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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA integrity checkpoint signaling
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Accession:GO:0031570 term browser browse the term
Definition:A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.
Synonyms:exact_synonym: DNA integrity checkpoint;   signal transduction involved in DNA integrity checkpoint
 alt_id: GO:0072401


show annotations for term's descendants           Sort by:
DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in
acts_upstream_of_or_within		 IBA
IDA
IEA
ISO		 (PMID:21873635)
(PMID:30886146)
(MGI:2679752|PMID:12937170)		 GO_Central
UniProt
GO_Central
Ensembl
MGI
InterPro		 PMID:12937170 PMID:21873635 PMID:30886146 GO_REF:0000002 GO_REF:0000107 MGI:2679752 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,223,044...108,369,102 		JBrowse link
G ATR ATR serine/threonine kinase involved_in
acts_upstream_of_or_within		 IDA
IBA
ISO		 (PMID:14657349)
(PMID:21873635)
(MGI:2679752|PMID:12937170)		 UniProt
GO_Central
UniProt
MGI
GO_Central		 PMID:12937170 PMID:14657349 PMID:21873635 MGI:2679752 NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733 		JBrowse link
G ATRIP ATR interacting protein involved_in TAS
IEA		 (PMID:14657349) UniProt
UniProt
InterPro
InterPro		 PMID:14657349 GO_REF:0000002 NCBI chr 3:48,446,737...48,467,645
Ensembl chr 3:48,446,710...48,467,645 		JBrowse link
G BRIP1 BRCA1 interacting helicase 1 involved_in NAS (PMID:14576433) UniProt
UniProt		 PMID:14576433 NCBI chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,559 		JBrowse link
G CDC5L cell division cycle 5 like involved_in IMP (PMID:24332808) UniProt
UniProt		 PMID:24332808 NCBI chr 6:44,387,706...44,450,425
Ensembl chr 6:44,387,706...44,450,425 		JBrowse link
G CEP63 centrosomal protein 63 involved_in ISS UniProt
UniProt		 GO_REF:0000024 NCBI chr 3:134,485,724...134,782,559
Ensembl chr 3:134,485,699...134,587,789 		JBrowse link
G CHEK1 checkpoint kinase 1 involved_in
acts_upstream_of_or_within		 IMP
IDA
IEA
ISO		 (PMID:19716789)
(PMID:16963448)
(MGI:1860049|PMID:10859164)
(MGI:2449744|PMID:12529385)		 UniProt
UniProt
Ensembl
InterPro
MGI
InterPro		 PMID:10859164 PMID:12529385 PMID:16963448 PMID:19716789 GO_REF:0000002 GO_REF:0000107 MGI:1860049 MGI:2449744 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255 		JBrowse link
G CHEK2 checkpoint kinase 2 involved_in TAS
IEA
ISO		 (PMID:10617473), (PMID:9889122) UniProt
Ensembl
UniProt
RGD		 PMID:9889122 PMID:10435585 PMID:10617473 GO_REF:0000107 RGD:633752 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G CLOCK clock circadian regulator involved_in IMP (PMID:21659603) UniProt
UniProt		 PMID:21659603 NCBI chr 4:55,427,903...55,546,909
Ensembl chr 4:55,427,903...55,546,909 		JBrowse link
G CLSPN claspin involved_in IMP (PMID:16963448) UniProt
UniProt		 PMID:16963448 NCBI chr 1:35,720,213...35,769,978
Ensembl chr 1:35,720,218...35,769,978 		JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IMP (PMID:28191891) UniProt
UniProt		 PMID:28191891 NCBI chr21:33,577,551...33,588,684
Ensembl chr21:33,559,542...33,588,706 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
UniProt		 PMID:21873635 GO_REF:0000104 NCBI chr19:2,163,933...2,232,578
Ensembl chr19:2,163,933...2,232,578 		JBrowse link
G DTX3L deltex E3 ubiquitin ligase 3L involved_in IMP (PMID:28525742) UniProt PMID:28525742 NCBI chr 3:122,564,338...122,575,203
Ensembl chr 3:122,564,338...122,575,203 		JBrowse link
G E2F1 E2F transcription factor 1 involved_in IMP (PMID:12717439) UniProt
UniProt		 PMID:12717439 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr15:39,934,115...40,035,591
Ensembl chr15:39,934,115...40,035,591 		JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in IMP (PMID:25820262) UniProt
UniProt		 PMID:25820262 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538 		JBrowse link
G FBXO6 F-box protein 6 involved_in TAS (PMID:19716789) UniProt
UniProt		 PMID:19716789 NCBI chr 1:11,664,200...11,674,354
Ensembl chr 1:11,664,200...11,674,354 		JBrowse link
G H2AX H2A.X variant histone involved_in
NOT|acts_upstream_of_or_within		 IDA
ISO		 (PMID:17974976)
(MGI:2179182|PMID:11934988)		 UniProt
UniProt
MGI		 PMID:11934988 PMID:17974976 MGI:2179182 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HINFP histone H4 transcription factor involved_in IMP (PMID:17974976) UniProt
UniProt		 PMID:17974976 NCBI chr11:119,121,580...119,136,059
Ensembl chr11:119,121,580...119,136,059 		JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in
acts_upstream_of_or_within		 IMP
TAS
IEA
ISO		 (PMID:21659603)
(PMID:9878245)
(MGI:2449744|PMID:12529385)		 UniProt
PINC
Ensembl
UniProt
InterPro
MGI
InterPro		 PMID:9878245 PMID:12529385 PMID:21659603 GO_REF:0000002 GO_REF:0000107 MGI:2449744 NCBI chr 7:47,963,288...47,979,615
