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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA integrity checkpoint signaling
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Accession:GO:0031570 term browser browse the term
Definition:A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.
Synonyms:exact_synonym: DNA integrity checkpoint;   signal transduction involved in DNA integrity checkpoint
 alt_id: GO:0072401


show annotations for term's descendants           Sort by:
DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in
acts_upstream_of_or_within		 IBA
ISS
IEA
ISO		 (PMID:21873635)
(MGI:2679752|PMID:12937170)		 GO_Central
UniProt
Ensembl
GO_Central
MGI
InterPro		 PMID:12937170 PMID:21873635 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:2679752 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552 		JBrowse link
G ATR ATR serine/threonine kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:2679752|PMID:12937170)		 GO_Central
GO_Central
MGI		 PMID:12937170 PMID:21873635 MGI:2679752 NCBI chr13:83,175,515...83,289,986
Ensembl chr13:83,174,824...83,289,989 		JBrowse link
G ATRIP ATR interacting protein involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr13:31,159,849...31,178,716
Ensembl chr13:31,159,843...31,178,715 		JBrowse link
G CDC5L cell division cycle 5 like involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:39,384,397...39,427,729
Ensembl chr 7:39,384,556...39,431,248 		JBrowse link
G CHEK1 checkpoint kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2449744|PMID:12529385)
(MGI:1860049|PMID:10859164)		 InterPro
Ensembl
InterPro
MGI		 PMID:10859164 PMID:12529385 GO_REF:0000002 GO_REF:0000107 MGI:1860049 MGI:2449744 NCBI chr 9:52,759,224...52,790,878
Ensembl chr 9:52,753,528...52,790,700 		JBrowse link
G CHEK2 checkpoint kinase 2 ISO RGD PMID:10435585 RGD:633752 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290 		JBrowse link
G CLOCK clock circadian regulator involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:54,793,323...54,910,192
Ensembl chr 8:54,793,342...54,877,777 		JBrowse link
G CLSPN claspin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:91,906,325...91,968,070
Ensembl chr 6:91,906,320...91,967,901 		JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:197,192,661...197,204,243
Ensembl chr13:197,193,658...197,203,932 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
UniProt
UniProt		 PMID:21873635 GO_REF:0000104 NCBI chr 2:76,339,452...76,401,974
Ensembl chr 2:76,339,470...76,401,965 		JBrowse link
G DTX3L deltex E3 ubiquitin ligase 3L involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:137,950,266...137,961,381
Ensembl chr13:137,950,272...137,961,343 		JBrowse link
G E2F1 E2F transcription factor 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr17:37,178,587...37,190,118
Ensembl chr17:37,178,599...37,189,883 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 1:131,244,818...131,355,240
Ensembl chr 1:131,245,466...131,355,226 		JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:89,998,125...90,075,911
Ensembl chr14:90,002,024...90,075,898 		JBrowse link
G H2AX H2A.X variant histone involved_in
NOT|acts_upstream_of_or_within		 IEA
ISO		 (MGI:2179182|PMID:11934988) Ensembl
Ensembl
MGI		 PMID:11934988 GO_REF:0000107 MGI:2179182 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084 		JBrowse link
G HINFP histone H4 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:46,336,130...46,354,623
Ensembl chr 9:46,336,155...46,347,353 		JBrowse link
G HUS1 HUS1 checkpoint clamp component acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2449744|PMID:12529385) MGI
Ensembl
InterPro		 PMID:12529385 GO_REF:0000002 GO_REF:0000107 MGI:2449744 NCBI chr18:48,522,914...48,539,267
Ensembl chr18:48,522,998...48,534,682 		JBrowse link
G INTS7 integrator complex subunit 7 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:131,275,530...131,364,490
Ensembl chr 9:131,275,626...131,354,592 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:79,174,444...79,378,520
Ensembl chr15:79,173,033...79,380,993 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2679752|PMID:12937170) Ensembl
Ensembl
MGI		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031 		JBrowse link
G NBN nibrin acts_upstream_of_or_within ISO (PMID:12529385) MGI PMID:12529385 NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,691...46,874,603 		JBrowse link
G PARP9 poly(ADP-ribose) polymerase family member 9 involved_in ISO (PMID:28525742) UniProt PMID:28525742 NCBI chr13:137,960,987...138,000,862
Ensembl chr13:137,966,562...138,000,846 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 2:10,851,779...10,860,315
