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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA integrity checkpoint signaling
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Accession:GO:0031570 term browser browse the term
Definition:A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.
Synonyms:exact_synonym: DNA integrity checkpoint;   signal transduction involved in DNA integrity checkpoint
 alt_id: GO:0072401



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DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase acts_upstream_of_or_within
involved_in
ISO
IBA
IEA
(MGI:2679752|PMID:12937170)
(PMID:21873635)
MGI
GO_Central
InterPro
GO_Central
InterPro
PMID:12937170 PMID:21873635 GO_REF:0000002 MGI:2679752 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
JBrowse link
G ATR ATR serine/threonine kinase acts_upstream_of_or_within
involved_in
ISO
IBA
IEA
(MGI:2679752|PMID:12937170)
(PMID:21873635)
MGI
GO_Central
Ensembl
GO_Central
PMID:12937170 PMID:21873635 GO_REF:0000107 MGI:2679752 NCBI chr23:38,131,956...38,223,888
Ensembl chr23:38,132,788...38,224,016
JBrowse link
G ATRIP ATR interacting protein involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr20:40,626,828...40,642,689
Ensembl chr20:40,626,831...40,642,594
JBrowse link
G CDC5L cell division cycle 5 like involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:12,779,936...12,822,978
Ensembl chr12:12,780,010...12,822,801
JBrowse link
G CHEK1 checkpoint kinase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1860049|PMID:10859164)
(MGI:2449744|PMID:12529385)
MGI
InterPro
InterPro
PMID:10859164 PMID:12529385 GO_REF:0000002 MGI:1860049 MGI:2449744 NCBI chr 5:8,878,511...8,910,626
Ensembl chr 5:8,879,147...8,907,669
JBrowse link
G CHEK2 checkpoint kinase 2 ISO RGD PMID:10435585 RGD:633752 NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G CLOCK clock circadian regulator involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr13:47,684,409...47,825,733
Ensembl chr13:47,691,709...47,758,784
JBrowse link
G CLSPN claspin involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:6,400,084...6,430,295
Ensembl chr15:6,400,062...6,430,279
JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:28,192,338...28,209,512 JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase involved_in IEA
IBA
(PMID:21873635) UniProt
UniProt
GO_Central
GO_Central
PMID:21873635 GO_REF:0000104 NCBI chr20:56,805,030...56,868,771
Ensembl chr20:56,803,242...56,852,539
JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr30:7,144,727...7,248,014
Ensembl chr30:7,144,570...7,248,000
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr28:1,358,383...1,432,276
Ensembl chr28:1,361,107...1,427,162
JBrowse link
G H2AX H2A.X variant histone involved_in
NOT|acts_upstream_of_or_within
IEA
ISO
(MGI:2179182|PMID:11934988) Ensembl
Ensembl
MGI
PMID:11934988 GO_REF:0000107 MGI:2179182 NCBI chr 5:14,765,625...14,766,590
Ensembl chr 5:14,766,126...14,766,557
JBrowse link
G HINFP histone H4 transcription factor involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 5:14,731,592...14,742,893
Ensembl chr 5:14,731,588...14,742,559
JBrowse link
G HUS1 HUS1 checkpoint clamp component acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2449744|PMID:12529385) MGI
InterPro
InterPro
PMID:12529385 GO_REF:0000002 MGI:2449744 NCBI chr16:93,596...104,908
Ensembl chr16:93,626...125,597
JBrowse link
G INTS7 integrator complex subunit 7 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:10,238,809...10,323,699
Ensembl chr 7:10,239,711...10,323,611
JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:11836244) UniProt PMID:11836244 NCBI chr36:17,353,829...17,515,247
Ensembl chr36:17,341,300...17,514,869
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 acts_upstream_of_or_within ISO (MGI:2679752|PMID:12937170) MGI PMID:12937170 MGI:2679752 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603
JBrowse link
G NBN nibrin acts_upstream_of_or_within ISO (PMID:12529385) MGI PMID:12529385 NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563
JBrowse link
G NECAB3 N-terminal EF-hand calcium binding protein 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656
JBrowse link
G PRPF19 pre-mRNA processing factor 19 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr18:55,389,902...55,400,241
Ensembl chr18:55,389,897...55,400,240
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 acts_upstream_of_or_within ISO (MGI:2679752|PMID:12937170) MGI PMID:12937170 MGI:2679752 NCBI chr26:9,989,218...10,072,245
Ensembl chr26:9,989,425...10,067,481
JBrowse link
G RAD1 RAD1 checkpoint DNA exonuclease involved_in IBA
IEA
(PMID:21873635) GO_Central
