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ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic intra-S DNA damage checkpoint signaling
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Accession:GO:0031573 term browser browse the term
Definition:A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
Synonyms:exact_synonym: intra-S DNA damage checkpoint;   mitotic intra-S DNA damage checkpoint;   signal transduction involved in intra-S DNA damage checkpoint
 broad_synonym: S-phase checkpoint
 alt_id: GO:0072428



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mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
ISS
(PMID:15916964)
GO_REF:0000024
RGD
UniProt
PMID:15916964 GO_REF:0000024 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Chek2 checkpoint kinase 2 involved_in ISO (PMID:11298456) RGD PMID:11298456 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:79,586,736...79,595,515
Ensembl chr10:79,586,729...79,595,435
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968
JBrowse link
G Fancd2 FA complementation group D2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
JBrowse link
G LOC103690165 checkpoint protein HUS1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:3027036 (MGI:2683367|PMID:14690604), (MGI:3805397|PMID:18614044)
PMID:21873635
Ensembl
RGD
PMID:14690604 PMID:18614044 PMID:21873635 GO_REF:0000107 MGI:2683367 MGI:3805397, RGD:13792537 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:103557 (MGI:3512823|PMID:15533840)
Ensembl
RGD
PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843
JBrowse link
G Nek11 NIMA-related kinase 11 involved_in ISO
IBA
(PMID:15161910)
PMID:21873635
RGD PMID:15161910 PMID:21873635 RGD:13792537 NCBI chr 8:105,767,230...106,026,676
Ensembl chr 8:105,770,548...106,026,676
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in ISO (PMID:15538388) RGD PMID:15538388 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
JBrowse link
G Rad9a RAD9 checkpoint clamp component A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
UniProtKB:P26306 (MGI:1289930|PMID:9766521)
RGD PMID:9766521 PMID:21873635 MGI:1289930, RGD:13792537 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
JBrowse link
G Rad9b RAD9 checkpoint clamp component B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:34,217,868...34,248,380
Ensembl chr12:34,218,024...34,248,372
JBrowse link
G Tipin timeless interacting protein involved_in ISS
ISO
GO_REF:0000024
(PMID:17102137)
UniProt
RGD
PMID:17102137 GO_REF:0000024 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor acts_upstream_of_or_within ISO MGI:101816 (MGI:3512823|PMID:15533840) RGD PMID:15533840 MGI:3512823 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    signaling 7540
      signal transduction 6952
        intracellular signal transduction 2643
          signal transduction in response to DNA damage 175
            DNA damage checkpoint signaling 116
              mitotic DNA damage checkpoint signaling 82
                mitotic intra-S DNA damage checkpoint signaling 16
Path 2
Term Annotations click to browse term
  biological_process 19512
    biological regulation 13616
      regulation of biological process 12887
        regulation of cellular process 12364
          negative regulation of cellular process 5142
            negative regulation of cell cycle 372
              negative regulation of cell cycle process 290
                negative regulation of cell cycle phase transition 242
                  cell cycle checkpoint signaling 174
                    mitotic cell cycle checkpoint signaling 133
                      mitotic DNA integrity checkpoint signaling 86
                        mitotic DNA damage checkpoint signaling 82
                          mitotic intra-S DNA damage checkpoint signaling 16
paths to the root