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ONTOLOGY REPORT - ANNOTATIONS

Term:protein destabilization
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Accession:GO:0031648 term browser browse the term
Definition:Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
Synonyms:exact_synonym: negative regulation of protein stability;   protein destabilisation


show annotations for term's descendants           Sort by:
protein destabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07001519.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Bmp2 bone morphogenetic protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:96396 (MGI:3512872|PMID:15322112)		 Ensembl
RGD		 PMID:15322112 GO_REF:0000107 MGI:3512872 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase involved_in ISO (PMID:16885022) RGD PMID:16885022 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Capn3 calpain 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:23357851)		 Ensembl
RGD		 PMID:23357851 GO_REF:0000107 NCBI chr 3:107,407,518...107,457,858
Ensembl chr 3:107,407,850...107,457,858 		JBrowse link
G Ccdc88c coiled-coil domain containing 88C involved_in ISO (MGI:3042001|PMID:14750955) RGD PMID:14750955 MGI:3042001 NCBI chr 6:120,169,752...120,289,459
Ensembl chr 6:120,169,738...120,289,555 		JBrowse link
G Cdc73 cell division cycle 73 involved_in ISO
IEA		 (PMID:18987311)
GO_REF:0000107		 RGD
Ensembl		 PMID:18987311 GO_REF:0000107 NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:9529249) RGD PMID:9529249 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains acts_upstream_of_or_within ISO (MGI:5310666|PMID:22285184) RGD PMID:22285184 MGI:5310666 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
G Commd1 copper metabolism domain containing 1 acts_upstream_of_or_within ISO MGI:3714157 (MGI:3713589|PMID:17371845) RGD PMID:17371845 MGI:3713589 NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501 		JBrowse link
G Crebbp CREB binding protein involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:24939902)		 Ensembl
UniProt
RGD		 PMID:24939902 GO_REF:0000024 GO_REF:0000107 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ctsh cathepsin H involved_in ISO
ISS
IEA		 (PMID:17500053)
GO_REF:0000024
(MGI:3722010|PMID:17500053)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:17500053 GO_REF:0000024 GO_REF:0000107 MGI:3722010 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Cul3 cullin 3 involved_in ISO
IEA		 RNAcentral:URS00001230A0_9606 (PMID:24844779)
GO_REF:0000107		 RGD
Ensembl		 PMID:24844779 GO_REF:0000107 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Dazap2 DAZ associated protein 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:33591310)		 UniProt
RGD		 PMID:33591310 GO_REF:0000024 NCBI chr 7:131,714,723...131,720,266
Ensembl chr 7:131,714,745...131,720,265 		JBrowse link
G Derl1 derlin 1 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:24939902) RGD PMID:24939902 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fbxl3 F-box and leucine-rich repeat protein 3 involved_in ISO (MGI:5490394|PMID:23616524) RGD PMID:23616524 MGI:5490394 NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867 		JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within ISO MGI:5301830 (MGI:5299398|PMID:21911473) RGD PMID:21911473 MGI:5299398 NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792 		JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 involved_in ISO (PMID:16885022) RGD PMID:16885022 NCBI chr10:17,232,735...17,330,584
Ensembl chr10:17,227,181...17,330,571 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 acts_upstream_of_or_within ISO (MGI:3805393|PMID:18625840) RGD PMID:18625840 MGI:3805393 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:20484053) RGD PMID:20484053 NCBI chr10:100,825,426...100,844,462
Ensembl chr10:100,825,426...100,844,462 		JBrowse link
G Gsn gelsolin involved_in ISO
IEA		 (PMID:19549824)
GO_REF:0000107		 RGD
Ensembl		 PMID:19549824 GO_REF:0000107 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Hdac6 histone deacetylase 6 involved_in ISO (MGI:5605128|PMID:24882211) RGD PMID:24882211 MGI:5605128 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Htt huntingtin involved_in ISO
IEA		 (PMID:17947297)
GO_REF:0000107		 RGD
Ensembl		 PMID:17947297 GO_REF:0000107 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Iapp islet amyloid polypeptide involved_in ISO (PMID:22944668) RGD PMID:22944668 NCBI chr 4:175,237,013...175,244,373
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G Id1 inhibitor of DNA binding 1 acts_upstream_of_or_within ISO MGI:88177 (MGI:3512872|PMID:15322112) RGD PMID:15322112 MGI:3512872 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:25891078) RGD PMID:25891078 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Isoc2b isochorismatase domain containing 2b involved_in ISO (PMID:17658461) RGD PMID:17658461 NCBI chr 1:68,972,960...68,993,760