Ensembl chr 2:10,851,579...10,860,836 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2679752|PMID:12937170) Ensembl
Ensembl
MGI		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,169...39,292,003 		JBrowse link
G RAD1 RAD1 checkpoint DNA exonuclease involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
InterPro
Ensembl		 PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr16:20,491,851...20,512,198
Ensembl chr16:20,466,889...20,512,135 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA
IBA		 (PMID:21873635) InterPro
InterPro
GO_Central
GO_Central		 PMID:21873635 GO_REF:0000002 NCBI chr16:47,499,669...47,529,703
Ensembl chr16:47,499,669...47,529,702 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IEA InterPro
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:5,123,142...5,129,740
Ensembl chr 2:5,123,134...5,129,703 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr14:31,869,570...31,903,485
Ensembl chr14:31,869,684...31,903,823 		JBrowse link
G RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
InterPro
GO_Central		 PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr 5:67,239,907...67,246,150
Ensembl chr 5:67,239,202...67,246,124 		JBrowse link
G TIPIN TIMELESS interacting protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3706226|PMID:17141802) MGI
Ensembl		 PMID:17141802 GO_REF:0000107 MGI:3706226 NCBI chr 1:164,349,196...164,369,297
Ensembl chr 1:164,350,705...164,369,223 		JBrowse link
G TIPRL TOR signaling pathway regulator involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:82,759,305...82,794,765
Ensembl chr 4:82,759,245...82,794,714 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:127,958,500...128,032,370
Ensembl chr 1:127,959,213...128,028,712 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3818783|PMID:18045533) MGI
Ensembl		 PMID:18045533 GO_REF:0000107 MGI:3818783 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in ISO (PMID:30886146) UniProt PMID:30886146 NCBI chr 1:63,638,589...63,698,931
Ensembl chr 1:63,638,596...63,700,476 		JBrowse link
G USP28 ubiquitin specific peptidase 28 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 9:41,417,560...41,481,044
Ensembl chr 9:41,417,564...41,480,994 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP2 caspase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,941,937...6,966,061 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761 		JBrowse link
G CLCN1 chloride voltage-gated channel 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:6,902,540...6,941,530
Ensembl chr18:6,902,542...6,940,449 		JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:89,257,603...89,480,414
Ensembl chr 5:89,267,944...89,479,712 		JBrowse link
G MDM2 MDM2 proto-oncogene involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 5:33,105,717...33,137,602
Ensembl chr 5:33,105,759...33,137,739 		JBrowse link
G MUC1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G PCBP4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chr13:34,090,015...34,099,959
Ensembl chr13:34,090,020...34,099,886 		JBrowse link
G PIDD1 p53-induced death domain protein 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 2:499,294...505,740
Ensembl chr 2:499,303...504,871 		JBrowse link
G PML PML nuclear body scaffold involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:59,405,044...59,450,155
Ensembl chr 7:59,405,053...59,450,105 		JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430
G PRAP1 proline rich acidic protein 1 involved_in ISO (PMID:23235459) UniProt PMID:23235459 NCBI chr14:141,325,965...141,329,955 JBrowse link
G RBM38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) UniProt PMID:17050675 NCBI chr17:57,783,156...57,802,495
Ensembl chr17:57,783,154...57,797,990 		JBrowse link
G RPL26 ribosomal protein L26 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:53,548,313...53,553,453
Ensembl chr12:53,548,321...53,553,455 		JBrowse link
G SOCS2 suppressor of cytokine signaling 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:89,581,081...89,587,424
Ensembl chr 5:89,581,090...89,584,581 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3589512|PMID:16107883) Ensembl
Ensembl
MGI		 PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:893,377...897,706
Ensembl chr 6:893,381...897,934 		JBrowse link
G CLSPN claspin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12766152)
(PMID:16123041)		 MGI
UniProt
Ensembl		 PMID:12766152 PMID:16123041 GO_REF:0000107 NCBI chr 6:91,906,325...91,968,070
Ensembl chr 6:91,906,320...91,967,901 		JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:71,550,405...71,607,067