InterPro
Ensembl
GO_Central
InterPro
PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:73,372,391...73,393,148
Ensembl chr 4:73,385,566...73,452,033
JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IBA
IEA
(PMID:21873635) GO_Central
InterPro
GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 2:54,407,184...54,437,676
Ensembl chr 2:54,407,228...54,437,632
JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IEA InterPro GO_REF:0000002 NCBI chr18:50,065,154...50,070,582
Ensembl chr18:50,065,685...50,070,710
JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr26:8,309,384...8,333,414
Ensembl chr26:8,309,592...8,343,424
JBrowse link
G RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr27:41,885,779...41,906,252
Ensembl chr27:41,886,052...41,891,759
JBrowse link
G TIPIN TIMELESS interacting protein acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3706226|PMID:17141802) MGI
Ensembl
PMID:17141802 GO_REF:0000107 MGI:3706226 NCBI chr30:30,641,557...30,657,353
Ensembl chr30:30,641,555...30,657,260
JBrowse link
G TIPRL TOR signaling pathway regulator involved_in ISO (PMID:17384681) UniProt PMID:17384681 NCBI chr 7:30,291,330...30,329,317
Ensembl chr 7:30,185,850...30,365,512
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr30:10,263,650...10,362,646
Ensembl chr30:10,263,650...10,336,134
JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3818783|PMID:18045533) MGI
Ensembl
PMID:18045533 GO_REF:0000107 MGI:3818783 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906
JBrowse link
G USP28 ubiquitin specific peptidase 28 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 5:19,431,313...19,480,709
Ensembl chr 5:19,435,451...19,479,640
JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP2 caspase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr16:6,378,447...6,396,251
Ensembl chr16:6,379,913...6,396,646
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in ISO (PMID:15149599) BHF-UCL PMID:15149599 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281
JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr15:33,873,600...34,052,498
Ensembl chr15:33,878,467...34,092,094
JBrowse link
G MDM2 MDM2 proto-oncogene involved_in ISO (PMID:21726810) UniProt PMID:21726810 NCBI chr10:10,936,288...10,963,118
Ensembl chr10:10,893,719...10,962,596
JBrowse link
G MUC1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690
JBrowse link
G PCBP4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chr20:37,748,854...37,759,072
Ensembl chr20:37,748,938...37,759,073
JBrowse link
G PIDD1 p53-induced death domain protein 1 involved_in ISO (PMID:21726810) UniProt PMID:21726810 NCBI chr18:45,168,244...45,174,085
Ensembl chr18:45,168,245...45,173,107
JBrowse link
G PML PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) UniProt PMID:15626733 MGI:3580934 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430 NCBI chr 8:69,846,311...69,969,409
Ensembl chr 8:69,846,446...69,967,578
JBrowse link
G PRAP1 proline rich acidic protein 1 involved_in ISO (PMID:23235459) UniProt PMID:23235459 NCBI chr28:40,927,744...40,931,355 JBrowse link
G RBM38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) UniProt PMID:17050675 NCBI chr24:42,396,356...42,410,543
Ensembl chr24:42,396,352...42,409,240
JBrowse link
G RPL26 ribosomal protein L26 involved_in ISO (PMID:16213212)
(MGI:5882892|PMID:16213212)
CAFA PMID:16213212 MGI:5882892 NCBI chr 5:33,152,114...33,158,237
Ensembl chr 5:33,152,113...33,158,302
JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3589512|PMID:16107883) MGI
Ensembl
Ensembl
PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 5:64,566,035...64,570,361
Ensembl chr 5:64,566,043...64,570,748
JBrowse link
G CLSPN claspin acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:12766152) MGI
Ensembl
PMID:12766152 GO_REF:0000107 NCBI chr15:6,400,084...6,430,295
Ensembl chr15:6,400,062...6,430,279
JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in ISO (PMID:22570476) UniProt PMID:22570476 NCBI chr 4:19,626,001...19,683,819
Ensembl chr 4:19,626,977...19,684,660
JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr18:50,065,154...50,070,582
Ensembl chr18:50,065,685...50,070,710
JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr26:8,309,384...8,333,414
Ensembl chr26:8,309,592...8,343,424
JBrowse link
G TIMELESS timeless circadian regulator involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr10:671,829...701,152
Ensembl chr10:671,269...687,016
JBrowse link
G TIPIN TIMELESS interacting protein involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
UniProt
InterPro
PMID:21873635 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr30:30,641,557...30,657,353
