO_REF:0000107 NCBI chr 3:37,883,233...37,919,141
Ensembl chr 3:37,883,244...37,919,324
JBrowse link
G MGME1 mitochondrial genome maintenance exonuclease 1 involved_in IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr17:26,381,561...26,395,201
Ensembl chr17:26,369,875...26,395,192
JBrowse link
G POLG DNA polymerase gamma, catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:15888483) Ensembl
MGI
GO_Central
InterPro
PMID:15888483 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:54,889,150...54,907,167
Ensembl chr 7:54,889,157...54,906,844
JBrowse link
G POLG2 DNA polymerase gamma 2, accessory subunit involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:23197651) Ensembl
MGI
GO_Central
PMID:23197651 GO_REF:0000033 GO_REF:0000107 NCBI chr12:14,582,075...14,601,576
Ensembl chr12:14,582,544...14,601,570
JBrowse link
G PRIMPOL primase and DNA directed polymerase involved_in IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr15:45,764,261...45,851,052
Ensembl chr15:45,709,710...45,819,919
JBrowse link
G RNASEH1 ribonuclease H1 acts_upstream_of_or_within ISO (PMID:12667461) MGI PMID:12667461 NCBI chr 3:131,268,908...131,277,072
Ensembl chr 3:131,268,926...131,281,930
JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143
JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17486094) Ensembl
MGI
PMID:17486094 GO_REF:0000107 NCBI chr 4:34,823,869...34,859,777
Ensembl chr 4:34,823,758...34,859,778
JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr18:8,084,292...8,167,983
Ensembl chr18:8,151,029...8,167,983
JBrowse link
G TEFM transcription elongation factor, mitochondrial NOT|involved_in ISO (PMID:21278163) UniProt PMID:21278163 NCBI chr12:42,864,582...42,875,705
Ensembl chr12:42,864,612...43,047,444
JBrowse link
G TK2 thymidine kinase 2 acts_upstream_of_or_within ISO (PMID:18434326) MGI PMID:18434326 NCBI chr 6:27,226,421...27,255,645
Ensembl chr 6:27,226,425...27,255,574
JBrowse link
G TWNK twinkle mtDNA helicase involved_in IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr14:112,068,463...112,076,169
Ensembl chr14:112,069,925...112,075,792
JBrowse link
negative regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG7 autophagy related 7 ISO RGD PMID:23800874 RGD:11557986 NCBI chr13:67,301,756...67,699,141
Ensembl chr13:67,417,938...67,707,654
JBrowse link
G LIG3 DNA ligase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:40,153,105...40,205,077
Ensembl chr12:40,153,397...40,183,622
JBrowse link
positive regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENDOG endonuclease G involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:269,153,955...269,157,789
Ensembl chr 1:269,154,090...269,157,788
JBrowse link
G MTNAP1 mitochondrial nucleoid associated protein 1 involved_in ISO (PMID:37676315) UniProt PMID:37676315 NCBI chr12:7,710,264...7,727,672
Ensembl chr12:7,710,279...7,725,080
JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:8,084,292...8,167,983
Ensembl chr18:8,151,029...8,167,983
JBrowse link
regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GTF3C2 general transcription factor IIIC subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:111,793,700...111,820,501
Ensembl chr 3:111,793,338...111,820,506
JBrowse link
G MPV17 mitochondrial inner membrane protein MPV17 involved_in IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr 3:111,823,075...111,833,929
Ensembl chr 3:111,821,690...111,833,928
JBrowse link
G STOX1 storkhead box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:71,927,387...71,985,239
Ensembl chr14:71,928,399...71,985,233
JBrowse link
regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G METTL4 methyltransferase 4, N6-adenosine involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:104,055,813...104,384,416
Ensembl chr 6:104,055,814...104,078,381
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17654
    cellular process 17186
      metabolic process 10534
        macromolecule metabolic process 8664
          nucleic acid metabolic process 4718
            DNA metabolic process 899
              mitochondrial DNA metabolic process 28
                DNA synthesis involved in mitochondrial DNA replication 0
                mitochondrial DNA catabolic process 1
                mitochondrial DNA repair 8
                mitochondrial DNA replication + 18
                mitochondrion DNA recombination 0
                negative regulation of mitochondrial DNA metabolic process + 2
                positive regulation of mitochondrial DNA metabolic process + 3
                regulation of mitochondrial DNA metabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 17654
    cellular process 17186
      cellular component organization or biogenesis 6710
        cellular component organization 6514
          organelle organization 3480
            mitochondrion organization 466
              mitochondrial genome maintenance 34
                mitochondrial DNA metabolic process 28
                  DNA synthesis involved in mitochondrial DNA replication 0
                  mitochondrial DNA catabolic process 1
                  mitochondrial DNA repair 8
                  mitochondrial DNA replication + 18
                  mitochondrion DNA recombination 0
                  negative regulation of mitochondrial DNA metabolic process + 2
                  positive regulation of mitochondrial DNA metabolic process + 3
                  regulation of mitochondrial DNA metabolic process + 9
paths to the root