Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:DNA integrity checkpoint signaling
go back to main search page
Accession:GO:0031570 term browser browse the term
Definition:A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.
Synonyms:exact_synonym: DNA integrity checkpoint;   signal transduction involved in DNA integrity checkpoint
 alt_id: GO:0072401

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chrNW_004936551:359,134...534,672
Ensembl chrNW_004936551:359,362...532,211 		JBrowse link
G Atr ATR serine/threonine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chrNW_004936540:4,074,543...4,178,859
Ensembl chrNW_004936540:4,074,570...4,178,898 		JBrowse link
G Atrip ATR interacting protein involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936529:245,134...264,456
Ensembl chrNW_004936529:245,092...264,351 		JBrowse link
G Cdc5l cell division cycle 5 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:15,647,470...15,698,095
Ensembl chrNW_004936476:15,648,678...15,698,106 		JBrowse link
G Chek1 checkpoint kinase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2449744|PMID:12529385)
(MGI:1860049|PMID:10859164)		 MGI
Ensembl
InterPro		 PMID:10859164 PMID:12529385 GO_REF:0000002 GO_REF:0000107 MGI:1860049 MGI:2449744 NCBI chrNW_004936743:2,004,535...2,027,287
Ensembl chrNW_004936743:2,005,851...2,026,587 		JBrowse link
G Chek2 checkpoint kinase 2 ISO RGD PMID:10435585 RGD:633752 NCBI chrNW_004936657:2,805,947...2,848,180
Ensembl chrNW_004936657:2,805,959...2,848,180 		JBrowse link
G Clock clock circadian regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936482:17,789,834...17,900,371
Ensembl chrNW_004936482:17,794,134...17,845,303 		JBrowse link
G Clspn claspin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:18,267,740...18,304,658
Ensembl chrNW_004936474:18,268,984...18,300,211 		JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:8,712,168...8,720,728
Ensembl chrNW_004936500:8,712,205...8,739,953 		JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase involved_in IEA UniProt GO_REF:0000104 NCBI chrNW_004936588:1,288,447...1,332,489
Ensembl chrNW_004936588:1,288,392...1,330,297 		JBrowse link
G Dtx3l deltex E3 ubiquitin ligase 3L involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936536:8,844,778...8,853,442
Ensembl chrNW_004936536:8,844,575...8,851,146 		JBrowse link
G E2f1 E2F transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936561:6,894,827...6,901,058
Ensembl chrNW_004936561:6,896,063...6,900,026 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936471:3,423,792...3,527,089
Ensembl chrNW_004936471:3,423,813...3,526,913 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936728:706,499...843,447
Ensembl chrNW_004936728:761,804...844,690 		JBrowse link
G Hinfp histone H4 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:4,072,771...4,083,973
Ensembl chrNW_004936542:4,072,624...4,084,064 		JBrowse link
G Hus1 HUS1 checkpoint clamp component acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2449744|PMID:12529385) MGI
Ensembl
InterPro		 PMID:12529385 GO_REF:0000002 GO_REF:0000107 MGI:2449744 NCBI chrNW_004936478:22,393,952...22,414,349
Ensembl chrNW_004936478:22,400,111...22,414,115 		JBrowse link
G Ints7 integrator complex subunit 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936557:1,389,728...1,456,397
Ensembl chrNW_004936557:1,389,728...1,457,042 		JBrowse link
G LOC101966907 histone H2AX NOT|acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2179182|PMID:11934988) MGI
Ensembl		 PMID:11934988 GO_REF:0000107 MGI:2179182 NCBI chrNW_004936542:4,046,930...4,049,017
Ensembl chrNW_004936542:4,047,915...4,048,346 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:3,029,942...3,203,319
Ensembl chrNW_004936509:3,029,979...3,202,796 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chrNW_004936476:23,237,762...23,310,211
Ensembl chrNW_004936476:23,237,277...23,310,232 		JBrowse link
G Nbn nibrin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12529385) MGI