Ensembl chr14:71,552,121...71,610,740 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 2:5,123,142...5,129,740
Ensembl chr 2:5,123,134...5,129,703 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:31,869,570...31,903,485
Ensembl chr14:31,869,684...31,903,823 		JBrowse link
G TIMELESS timeless circadian regulator involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 Ensembl chr 5:21,763,014...21,787,521 JBrowse link
G TIPIN TIMELESS interacting protein involved_in IBA
IEA		 (PMID:21873635) GO_Central
InterPro
UniProt
Ensembl
UniProt		 PMID:21873635 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr 1:164,349,196...164,369,297
Ensembl chr 1:164,350,705...164,369,223 		JBrowse link
meiotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr18:48,522,914...48,539,267
Ensembl chr18:48,522,998...48,534,682 		JBrowse link
mitotic DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHEK2 checkpoint kinase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290 		JBrowse link
G PHKG1 phosphorylase kinase catalytic subunit gamma 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:16,822,042...16,831,054
Ensembl chr 3:16,822,043...16,834,329 		JBrowse link
G STK33 serine/threonine kinase 33 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:786,619...937,978
Ensembl chr 9:786,650...936,723 		JBrowse link
G ZNF830 zinc finger protein 830 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:40,203,942...40,205,045 JBrowse link
G ZNF830 zinc finger protein 830 involved_in IEA
IBA		 (PMID:21873635) Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 Ensembl chr12:40,201,556...40,205,076 JBrowse link
mitotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100514009 histone-lysine N-methyltransferase SETMAR involved_in ISO (PMID:18790802) UniProt PMID:18790802 NCBI chr13:60,914,412...60,933,064 JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC6 cell division cycle 6 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr12:22,101,281...22,118,441
Ensembl chr12:22,101,282...22,118,593 		JBrowse link
G CLSPN claspin involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 6:91,906,325...91,968,070
Ensembl chr 6:91,906,320...91,967,901 		JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr18:48,522,914...48,539,267
Ensembl chr18:48,522,998...48,534,682 		JBrowse link
G NAE1 NEDD8 activating enzyme E1 subunit 1 involved_in ISO (PMID:10722740) UniProt PMID:10722740 NCBI chr 6:27,511,541...27,540,142
Ensembl chr 6:27,450,632...27,540,118 		JBrowse link
G ORC1 origin recognition complex subunit 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 6:159,819,302...159,852,306
Ensembl chr 6:159,819,339...159,852,305 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr16:47,499,669...47,529,703
Ensembl chr16:47,499,669...47,529,702 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IEA
IBA		 (PMID:21873635) InterPro
InterPro
GO_Central		 PMID:21873635 GO_REF:0000002 NCBI chr 7:55,142,957...55,200,259
Ensembl chr 7:55,143,240...55,200,640 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:74,768,251...74,846,377
Ensembl chr13:74,768,257...74,846,340 		JBrowse link
G ZNF830 zinc finger protein 830 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:40,203,942...40,205,045 JBrowse link
G ZNF830 zinc finger protein 830 involved_in IEA
IBA		 (PMID:21873635) Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 Ensembl chr12:40,201,556...40,205,076 JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G DGKZ diacylglycerol kinase zeta involved_in ISO (PMID:16286473) UniProt PMID:16286473 NCBI chr 2:16,134,046...16,176,043
Ensembl chr 2:16,134,048...16,176,238 		JBrowse link
G FBXO31 F-box protein 31 involved_in IEA Ensembl
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:1,949,254...1,995,459
Ensembl chr 6:1,949,276...1,995,462 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:4366664|PMID:19744960) Ensembl
MGI		 PMID:19744960 GO_REF:0000107 MGI:4366664 NCBI chr15:133,180,638...133,313,307
Ensembl chr15:133,260,113...133,311,887 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:79,687,375...79,850,146
Ensembl chr 4:79,687,375...79,846,656 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:12,952,243...12,994,053
Ensembl chr 6:12,952,253...12,994,052 		JBrowse link
G RPA2 replication protein A2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,582...85,045,915 		JBrowse link
G RPS27L ribosomal protein S27 like involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:108,881,330...108,886,334
Ensembl chr 1:108,881,552...108,890,283 		JBrowse link
G SDE2 SDE2 telomere maintenance homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:13,879,482...13,897,847
