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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial DNA metabolic process
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Accession:GO:0032042 term browser browse the term
Definition:The chemical reactions and pathways involving mitochondrial DNA.
Synonyms:exact_synonym: mitochondrial DNA metabolism;   mtDNA metabolic process;   mtDNA metabolism
 only_in_taxon: NCBITaxon:2759 ! Eukaryota



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mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (MGI:6304909|PMID:30705315) RGD PMID:30705315 MGI:6304909 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 acts_upstream_of_or_within ISO (PMID:25378300) RGD PMID:25378300 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit acts_upstream_of_or_within ISO MGI:5470227 (MGI:5465384|PMID:23197651) RGD PMID:23197651 MGI:5465384 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008
JBrowse link
G Sesn2 sestrin 2 acts_upstream_of_or_within ISO MGI:3587950 (MGI:5444071|PMID:22958918) RGD PMID:22958918 MGI:5444071 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Tk2 thymidine kinase 2 acts_upstream_of_or_within ISO MGI:3808750 (MGI:3807446|PMID:18467430) RGD PMID:18467430 MGI:3807446 NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924
JBrowse link
G Top3a DNA topoisomerase III alpha involved_in ISO (PMID:29290614) RGD PMID:29290614 NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559
JBrowse link
mitochondrial DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G involved_in ISO (PMID:29719607) RGD PMID:29719607 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
mitochondrial DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 acts_upstream_of_or_within ISO (MGI:5516376|PMID:24101517) RGD PMID:24101517 MGI:5516376 NCBI chr 4:123,968,264...123,977,398
Ensembl chr 4:123,968,265...123,977,414
JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in ISO
IEA
(PMID:19487465)
GO_REF:0000107
RGD
Ensembl
PMID:19487465 GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Lig3 DNA ligase 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:4943977|PMID:21390132), (MGI:4943978|PMID:21390131)
(PMID:21390132)
RGD PMID:21390131 PMID:21390132 PMID:21873635 MGI:4943977 MGI:4943978, RGD:13792537 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 acts_upstream_of_or_within ISO (PMID:25378300) RGD PMID:25378300 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO (MGI:6393030|PMID:29073063) RGD PMID:29073063 MGI:6393030 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565
JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,158...25,717,558
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:3528279 (MGI:5516376|PMID:24101517) RGD PMID:24101517 MGI:5516376 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:18995831), (PMID:19487465)
Ensembl
RGD
PMID:18995831 PMID:19487465 GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within ISO MGI:2182091|MGI:3040717 (MGI:3612004|PMID:16327803) RGD PMID:16327803 MGI:3612004 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161
JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 involved_in ISO
IBA
(PMID:23313956)
PMID:21873635
RGD PMID:23313956 PMID:21873635 RGD:13792537 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:19837034), (PMID:26554610)
MGI:3584444 (MGI:3583846|PMID:15888483)
RGD PMID:15888483 PMID:19837034 PMID:26554610 PMID:21873635 MGI:3583846, RGD:13792537 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit involved_in ISO
IBA
(PMID:19837034)
PMID:21873635
RGD PMID:19837034 PMID:21873635 RGD:13792537 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008
JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO
IBA
(PMID:24207056)
(MGI:5527006|PMID:24207056)
PMID:21873635
RGD PMID:24207056 PMID:21873635 MGI:5527006, RGD:13792537 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565
JBrowse link
G Rnaseh1 ribonuclease H1 acts_upstream_of_or_within ISO MGI:2655784 (MGI:2655010|PMID:12667461) RGD PMID:12667461 MGI:2655010 NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 involved_in ISO (PMID:17486094)
(MGI:3714223|PMID:17486094)
RGD PMID:17486094 MGI:3714223 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B acts_upstream_of_or_within
involved_in
ISO MGI:2672883 (MGI:3714223|PMID:17486094)
(PMID:17486094)
RGD PMID:17486094 MGI:3714223 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,158...25,717,558
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135
JBrowse link
G Tefm transcription elongation factor, mitochondrial NOT|involved_in ISO (PMID:21278163) RGD PMID:21278163 NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486
JBrowse link
G Tk2 thymidine kinase 2 acts_upstream_of_or_within ISO MGI:3802583 (MGI:3801405|PMID:18434326) RGD PMID:18434326 MGI:3801405 NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924
JBrowse link
G Twnk twinkle mtDNA helicase involved_in IBA
ISO
PMID:21873635
(MGI:3826298|PMID:18971204)
(PMID:18971204)
RGD PMID:18971204 PMID:21873635 MGI:3826298, RGD:13792537 NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802
JBrowse link
negative regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flcn folliculin involved_in ISO (MGI:5463828|PMID:23150719) RGD PMID:23150719 MGI:5463828 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
JBrowse link
negative regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 IMP RGD PMID:23800874 RGD:11557986 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Lig3 DNA ligase 3 involved_in ISO (PMID:21878356) RGD PMID:21878356 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414
JBrowse link
positive regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha involved_in ISO (MGI:5463828|PMID:23150719) RGD PMID:23150719 MGI:5463828 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
positive regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G involved_in ISO (PMID:29719607) RGD PMID:29719607 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in ISO
ISS
(PMID:31550240)
GO_REF:0000024
RGD
UniProt
PMID:31550240 GO_REF:0000024 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135
JBrowse link
G Stoml2 stomatin like 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:21746876)
UniProt
RGD
PMID:21746876 GO_REF:0000024 NCBI chr 5:57,256,227...57,259,824
Ensembl chr 5:57,256,220...57,259,920
JBrowse link
regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpv17 mitochondrial inner membrane protein MPV17 involved_in ISO
ISS
(PMID:26760297)
(MGI:5776643|PMID:26760297)
GO_REF:0000024
RGD
UniProt
PMID:26760297 GO_REF:0000024 MGI:5776643 NCBI chr 6:25,221,668...25,236,241
Ensembl chr 6:25,222,896...25,236,244
JBrowse link
G Stox1 storkhead box 1 involved_in ISO (PMID:24738702) RGD PMID:24738702 NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939
JBrowse link
regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl4 methyltransferase like 4 involved_in ISO (PMID:32183942) RGD PMID:32183942 NCBI chr 9:111,440,976...111,523,871
Ensembl chr 9:111,441,027...111,464,749
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    cellular process 17431
      cellular metabolic process 9697
        cellular macromolecule metabolic process 3403
          DNA metabolic process 992
            mitochondrial DNA metabolic process 29
              DNA synthesis involved in mitochondrial DNA replication 0
              mitochondrial DNA catabolic process 1
              mitochondrial DNA repair 7
              mitochondrial DNA replication + 19
              mitochondrion DNA recombination 0
              negative regulation of mitochondrial DNA metabolic process + 3
              positive regulation of mitochondrial DNA metabolic process + 4
              regulation of mitochondrial DNA metabolic process + 10
Path 2
Term Annotations click to browse term
  biological_process 18734
    cellular process 17431
      cellular component organization or biogenesis 6532
        cellular component organization 6307
          organelle organization 3900
            mitochondrion organization 576
              mitochondrial genome maintenance 38
                mitochondrial DNA metabolic process 29
                  DNA synthesis involved in mitochondrial DNA replication 0
                  mitochondrial DNA catabolic process 1
                  mitochondrial DNA repair 7
                  mitochondrial DNA replication + 19
                  mitochondrion DNA recombination 0
                  negative regulation of mitochondrial DNA metabolic process + 3
                  positive regulation of mitochondrial DNA metabolic process + 4
                  regulation of mitochondrial DNA metabolic process + 10
paths to the root