Ensembl chr 7:47,963,288...47,979,615 		JBrowse link
G HUS1B HUS1 checkpoint clamp component B involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:655,939...657,100
Ensembl chr 6:655,939...657,100 		JBrowse link
G INTS7 integrator complex subunit 7 involved_in IMP (PMID:21659603) UniProt
UniProt		 PMID:21659603 NCBI chr 1:211,940,403...212,035,557
Ensembl chr 1:211,940,399...212,035,557 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IMP (PMID:11836244) UniProt
UniProt		 PMID:11836244 NCBI chr 2:173,075,517...173,268,015
Ensembl chr 2:173,075,435...173,268,015 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2679752|PMID:12937170) Ensembl
Ensembl
MGI		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236 		JBrowse link
G NBN nibrin acts_upstream_of_or_within IDA (PMID:12529385) MGI
MGI		 PMID:12529385 NCBI chr 8:89,933,331...89,984,667
Ensembl chr 8:89,924,515...90,003,228 		JBrowse link
G PARP9 poly(ADP-ribose) polymerase family member 9 involved_in IMP (PMID:28525742) UniProt PMID:28525742 NCBI chr 3:122,527,924...122,564,784
Ensembl chr 3:122,527,924...122,564,577 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 involved_in IMP (PMID:24332808) UniProt
UniProt		 PMID:24332808 NCBI chr11:60,890,547...60,906,585
Ensembl chr11:60,890,547...60,906,585 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2679752|PMID:12937170) Ensembl
Ensembl
MGI		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr12:112,418,947...112,509,918
Ensembl chr12:112,418,351...112,509,918 		JBrowse link
G RAD1 RAD1 checkpoint DNA exonuclease involved_in IEA
IMP
IBA		 (PMID:21659603)
(PMID:21873635)		 InterPro
UniProt
InterPro
GO_Central
UniProt
GO_Central		 PMID:21659603 PMID:21873635 GO_REF:0000002 NCBI chr 5:34,905,260...34,915,504
Ensembl chr 5:34,905,260...34,918,989 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA
IBA		 (PMID:21873635) InterPro
GO_Central
InterPro
GO_Central		 PMID:21873635 GO_REF:0000002 NCBI chr 5:69,369,293...69,414,801
Ensembl chr 5:69,369,293...69,414,801 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IEA
IMP
TAS		 (PMID:21659603)
(PMID:8943031)		 InterPro
UniProt
PINC
InterPro
UniProt		 PMID:8943031 PMID:21659603 GO_REF:0000002 NCBI chr11:67,391,986...67,398,412
Ensembl chr11:67,317,871...67,398,410 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr12:110,502,331...110,533,556
Ensembl chr12:110,501,655...110,533,556 		JBrowse link
G RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in IMP
IBA
IEA		 (PMID:21659603)
(PMID:21873635)		 UniProt
UniProt
GO_Central
InterPro
InterPro
GO_Central		 PMID:21659603 PMID:21873635 GO_REF:0000002 NCBI chr12:2,876,265...2,889,524
Ensembl chr12:2,876,258...2,889,524 		JBrowse link
G RPA4 replication protein A4 involved_in IDA (PMID:19942684) UniProt
UniProt		 PMID:19942684 NCBI chr  X:96,883,908...96,885,467
Ensembl chr  X:96,883,908...96,885,467 		JBrowse link
G TIPIN TIMELESS interacting protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3706226|PMID:17141802) MGI
Ensembl		 PMID:17141802 GO_REF:0000107 MGI:3706226 NCBI chr15:66,336,191...66,386,717
Ensembl chr15:66,336,191...66,386,746 		JBrowse link
G TIPRL TOR signaling pathway regulator involved_in IMP (PMID:17384681) UniProt
UniProt		 PMID:17384681 NCBI chr 1:168,178,962...168,202,109
Ensembl chr 1:168,178,962...168,202,109 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3818783|PMID:18045533) MGI
Ensembl		 PMID:18045533 GO_REF:0000107 MGI:3818783 NCBI chr 3:48,465,830...48,467,645
Ensembl chr 3:48,465,811...48,467,645 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IDA (PMID:30886146) UniProt PMID:30886146 NCBI chr 6:96,521,806...96,555,276
Ensembl chr 6:96,521,595...96,555,276 		JBrowse link
G USP28 ubiquitin specific peptidase 28 involved_in IBA
IMP		 (PMID:21873635)
(PMID:18662541)		 GO_Central
UniProt
GO_Central
UniProt		 PMID:18662541 PMID:21873635 NCBI chr11:113,797,875...113,875,572
Ensembl chr11:113,797,874...113,875,572 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in TAS Reactome
Reactome		 Reactome:R-HSA-69563 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,223,044...108,369,102 		JBrowse link
G CASP2 caspase 2 involved_in IMP (PMID:21726810) UniProt
UniProt		 PMID:21726810 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in TAS
IDA		 (PMID:15149599) Reactome
Reactome
BHF-UCL
BHF-UCL		 PMID:15149599 Reactome:R-HSA-6791312 Reactome:R-HSA-69563 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B involved_in TAS Reactome
Reactome		 Reactome:R-HSA-6791312 Reactome:R-HSA-69563 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CHEK2 checkpoint kinase 2 involved_in TAS Reactome
Reactome		 Reactome:R-HSA-69563 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain involved_in IBA
IMP		 (PMID:21873635)
(PMID:21726810)		 GO_Central
GO_Central
UniProt
