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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
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Accession:GO:0031586 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms:exact_synonym: down regulation of IP3 receptor activity;   downregulation of IP3 receptor activity;   negative regulation of inositol 1,4,5-trisphosphate receptor activity
 narrow_synonym: inhibition of IP3 receptor activity
 related_synonym: negative regulation of IP3 receptor activity


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  biological_process 16408
    cellular process 15621
      negative regulation of cellular process 4786
        negative regulation of calcium ion transport into cytosol 20
          negative regulation of release of sequestered calcium ion into cytosol 16
            negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 16408
    biological regulation 11878
      regulation of biological quality 3949
        homeostatic process 1942
          chemical homeostasis 1231
            ion homeostasis 812
              cellular ion homeostasis 662
                cellular cation homeostasis 648
                  cellular metal ion homeostasis 583
                    cellular calcium ion homeostasis 475
                      regulation of cytosolic calcium ion concentration 378
                        positive regulation of cytosolic calcium ion concentration 331
                          calcium ion transport into cytosol 167
                            calcium ion transmembrane import into cytosol 144
                              release of sequestered calcium ion into cytosol 120
                                regulation of release of sequestered calcium ion into cytosol 83
                                  regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 6
                                    negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.