Ensembl chr10:13,876,386...13,897,862 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3589512|PMID:16107883) MGI
Ensembl		 PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3818783|PMID:18045533)
(MGI:5562498|PMID:23993650)		 MGI
Ensembl
Ensembl		 PMID:18045533 PMID:23993650 GO_REF:0000107 MGI:3818783 MGI:5562498 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747 		JBrowse link
G WAC WW domain containing adaptor with coiled-coil involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr10:39,932,562...40,024,114
Ensembl chr10:39,932,599...40,022,338 		JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABRAXAS1 abraxas 1, BRCA1 A complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:135,002,297...135,021,205
Ensembl chr 8:135,002,321...135,023,335 		JBrowse link
G ATM ATM serine/threonine kinase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552 		JBrowse link
G BABAM1 BRISC and BRCA1 A complex member 1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 2:60,398,170...60,407,742
Ensembl chr 2:60,398,191...60,407,557 		JBrowse link
G BABAM2 BRISC and BRCA1 A complex member 2 involved_in IEA Ensembl
UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr 3:110,897,250...111,328,414
Ensembl chr 3:110,897,360...111,328,402 		JBrowse link
G BLM BLM RecQ like helicase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:53,317,515...53,412,649
Ensembl chr 7:53,317,540...53,412,645 		JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668 		JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 involved_in IEA Ensembl
UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr  X:125,383,392...125,439,082
Ensembl chr  X:125,383,414...125,439,082 		JBrowse link
G BRSK1 BR serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:59,468,289...59,499,062
Ensembl chr 6:59,468,733...59,499,059 		JBrowse link
G C14H10orf90 chromosome 14 C10orf90 homolog involved_in ISO (MGI:4455105|PMID:20154723) UniProt PMID:20154723 MGI:4455105 NCBI chr14:135,718,618...135,954,019
Ensembl chr14:135,719,351...135,953,846 		JBrowse link
G CCNG1 cyclin G1 ISO RGD PMID:9464250 RGD:2316029 NCBI chr16:60,349,255...60,356,737
Ensembl chr16:60,349,258...60,356,738 		JBrowse link
G CDC14B cell division cycle 14B involved_in ISO (PMID:18662541) UniProt PMID:18662541 NCBI chr10:25,471,976...25,590,022 JBrowse link
G CDK1 cyclin dependent kinase 1 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:2679752|PMID:12937170)		 GO_Central
GO_Central
Ensembl
MGI		 PMID:12937170 PMID:21873635 GO_REF:0000107 MGI:2679752 NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:24,224,262...24,234,468
Ensembl chr12:24,224,263...24,234,467 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761 		JBrowse link
G CHEK1 checkpoint kinase 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:52,759,224...52,790,878
Ensembl chr 9:52,753,528...52,790,700 		JBrowse link
G CLSPN claspin involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 6:91,906,325...91,968,070
Ensembl chr 6:91,906,320...91,967,901 		JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:197,192,661...197,204,243
Ensembl chr13:197,193,658...197,203,932 		JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 9:131,225,840...131,275,426
Ensembl chr 9:131,227,705...131,275,451 		JBrowse link
G FOXN3 forkhead box N3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:111,036,492...111,454,106
Ensembl chr 7:111,039,633...111,451,893 		JBrowse link
G FOXO4 forkhead box O4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2183145|PMID:12048180) Ensembl
Ensembl
MGI		 PMID:12048180 GO_REF:0000107 MGI:2183145 NCBI chr  X:57,132,549...57,140,377
Ensembl chr  X:57,132,548...57,140,356 		JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 2:75,122,599...75,164,134
Ensembl chr 2:75,121,835...75,146,835 		JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in ISO (PMID:16061642) UniProt PMID:16061642 NCBI chr 5:30,188,521...30,329,635 JBrowse link
G IER3 immediate early response 3 acts_upstream_of_or_within ISO (MGI:5432078|PMID:20467439) MGI PMID:20467439 MGI:5432078 NCBI chr 7:23,265,560...23,266,905
Ensembl chr 7:23,265,564...23,266,827 		JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase acts_upstream_of_or_within ISO (MGI:2682526|PMID:14614141) MGI PMID:14614141 MGI:2682526 NCBI chr13:68,816,677...68,828,559
Ensembl chr13:68,816,679...68,828,580 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:2683367|PMID:14690604)		 GO_Central
GO_Central
MGI		 PMID:14690604 PMID:21873635 MGI:2683367 NCBI chr 9:26,572,352...26,634,596
Ensembl chr 9:26,572,361...26,634,567 		JBrowse link