UniProt		 PMID:21726810 PMID:21873635 NCBI chr12:93,677,375...93,894,840
Ensembl chr12:93,677,375...93,894,840 		JBrowse link
G GML glycosylphosphatidylinositol anchored molecule like involved_in TAS (PMID:8934543) PINC
PINC		 PMID:8934543 NCBI chr 8:142,834,801...142,846,851
Ensembl chr 8:142,834,247...142,916,506 		JBrowse link
G GTSE1 G2 and S-phase expressed 1 involved_in NAS (PMID:10974554) UniProt
UniProt		 PMID:10974554 NCBI chr22:46,296,870...46,330,810
Ensembl chr22:46,296,870...46,330,810 		JBrowse link
G MDM2 MDM2 proto-oncogene involved_in IMP (PMID:21726810) UniProt
UniProt		 PMID:21726810 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544 		JBrowse link
G MUC1 mucin 1, cell surface associated involved_in IDA (PMID:15710329) BHF-UCL
BHF-UCL		 PMID:15710329 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916 		JBrowse link
G PCBP4 poly(rC) binding protein 4 involved_in IDA (PMID:10891498) UniProt PMID:10891498 NCBI chr 3:51,957,454...51,967,466
Ensembl chr 3:51,957,454...51,974,016 		JBrowse link
G PIDD1 p53-induced death domain protein 1 involved_in IMP (PMID:21726810) UniProt
UniProt		 PMID:21726810 NCBI chr11:799,184...809,501
Ensembl chr11:799,179...809,753 		JBrowse link
G PLK2 polo like kinase 2 involved_in TAS Reactome
Reactome		 Reactome:R-HSA-6791312 NCBI chr 5:58,453,982...58,460,086
Ensembl chr 5:58,453,982...58,460,139 		JBrowse link
G PLK3 polo like kinase 3 involved_in TAS Reactome
Reactome		 Reactome:R-HSA-6791312 NCBI chr 1:44,800,377...44,805,990
Ensembl chr 1:44,800,377...44,805,990 		JBrowse link
G PML PML nuclear body scaffold involved_in ISS
IEA		 UniProt
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827 		JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma involved_in IDA (PMID:17245430) UniProt
UniProt		 PMID:17245430 NCBI chr14:101,760,573...101,927,992
Ensembl chr14:101,761,709...101,927,989 		JBrowse link
G PRAP1 proline rich acidic protein 1 involved_in IMP (PMID:23235459) UniProt
UniProt		 PMID:23235459 NCBI chr10:133,347,373...133,352,683
Ensembl chr10:133,347,368...133,352,683 		JBrowse link
G PTPRVP protein tyrosine phosphatase receptor type V, pseudogene acts_upstream_of_or_within ISO (MGI:3589512|PMID:16107883) MGI PMID:16107883 MGI:3589512 NCBI chr 1:202,168,051...202,189,449
Ensembl chr 1:202,168,051...202,189,455 		JBrowse link
G RBM38 RNA binding motif protein 38 involved_in IDA (PMID:17050675) UniProt
UniProt		 PMID:17050675 NCBI chr20:57,391,396...57,409,333
Ensembl chr20:57,391,396...57,409,333 		JBrowse link
G RPL26 ribosomal protein L26 involved_in IMP
IEA		 (PMID:16213212) CAFA
Ensembl
CAFA		 PMID:16213212 GO_REF:0000107 NCBI chr17:8,377,516...8,383,193
Ensembl chr17:8,377,516...8,383,213 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IMP
IEA
ISO		 (PMID:16213212)
(MGI:3589512|PMID:16107883)		 CAFA
CAFA
Ensembl
MGI		 PMID:16107883 PMID:16213212 GO_REF:0000107 MGI:3589512 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TRIAP1 TP53 regulated inhibitor of apoptosis 1 involved_in TAS (PMID:15735003) HGNC-UCL
HGNC-UCL		 PMID:15735003 NCBI chr12:120,443,964...120,446,384
Ensembl chr12:120,443,964...120,446,384 		JBrowse link
DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMSAP3 calmodulin regulated spectrin associated protein family member 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:7,595,863...7,618,304
Ensembl chr19:7,595,863...7,618,304 		JBrowse link
G CDC45 cell division cycle 45 involved_in TAS (PMID:9660782) PINC
PINC		 PMID:9660782 NCBI chr22:19,479,466...19,520,612
Ensembl chr22:19,479,457...19,520,612 		JBrowse link
G CDC6 cell division cycle 6 involved_in TAS (PMID:9566895) PINC
PINC		 PMID:9566895 NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657 		JBrowse link
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IDA
IBA
IEA		 (PMID:14672932)
(PMID:21873635)		 UniProt
GO_Central
Ensembl
UniProt
GO_Central		 PMID:14672932 PMID:21873635 GO_REF:0000107 NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258 		JBrowse link
G CLSPN claspin acts_upstream_of_or_within IDA (PMID:12766152)
(PMID:16123041)		 MGI
UniProt
MGI		 PMID:12766152 PMID:16123041 NCBI chr 1:35,720,213...35,769,978
Ensembl chr 1:35,720,218...35,769,978 		JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IMP (PMID:22570476) UniProt
UniProt		 PMID:22570476 NCBI chr10:68,414,064...68,472,521
Ensembl chr10:68,414,064...68,472,121 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in TAS (PMID:9660800) PINC
PINC		 PMID:9660800 NCBI chr 5:69,369,293...69,414,801
Ensembl chr 5:69,369,293...69,414,801 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IBA
TAS		 (PMID:21873635)
(PMID:8943031)		 GO_Central
GO_Central
PINC		 PMID:8943031 PMID:21873635 NCBI chr11:67,391,986...67,398,412
Ensembl chr11:67,317,871...67,398,410 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr12:110,502,331...110,533,556