Ensembl		 PMID:12529385 GO_REF:0000107 NCBI chrNW_004936544:3,773,828...3,812,673
Ensembl chrNW_004936544:3,775,220...3,808,837 		JBrowse link
G Parp9 poly(ADP-ribose) polymerase family member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936536:8,806,824...8,845,099
Ensembl chrNW_004936536:8,806,818...8,840,746 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:2,031,894...2,042,294
Ensembl chrNW_004936581:2,031,822...2,042,424 		JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chrNW_004936668:2,602,261...2,687,903
Ensembl chrNW_004936668:2,628,706...2,682,448 		JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936518:6,620,325...6,626,328
Ensembl chrNW_004936518:6,620,325...6,628,393 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936480:216,216...252,178
Ensembl chrNW_004936480:216,208...252,070 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936599:2,348,869...2,353,907
Ensembl chrNW_004936599:2,345,646...2,354,029 		JBrowse link
G Rad9b RAD9 checkpoint clamp component B involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936558:3,462,187...3,489,741
Ensembl chrNW_004936558:3,459,223...3,489,413 		JBrowse link
G Rhno1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936606:3,201,540...3,208,019
Ensembl chrNW_004936606:3,201,504...3,208,342 		JBrowse link
G Tipin TIMELESS interacting protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3706226|PMID:17141802) MGI
Ensembl		 PMID:17141802 GO_REF:0000107 MGI:3706226 NCBI chrNW_004936471:26,516,511...26,531,403
Ensembl chrNW_004936471:26,517,042...26,531,410 		JBrowse link
G Tiprl TOR signaling pathway regulator involved_in ISO (PMID:17384681) UniProt PMID:17384681 NCBI chrNW_004936481:18,050,020...18,072,906 JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3818783|PMID:18045533) MGI
Ensembl		 PMID:18045533 GO_REF:0000107 MGI:3818783 NCBI chrNW_004936529:264,535...266,451
Ensembl chrNW_004936529:264,468...266,422 		JBrowse link
G Ufl1 UFM1 specific ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936699:1,131,385...1,163,310
Ensembl chrNW_004936699:1,129,344...1,163,530 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 involved_in ISO (PMID:18662541) UniProt PMID:18662541 NCBI chrNW_004936612:742,777...804,919
Ensembl chrNW_004936612:742,725...804,921 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:739,325...754,259
Ensembl chrNW_004936527:739,281...754,331 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:22,717,308...22,725,127
Ensembl chrNW_004936476:22,717,260...22,725,182 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936507:10,077,345...10,264,705
Ensembl chrNW_004936507:10,098,171...10,264,716 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:21726810) UniProt PMID:21726810 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Muc1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Pcbp4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chrNW_004936529:3,304,171...3,308,422
Ensembl chrNW_004936529:3,300,712...3,308,288 		JBrowse link
G Pidd1 p53-induced death domain protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936888:565,889...571,273
Ensembl chrNW_004936888:565,912...571,247 		JBrowse link
G Pml PML nuclear body scaffold involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:33,135,186...33,173,218
Ensembl chrNW_004936471:33,135,164...33,177,666 		JBrowse link
G Ppp2r5c protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430 NCBI chrNW_004936835:54,478...192,486
Ensembl chrNW_004936835:96,930...192,756 		JBrowse link
G Prap1 proline rich acidic protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:19,477,278...19,480,387
Ensembl chrNW_004936486:19,477,453...19,480,297 		JBrowse link
G Rbm38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) UniProt PMID:17050675 NCBI chrNW_004936530:227,266...249,285 JBrowse link
G Rpl26 ribosomal protein L26 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:1,603,913...1,609,125
Ensembl chrNW_004936595:1,603,413...1,609,132 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3589512|PMID:16107883) MGI