Ensembl chr30:30,641,555...30,657,260
JBrowse link
meiotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr16:93,596...104,908
Ensembl chr16:93,626...125,597
JBrowse link
mitotic DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHEK2 checkpoint kinase 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G PHKG1 phosphorylase kinase catalytic subunit gamma 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 6:565,560...577,754
Ensembl chr 6:565,711...577,739
JBrowse link
G STK33 serine/threonine kinase 33 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr21:31,878,118...32,025,342
Ensembl chr21:31,878,275...32,025,310
JBrowse link
G TTC28 tetratricopeptide repeat domain 28 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr26:21,424,249...22,049,579
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G ZNF830 zinc finger protein 830 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:5428139|PMID:23213458)
(PMID:21873635)
MGI
GO_Central
GO_Central
PMID:21873635 PMID:23213458 MGI:5428139 NCBI chr 9:38,382,508...38,384,060
Ensembl chr 9:38,382,900...38,384,015
JBrowse link
mitotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SETMAR SET domain without mariner transposase fusion involved_in ISO (PMID:18790802) UniProt PMID:18790802 NCBI chr20:13,214,241...13,224,020
Ensembl chr20:13,214,241...13,224,020
JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC6 cell division cycle 6 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 9:22,303,549...22,317,046
Ensembl chr 9:22,226,719...22,316,963
JBrowse link
G CLSPN claspin involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr15:6,400,084...6,430,295
Ensembl chr15:6,400,062...6,430,279
JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr16:93,596...104,908
Ensembl chr16:93,626...125,597
JBrowse link
G NAE1 NEDD8 activating enzyme E1 subunit 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 5:82,462,690...82,486,097
Ensembl chr 5:82,462,744...82,486,100
JBrowse link
G ORC1 origin recognition complex subunit 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr15:8,965,339...8,995,527
Ensembl chr15:8,971,732...8,995,481
JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 2:54,407,184...54,437,676
Ensembl chr 2:54,407,228...54,437,632
JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IEA
IBA
(PMID:21873635) InterPro
InterPro
GO_Central
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 3:52,584,913...52,629,731
Ensembl chr 3:52,584,454...52,629,164
JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr23:30,517,172...30,578,664
Ensembl chr23:30,516,125...30,578,108
JBrowse link
G ZNF830 zinc finger protein 830 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 9:38,382,508...38,384,060
Ensembl chr 9:38,382,900...38,384,015
JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 involved_in ISS UniProt
UniProt
GO_REF:0000024 NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005
JBrowse link
G DGKZ diacylglycerol kinase zeta involved_in ISO (PMID:16286473) UniProt PMID:16286473 NCBI chr18:43,088,169...43,103,820
Ensembl chr18:43,088,525...43,129,294
JBrowse link
G FBXO31 F-box protein 31 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 5:65,703,591...65,734,956
Ensembl chr 5:65,703,575...65,731,056
JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 acts_upstream_of_or_within ISO (MGI:4366664|PMID:19744960) MGI PMID:19744960 MGI:4366664 NCBI chr25:44,317,540...44,453,761
Ensembl chr25:44,317,517...44,452,064
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in ISS UniProt
UniProt
GO_REF:0000024 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895
JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in ISO (PMID:20173098) UniProt PMID:20173098 NCBI chr 5:75,960,909...76,001,088
Ensembl chr 5:75,960,955...76,000,467
JBrowse link
G RPA2 replication protein A2 involved_in ISO (PMID:21731742) UniProt PMID:21731742 NCBI chr 2:72,463,951...72,479,864
Ensembl chr 2:72,419,459...72,479,227
JBrowse link
G RPS27L ribosomal protein S27 like involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr30:27,749,297...27,753,226 JBrowse link
G SDE2 SDE2 telomere maintenance homolog involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:38,857,220...38,871,584
Ensembl chr 7:38,857,234...38,870,157
JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3589512|PMID:16107883) MGI
Ensembl
PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5562498|PMID:23993650)
(MGI:3818783|PMID:18045533)
MGI
Ensembl
Ensembl
PMID:18045533 PMID:23993650 GO_REF:0000107 MGI:3818783 MGI:5562498 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906
JBrowse link