Ensembl chr12:110,501,655...110,533,556 		JBrowse link
G TIMELESS timeless circadian regulator involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr12:56,416,363...56,449,426
Ensembl chr12:56,416,363...56,449,426 		JBrowse link
G TIPIN TIMELESS interacting protein involved_in IBA
IMP
IEA		 (PMID:21873635)
(PMID:17102137)		 GO_Central
HGNC-UCL
InterPro
GO_Central
UniProt
HGNC-UCL
UniProt		 PMID:17102137 PMID:21873635 GO_REF:0000002 GO_REF:0000104 NCBI chr15:66,336,191...66,386,717
Ensembl chr15:66,336,191...66,386,746 		JBrowse link
meiotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 7:47,963,288...47,979,615
Ensembl chr 7:47,963,288...47,979,615 		JBrowse link
G HUS1B HUS1 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 6:655,939...657,100
Ensembl chr 6:655,939...657,100 		JBrowse link
mitotic DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHEK2 checkpoint kinase 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G STK33 serine/threonine kinase 33 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr11:8,334,824...8,594,228
Ensembl chr11:8,391,868...8,594,289 		JBrowse link
G ZNF830 zinc finger protein 830 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:5428139|PMID:23213458)		 GO_Central
GO_Central
Ensembl
MGI		 PMID:21873635 PMID:23213458 GO_REF:0000107 MGI:5428139 NCBI chr17:34,961,540...34,963,777
Ensembl chr17:34,961,540...34,963,777 		JBrowse link
mitotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SETMAR SET domain and mariner transposase fusion gene involved_in IMP
IBA		 (PMID:18790802)
(PMID:21873635)		 UniProt
GO_Central
UniProt		 PMID:18790802 PMID:21873635 NCBI chr 3:4,303,369...4,317,265
Ensembl chr 3:4,303,332...4,317,265 		JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC6 cell division cycle 6 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657 		JBrowse link
G CLSPN claspin involved_in IMP
IBA		 (PMID:16885022)
(PMID:21873635)		 UniProt
GO_Central
UniProt
GO_Central		 PMID:16885022 PMID:21873635 NCBI chr 1:35,720,213...35,769,978
Ensembl chr 1:35,720,218...35,769,978 		JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 7:47,963,288...47,979,615
Ensembl chr 7:47,963,288...47,979,615 		JBrowse link
G HUS1B HUS1 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 6:655,939...657,100
Ensembl chr 6:655,939...657,100 		JBrowse link
G NAE1 NEDD8 activating enzyme E1 subunit 1 involved_in IDA (PMID:10722740) UniProt
UniProt		 PMID:10722740 NCBI chr16:66,802,878...66,830,976
Ensembl chr16:66,802,875...66,873,256 		JBrowse link
G ORC1 origin recognition complex subunit 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 1:52,372,829...52,409,503
Ensembl chr 1:52,372,829...52,404,423 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 5:69,369,293...69,414,801
Ensembl chr 5:69,369,293...69,414,801 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in ISS
IBA
IEA		 (PMID:21873635) UniProt
UniProt
GO_Central
InterPro
GO_Central
InterPro		 PMID:21873635 GO_REF:0000002 GO_REF:0000024 NCBI chr15:89,575,469...89,628,023
Ensembl chr15:89,575,469...89,631,056 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:133,600,238...133,661,941
Ensembl chr 3:133,598,175...133,662,380 		JBrowse link
G ZNF830 zinc finger protein 830 involved_in ISS
IEA
IBA		 (PMID:21873635) UniProt
Ensembl
UniProt
GO_Central
GO_Central		 PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr17:34,961,540...34,963,777
Ensembl chr17:34,961,540...34,963,777 		JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 involved_in IDA (PMID:19412162) UniProt
UniProt		 PMID:19412162 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDK2 cyclin dependent kinase 2 involved_in TAS (PMID:21319273) UniProt
UniProt		 PMID:21319273 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G DGKZ diacylglycerol kinase zeta involved_in IGI (PMID:16286473) UniProt
UniProt		 PMID:16286473 NCBI chr11:46,332,926...46,380,554
Ensembl chr11:46,332,905...46,380,554 		JBrowse link
G FBXO31 F-box protein 31 involved_in IMP
IEA		 (PMID:19412162) UniProt
UniProt
InterPro		 PMID:19412162 GO_REF:0000002 NCBI chr16:87,326,987...87,392,121
Ensembl chr16:87,326,987...87,392,142 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:4366664|PMID:19744960) Ensembl
Ensembl
MGI		 PMID:19744960 GO_REF:0000107 MGI:4366664 NCBI chr 2:232,697,331...232,860,605
Ensembl chr 2:232,697,299...232,860,605 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IMP (PMID:21731742) UniProt
UniProt		 PMID:21731742 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178 		JBrowse link
G PTPRVP protein tyrosine phosphatase receptor type V, pseudogene acts_upstream_of_or_within ISO (MGI:3589512|PMID:16107883) MGI PMID:16107883 MGI:3589512 NCBI chr 1:202,168,051...202,189,449
Ensembl chr 1:202,168,051...202,189,455 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IMP (PMID:20173098) UniProt