Ensembl		 PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:916,695...925,411
Ensembl chrNW_004936641:917,435...920,981 		JBrowse link
G Clspn claspin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12766152)
(PMID:16123041)		 MGI
UniProt
Ensembl		 PMID:12766152 PMID:16123041 GO_REF:0000107 NCBI chrNW_004936474:18,267,740...18,304,658
Ensembl chrNW_004936474:18,268,984...18,300,211 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:9,843,867...9,884,248
Ensembl chrNW_004936521:9,843,900...9,883,932 		JBrowse link
G Tipin TIMELESS interacting protein involved_in IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936471:26,516,511...26,531,403
Ensembl chrNW_004936471:26,517,042...26,531,410 		JBrowse link
mitotic DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Znf830 zinc finger protein 830 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5428139|PMID:23213458) MGI
Ensembl		 PMID:23213458 GO_REF:0000107 MGI:5428139 NCBI chrNW_004936538:243,557...245,353
Ensembl chrNW_004936538:244,188...245,300 		JBrowse link
mitotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101962206 histone-lysine N-methyltransferase SETMAR involved_in ISO (PMID:18790802) UniProt PMID:18790802 NCBI chrNW_004936577:3,761,078...3,771,864 JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clspn claspin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:18,267,740...18,304,658
Ensembl chrNW_004936474:18,268,984...18,300,211 		JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:17,083,175...17,105,098
Ensembl chrNW_004936475:17,083,077...17,105,133 		JBrowse link
G Znf830 zinc finger protein 830 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:243,557...245,353
Ensembl chrNW_004936538:244,188...245,300 		JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chrNW_004936599:973,838...983,316 JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISO (PMID:16286473) UniProt PMID:16286473 NCBI chrNW_004936562:2,690,907...2,733,455
Ensembl chrNW_004936562:2,690,858...2,733,620 		JBrowse link
G Fbxo31 F-box protein 31 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:1,801,539...1,831,988
Ensembl chrNW_004936641:1,801,548...1,830,440 		JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4366664|PMID:19744960) MGI
Ensembl		 PMID:19744960 GO_REF:0000107 MGI:4366664 NCBI chrNW_004936525:4,301,003...4,432,125
Ensembl chrNW_004936525:4,304,629...4,403,089 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936590:4,722,914...4,887,615
Ensembl chrNW_004936590:4,722,873...4,890,156 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:23,544,974...23,586,716
Ensembl chrNW_004936475:23,544,953...23,586,740 		JBrowse link
G Rpa2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:12,127,026...12,147,120
Ensembl chrNW_004936474:12,126,245...12,147,130 		JBrowse link
G Rps27l ribosomal protein S27 like involved_in ISO (PMID:18056458) UniProt PMID:18056458 NCBI chrNW_004936471:23,738,896...23,742,355
Ensembl chrNW_004936471:23,738,823...23,745,382 		JBrowse link
G Sde2 SDE2 telomere maintenance homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936526:2,763,243...2,779,506
Ensembl chrNW_004936526:2,760,639...2,779,657 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3589512|PMID:16107883) MGI
Ensembl		 PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5562498|PMID:23993650)
(MGI:3818783|PMID:18045533)		 MGI
Ensembl		 PMID:18045533 PMID:23993650 GO_REF:0000107 MGI:3818783 MGI:5562498 NCBI chrNW_004936529:264,535...266,451
Ensembl chrNW_004936529:264,468...266,422 		JBrowse link
G Wac WW domain containing adaptor with coiled-coil involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936613:2,793,706...2,862,984
Ensembl chrNW_004936613:2,794,732...2,865,913 		JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas1 abraxas 1, BRCA1 A complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936738:1,202,668...1,217,825
Ensembl chrNW_004936738:1,202,608...1,221,321 		JBrowse link
