Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:receptor internalization
go back to main search page
Accession:GO:0031623 term browser browse the term
Definition:A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.


show annotations for term's descendants       view all columns           Sort by:
 
receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:1624291
RGD:1600115
G Ackr3 atypical chemokine receptor 3 JBrowse link 9 97,355,881 97,367,455 RGD:1600115
RGD:1624291
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:1624291
G Ap2m1 adaptor related protein complex 2 subunit mu 1 JBrowse link 11 84,041,184 84,047,542 RGD:1624291
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:1624291
G Calcrl calcitonin receptor like receptor JBrowse link 3 71,747,938 71,845,487 RGD:1624291
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:1624291
RGD:1600115
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Cd9 CD9 molecule JBrowse link 4 157,977,163 158,010,091 RGD:1624291
RGD:1600115
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:1624291
G Cntn2 contactin 2 JBrowse link 13 49,280,913 49,314,061 RGD:1624291
RGD:1600115
G Cxcr1 C-X-C motif chemokine receptor 1 JBrowse link 9 81,466,430 81,469,299 RGD:1624291
G Cxcr2 C-X-C motif chemokine receptor 2 JBrowse link 9 81,427,275 81,435,065 RGD:1624291
G Dnm1 dynamin 1 JBrowse link 3 11,338,081 11,382,043 RGD:8554168
RGD:13792537
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:1624291
RGD:13792537
G Dnm3 dynamin 3 JBrowse link 13 79,906,711 80,379,967 RGD:13792537
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:1624291
RGD:1600115
G Ghr growth hormone receptor JBrowse link 2 53,149,225 53,413,954 RGD:1624291
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:1624291
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:8554168
RGD:1624291
RGD:1600115
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:8554168
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:1600115
RGD:1624291
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:1600115
RGD:1624291
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:1624291
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1600115
RGD:1624291
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1624291
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 JBrowse link 5 152,964,294 152,987,286 RGD:1624291
G Mx1 myxovirus (influenza virus) resistance 1 JBrowse link 11 37,891,150 37,916,775 RGD:13792537
G Mx2 MX dynamin like GTPase 2 JBrowse link 11 38,035,306 38,066,185 RGD:13792537
G Nedd4 NEDD4 E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:1600115
RGD:13792537
RGD:1624291
G Picalm phosphatidylinositol binding clathrin assembly protein JBrowse link 1 154,377,229 154,458,966 RGD:1600115
RGD:1624291
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:10043344
G Rab31 RAB31, member RAS oncogene family JBrowse link 9 113,370,072 113,504,606 RGD:1600115
RGD:1624291
G Ramp1 receptor activity modifying protein 1 JBrowse link 9 98,313,632 98,364,206 RGD:8554018
RGD:13792537
RGD:1624291
G Ramp2 receptor activity modifying protein 2 JBrowse link 10 89,166,170 89,168,962 RGD:8554018
RGD:13792537
RGD:1624291
G Ramp3 receptor activity modifying protein 3 JBrowse link 14 86,922,223 86,939,722 RGD:1624291
RGD:13792537
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
G Snx1 sorting nexin 1 JBrowse link 8 71,745,687 71,786,182 RGD:1624291
RGD:1600115
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1600115
RGD:1624291
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:1624291
RGD:1600115
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:1624291
G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:1624291
G Arr3 arrestin 3 JBrowse link X 70,438,590 70,452,140 RGD:13792537
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:1624291
RGD:13792537
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
RGD:13792537
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:1624291
G Dnm1 dynamin 1 JBrowse link 3 11,338,081 11,382,043 RGD:9685157
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:9685157
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1581465
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:1581465
RGD:1624291
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:1304268
G Htr1b 5-hydroxytryptamine receptor 1B JBrowse link 8 89,113,984 89,130,830 RGD:1624291
G Htr2b 5-hydroxytryptamine receptor 2B JBrowse link 9 93,112,781 93,130,135 RGD:1600115
RGD:1624291
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:1624291
G Sag S-antigen visual arrestin JBrowse link 9 94,926,901 94,972,162 RGD:13792537
insulin receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1600115
RGD:1624291
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:11059580
RGD:11059573
G Lmbrd1 LMBR1 domain containing 1 JBrowse link 9 30,939,555 31,038,381 RGD:1624291
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Necab2 N-terminal EF-hand calcium binding protein 2 JBrowse link 19 52,086,325 52,112,633 RGD:1624291
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
negative regulation of receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ankrd13a ankyrin repeat domain 13a JBrowse link 12 47,558,587 47,588,486 RGD:1624291
G Ankrd13b ankyrin repeat domain 13B JBrowse link 10 62,674,416 62,691,949 RGD:1624291
