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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial DNA metabolic process
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Accession:GO:0032042 term browser browse the term
Definition:The chemical reactions and pathways involving mitochondrial DNA.
Synonyms:exact_synonym: mitochondrial DNA metabolism;   mtDNA metabolic process;   mtDNA metabolism
 only_in_taxon: NCBITaxon:2759 ! Eukaryota



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mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H acts_upstream_of_or_within ISO (PMID:30705315) MGI PMID:30705315 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476
JBrowse link
G LONP1 lon peptidase 1, mitochondrial involved_in NAS (PMID:14739292) UniProt PMID:14739292 NCBI chr19:5,691,834...5,720,452
Ensembl chr19:5,691,834...5,720,572
JBrowse link
G MTNAP1 mitochondrial nucleoid associated protein 1 involved_in ISO (PMID:37676315) UniProt PMID:37676315 NCBI chr17:73,232,433...73,248,959
Ensembl chr17:73,232,233...73,248,959
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 acts_upstream_of_or_within IMP (PMID:25378300) MGI PMID:25378300 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G POLG2 DNA polymerase gamma 2, accessory subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23197651) Ensembl
MGI
PMID:23197651 GO_REF:0000107 NCBI chr17:64,477,785...64,497,054
Ensembl chr17:64,477,785...64,497,054
JBrowse link
G SESN2 sestrin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22958918) Ensembl
MGI
PMID:22958918 GO_REF:0000107 NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491
JBrowse link
G TK2 thymidine kinase 2 acts_upstream_of_or_within ISO (PMID:18467430) MGI PMID:18467430 NCBI chr16:66,508,003...66,550,291
Ensembl chr16:66,508,003...66,552,544
JBrowse link
G TOP3A DNA topoisomerase III alpha involved_in IMP (PMID:29290614) UniProt PMID:29290614 NCBI chr17:18,271,428...18,314,994
Ensembl chr17:18,271,428...18,315,007
JBrowse link
mitochondrial DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENDOG endonuclease G involved_in IMP (PMID:29719607) UniProt PMID:29719607 NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676
JBrowse link
mitochondrial DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24101517) Ensembl
MGI
PMID:24101517 GO_REF:0000107 NCBI chr 3:14,112,077...14,124,870
Ensembl chr 3:14,112,077...14,124,870
JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IDA (PMID:19487465) UniProt PMID:19487465 NCBI chr10:68,414,064...68,472,521
Ensembl chr10:68,414,064...68,472,121
JBrowse link
G LIG3 DNA ligase 3 involved_in
acts_upstream_of_or_within
IMP
ISO
(PMID:21390132)
(PMID:21390131), (PMID:21390132)
BHF-UCL
MGI
PMID:21390131 PMID:21390132 NCBI chr17:34,980,512...35,010,872
Ensembl chr17:34,980,512...35,009,743
JBrowse link
G MGME1 mitochondrial genome maintenance exonuclease 1 involved_in TAS
IEA
(PMID:23313956) UniProt PMID:23313956 GO_REF:0000104 NCBI chr20:17,968,590...17,991,122
Ensembl chr20:17,969,018...17,991,122
JBrowse link
G NEURL4 neuralized E3 ubiquitin protein ligase 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:35157000) MGI
Ensembl
PMID:35157000 GO_REF:0000107 NCBI chr17:7,315,628...7,329,335
Ensembl chr17:7,315,628...7,329,393
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 acts_upstream_of_or_within IMP (PMID:25378300) MGI PMID:25378300 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PRIMPOL primase and DNA directed polymerase involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 4:184,649,738...184,694,952
Ensembl chr 4:184,649,667...184,694,963
JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24101517) Ensembl
MGI
PMID:24101517 GO_REF:0000107 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNA2 DNA replication helicase/nuclease 2 involved_in IDA (PMID:18995831), (PMID:19487465) UniProt PMID:18995831 PMID:19487465 NCBI chr10:68,414,064...68,472,521
Ensembl chr10:68,414,064...68,472,121
JBrowse link
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16327803) Ensembl
MGI
PMID:16327803 GO_REF:0000107 NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775
JBrowse link
G MGME1 mitochondrial genome maintenance exonuclease 1 involved_in IMP
IBA
(PMID:23313956) UniProt
GO_Central
PMID:23313956 GO_REF:0000033 NCBI chr20:17,968,590...17,991,122
Ensembl chr20:17,969,018...17,991,122
JBrowse link
G POLG DNA polymerase gamma, catalytic subunit involved_in
acts_upstream_of_or_within
IMP
ISO
IBA
IEA
IDA
(PMID:26554610)
(PMID:15888483)
(PMID:19837034)
UniProt
MGI
GO_Central
InterPro
ComplexPortal
PMID:15888483 PMID:19837034 PMID:26554610 GO_REF:0000002 GO_REF:0000033 NCBI chr15:89,316,320...89,334,824
Ensembl chr15:89,305,198...89,334,861
JBrowse link
G POLG2 DNA polymerase gamma 2, accessory subunit involved_in
acts_upstream_of_or_within
IC
ISO
IBA
IEA
IDA
(PMID:26123486)
(PMID:23197651)
(PMID:19837034)
FlyBase
MGI
GO_Central
Ensembl
ComplexPortal
PMID:19837034 PMID:23197651 PMID:26123486 GO_REF:0000033 GO_REF:0000107 NCBI chr17:64,477,785...64,497,054