G Atm ATM serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936551:359,134...534,672
Ensembl chrNW_004936551:359,362...532,211 		JBrowse link
G Babam1 BRISC and BRCA1 A complex member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936596:3,574,507...3,582,370
Ensembl chrNW_004936596:3,574,476...3,582,421 		JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 involved_in IEA Ensembl
UniProt		 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936493:4,375,393...4,863,050
Ensembl chrNW_004936493:4,375,393...4,768,399 		JBrowse link
G Blm BLM RecQ like helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:16,194,092...16,295,803
Ensembl chrNW_004936483:16,194,092...16,255,905 		JBrowse link
G Brca1 BRCA1 DNA repair associated involved_in ISO (PMID:17525340), (PMID:17643121), (PMID:19261748) UniProt PMID:17525340 PMID:17643121 PMID:19261748 NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex subunit 3 involved_in IEA Ensembl
UniProt		 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936927:341,114...380,817
Ensembl chrNW_004936927:341,253...376,700 		JBrowse link
G Brsk1 BR serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936886:541,831...567,197
Ensembl chrNW_004936886:546,222...570,521 		JBrowse link
G Ccng1 cyclin G1 ISO RGD PMID:9464250 RGD:2316029 NCBI chrNW_004936515:614,287...621,213
Ensembl chrNW_004936515:614,290...619,963 		JBrowse link
G Cdc14b cell division cycle 14B involved_in ISO (PMID:18662541) UniProt PMID:18662541 NCBI chrNW_004936487:430,449...482,517
Ensembl chrNW_004936487:554,611...564,782 		JBrowse link
G Cdk1 cyclin dependent kinase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chrNW_004936614:2,300,682...2,313,611
Ensembl chrNW_004936614:2,300,513...2,313,624 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,345,443...13,355,841
Ensembl chrNW_004936490:13,345,443...13,355,841 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:22,717,308...22,725,127
Ensembl chrNW_004936476:22,717,260...22,725,182 		JBrowse link
G Chek1 checkpoint kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936743:2,004,535...2,027,287
Ensembl chrNW_004936743:2,005,851...2,026,587 		JBrowse link
G Clspn claspin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:18,267,740...18,304,658
Ensembl chrNW_004936474:18,268,984...18,300,211 		JBrowse link
G CUNH10orf90 chromosome unknown C10orf90 homolog involved_in ISO (MGI:4455105|PMID:20154723) UniProt PMID:20154723 MGI:4455105 NCBI chrNW_004936486:14,311,976...14,499,733
Ensembl chrNW_004936486:14,311,431...14,499,902 		JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:8,712,168...8,720,728
Ensembl chrNW_004936500:8,712,205...8,739,953 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936557:1,347,991...1,389,836
Ensembl chrNW_004936557:1,347,991...1,389,836 		JBrowse link
G Foxn3 forkhead box N3 involved_in ISO (PMID:9154802) UniProt PMID:9154802 NCBI chrNW_004936488:16,560,732...16,828,972 JBrowse link
G Foxo4 forkhead box O4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2183145|PMID:12048180) MGI
Ensembl		 PMID:12048180 GO_REF:0000107 MGI:2183145 NCBI chrNW_004936762:495,271...501,278
Ensembl chrNW_004936762:493,910...501,531 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:2,000,872...2,007,569
Ensembl chrNW_004936588:1,993,721...2,009,240 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO (PMID:16061642) UniProt PMID:16061642 NCBI chrNW_004936545:3,944,419...3,958,289
Ensembl chrNW_004936545:3,944,419...4,064,193 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5432078|PMID:20467439) MGI
Ensembl		 PMID:20467439 GO_REF:0000107 MGI:5432078 NCBI chrNW_004936837:401,475...402,769
Ensembl chrNW_004936837:401,524...402,741 		JBrowse link
G LOC101960348 E3 ubiquitin-protein ligase TRIM39 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936837:88,387...104,420
Ensembl chrNW_004936837:105,575...107,719
Ensembl chrNW_004936837:105,575...107,719 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2683367|PMID:14690604) MGI
Ensembl		 PMID:14690604 GO_REF:0000107 MGI:2683367 NCBI chrNW_004936674:466,495...528,072
