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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
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Accession:GO:0031586 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms:exact_synonym: down regulation of IP3 receptor activity;   downregulation of IP3 receptor activity;   negative regulation of inositol 1,4,5-trisphosphate receptor activity
 narrow_synonym: inhibition of IP3 receptor activity
 related_synonym: negative regulation of IP3 receptor activity


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Term Annotations click to browse term
  biological_process 11828
    cellular process 11038
      negative regulation of cellular process 4202
        negative regulation of calcium ion transport into cytosol 18
          negative regulation of release of sequestered calcium ion into cytosol 15
            negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 11828
    biological regulation 8664
      regulation of biological quality 3327
        homeostatic process 1687
          chemical homeostasis 1040
            ion homeostasis 679
              cellular ion homeostasis 541
                cellular cation homeostasis 528
                  cellular metal ion homeostasis 481
                    cellular calcium ion homeostasis 398
                      regulation of cytosolic calcium ion concentration 307
                        positive regulation of cytosolic calcium ion concentration 268
                          calcium ion transport into cytosol 152
                            calcium ion transmembrane import into cytosol 129
                              release of sequestered calcium ion into cytosol 108
                                regulation of release of sequestered calcium ion into cytosol 82
                                  regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 5
                                    negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.