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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
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Accession:GO:0031586 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms:exact_synonym: down regulation of IP3 receptor activity;   downregulation of IP3 receptor activity;   negative regulation of inositol 1,4,5-trisphosphate receptor activity
 narrow_synonym: inhibition of IP3 receptor activity
 related_synonym: negative regulation of IP3 receptor activity


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  biological_process 19676
    cellular process 18449
      negative regulation of cellular process 5072
        negative regulation of calcium ion transport into cytosol 22
          negative regulation of release of sequestered calcium ion into cytosol 18
            negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 19676
    biological regulation 13597
      regulation of biological quality 4250
        homeostatic process 2062
          chemical homeostasis 1322
            ion homeostasis 878
              cellular ion homeostasis 723
                cellular cation homeostasis 709
                  cellular metal ion homeostasis 644
                    cellular calcium ion homeostasis 513
                      regulation of cytosolic calcium ion concentration 413
                        positive regulation of cytosolic calcium ion concentration 359
                          calcium ion transport into cytosol 174
                            calcium ion transmembrane import into cytosol 150
                              release of sequestered calcium ion into cytosol 127
                                regulation of release of sequestered calcium ion into cytosol 88
                                  regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 6
                                    negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.