Ensembl chr 1:68,972,960...68,993,757 		JBrowse link
G Kdm8 lysine demethylase 8 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:30500822)
(MGI:6270295|PMID:30500822)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30500822 GO_REF:0000024 GO_REF:0000107 MGI:6270295 NCBI chr 1:180,013,969...180,028,829
Ensembl chr 1:180,020,656...180,028,841 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:10360174), (PMID:15314173), (PMID:16479015), (PMID:18560357), (PMID:9529249) RGD PMID:9529249 PMID:10360174 PMID:15314173 PMID:16479015 PMID:18560357 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:24898855) RGD PMID:24898855 NCBI chr 5:150,652,812...150,661,863
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Mylip myosin regulatory light chain interacting protein involved_in ISO (MGI:3849777|PMID:19520913) RGD PMID:19520913 MGI:3849777 NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295 		JBrowse link
G Npm1 nucleophosmin 1 acts_upstream_of_or_within ISO RGD MGI:62033 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(MGI:5922302|PMID:27686098)		 Ensembl
UniProt
RGD		 PMID:27686098 GO_REF:0000024 GO_REF:0000107 MGI:5922302 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 involved_in ISO (PMID:18987311) RGD PMID:18987311 NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404 		JBrowse link
G Plk1 polo-like kinase 1 involved_in ISO
IEA		 (PMID:16885022)
GO_REF:0000107		 RGD
Ensembl		 PMID:16885022 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (MGI:3052572|PMID:15194694) RGD PMID:15194694 MGI:3052572 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
ISS
IEA		 (PMID:19591802), (PMID:29311685)
(MGI:4365473|PMID:19591802)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:19591802 PMID:29311685 GO_REF:0000024 GO_REF:0000107 MGI:4365473 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Prnp prion protein involved_in ISO (PMID:20564047) RGD PMID:20564047 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein involved_in ISO (PMID:26296656) RGD PMID:26296656 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rnf139 ring finger protein 139 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 7:90,439,726...90,450,911
Ensembl chr 7:90,436,621...90,488,009 		JBrowse link
G Rnf5 ring finger protein 5 acts_upstream_of_or_within ISO (MGI:5469257|PMID:23093945) RGD PMID:23093945 MGI:5469257 NCBI chr20:4,145,539...4,147,985
Ensembl chr20:4,145,507...4,147,985 		JBrowse link
G Senp2 SUMO specific peptidase 2 involved_in ISO (PMID:22028379) RGD PMID:22028379 NCBI chr11:78,981,429...79,018,274
Ensembl chr11:78,981,432...79,018,238 		JBrowse link
G Serf1 small EDRK-rich factor 1 involved_in ISO (PMID:20723760), (PMID:22854022), (PMID:31034892) RGD PMID:20723760 PMID:22854022 PMID:31034892 NCBI chr 2:31,475,777...31,482,030
Ensembl chr 2:31,475,703...31,482,032 		JBrowse link
G Serf2 small EDRK-rich factor 2 involved_in ISO (PMID:20723760) RGD PMID:20723760 NCBI chr 3:108,427,013...108,430,721
Ensembl chr 3:108,426,887...108,430,724 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 IMP synaptophysin RGD PMID:2129524 RGD:727236 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (MGI:3790014|PMID:17936707)
GO_REF:0000107		 RGD
Ensembl		 PMID:17936707 GO_REF:0000107 MGI:3790014 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (MGI:4881401|PMID:20141841)
(PMID:29474172)		 RGD PMID:20141841 PMID:29474172 MGI:4881401 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Snca synuclein alpha involved_in ISO
IEA		 (PMID:21320589)
GO_REF:0000107		 RGD
Ensembl		 PMID:21320589 GO_REF:0000107 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (PMID:17875931) RGD PMID:17875931 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (MGI:5619912|PMID:25259869) RGD PMID:25259869 MGI:5619912 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Trim21 tripartite motif-containing 21 involved_in ISO (PMID:16880511) RGD PMID:16880511 NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440 		JBrowse link
G Utp25 UTP25 small subunit processome component involved_in ISO
ISS		 (PMID:23357851)
GO_REF:0000024		 RGD
UniProt		 PMID:23357851 GO_REF:0000024 NCBI chr13:104,630,390...104,651,681
Ensembl chr13:104,630,391...104,651,662 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (MGI:5694519|PMID:26203154) RGD PMID:26203154 MGI:5694519 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
ISS		 (PMID:25280941)
(PMID:16461360), (PMID:25239945)
GO_REF:0000024
(MGI:5573106|PMID:24753614)		 RGD
UniProt		 PMID:16461360 PMID:24753614 PMID:25239945 PMID:25280941 GO_REF:0000024 MGI:5573106 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    biological regulation 13487
      regulation of biological quality 3351
        regulation of protein stability 315
          protein destabilization 54
paths to the root