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Term:wybutosine biosynthetic process
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Accession:GO:0031591 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.
Comment:Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe.
Synonyms:exact_synonym: yW biosynthesis;   yW biosynthetic process

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wybutosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcmt2 leucine carboxyl methyltransferase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:108,099,960...108,102,084
Ensembl chr 3:108,099,961...108,102,084
JBrowse link
G Tyw1 tRNA-yW synthesizing protein 1 homolog involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:26,332,020...26,418,286
Ensembl chr12:26,330,351...26,418,208
JBrowse link
G Tyw5 tRNA-yW synthesizing protein 5 involved_in IBA
(PMID:20739293), (PMID:20972222)
RGD PMID:20739293 PMID:20972222 PMID:21873635 RGD:13792537 NCBI chr 9:58,961,100...58,979,188
Ensembl chr 9:58,961,106...58,979,188
JBrowse link

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Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      nitrogen compound metabolic process 9983
        organonitrogen compound metabolic process 6802
          organonitrogen compound biosynthetic process 1998
            wybutosine biosynthetic process 3
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      cellular metabolic process 10721
        heterocycle metabolic process 5522
          nucleobase-containing compound metabolic process 5380
            nucleic acid metabolic process 4890
              RNA metabolic process 4360
                ncRNA metabolic process 513
                  ncRNA processing 413
                    tRNA processing 121
                      tRNA modification 86
                        wybutosine biosynthetic process 3
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