UniProt		 PMID:20173098 NCBI chr16:74,621,399...74,666,877
Ensembl chr16:74,621,399...74,666,877 		JBrowse link
G RPA2 replication protein A2 involved_in IMP (PMID:21731742) UniProt
UniProt		 PMID:21731742 NCBI chr 1:27,891,524...27,914,797
Ensembl chr 1:27,891,524...27,914,746 		JBrowse link
G RPS27L ribosomal protein S27 like involved_in IMP (PMID:18056458) UniProt
UniProt		 PMID:18056458 NCBI chr15:63,148,249...63,157,477
Ensembl chr15:63,125,872...63,158,021 		JBrowse link
G SDE2 SDE2 telomere maintenance homolog involved_in IDA (PMID:27906959) UniProt
UniProt		 PMID:27906959 NCBI chr 1:225,982,702...225,999,343
Ensembl chr 1:225,982,702...225,999,343 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IMP
IEA
ISO		 (PMID:7958916)
(MGI:3589512|PMID:16107883)		 BHF-UCL
BHF-UCL
Ensembl
MGI		 PMID:7958916 PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3818783|PMID:18045533)
(MGI:5562498|PMID:23993650)		 MGI
Ensembl
Ensembl		 PMID:18045533 PMID:23993650 GO_REF:0000107 MGI:3818783 MGI:5562498 NCBI chr 3:48,465,830...48,467,645
Ensembl chr 3:48,465,811...48,467,645 		JBrowse link
G WAC WW domain containing adaptor with coiled-coil involved_in IMP (PMID:21329877) UniProt
UniProt		 PMID:21329877 NCBI chr10:28,532,779...28,623,112
Ensembl chr10:28,532,493...28,623,112 		JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABRAXAS1 abraxas 1, BRCA1 A complex subunit involved_in IMP (PMID:17525340), (PMID:17643121), (PMID:19261748) UniProt
UniProt		 PMID:17525340 PMID:17643121 PMID:19261748 NCBI chr 4:83,459,517...83,485,100
Ensembl chr 4:83,459,517...83,523,348 		JBrowse link
G ATM ATM serine/threonine kinase involved_in IMP (PMID:15149599) BHF-UCL
BHF-UCL		 PMID:15149599 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,223,044...108,369,102 		JBrowse link
G BABAM1 BRISC and BRCA1 A complex member 1 involved_in IMP
IBA		 (PMID:19261746), (PMID:19261748), (PMID:19261749)
(PMID:21873635)		 UniProt
UniProt
GO_Central
GO_Central		 PMID:19261746 PMID:19261748 PMID:19261749 PMID:21873635 NCBI chr19:17,267,443...17,279,337
Ensembl chr19:17,267,376...17,281,249 		JBrowse link
G BABAM2 BRISC and BRCA1 A complex member 2 involved_in IMP
IEA		 (PMID:19261748) UniProt
UniProt		 PMID:19261748 GO_REF:0000104 NCBI chr 2:27,888,709...28,338,901
Ensembl chr 2:27,889,941...28,338,901 		JBrowse link
G BLM BLM RecQ like helicase involved_in IDA (PMID:11309417) UniProt
UniProt		 PMID:11309417 NCBI chr15:90,717,346...90,816,166
Ensembl chr15:90,717,346...90,816,166 		JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IMP (PMID:17525340), (PMID:17643121), (PMID:19261748) UniProt
UniProt		 PMID:17525340 PMID:17643121 PMID:19261748 NCBI chr17:43,044,295...43,125,364
Ensembl chr17:43,044,295...43,170,245 		JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 involved_in IMP
IEA		 (PMID:17525341), (PMID:19261746), (PMID:19261748) UniProt
UniProt		 PMID:17525341 PMID:19261746 PMID:19261748 GO_REF:0000104 NCBI chr  X:155,071,508...155,123,077
Ensembl chr  X:155,071,420...155,123,077 		JBrowse link
G BRSK1 BR serine/threonine kinase 1 involved_in IDA (PMID:15150265) UniProt
UniProt		 PMID:15150265 NCBI chr19:55,283,997...55,312,562
Ensembl chr19:55,282,072...55,312,562 		JBrowse link
G C10orf90 chromosome 10 open reading frame 90 involved_in ISO (MGI:4455105|PMID:20154723) UniProt PMID:20154723 MGI:4455105 NCBI chr10:126,424,997...126,670,693
Ensembl chr10:126,424,997...126,798,708 		JBrowse link
G CCNG1 cyclin G1 involved_in ISO
IEA		 RGD
Ensembl
Ensembl		 PMID:9464250 GO_REF:0000107 RGD:2316029 NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,446,151 		JBrowse link
G CDC14B cell division cycle 14B involved_in IDA (PMID:18662541) UniProt
UniProt		 PMID:18662541 NCBI chr 9:96,490,939...96,619,843
Ensembl chr 9:96,490,241...96,619,843 		JBrowse link
G CDK1 cyclin dependent kinase 1 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:2679752|PMID:12937170)		 GO_Central
GO_Central
Ensembl
MGI		 PMID:12937170 PMID:21873635 GO_REF:0000107 MGI:2679752 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in IMP (PMID:15790566) UniProt
UniProt		 PMID:15790566 NCBI chr17:47,967,904...47,981,781
Ensembl chr17:47,967,810...47,981,781 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in IMP (PMID:23213251) UniProt
UniProt		 PMID:23213251 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CHEK1 checkpoint kinase 1 involved_in IMP (PMID:20932473) UniProt
UniProt		 PMID:20932473 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255 		JBrowse link
G CLSPN claspin involved_in IDA
IBA		 (PMID:18662541)
(PMID:21873635)		 UniProt
GO_Central
UniProt
GO_Central		 PMID:18662541 PMID:21873635 NCBI chr 1:35,720,213...35,769,978
Ensembl chr 1:35,720,218...35,769,978 		JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IMP (PMID:28191891) UniProt
