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Term:wybutosine biosynthetic process
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Accession:GO:0031591 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.
Comment:Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe.
Synonyms:exact_synonym: yW biosynthesis;   yW biosynthetic process

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wybutosine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcmt2 leucine carboxyl methyltransferase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:113,089,646...113,091,770
Ensembl chr 3:113,089,647...113,091,770
JBrowse link
G Tyw1 tRNA-yW synthesizing protein 1 homolog IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:29,824,990...29,919,240
Ensembl chr12:29,824,981...29,919,320
JBrowse link
G Tyw5 tRNA-yW synthesizing protein 5 ISO
(PMID:20739293), (PMID:20972222)
RGD PMID:20739293, PMID:20972222, PMID:21873635 RGD:13792537 NCBI chr 9:64,077,841...64,096,265
Ensembl chr 9:64,077,845...64,096,265
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      nitrogen compound metabolic process 10366
        organonitrogen compound metabolic process 7153
          organonitrogen compound biosynthetic process 2023
            wybutosine biosynthetic process 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      cellular metabolic process 11085
        heterocycle metabolic process 5640
          nucleobase-containing compound metabolic process 5489
            nucleic acid metabolic process 4985
              RNA metabolic process 4469
                ncRNA metabolic process 523
                  ncRNA processing 424
                    tRNA processing 120
                      tRNA modification 85
                        wybutosine biosynthetic process 3
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.