Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:mitochondrial DNA metabolic process
go back to main search page
Accession:GO:0032042 term browser browse the term
Definition:The chemical reactions and pathways involving mitochondrial DNA.
Synonyms:exact_synonym: mitochondrial DNA metabolism;   mtDNA metabolic process;   mtDNA metabolism
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


show annotations for term's descendants           Sort by:
mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (MGI:6304909|PMID:30705315) RGD PMID:30705315 MGI:6304909 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 acts_upstream_of_or_within ISO (PMID:25378300) RGD PMID:25378300 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit acts_upstream_of_or_within ISO MGI:5470227 (MGI:5465384|PMID:23197651) RGD PMID:23197651 MGI:5465384 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008 		JBrowse link
G Sesn2 sestrin 2 acts_upstream_of_or_within ISO MGI:3587950 (MGI:5444071|PMID:22958918) RGD PMID:22958918 MGI:5444071 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Tk2 thymidine kinase 2 acts_upstream_of_or_within ISO MGI:3808750 (MGI:3807446|PMID:18467430) RGD PMID:18467430 MGI:3807446 NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924 		JBrowse link
G Top3a DNA topoisomerase III alpha involved_in ISO (PMID:29290614) RGD PMID:29290614 NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559 		JBrowse link
mitochondrial DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G involved_in ISO (PMID:29719607) RGD PMID:29719607 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
mitochondrial DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 acts_upstream_of_or_within ISO (MGI:5516376|PMID:24101517) RGD PMID:24101517 MGI:5516376 NCBI chr 4:123,968,264...123,977,398
Ensembl chr 4:123,968,265...123,977,414 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Lig3 DNA ligase 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:21390132)
(MGI:4943977|PMID:21390132), (MGI:4943978|PMID:21390131)		 RGD PMID:21390131 PMID:21390132 MGI:4943977 MGI:4943978 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 acts_upstream_of_or_within ISO (PMID:25378300) RGD PMID:25378300 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO (MGI:6393030|PMID:29073063) RGD PMID:29073063 MGI:6393030 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,158...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:3528279 (MGI:5516376|PMID:24101517)
GO_REF:0000107		 RGD
Ensembl		 PMID:24101517 GO_REF:0000107 MGI:5516376 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within ISO MGI:2182091|MGI:3040717 (MGI:3612004|PMID:16327803) RGD PMID:16327803 MGI:3612004 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 involved_in ISO
IBA		 (PMID:23313956)
PMID:21873635		 RGD PMID:23313956 PMID:21873635 RGD:13792537 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 PMID:21873635
GO_REF:0000002
(PMID:19837034), (PMID:26554610)
MGI:3584444 (MGI:3583846|PMID:15888483)		 InterPro
RGD		 PMID:15888483 PMID:19837034 PMID:26554610 PMID:21873635 GO_REF:0000002 MGI:3583846, RGD:13792537 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit involved_in ISO
IBA		 (PMID:19837034)
PMID:21873635		 RGD PMID:19837034 PMID:21873635 RGD:13792537 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO
IBA		 (PMID:24207056)
(MGI:5527006|PMID:24207056)
PMID:21873635		 RGD PMID:24207056 PMID:21873635 MGI:5527006, RGD:13792537 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565 		JBrowse link
G Rnaseh1 ribonuclease H1 acts_upstream_of_or_within ISO MGI:2655784 (MGI:2655010|PMID:12667461) RGD PMID:12667461 MGI:2655010 NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 involved_in ISO (PMID:17486094)
(MGI:3714223|PMID:17486094)		 RGD PMID:17486094 MGI:3714223 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B acts_upstream_of_or_within
involved_in		 ISO MGI:2672883 (MGI:3714223|PMID:17486094)
(PMID:17486094)		 RGD PMID:17486094 MGI:3714223 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,158...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
G Tefm transcription elongation factor, mitochondrial NOT|involved_in ISO (PMID:21278163) RGD PMID:21278163 NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486 		JBrowse link
G Tk2 thymidine kinase 2 acts_upstream_of_or_within ISO MGI:3802583 (MGI:3801405|PMID:18434326) RGD PMID:18434326 MGI:3801405 NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924 		JBrowse link
G Twnk twinkle mtDNA helicase involved_in IBA
ISO		 PMID:21873635
(MGI:3826298|PMID:18971204)
(PMID:18971204)		 RGD PMID:18971204 PMID:21873635 MGI:3826298, RGD:13792537 NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802 		JBrowse link
negative regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flcn folliculin involved_in ISO (MGI:5463828|PMID:23150719) RGD PMID:23150719 MGI:5463828 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
negative regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 IMP RGD PMID:23800874 RGD:11557986 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Lig3 DNA ligase 3 involved_in ISO (PMID:21878356) RGD PMID:21878356 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
positive regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha involved_in ISO
IEA		 (MGI:5463828|PMID:23150719)
GO_REF:0000107		 RGD
Ensembl		 PMID:23150719 GO_REF:0000107 MGI:5463828 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
positive regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G involved_in ISO (PMID:29719607) RGD PMID:29719607 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in ISO
ISS
IEA		 (PMID:31550240)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:31550240 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpv17 mitochondrial inner membrane protein MPV17 involved_in ISO
IEA
ISS		 (PMID:26760297)
GO_REF:0000107
(MGI:5776643|PMID:26760297)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26760297 GO_REF:0000024 GO_REF:0000107 MGI:5776643 NCBI chr 6:25,221,668...25,236,241
Ensembl chr 6:25,222,896...25,236,244 		JBrowse link
G Stox1 storkhead box 1 involved_in ISO (PMID:24738702) RGD PMID:24738702 NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939 		JBrowse link
regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl4 methyltransferase 4, N6-adenosine involved_in ISO (PMID:32183942) RGD PMID:32183942 NCBI chr 9:111,440,976...111,523,871
Ensembl chr 9:111,441,027...111,464,749 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      organic substance metabolic process 11623
        macromolecule metabolic process 9355
          nucleic acid metabolic process 2315
            DNA metabolic process 1001
              mitochondrial DNA metabolic process 28
                DNA synthesis involved in mitochondrial DNA replication 0
                mitochondrial DNA catabolic process 1
                mitochondrial DNA repair 8
                mitochondrial DNA replication + 18
                mitochondrion DNA recombination 0
                negative regulation of mitochondrial DNA metabolic process + 3
                positive regulation of mitochondrial DNA metabolic process + 3
                regulation of mitochondrial DNA metabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 19818
    cellular process 17392
      cellular component organization or biogenesis 6828
        cellular component organization 6579
          organelle organization 3641
            mitochondrion organization 614
              mitochondrial genome maintenance 36
                mitochondrial DNA metabolic process 28
                  DNA synthesis involved in mitochondrial DNA replication 0
                  mitochondrial DNA catabolic process 1
                  mitochondrial DNA repair 8
                  mitochondrial DNA replication + 18
                  mitochondrion DNA recombination 0
                  negative regulation of mitochondrial DNA metabolic process + 3
                  positive regulation of mitochondrial DNA metabolic process + 3
                  regulation of mitochondrial DNA metabolic process + 9
paths to the root