UniProt		 PMID:28191891 NCBI chr21:33,577,551...33,588,684
Ensembl chr21:33,559,542...33,588,706 		JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog involved_in IMP
IBA		 (PMID:17085480)
(PMID:21873635)		 UniProt
GO_Central
UniProt
GO_Central		 PMID:17085480 PMID:21873635 NCBI chr 1:212,035,748...212,105,013
Ensembl chr 1:212,035,553...212,107,400 		JBrowse link
G FOXN3 forkhead box N3 involved_in IGI (PMID:9154802) UniProt
UniProt		 PMID:9154802 NCBI chr14:89,156,177...89,619,165
Ensembl chr14:89,124,871...89,619,149 		JBrowse link
G FOXO4 forkhead box O4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2183145|PMID:12048180) Ensembl
Ensembl
MGI		 PMID:12048180 GO_REF:0000107 MGI:2183145 NCBI chr  X:71,095,851...71,103,532
Ensembl chr  X:71,095,851...71,103,532 		JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 involved_in IDA (PMID:18662541) UniProt
UniProt		 PMID:18662541 NCBI chr19:3,506,311...3,538,334
Ensembl chr19:3,506,311...3,538,334 		JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in IDA (PMID:16061642) UniProt PMID:16061642 NCBI chr12:65,824,460...65,966,291
Ensembl chr12:65,824,460...65,966,291 		JBrowse link
G IER3 immediate early response 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5432078|PMID:20467439) MGI
Ensembl		 PMID:20467439 GO_REF:0000107 MGI:5432078 NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548 		JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase acts_upstream_of_or_within ISO (MGI:2682526|PMID:14614141) MGI PMID:14614141 MGI:2682526 NCBI chr 3:129,430,947...129,439,948
Ensembl chr 3:129,430,947...129,440,179 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:2683367|PMID:14690604)		 GO_Central
Ensembl
GO_Central
MGI		 PMID:14690604 PMID:21873635 GO_REF:0000107 MGI:2683367 NCBI chr11:94,415,570...94,512,412
Ensembl chr11:94,415,570...94,493,885 		JBrowse link
G MRNIP MRN complex interacting protein involved_in IMP
IBA		 (PMID:27568553)
(PMID:21873635)		 UniProt
GO_Central
UniProt
GO_Central		 PMID:21873635 PMID:27568553 NCBI chr 5:179,837,276...179,858,817
Ensembl chr 5:179,835,133...179,862,173 		JBrowse link
G NBN nibrin involved_in
acts_upstream_of_or_within		 IBA
IEA
IDA
ISO		 (PMID:21873635)
(PMID:11438675)
(MGI:3805397|PMID:18614044)		 GO_Central
InterPro
Ensembl
UniProt
GO_Central
MGI
UniProt
InterPro		 PMID:11438675 PMID:18614044 PMID:21873635 GO_REF:0000002 GO_REF:0000107 MGI:3805397 NCBI chr 8:89,933,331...89,984,667
Ensembl chr 8:89,924,515...90,003,228 		JBrowse link
G NOP53 NOP53 ribosome biogenesis factor involved_in IMP (PMID:21741933) UniProt
UniProt		 PMID:21741933 NCBI chr19:47,745,546...47,757,058
Ensembl chr19:47,745,546...47,757,058 		JBrowse link
G PLK1 polo like kinase 1 involved_in IDA (PMID:18662541) UniProt
UniProt		 PMID:18662541 NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367 		JBrowse link
G RINT1 RAD50 interactor 1 involved_in IMP (PMID:11096100) BHF-UCL
BHF-UCL		 PMID:11096100 NCBI chr 7:105,532,201...105,567,677
Ensembl chr 7:105,532,169...105,567,677 		JBrowse link
G SYF2 SYF2 pre-mRNA splicing factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5435138|PMID:22448250) Ensembl
Ensembl
MGI		 PMID:22448250 GO_REF:0000107 MGI:5435138 NCBI chr 1:25,222,276...25,232,502
Ensembl chr 1:25,222,276...25,232,502 		JBrowse link
G TAOK1 TAO kinase 1 involved_in IMP (PMID:17396146) UniProt
UniProt		 PMID:17396146 NCBI chr17:29,390,363...29,551,903
Ensembl chr17:29,390,363...29,551,903 		JBrowse link
G TAOK2 TAO kinase 2 involved_in IMP (PMID:17396146) UniProt
UniProt		 PMID:17396146 NCBI chr16:29,973,868...29,992,261
Ensembl chr16:29,973,868...29,992,261 		JBrowse link
G TAOK3 TAO kinase 3 involved_in IMP (PMID:17396146) UniProt
UniProt		 PMID:17396146 NCBI chr12:118,149,801...118,372,907
Ensembl chr12:118,149,801...118,372,907 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IBA
ISS		 (PMID:21873635) GO_Central
UniProt
GO_Central
UniProt		 PMID:21873635 GO_REF:0000024 NCBI chr15:89,575,469...89,628,023
Ensembl chr15:89,575,469...89,631,056 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:133,600,238...133,661,941
Ensembl chr 3:133,598,175...133,662,380 		JBrowse link
G TRIM39 tripartite motif containing 39 involved_in IMP (PMID:23213251) UniProt
UniProt		 PMID:23213251 NCBI chr 6:30,326,469...30,343,729
Ensembl chr 6:30,326,479...30,343,729 		JBrowse link
G UIMC1 ubiquitin interaction motif containing 1 involved_in IMP (PMID:17525340), (PMID:17525341), (PMID:17525342), (PMID:17643121), (PMID:19261748) UniProt
UniProt		 PMID:17525340 PMID:17525341 PMID:17525342 PMID:17643121 PMID:19261748 NCBI chr 5:176,905,005...177,022,602
Ensembl chr 5:176,905,005...177,022,633 		JBrowse link
mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 involved_in IMP (PMID:15916964) UniProt