G Ankrd13d ankyrin repeat domain 13D JBrowse link 1 219,520,316 219,532,718 RGD:1624291
G Atxn2 ataxin 2 JBrowse link 12 40,264,601 40,335,637 RGD:1624291
G Dlg4 discs large MAGUK scaffold protein 4 JBrowse link 10 56,625,845 56,655,543 RGD:8554437
G Fmr1 FMRP translational regulator 1 JBrowse link X 154,684,924 154,722,369 RGD:12050150
G Lrpap1 LDL receptor related protein associated protein 1 JBrowse link 14 80,911,281 80,923,290 RGD:1624291
RGD:13792537
G LRRTM1 leucine rich repeat transmembrane neuronal 1 JBrowse link 4 108,300,927 108,316,373 RGD:1624291
G Lrrtm2 leucine rich repeat transmembrane neuronal 2 JBrowse link 18 28,012,877 28,017,925 RGD:1624291
G Mtmr2 myotubularin related protein 2 JBrowse link 8 12,283,471 12,334,014 RGD:8553482
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
RGD:1600115
G Wdr54 WD repeat domain 54 JBrowse link 4 114,847,722 114,871,989 RGD:1624291
neurotransmitter receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap2b1 adaptor related protein complex 2 subunit beta 1 JBrowse link 10 70,516,462 70,621,973 RGD:1624291
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 JBrowse link 7 119,228,112 119,353,332 RGD:1624291
RGD:13792537
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 JBrowse link 1 192,613,766 192,708,371 RGD:13792537
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 JBrowse link 10 95,954,160 96,015,484 RGD:13792537
G Cacng5 calcium voltage-gated channel auxiliary subunit gamma 5 JBrowse link 10 96,122,240 96,166,606 RGD:13792537
G Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 JBrowse link 1 64,374,547 64,405,380 RGD:13792537
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 JBrowse link 1 64,330,106 64,350,338 RGD:13792537
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:1624291
RGD:1600115
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apln apelin JBrowse link X 134,856,719 134,866,210 RGD:12907555
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
positive regulation of receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahi1 Abelson helper integration site 1 JBrowse link 1 16,478,127 16,601,769 RGD:1624291
RGD:1600115
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1600115
RGD:1624291
G Ap2m1 adaptor related protein complex 2 subunit mu 1 JBrowse link 11 84,041,184 84,047,542 RGD:13461854
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:1624291
RGD:1600115
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5510008
RGD:1624291
G Atad1 ATPase family, AAA domain containing 1 JBrowse link 1 251,234,702 251,386,996 RGD:1624291
RGD:1600115
G Cd63 Cd63 molecule JBrowse link 7 3,320,250 3,335,583 RGD:1600115
RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1624291
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:2311559
G Dtnbp1 dystrobrevin binding protein 1 JBrowse link 17 20,090,136 20,182,332 RGD:8553895
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:1624291
G Fmr1 FMRP translational regulator 1 JBrowse link X 154,684,924 154,722,369 RGD:1600115
RGD:1624291
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:1624291
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
G Hamp hepcidin antimicrobial peptide JBrowse link 1 89,368,021 89,369,960 RGD:1624291
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:1600115
RGD:1624291
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 JBrowse link 4 10,995,241 12,472,423 RGD:1600115
RGD:1624291
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:1624291
RGD:1600115
G Pard3 par-3 family cell polarity regulator JBrowse link 19 60,017,746 60,580,628 RGD:1624291
G Pcsk9 proprotein convertase subtilisin/kexin type 9 JBrowse link 5 126,031,368 126,053,726 RGD:1624291
G Pick1 protein interacting with PRKCA 1 JBrowse link 7 120,465,472 120,484,824 RGD:8554748
RGD:13792537
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:1624291
RGD:1600115
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:9835004
G Scyl2 SCY1 like pseudokinase 2 JBrowse link 7 30,291,087 30,344,464 RGD:1624291
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:1624291
RGD:1600115
G Sfrp4 secreted frizzled-related protein 4 JBrowse link 17 47,383,983 47,394,065 RGD:1624291
RGD:1600115
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1600115
RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
G Tbc1d5 TBC1 domain family, member 5 JBrowse link 9 1,144,641 1,747,732 RGD:1624291
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
postsynaptic neurotransmitter receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap2b1 adaptor related protein complex 2 subunit beta 1 JBrowse link 10 70,516,462 70,621,973 RGD:1624291
G Ap2m1 adaptor related protein complex 2 subunit mu 1 JBrowse link 11 84,041,184 84,047,542 RGD:13432317
RGD:1624291
G Caly calcyon neuron-specific vesicular protein JBrowse link 1 212,537,851 212,549,040 RGD:1624291
G Dnm1 dynamin 1 JBrowse link 3 11,338,081 11,382,043 RGD:13792537
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:13792537
G Dnm3 dynamin 3 JBrowse link 13 79,906,711 80,379,967 RGD:8553820
RGD:13792537
G Eps15 epidermal growth factor receptor pathway substrate 15 JBrowse link 5 128,923,809 129,022,268 RGD:13702241
G Mx1 myxovirus (influenza virus) resistance 1 JBrowse link 11 37,891,150 37,916,775 RGD:13792537