Ensembl chrNW_004936674:466,456...530,317 		JBrowse link
G Mrnip MRN complex interacting protein involved_in ISO (PMID:27568553) UniProt PMID:27568553 NCBI chrNW_004936739:926,678...955,024 JBrowse link
G Nbn nibrin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3805397|PMID:18614044) MGI
InterPro
Ensembl		 PMID:18614044 GO_REF:0000002 GO_REF:0000107 MGI:3805397 NCBI chrNW_004936544:3,773,828...3,812,673
Ensembl chrNW_004936544:3,775,220...3,808,837 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:1,334,487...1,343,867
Ensembl chrNW_004936664:1,334,510...1,342,321 		JBrowse link
G Plk1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:8,321,415...8,332,414
Ensembl chrNW_004936501:8,321,305...8,332,424 		JBrowse link
G Rint1 RAD50 interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:18,311,698...18,334,946
Ensembl chrNW_004936479:18,311,699...18,340,816 		JBrowse link
G Syf2 SYF2 pre-mRNA splicing factor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5435138|PMID:22448250) MGI
Ensembl		 PMID:22448250 GO_REF:0000107 MGI:5435138 NCBI chrNW_004936474:9,970,047...9,975,260
Ensembl chrNW_004936474:9,968,469...9,972,799 		JBrowse link
G Taok1 TAO kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:5,531,639...5,668,119
Ensembl chrNW_004936538:5,531,633...5,659,239 		JBrowse link
G Taok2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:12,477,032...12,495,298
Ensembl chrNW_004936501:12,477,032...12,495,501 		JBrowse link
G Taok3 TAO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:2,116,804...2,305,331
Ensembl chrNW_004936668:2,222,866...2,304,151 		JBrowse link
G Uimc1 ubiquitin interaction motif containing 1 involved_in ISO (PMID:17525340), (PMID:17525341), (PMID:17525342), (PMID:17643121), (PMID:19261748) UniProt PMID:17525340 PMID:17525341 PMID:17525342 PMID:17643121 PMID:19261748 NCBI chrNW_004936597:1,143,835...1,260,339 JBrowse link
mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:4,729,984...4,826,367
Ensembl chrNW_004936509:4,732,930...4,826,443 		JBrowse link
G Chek2 checkpoint kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936657:2,805,947...2,848,180
Ensembl chrNW_004936657:2,805,959...2,848,180 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2683367|PMID:14690604), (MGI:3805397|PMID:18614044) MGI
Ensembl		 PMID:14690604 PMID:18614044 GO_REF:0000107 MGI:2683367 MGI:3805397 NCBI chrNW_004936674:466,495...528,072
Ensembl chrNW_004936674:466,456...530,317 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3512823|PMID:15533840) MGI
Ensembl		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chrNW_004936508:4,943,987...5,013,356
Ensembl chrNW_004936508:4,944,007...5,013,356 		JBrowse link
G Nek11 NIMA related kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:4,484,397...4,785,902
Ensembl chrNW_004936529:4,487,656...4,785,912 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936480:216,216...252,178
Ensembl chrNW_004936480:216,208...252,070 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1289930|PMID:9766521) MGI
Ensembl		 PMID:9766521 GO_REF:0000107 MGI:1289930 NCBI chrNW_004936599:2,348,869...2,353,907
Ensembl chrNW_004936599:2,345,646...2,354,029 		JBrowse link
G Tipin TIMELESS interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:26,516,511...26,531,403
Ensembl chrNW_004936471:26,517,042...26,531,410 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3512823|PMID:15533840) MGI
Ensembl		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chrNW_004936602:118,173...139,884
Ensembl chrNW_004936602:118,188...139,675 		JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 involved_in ISO (PMID:23728299) UniProt PMID:23728299 NCBI chrNW_004936596:5,176,682...5,246,102
Ensembl chrNW_004936596:5,177,147...5,246,518 		JBrowse link
G Chek2 checkpoint kinase 2 ISO RGD PMID:20637979 RGD:10401658 NCBI chrNW_004936657:2,805,947...2,848,180
Ensembl chrNW_004936657:2,805,959...2,848,180 		JBrowse link
G Ddx39b DExD-box helicase 39B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,968,032...1,980,789
