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ONTOLOGY REPORT - ANNOTATIONS


Term:neuromuscular junction
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Accession:GO:0031594 term browser browse the term
Definition:The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
Comment:In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
Synonyms:related_synonym: NMJ;   motor endplate
 xref: NIF_Subcellular:sao1124888485;   Wikipedia:Neuromuscular_junction


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neuromuscular junction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:1624291
RGD:1600115
RGD:12050110
G Adora3 adenosine A3 receptor JBrowse link 2 208,336,909 208,379,217 RGD:1624291
G Akap1 A-kinase anchoring protein 1 JBrowse link 10 76,151,013 76,183,987 RGD:2313126
G Ank3 ankyrin 3 JBrowse link 20 19,948,767 20,480,628 RGD:6767302
G Apbb1 amyloid beta precursor protein binding family B member 1 JBrowse link 1 170,387,625 170,411,263 RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
RGD:1600115
G Ascc1 activating signal cointegrator 1 complex subunit 1 JBrowse link 20 29,558,330 29,648,899 RGD:1624291
RGD:1600115
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:1624291
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1600290
G Cdh15 cadherin 15 JBrowse link 19 55,669,661 55,689,986 RGD:1624291
RGD:1600115
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:8554712
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 JBrowse link 10 67,862,054 67,863,255 RGD:8554712
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit JBrowse link 3 60,445,657 60,460,724 RGD:1624291
RGD:1600115
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit JBrowse link 10 56,390,671 56,403,255 RGD:1600115
RGD:1624291
G Chrnd cholinergic receptor nicotinic delta subunit JBrowse link 9 94,286,550 94,294,968 RGD:1600115
RGD:1624291
G Chrne cholinergic receptor nicotinic epsilon subunit JBrowse link 10 57,238,960 57,246,750 RGD:1600115
RGD:1624291
G Cib2 calcium and integrin binding family member 2 JBrowse link 8 59,123,078 59,139,946 RGD:1624291
RGD:1600115
G Col4a5 collagen type IV alpha 5 chain JBrowse link X 112,769,595 112,983,720 RGD:1624291
RGD:1600115
G Colq collagen like tail subunit of asymmetric acetylcholinesterase JBrowse link 16 7,626,380 7,681,621 RGD:1624291
RGD:1600115
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:1600115
RGD:1624291
G Cxadr CXADR, Ig-like cell adhesion molecule JBrowse link 11 16,826,269 16,873,564 RGD:1624291
G Cyth1 cytohesin 1 JBrowse link 10 107,197,983 107,281,285 RGD:13702340
G Des desmin JBrowse link 9 82,556,574 82,564,288 RGD:1624291
RGD:1600115
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1624291
RGD:13792537
RGD:1600115
G Dlg2 discs large MAGUK scaffold protein 2 JBrowse link 1 154,916,274 157,274,077 RGD:13792537
G Dlg4 discs large MAGUK scaffold protein 4 JBrowse link 10 56,625,845 56,655,543 RGD:13792537
G Dlgap3 DLG associated protein 3 JBrowse link 5 145,234,757 145,304,536 RGD:1600115
RGD:1624291
G Dlgap4 DLG associated protein 4 JBrowse link 3 152,752,091 152,846,118 RGD:1600115
RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
RGD:1600115
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 JBrowse link 3 177,012,714 177,047,787 RGD:1600115
RGD:1624291
G Dok7 docking protein 7 JBrowse link 14 80,925,409 80,963,454 RGD:1624291
G Efna2 ephrin A2 JBrowse link 7 12,382,636 12,393,266 RGD:2301728
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:2301728
G Epha7 Eph receptor A7 JBrowse link 5 43,602,744 43,761,198 RGD:2301728
G Erbin erbb2 interacting protein JBrowse link 2 33,880,860 33,952,806 RGD:13702240
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:1582330
G Fchsd1 FCH and double SH3 domains 1 JBrowse link 18 31,096,815 31,109,077 RGD:13792537
G Fchsd2 FCH and double SH3 domains 2 JBrowse link 1 166,140,025 166,395,915 RGD:13792537
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:4107718
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:1624291
RGD:1600115
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:1624291
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1624291
RGD:1600115
G Kcnc3 potassium voltage-gated channel subfamily C member 3 JBrowse link 1 100,593,453 100,607,874 RGD:1624291
G Kcnc4 potassium voltage-gated channel subfamily C member 4 JBrowse link 2 210,220,908 210,241,447 RGD:1624291
RGD:1600115
G Kcnn3 potassium calcium-activated channel subfamily N member 3 JBrowse link 2 188,837,280 188,991,794 RGD:7175517
G Lama2 laminin subunit alpha 2 JBrowse link 1 18,491,264 19,143,486 RGD:1600115
RGD:1624291
G Lama4 laminin subunit alpha 4 JBrowse link 20 44,060,715 44,201,966 RGD:1600115
RGD:1624291
G Lama5 laminin subunit alpha 5 JBrowse link 3 175,553,042 175,601,112 RGD:1600115
RGD:1624291
