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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
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Accession:GO:0031586 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms:exact_synonym: down regulation of IP3 receptor activity;   downregulation of IP3 receptor activity;   negative regulation of inositol 1,4,5-trisphosphate receptor activity
 narrow_synonym: inhibition of IP3 receptor activity
 related_synonym: negative regulation of IP3 receptor activity


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  biological_process 23164
    cellular process 17043
      negative regulation of cellular process 5031
        negative regulation of calcium ion transport into cytosol 21
          negative regulation of release of sequestered calcium ion into cytosol 17
            negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 23164
    biological regulation 12764
      regulation of biological quality 4231
        homeostatic process 2049
          chemical homeostasis 1300
            ion homeostasis 861
              cellular ion homeostasis 699
                cellular cation homeostasis 684
                  cellular metal ion homeostasis 619
                    cellular calcium ion homeostasis 499
                      regulation of cytosolic calcium ion concentration 397
                        positive regulation of cytosolic calcium ion concentration 349
                          calcium ion transport into cytosol 169
                            calcium ion transmembrane import into cytosol 145
                              release of sequestered calcium ion into cytosol 119
                                regulation of release of sequestered calcium ion into cytosol 86
                                  regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 6
                                    negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.