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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
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Accession:GO:0031586 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms:exact_synonym: down regulation of IP3 receptor activity;   downregulation of IP3 receptor activity;   negative regulation of inositol 1,4,5-trisphosphate receptor activity
 narrow_synonym: inhibition of IP3 receptor activity
 related_synonym: negative regulation of IP3 receptor activity


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  biological_process 16041
    cellular process 15295
      negative regulation of cellular process 4768
        negative regulation of calcium ion transport into cytosol 20
          negative regulation of release of sequestered calcium ion into cytosol 16
            negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 16041
    biological regulation 11408
      regulation of biological quality 3960
        homeostatic process 1934
          chemical homeostasis 1230
            ion homeostasis 815
              cellular ion homeostasis 662
                cellular cation homeostasis 648
                  cellular metal ion homeostasis 586
                    cellular calcium ion homeostasis 478
                      regulation of cytosolic calcium ion concentration 381
                        positive regulation of cytosolic calcium ion concentration 330
                          calcium ion transport into cytosol 169
                            calcium ion transmembrane import into cytosol 145
                              release of sequestered calcium ion into cytosol 120
                                regulation of release of sequestered calcium ion into cytosol 83
                                  regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 6
                                    negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.