G Mx2 MX dynamin like GTPase 2 JBrowse link 11 38,035,306 38,066,185 RGD:13792537
G Myo6 myosin VI JBrowse link 8 87,583,649 87,731,271 RGD:1624291
G Synj1 synaptojanin 1 JBrowse link 11 31,105,784 31,181,573 RGD:1624291
prostaglandin receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:10043344
receptor internalization involved in canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Rab5a RAB5A, member RAS oncogene family JBrowse link 9 5,910 6,065 RGD:1624291
G Scyl2 SCY1 like pseudokinase 2 JBrowse link 7 30,291,087 30,344,464 RGD:1624291
regulation of postsynaptic neurotransmitter receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akap5 A-kinase anchoring protein 5 JBrowse link 6 99,356,509 99,361,909 RGD:2313185
G Arc activity-regulated cytoskeleton-associated protein JBrowse link 7 115,907,097 115,911,059 RGD:1624291
G Atad1 ATPase family, AAA domain containing 1 JBrowse link 1 251,234,702 251,386,996 RGD:1624291
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:13702467
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:1600115
RGD:1624291
G Efnb2 ephrin B2 JBrowse link 16 86,631,151 86,672,050 RGD:1624291
G Gsg1l GSG1-like JBrowse link 1 197,271,704 197,482,776 RGD:1624291
G Hap1 huntingtin-associated protein 1 JBrowse link 10 88,257,975 88,266,210 RGD:13702182
G Hpca hippocalcin JBrowse link 5 147,295,124 147,305,757 RGD:13702412
G Iqsec1 IQ motif and Sec7 domain ArfGEF 1 JBrowse link 4 123,400,717 123,454,656 RGD:1624291
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:1624291
G Nedd4 NEDD4 E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:13702142
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:1624291
G Numb NUMB, endocytic adaptor protein JBrowse link 6 107,279,917 107,325,345 RGD:1600115
RGD:1624291
G Ophn1 oligophrenin 1 JBrowse link X 68,185,865 68,579,518 RGD:1624291
G Pacsin1 protein kinase C and casein kinase substrate in neurons 1 JBrowse link 20 7,241,248 7,286,702 RGD:13702454
RGD:13702399
G Pick1 protein interacting with PRKCA 1 JBrowse link 7 120,465,472 120,484,824 RGD:13702248
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma JBrowse link 7 11,267,207 11,294,291 RGD:1624291
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:1624291
G Scrib scribble planar cell polarity protein JBrowse link 7 117,105,810 117,128,802 RGD:12050130
G Sirt2 sirtuin 2 JBrowse link 1 86,948,866 86,971,954 RGD:13702139
G Syne1 spectrin repeat containing nuclear envelope protein 1 JBrowse link 1
1
41,608,287
41,844,840
41,763,591
42,086,662
RGD:13209020
G Synj1 synaptojanin 1 JBrowse link 11 31,105,784 31,181,573 RGD:1624291
G Usp46 ubiquitin specific peptidase 46 JBrowse link 14 36,687,134 36,755,360 RGD:11056935
regulation of receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arf1 ADP-ribosylation factor 1 JBrowse link 10 45,562,700 45,579,214 RGD:8553918
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
G Mkln1 muskelin 1 JBrowse link 4 58,693,384 58,817,924 RGD:13702173
G Napb NSF attachment protein beta JBrowse link 3 143,017,571 143,063,904 RGD:633462
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase JBrowse link 10 91,879,608 91,986,242 RGD:633462
G Rspo1 R-spondin 1 JBrowse link 5 142,986,526 143,007,847 RGD:1624291
G Sh3gl2 SH3 domain containing GRB2 like 2, endophilin A1 JBrowse link 5 103,479,767 103,654,507 RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
regulation of signal transduction by receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    metabolic process 11953
      cellular metabolic process 10781
        cellular macromolecule metabolic process 8270
          receptor metabolic process 218
            receptor internalization 136
              B cell receptor internalization + 0
              G protein-coupled receptor internalization + 19
              Wnt receptor internalization + 0
              insulin receptor internalization + 3
              negative regulation of receptor internalization + 14
              neurotransmitter receptor internalization + 41
              positive regulation of receptor internalization + 33
              receptor internalization involved in canonical Wnt signaling pathway 3
              regulation of receptor internalization + 76
              regulation of signal transduction by receptor internalization + 1
Path 2
Term Annotations click to browse term
  biological_process 19678
    localization 6437
      establishment of localization 4887
        transport 4744
          vesicle-mediated transport 1639
            endocytosis 658
              receptor-mediated endocytosis 250
                receptor internalization 136
                  B cell receptor internalization + 0
                  G protein-coupled receptor internalization + 19
                  Wnt receptor internalization + 0
                  insulin receptor internalization + 3
                  negative regulation of receptor internalization + 14
                  neurotransmitter receptor internalization + 41
                  positive regulation of receptor internalization + 33
                  receptor internalization involved in canonical Wnt signaling pathway 3
                  regulation of receptor internalization + 76
                  regulation of signal transduction by receptor internalization + 1
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.