UniProt		 PMID:15916964 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382 		JBrowse link
G CHEK2 checkpoint kinase 2 involved_in IMP (PMID:11298456) UniProt
UniProt		 PMID:11298456 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G EME1 essential meiotic structure-specific endonuclease 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr17:50,373,229...50,381,483
Ensembl chr17:50,373,220...50,381,483 		JBrowse link
G EME2 essential meiotic structure-specific endonuclease subunit 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr16:1,772,810...1,781,702
Ensembl chr16:1,772,810...1,781,708 		JBrowse link
G FANCD2 FA complementation group D2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,370...10,101,932 		JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 7:47,963,288...47,979,615
Ensembl chr 7:47,963,288...47,979,615 		JBrowse link
G HUS1B HUS1 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 6:655,939...657,100
Ensembl chr 6:655,939...657,100 		JBrowse link
G MDC1 mediator of DNA damage checkpoint 1 involved_in TAS (PMID:17577209) UniProt
UniProt		 PMID:17577209 NCBI chr 6:30,699,807...30,717,281
Ensembl chr 6:30,699,807...30,717,447 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:2683367|PMID:14690604), (MGI:3805397|PMID:18614044)		 GO_Central
GO_Central
Ensembl
MGI		 PMID:14690604 PMID:18614044 PMID:21873635 GO_REF:0000107 MGI:2683367 MGI:3805397 NCBI chr11:94,415,570...94,512,412
Ensembl chr11:94,415,570...94,493,885 		JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3512823|PMID:15533840) Ensembl
Ensembl
MGI		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr 2:47,403,067...47,634,501
Ensembl chr 2:47,403,067...47,663,146 		JBrowse link
G MUS81 MUS81 structure-specific endonuclease subunit involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr11:65,859,674...65,867,653
Ensembl chr11:65,857,126...65,867,653 		JBrowse link
G NEK11 NIMA related kinase 11 involved_in IBA
IDA		 (PMID:21873635)
(PMID:15161910)		 GO_Central
GO_Central
UniProt
UniProt		 PMID:15161910 PMID:21873635 NCBI chr 3:131,026,877...131,350,465
Ensembl chr 3:131,026,850...131,350,465 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IMP (PMID:15538388) UniProt
UniProt		 PMID:15538388 NCBI chr 5:69,369,293...69,414,801
Ensembl chr 5:69,369,293...69,414,801 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:1289930|PMID:9766521)		 GO_Central
GO_Central
Ensembl
MGI		 PMID:9766521 PMID:21873635 GO_REF:0000107 MGI:1289930 NCBI chr11:67,391,986...67,398,412
Ensembl chr11:67,317,871...67,398,410 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr12:110,502,331...110,533,556
Ensembl chr12:110,501,655...110,533,556 		JBrowse link
G TIPIN TIMELESS interacting protein involved_in IMP (PMID:17102137) HGNC-UCL
HGNC-UCL		 PMID:17102137 NCBI chr15:66,336,191...66,386,717
Ensembl chr15:66,336,191...66,386,746 		JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3512823|PMID:15533840) Ensembl
Ensembl
MGI		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr 3:14,145,147...14,178,601
Ensembl chr 3:14,145,147...14,178,621 		JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD4 bromodomain containing 4 involved_in IMP (PMID:23728299) UniProt
UniProt		 PMID:23728299 NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545 		JBrowse link
G CHEK2 checkpoint kinase 2 involved_in IEA
ISO		 Ensembl
RGD
Ensembl		 PMID:20637979 GO_REF:0000107 RGD:10401658 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G DDX39B DExD-box helicase 39B involved_in IMP (PMID:22144908) UniProt
UniProt		 PMID:22144908 NCBI chr 6:31,530,226...31,542,003
Ensembl chr 6:31,530,219...31,542,448 		JBrowse link
G THOC1 THO complex subunit 1 involved_in IMP (PMID:22144908) UniProt
UniProt		 PMID:22144908 NCBI chr18:214,520...268,047
Ensembl chr18:214,520...268,050 		JBrowse link
G THOC5 THO complex subunit 5 involved_in IMP (PMID:22144908) UniProt
UniProt		 PMID:22144908 NCBI chr22:29,505,879...29,553,757
Ensembl chr22:29,505,879...29,555,216 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R10 protein phosphatase 1 regulatory subunit 10 involved_in IGI (PMID:23426265) BHF-UCL
BHF-UCL		 PMID:23426265 NCBI chr 6:30,600,413...30,617,243
Ensembl chr 6:30,600,413...30,618,612 		JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCAR2 cell cycle and apoptosis regulator 2 involved_in IMP (PMID:23352644) UniProt
UniProt		 PMID:23352644 NCBI chr 8:22,604,757...22,621,514
Ensembl chr 8:22,604,757...22,620,964 		JBrowse link
G TELO2 telomere maintenance 2 involved_in NAS (PMID:20810650) ComplexPortal PMID:20810650 NCBI chr16:1,493,360...1,510,454
Ensembl chr16:1,493,344...1,510,457 		JBrowse link
G TTI1 TELO2 interacting protein 1 involved_in NAS (PMID:20810650) ComplexPortal PMID:20810650 NCBI chr20:37,983,021...38,033,456
Ensembl chr20:37,983,007...38,033,461 		JBrowse link