G Lamb2 laminin subunit beta 2 JBrowse link 8 117,268,335 117,280,517 RGD:1600115
RGD:1624291
G Lamc1 laminin subunit gamma 1 JBrowse link 13 70,656,727 70,783,515 RGD:1624291
G LOC100911248 crk-like protein-like JBrowse link 11 87,778,338 87,815,049 RGD:1600115
G Lrp4 LDL receptor related protein 4 JBrowse link 3 80,362,643 80,416,684 RGD:1624291
RGD:1600115
G Lrrc1 leucine rich repeat containing 1 JBrowse link 8 84,721,621 84,835,074 RGD:13792537
G Musk muscle associated receptor tyrosine kinase JBrowse link 5 75,392,790 75,498,694 RGD:2317114
RGD:1624291
G Myh10 myosin heavy chain 10 JBrowse link 10 55,274,910 55,406,738 RGD:1624291
RGD:1600115
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:1600115
RGD:1624291
G Nefm neurofilament medium JBrowse link 15 44,855,307 44,860,604 RGD:1624291
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Pclo piccolo (presynaptic cytomatrix protein) JBrowse link 4 16,454,904 17,058,921 RGD:9850148
G Pdzrn3 PDZ domain containing RING finger 3 JBrowse link 4 133,717,139 133,951,282 RGD:1600115
RGD:13792537
RGD:1624291
G Pls3 plastin 3 JBrowse link X 119,030,311 119,124,268 RGD:1624291
G Postn periostin JBrowse link 2 143,656,820 143,688,087 RGD:10040958
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A JBrowse link 4 29,976,485 30,247,371 RGD:625592
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:1624291
RGD:1600115
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha JBrowse link 10 97,940,705 97,959,199 RGD:1624291
RGD:1600115
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:11353024
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:1625624
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1601507
RGD:13792537
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:13792537
G Ptn pleiotrophin JBrowse link 4 64,239,156 64,330,996 RGD:10043837
G Rapsn receptor-associated protein of the synapse JBrowse link 3 79,859,815 79,869,486 RGD:8549750
RGD:1624291
G Rph3a rabphilin 3A JBrowse link 12 41,073,296 41,149,799 RGD:13702383
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:1624291
RGD:1600115
G Slc18a3 solute carrier family 18 member A3 JBrowse link 16 8,682,668 8,685,529 RGD:13702308
RGD:13702424
G Slc5a7 solute carrier family 5 member 7 JBrowse link 9 5,294,377 5,330,822 RGD:1600115
RGD:1624291
G Slc8a3 solute carrier family 8 member A3 JBrowse link 6 104,889,500 105,099,408 RGD:1624291
RGD:1600115
G Snta1 syntrophin, alpha 1 JBrowse link 3 149,874,023 149,905,980 RGD:6771371
RGD:13792537
G Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 JBrowse link 17 7,675,531 7,797,863 RGD:1624291
G Stx1b syntaxin 1B JBrowse link 1 199,251,842 199,270,465 RGD:1600115
RGD:1624291
G Stxbp5 syntaxin binding protein 5 JBrowse link 1 3,858,917 4,011,684 RGD:1299498
G Stxbp5l syntaxin binding protein 5-like JBrowse link 11 66,246,624 66,566,331 RGD:1600115
RGD:1624291
G Sv2a synaptic vesicle glycoprotein 2a JBrowse link 2 198,321,100 198,336,889 RGD:1624291
RGD:1600115
G Sync syncoilin, intermediate filament protein JBrowse link 5 147,476,136 147,500,193 RGD:1624291
RGD:1600115
G Syngr1 synaptogyrin 1 JBrowse link 7 121,311,008 121,334,437 RGD:13792537
G Syngr2 synaptogyrin 2 JBrowse link 10 106,812,740 106,816,675 RGD:13792537
G Syngr3 synaptogyrin 3 JBrowse link 10 14,051,413 14,056,169 RGD:1624291
RGD:13792537
G Syngr4 synaptogyrin 4 JBrowse link 1 101,872,541 101,883,897 RGD:13792537
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:13792537
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:1624291
RGD:1600115
G Syt2 synaptotagmin 2 JBrowse link 13 51,569,248 51,577,824 RGD:1624291
G Tbc1d24 TBC1 domain family, member 24 JBrowse link 10 13,551,100 13,576,739 RGD:1600115
G Thbs4 thrombospondin 4 JBrowse link 2 22,343,727 22,385,855 RGD:61768
G Trip4 thyroid hormone receptor interactor 4 JBrowse link 8 71,369,121 71,533,281 RGD:1624291
RGD:1600115
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:1600115
RGD:1624291
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:1624291
RGD:13792537
RGD:1600115
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1624291
RGD:13792537
G Unc13c unc-13 homolog C JBrowse link 8 80,202,736 80,656,363 RGD:13792537
G Utrn utrophin JBrowse link 1 6,451,809 6,970,040 RGD:634446
RGD:1624291
G Vamp1 vesicle-associated membrane protein 1 JBrowse link 4 157,726,941 157,733,644 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19644
    cellular anatomical entity 19270
      synapse 1549
        neuromuscular junction 101
          excitatory neuromuscular junction + 0
          inhibitory neuromuscular junction + 0
          neuromuscular junction of myotube + 0
          neuromuscular junction of somatic muscle + 0
          postsynapse of neuromuscular junction + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.