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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
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Accession:GO:0031586 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms:exact_synonym: down regulation of IP3 receptor activity;   downregulation of IP3 receptor activity;   negative regulation of inositol 1,4,5-trisphosphate receptor activity
 narrow_synonym: inhibition of IP3 receptor activity
 related_synonym: negative regulation of IP3 receptor activity


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  biological_process 19578
    cellular process 18362
      negative regulation of cellular process 5082
        negative regulation of calcium ion transport into cytosol 22
          negative regulation of release of sequestered calcium ion into cytosol 18
            negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 19578
    biological regulation 13539
      regulation of biological quality 4290
        homeostatic process 2064
          chemical homeostasis 1329
            ion homeostasis 887
              cellular ion homeostasis 733
                cellular cation homeostasis 720
                  cellular metal ion homeostasis 658
                    cellular calcium ion homeostasis 528
                      regulation of cytosolic calcium ion concentration 427
                        positive regulation of cytosolic calcium ion concentration 373
                          calcium ion transport into cytosol 187
                            calcium ion transmembrane import into cytosol 163
                              release of sequestered calcium ion into cytosol 140
                                regulation of release of sequestered calcium ion into cytosol 88
                                  regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 6
                                    negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.