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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
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Accession:GO:0031586 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms:exact_synonym: down regulation of IP3 receptor activity;   downregulation of IP3 receptor activity;   negative regulation of inositol 1,4,5-trisphosphate receptor activity
 narrow_synonym: inhibition of IP3 receptor activity
 related_synonym: negative regulation of IP3 receptor activity


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  biological_process 11931
    cellular process 11114
      negative regulation of cellular process 4234
        negative regulation of calcium ion transport into cytosol 18
          negative regulation of release of sequestered calcium ion into cytosol 15
            negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 11931
    biological regulation 8731
      regulation of biological quality 3357
        homeostatic process 1696
          chemical homeostasis 1050
            ion homeostasis 682
              cellular ion homeostasis 540
                cellular cation homeostasis 527
                  cellular metal ion homeostasis 481
                    cellular calcium ion homeostasis 395
                      regulation of cytosolic calcium ion concentration 305
                        positive regulation of cytosolic calcium ion concentration 267
                          calcium ion transport into cytosol 153
                            calcium ion transmembrane import into cytosol 130
                              release of sequestered calcium ion into cytosol 108
                                regulation of release of sequestered calcium ion into cytosol 80
                                  regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 6
                                    negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.