G MRNIP MRN complex interacting protein involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 2:78,730,611...78,753,152 JBrowse link
G NBN nibrin involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:3805397|PMID:18614044)		 GO_Central
GO_Central
InterPro
MGI
InterPro		 PMID:18614044 PMID:21873635 GO_REF:0000002 MGI:3805397 NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,691...46,874,603 		JBrowse link
G NOP53 NOP53 ribosome biogenesis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:53,443,453...53,451,707
Ensembl chr 6:53,443,385...53,452,017 		JBrowse link
G PLK1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:22,537,814...22,550,901
Ensembl chr 3:22,537,831...22,552,380 		JBrowse link
G RINT1 RAD50 interactor 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:105,392,853...105,430,198
Ensembl chr 9:105,392,864...105,430,160 		JBrowse link
G SYF2 SYF2 pre-mRNA splicing factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5435138|PMID:22448250) Ensembl
Ensembl
MGI		 PMID:22448250 GO_REF:0000107 MGI:5435138 NCBI chr 6:82,836,894...82,843,484
Ensembl chr 6:82,836,455...82,843,407 		JBrowse link
G TAOK1 TAO kinase 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:45,597,067...45,750,117
Ensembl chr12:45,597,072...45,744,356 		JBrowse link
G TAOK2 TAO kinase 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:18,178,347...18,198,092
Ensembl chr 3:18,177,737...18,198,085 		JBrowse link
G TAOK3 TAO kinase 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:34,322,016...34,514,234
Ensembl chr14:34,409,070...34,513,025 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:55,142,957...55,200,259
Ensembl chr 7:55,143,240...55,200,640 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:74,768,251...74,846,377
Ensembl chr13:74,768,257...74,846,340 		JBrowse link
G TRIM39 tripartite motif containing 39 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:23,047,048...23,062,974
Ensembl chr 7:23,047,520...23,062,487 		JBrowse link
G UIMC1 ubiquitin interaction motif containing 1 involved_in IEA
ISS		 Ensembl
Ensembl
UniProt
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:80,895,631...81,040,712
Ensembl chr 2:80,929,267...81,036,448 		JBrowse link
mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:80,984,969...81,076,573
Ensembl chr15:80,985,126...81,081,014 		JBrowse link
G CHEK2 checkpoint kinase 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290 		JBrowse link
G EME1 essential meiotic structure-specific endonuclease 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr12:26,670,126...26,680,097
Ensembl chr12:26,670,176...26,680,601 		JBrowse link
G EME2 essential meiotic structure-specific endonuclease subunit 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:40,190,545...40,193,994
Ensembl chr 3:40,186,846...40,193,957 		JBrowse link
G FANCD2 FA complementation group D2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr13:66,241,951...66,308,601
Ensembl chr13:66,241,967...66,310,433 		JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr18:48,522,914...48,539,267
Ensembl chr18:48,522,998...48,534,682 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:2683367|PMID:14690604), (MGI:3805397|PMID:18614044)		 GO_Central
GO_Central
MGI		 PMID:14690604 PMID:18614044 PMID:21873635 MGI:2683367 MGI:3805397 NCBI chr 9:26,572,352...26,634,596
Ensembl chr 9:26,572,361...26,634,567 		JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3512823|PMID:15533840) Ensembl
Ensembl
MGI		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,585 		JBrowse link
G MUS81 MUS81 structure-specific endonuclease subunit involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 2:6,462,825...6,470,780
Ensembl chr 2:6,463,413...6,469,112 		JBrowse link
G NEK11 NIMA related kinase 11 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr13:1,145,225...1,435,690
Ensembl chr13:1,145,284...1,435,652 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr16:47,499,669...47,529,703
Ensembl chr16:47,499,669...47,529,702 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:1289930|PMID:9766521)		 GO_Central
GO_Central
Ensembl
MGI		 PMID:9766521 PMID:21873635 GO_REF:0000107 MGI:1289930 NCBI chr 2:5,123,142...5,129,740
Ensembl chr 2:5,123,134...5,129,703 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:31,869,570...31,903,485
Ensembl chr14:31,869,684...31,903,823 		JBrowse link
G TIPIN TIMELESS interacting protein involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:164,349,196...164,369,297
Ensembl chr 1:164,350,705...164,369,223 		JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3512823|PMID:15533840) Ensembl
Ensembl
MGI		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr13:70,348,841...70,397,194