Ensembl chr17:64,477,785...64,497,054
JBrowse link
G PRIMPOL primase and DNA directed polymerase involved_in IMP
IBA
IEA
(PMID:24207056) UniProt
GO_Central
Ensembl
PMID:24207056 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:184,649,738...184,694,952
Ensembl chr 4:184,649,667...184,694,963
JBrowse link
G RNASEH1 ribonuclease H1 acts_upstream_of_or_within ISO (PMID:12667461) MGI PMID:12667461 NCBI chr 2:3,531,813...3,558,333
Ensembl chr 2:3,541,430...3,558,333
JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 involved_in IEA
IMP
(PMID:17486094) Ensembl
ComplexPortal
PMID:17486094 GO_REF:0000107 NCBI chr11:4,094,685...4,138,932
Ensembl chr11:4,094,707...4,138,932
JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B involved_in
acts_upstream_of_or_within
IMP
ISO
IEA
(PMID:17486094) ComplexPortal
MGI
Ensembl
PMID:17486094 GO_REF:0000107 NCBI chr 8:102,204,501...102,238,961
Ensembl chr 8:102,204,502...102,238,961
JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:141,738,321...141,750,488
Ensembl chr 7:141,738,334...141,787,922
JBrowse link
G TEFM transcription elongation factor, mitochondrial NOT|involved_in IMP (PMID:21278163) UniProt PMID:21278163 NCBI chr17:30,898,986...30,906,238
Ensembl chr17:30,897,336...30,906,238
JBrowse link
G TK2 thymidine kinase 2 acts_upstream_of_or_within ISO (PMID:18434326) MGI PMID:18434326 NCBI chr16:66,508,003...66,550,291
Ensembl chr16:66,508,003...66,552,544
JBrowse link
G TWNK twinkle mtDNA helicase involved_in IEA
IBA
IMP
NAS
(PMID:18971204)
(PMID:12975372)
Ensembl
GO_Central
UniProt
PMID:12975372 PMID:18971204 GO_REF:0000033 GO_REF:0000107 NCBI chr10:100,987,543...100,994,403
Ensembl chr10:100,987,367...100,994,403
JBrowse link
negative regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG7 autophagy related 7 ISO RGD PMID:23800874 RGD:11557986 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665
JBrowse link
G LIG3 DNA ligase 3 involved_in IMP (PMID:21878356) CACAO PMID:21878356 NCBI chr17:34,980,512...35,010,872
Ensembl chr17:34,980,512...35,009,743
JBrowse link
positive regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENDOG endonuclease G involved_in IMP (PMID:29719607) UniProt PMID:29719607 NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676
JBrowse link
G MTNAP1 mitochondrial nucleoid associated protein 1 involved_in ISO (PMID:37676315) UniProt PMID:37676315 NCBI chr17:73,232,433...73,248,959
Ensembl chr17:73,232,233...73,248,959
JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in IDA (PMID:31550240) UniProt PMID:31550240 NCBI chr 7:141,738,321...141,750,488
Ensembl chr 7:141,738,334...141,787,922
JBrowse link
regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPV17 mitochondrial inner membrane protein MPV17 involved_in IMP
IBA
(PMID:26760297) UniProt
GO_Central
PMID:26760297 GO_REF:0000033 NCBI chr 2:27,309,492...27,323,097
Ensembl chr 2:27,309,492...27,325,680
JBrowse link
G STOX1 storkhead box 1 involved_in IMP (PMID:24738702) UniProt PMID:24738702 NCBI chr10:68,827,531...68,895,432
Ensembl chr10:68,827,531...68,895,432
JBrowse link
regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G METTL4 methyltransferase 4, N6-adenosine involved_in IMP (PMID:32183942) UniProt PMID:32183942 NCBI chr18:2,537,530...2,571,505
Ensembl chr18:2,537,525...2,571,509
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19696
    cellular process 18947
      metabolic process 12898
        macromolecule metabolic process 10775
          nucleic acid metabolic process 6165
            DNA metabolic process 1081
              mitochondrial DNA metabolic process 28
                DNA synthesis involved in mitochondrial DNA replication 0
                mitochondrial DNA catabolic process 1
                mitochondrial DNA repair 8
                mitochondrial DNA replication + 18
                mitochondrion DNA recombination 0
                negative regulation of mitochondrial DNA metabolic process + 2
                positive regulation of mitochondrial DNA metabolic process + 3
                regulation of mitochondrial DNA metabolic process + 8
Path 2
Term Annotations click to browse term
  biological_process 19696
    cellular process 18947
      cellular component organization or biogenesis 7835
        cellular component organization 7612
          organelle organization 3944
            mitochondrion organization 508
              mitochondrial genome maintenance 36
                mitochondrial DNA metabolic process 28
                  DNA synthesis involved in mitochondrial DNA replication 0
                  mitochondrial DNA catabolic process 1
                  mitochondrial DNA repair 8
                  mitochondrial DNA replication + 18
                  mitochondrion DNA recombination 0
                  negative regulation of mitochondrial DNA metabolic process + 2
                  positive regulation of mitochondrial DNA metabolic process + 3
                  regulation of mitochondrial DNA metabolic process + 8
paths to the root