wybutosine biosynthetic process - Ontology Report - Rat Genome Database

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	wybutosine biosynthetic process	go back to main search page
Accession:	GO:0031591	browse the term
Definition:	The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.
Comment:	Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe.
Synonyms:	exact_synonym:	yW biosynthesis; yW biosynthetic process

show annotations for term's descendants Sort by:
Rat (5) Mouse (5) Human (6) Chinchilla (1) Bonobo (1) Dog (1) Squirrel (1) Pig (2) Green Monkey (1) Naked Mole-rat (1) All
Genes (5)

wybutosine biosynthetic process

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

leucine carboxyl methyltransferase 2

involved_in

PMID:21873635

GO_Central

NCBI chr 3:108,099,960...108,102,084
Ensembl chr 3:108,099,961...108,102,084

G

tRNA methyltransferase 12

involved_in

PMID:21873635

GO_Central

NCBI chr 7:90,417,846...90,419,472
Ensembl chr 7:90,417,862...90,419,867

G

tRNA-yW synthesizing protein 1 homolog

involved_in

PMID:21873635

GO_Central

NCBI chr12:26,332,020...26,418,286
Ensembl chr12:26,330,351...26,418,208

G

tRNA-yW synthesizing protein 3 homolog

involved_in

PMID:21873635

GO_Central

NCBI chr 2:243,529,912...243,552,043
Ensembl chr 2:243,529,946...243,552,039

G

tRNA-yW synthesizing protein 5

involved_in

PMID:21873635
(PMID:20739293), (PMID:20972222)

PMID:20739293 PMID:20972222 PMID:21873635

NCBI chr 9:58,961,100...58,979,188
Ensembl chr 9:58,961,106...58,979,188

Term paths to the root

Path 1
Term	Annotations
biological_process	19574
metabolic process	11556
organic substance metabolic process	10908
organonitrogen compound metabolic process	5634
wybutosine metabolic process	5
wybutosine biosynthetic process	5
Path 2
Term	Annotations
biological_process	19574
metabolic process	11556
cellular metabolic process	10142
cellular aromatic compound metabolic process	5701
nucleobase-containing compound metabolic process	5468
nucleic acid metabolic process	4981
RNA metabolic process	4384
ncRNA metabolic process	658
tRNA metabolic process	190
tRNA processing	128
tRNA modification	90
wybutosine biosynthetic process	5

paths to the root