Ensembl chr13:70,348,864...70,397,772 		JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD4 bromodomain containing 4 involved_in ISO (PMID:23728299) UniProt PMID:23728299 NCBI chr 2:62,250,958...62,345,851
Ensembl chr 2:62,250,989...62,345,362 		JBrowse link
G CHEK2 checkpoint kinase 2 ISO RGD PMID:20637979 RGD:10401658 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290 		JBrowse link
G DDX39B DExD-box helicase 39B involved_in ISS
IEA		 UniProt
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:23,658,089...23,669,095
Ensembl chr 7:23,658,088...23,670,031 		JBrowse link
G THOC1 THO complex subunit 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:106,039,262...106,088,125
Ensembl chr 6:106,040,042...106,088,021 		JBrowse link
G THOC5 THO complex subunit 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:46,578,973...46,624,237
Ensembl chr14:46,579,838...46,623,501 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R10 protein phosphatase 1 regulatory subunit 10 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:23,148,834...23,166,933
Ensembl chr 7:23,147,478...23,165,689 		JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCAR2 cell cycle and apoptosis regulator 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:6,860,052...6,874,334
Ensembl chr14:6,859,664...6,874,327 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:79,174,444...79,378,520
Ensembl chr15:79,173,033...79,380,993 		JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRY1 cryptochrome circadian regulator 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 5:13,275,265...13,429,566
Ensembl chr 5:13,275,545...13,364,593 		JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3850765|PMID:19481525) Ensembl
Ensembl
MGI		 PMID:19481525 GO_REF:0000107 MGI:3850765 NCBI chr11:78,557,030...78,588,964
Ensembl chr11:78,557,013...78,589,193 		JBrowse link
G ETAA1 ETAA1 activator of ATR kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:74,721,313...74,736,784
Ensembl chr 3:74,724,291...74,736,764 		JBrowse link
G FBXO4 F-box protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5299398|PMID:21911473) Ensembl
Ensembl
MGI		 PMID:21911473 GO_REF:0000107 MGI:5299398 NCBI chr16:26,707,470...26,751,134
Ensembl chr16:26,707,470...26,752,024 		JBrowse link
G FEM1B fem-1 homolog B involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:166,161,548...166,178,086
Ensembl chr 1:166,162,883...166,175,937 		JBrowse link
G NEK1 NIMA related kinase 1 involved_in ISO (MGI:5619475|PMID:18843199) CACAO PMID:18843199 MGI:5619475 NCBI chr14:20,144,631...20,332,248
Ensembl chr14:20,144,659...20,332,245 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:12,952,243...12,994,053
Ensembl chr 6:12,952,253...12,994,052 		JBrowse link
G RNASEH2B ribonuclease H2 subunit B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5435090|PMID:22802351) Ensembl
Ensembl
MGI		 PMID:22802351 GO_REF:0000107 MGI:5435090 NCBI chr11:16,825,799...16,911,959
Ensembl chr11:16,825,128...16,911,969 		JBrowse link
G RPA2 replication protein A2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,582...85,045,915 		JBrowse link
G WDR76 WD repeat domain 76 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:127,651,765...127,741,357
Ensembl chr 1:127,654,178...127,741,354 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17636
    cellular process 16423
      signal transduction 6680
        intracellular signal transduction 2708
          cell cycle checkpoint signaling 176
            DNA integrity checkpoint signaling 125
              DNA damage checkpoint signaling + 118
              DNA replication checkpoint signaling + 16
              meiotic DNA integrity checkpoint signaling + 1
              mitotic DNA integrity checkpoint signaling + 87
Path 2
Term Annotations click to browse term
  biological_process 17636
    biological regulation 12895
      regulation of biological process 12452
        negative regulation of biological process 5746
          negative regulation of cellular process 4971
            negative regulation of cell cycle 390
              negative regulation of cell cycle process 309
                negative regulation of cell cycle phase transition 258
                  cell cycle checkpoint signaling 176
                    DNA integrity checkpoint signaling 125
                      DNA damage checkpoint signaling + 118
                      DNA replication checkpoint signaling + 16
                      meiotic DNA integrity checkpoint signaling + 1
                      mitotic DNA integrity checkpoint signaling + 87
paths to the root