G TTI2 TELO2 interacting protein 2 involved_in NAS (PMID:20810650) ComplexPortal PMID:20810650 NCBI chr 8:33,498,722...33,513,135
Ensembl chr 8:33,473,386...33,513,185 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IDA (PMID:15342622) UniProt
UniProt		 PMID:15342622 NCBI chr 2:173,075,517...173,268,015
Ensembl chr 2:173,075,435...173,268,015 		JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BABAM2 BRISC and BRCA1 A complex member 2 involved_in NAS (PMID:14636569) ComplexPortal PMID:14636569 NCBI chr 2:27,888,709...28,338,901
Ensembl chr 2:27,889,941...28,338,901 		JBrowse link
G BARD1 BRCA1 associated RING domain 1 involved_in NAS (PMID:14636569) ComplexPortal PMID:14636569 NCBI chr 2:214,725,646...214,809,683
Ensembl chr 2:214,725,646...214,809,683 		JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in NAS (PMID:14636569) ComplexPortal PMID:14636569 NCBI chr17:43,044,295...43,125,364
Ensembl chr17:43,044,295...43,170,245 		JBrowse link
G BRCA2 BRCA2 DNA repair associated involved_in NAS (PMID:14636569) ComplexPortal PMID:14636569 NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268 		JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 involved_in NAS (PMID:14636569) ComplexPortal PMID:14636569 NCBI chr  X:155,071,508...155,123,077
Ensembl chr  X:155,071,420...155,123,077 		JBrowse link
G CRY1 cryptochrome circadian regulator 1 involved_in ISS
IEA		 UniProt
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:106,991,364...107,093,549
Ensembl chr12:106,991,364...107,093,549 		JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3850765|PMID:19481525) Ensembl
Ensembl
MGI		 PMID:19481525 GO_REF:0000107 MGI:3850765 NCBI chr13:113,208,193...113,267,108
Ensembl chr13:113,208,193...113,267,108 		JBrowse link
G ETAA1 ETAA1 activator of ATR kinase involved_in IDA
IBA		 (PMID:27723717), (PMID:27723720)
(PMID:21873635)		 UniProt
GO_Central
UniProt
GO_Central		 PMID:21873635 PMID:27723717 PMID:27723720 NCBI chr 2:67,397,333...67,412,089
Ensembl chr 2:67,397,322...67,412,089 		JBrowse link
G FBXO4 F-box protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5299398|PMID:21911473) Ensembl
Ensembl
MGI		 PMID:21911473 GO_REF:0000107 MGI:5299398 NCBI chr 5:41,925,281...42,040,404
Ensembl chr 5:41,925,254...41,941,743 		JBrowse link
G FEM1B fem-1 homolog B involved_in IMP (PMID:19330022) UniProt
UniProt		 PMID:19330022 NCBI chr15:68,277,745...68,295,862
Ensembl chr15:68,277,745...68,295,862 		JBrowse link
G NEK1 NIMA related kinase 1 involved_in ISO (MGI:5619475|PMID:18843199) CACAO PMID:18843199 MGI:5619475 NCBI chr 4:169,392,809...169,612,583
Ensembl chr 4:169,369,704...169,612,632 		JBrowse link
G RAD51 RAD51 recombinase involved_in NAS (PMID:14636569) ComplexPortal PMID:14636569 NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IMP (PMID:21504906) UniProt
UniProt		 PMID:21504906 NCBI chr16:74,621,399...74,666,877
Ensembl chr16:74,621,399...74,666,877 		JBrowse link
G RNASEH2B ribonuclease H2 subunit B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5435090|PMID:22802351) Ensembl
Ensembl
MGI		 PMID:22802351 GO_REF:0000107 MGI:5435090 NCBI chr13:50,909,678...50,970,460
Ensembl chr13:50,909,747...51,024,120 		JBrowse link
G RPA2 replication protein A2 involved_in IMP (PMID:21504906) UniProt
UniProt		 PMID:21504906 NCBI chr 1:27,891,524...27,914,797
Ensembl chr 1:27,891,524...27,914,746 		JBrowse link
G WDR76 WD repeat domain 76 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr15:43,827,002...43,868,412
Ensembl chr15:43,826,980...43,868,412 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19815
    cellular process 18111
      signal transduction 6621
        intracellular signal transduction 3051
          cell cycle checkpoint signaling 203
            DNA integrity checkpoint signaling 143
              DNA damage checkpoint signaling + 134
              DNA replication checkpoint signaling + 18
              meiotic DNA integrity checkpoint signaling + 2
              mitotic DNA integrity checkpoint signaling + 93
Path 2
Term Annotations click to browse term
  biological_process 19815
    biological regulation 13809
      regulation of biological process 13290
        negative regulation of biological process 6696
          negative regulation of cellular process 5620
            negative regulation of cell cycle 474
              negative regulation of cell cycle process 375
                negative regulation of cell cycle phase transition 316
                  cell cycle checkpoint signaling 203
                    DNA integrity checkpoint signaling 143
                      DNA damage checkpoint signaling + 134
                      DNA replication checkpoint signaling + 18
                      meiotic DNA integrity checkpoint signaling + 2
                      mitotic DNA integrity checkpoint signaling + 93
paths to the root