Ensembl chrNW_004936727:1,968,094...1,980,785 		JBrowse link
G Thoc1 THO complex 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:590,119...638,152
Ensembl chrNW_004936550:590,058...641,390 		JBrowse link
G Thoc5 THO complex subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936657:3,465,707...3,503,966
Ensembl chrNW_004936657:3,461,789...3,503,976 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r10 protein phosphatase 1 regulatory subunit 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936837:276,423...296,600
Ensembl chrNW_004936837:277,618...286,515 		JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccar2 cell cycle and apoptosis regulator 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936555:6,341,455...6,356,677
Ensembl chrNW_004936555:6,341,390...6,356,668 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:3,029,942...3,203,319
Ensembl chrNW_004936509:3,029,979...3,202,796 		JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cry1 cryptochrome circadian regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:7,929,138...7,994,797
Ensembl chrNW_004936492:7,929,138...7,995,579 		JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3850765|PMID:19481525) MGI
Ensembl		 PMID:19481525 GO_REF:0000107 MGI:3850765 NCBI chrNW_004936472:409,083...432,442
Ensembl chrNW_004936472:408,659...432,379 		JBrowse link
G Etaa1 ETAA1 activator of ATR kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:11,962,161...11,975,164
Ensembl chrNW_004936491:11,962,087...11,979,349 		JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5299398|PMID:21911473) MGI
Ensembl		 PMID:21911473 GO_REF:0000107 MGI:5299398 NCBI chrNW_004936518:855,304...873,927
Ensembl chrNW_004936518:854,721...874,018 		JBrowse link
G Fem1b fem-1 homolog B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:28,115,873...28,135,834
Ensembl chrNW_004936471:28,115,684...28,135,825 		JBrowse link
G Nek1 NIMA related kinase 1 involved_in ISO (MGI:5619475|PMID:18843199) CACAO PMID:18843199 MGI:5619475 NCBI chrNW_004936516:1,508,800...1,666,841
Ensembl chrNW_004936516:1,508,811...1,666,869 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:23,544,974...23,586,716
Ensembl chrNW_004936475:23,544,953...23,586,740 		JBrowse link
G Rnaseh2b ribonuclease H2 subunit B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5435090|PMID:22802351) MGI
Ensembl		 PMID:22802351 GO_REF:0000107 MGI:5435090 NCBI chrNW_004936565:3,791,305...3,839,991
Ensembl chrNW_004936565:3,791,329...3,840,016 		JBrowse link
G Rpa2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:12,127,026...12,147,120
Ensembl chrNW_004936474:12,126,245...12,147,130 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15015
    cellular process 13870
      signal transduction 5289
        intracellular signal transduction 2359
          cell cycle checkpoint signaling 151
            DNA integrity checkpoint signaling 108
              DNA damage checkpoint signaling + 104
              DNA replication checkpoint signaling + 6
              meiotic DNA integrity checkpoint signaling + 0
              mitotic DNA integrity checkpoint signaling + 71
Path 2
Term Annotations click to browse term
  biological_process 15015
    biological regulation 10547
      regulation of biological process 10236
        negative regulation of biological process 4981
          negative regulation of cellular process 4429
            negative regulation of cell cycle 323
              negative regulation of cell cycle process 255
                negative regulation of cell cycle phase transition 211
                  cell cycle checkpoint signaling 151
                    DNA integrity checkpoint signaling 108
                      DNA damage checkpoint signaling + 104
                      DNA replication checkpoint signaling + 6
                      meiotic DNA integrity checkpoint signaling + 0
                      mitotic DNA integrity checkpoint signaling + 71
paths to the root