G WAC WW domain containing adaptor with coiled-coil involved_in ISO (PMID:21329877) UniProt PMID:21329877 NCBI chr 2:17,504,949...17,588,037 JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABRAXAS1 abraxas 1, BRCA1 A complex subunit involved_in ISO (PMID:17525340), (PMID:17643121), (PMID:19261748) UniProt PMID:17525340 PMID:17643121 PMID:19261748 NCBI chr32:7,298,789...7,316,665
Ensembl chr32:7,298,790...7,317,001
JBrowse link
G ATM ATM serine/threonine kinase involved_in ISO (PMID:15149599) BHF-UCL PMID:15149599 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
JBrowse link
G BABAM1 BRISC and BRCA1 A complex member 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr20:45,466,808...45,474,953
Ensembl chr20:45,466,805...45,473,009
JBrowse link
G BABAM2 BRISC and BRCA1 A complex member 2 involved_in ISO (PMID:19261748) UniProt PMID:19261748 NCBI chr17:21,886,127...22,288,513
Ensembl chr17:21,889,862...22,288,504
JBrowse link
G BLM BLM RecQ like helicase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 3:53,408,120...53,506,728
Ensembl chr 3:53,408,217...53,473,146
JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494
JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 involved_in ISO (PMID:17525341), (PMID:19261746), (PMID:19261748) UniProt PMID:17525341 PMID:19261746 PMID:19261748 NCBI chr  X:123,081,262...123,143,509
Ensembl chr  X:123,081,050...123,140,133
JBrowse link
G BRSK1 BR serine/threonine kinase 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:102,367,050...102,384,942
Ensembl chr 1:102,367,581...102,385,466
JBrowse link
G C28H10orf90 chromosome 28 C10orf90 homolog involved_in ISO (MGI:4455105|PMID:20154723) UniProt PMID:20154723 MGI:4455105 NCBI chr28:35,514,489...35,721,091
Ensembl chr28:35,515,286...35,720,509
JBrowse link
G CCNG1 cyclin G1 ISO RGD PMID:9464250 RGD:2316029 NCBI chr 4:47,800,697...47,808,259
Ensembl chr 4:47,801,575...47,808,211
JBrowse link
G CDC14B cell division cycle 14B involved_in ISO (PMID:18662541) UniProt PMID:18662541 NCBI chr 1:70,232,932...70,335,950
Ensembl chr 1:70,232,947...70,335,943
JBrowse link
G CDK1 cyclin dependent kinase 1 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:2679752|PMID:12937170)
GO_Central
GO_Central
Ensembl
MGI
PMID:12937170 PMID:21873635 GO_REF:0000107 MGI:2679752 NCBI chr 4:12,884,106...12,899,203
Ensembl chr 4:12,883,385...12,899,197
JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:24,276,660...24,286,273
Ensembl chr 9:24,276,768...24,286,272
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in ISO (PMID:23213251) UniProt PMID:23213251 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281
JBrowse link
G CHEK1 checkpoint kinase 1 involved_in ISO (PMID:20932473) UniProt PMID:20932473 NCBI chr 5:8,878,511...8,910,626
Ensembl chr 5:8,879,147...8,907,669
JBrowse link
G CLSPN claspin involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr15:6,400,084...6,430,295
Ensembl chr15:6,400,062...6,430,279
JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr31:28,192,338...28,209,512 JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 7:10,323,842...10,368,529
Ensembl chr 7:10,323,559...10,369,560
JBrowse link
G FOXN3 forkhead box N3 involved_in ISO (PMID:9154802) UniProt PMID:9154802 NCBI chr 8:60,324,808...60,612,959
Ensembl chr34:12,398,370...12,399,773
JBrowse link
G FOXO4 forkhead box O4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2183145|PMID:12048180) MGI
Ensembl
Ensembl
PMID:12048180 GO_REF:0000107 MGI:2183145 NCBI chr  X:55,469,738...55,477,699
Ensembl chr  X:55,469,382...55,477,699
JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 involved_in ISO (PMID:18662541) UniProt PMID:18662541 NCBI chr20:55,866,893...55,877,077
Ensembl chr20:55,869,693...55,876,936
JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:8,348,101...8,491,435 JBrowse link
G IER3 immediate early response 3 acts_upstream_of_or_within ISO (MGI:5432078|PMID:20467439) MGI PMID:20467439 MGI:5432078 NCBI chr12:529,002...530,328
Ensembl chr12:529,339...530,232
JBrowse link
G LOC478184 pre-mRNA-splicing factor SYF2 acts_upstream_of_or_within ISO (MGI:5435138|PMID:22448250) MGI PMID:22448250 MGI:5435138 NCBI chr 2:74,573,023...74,580,061 JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase acts_upstream_of_or_within ISO (MGI:2682526|PMID:14614141) MGI PMID:14614141 MGI:2682526 NCBI chr20:5,716,162...5,725,068
Ensembl chr20:5,716,239...5,724,881
JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within
IEA
IBA
ISO
(PMID:21873635)
(MGI:2683367|PMID:14690604)
Ensembl
Ensembl
GO_Central
GO_Central
MGI
PMID:14690604 PMID:21873635 GO_REF:0000107 MGI:2683367 NCBI chr21:6,448,909...6,528,185
Ensembl chr21:6,449,822...6,527,119
JBrowse link
G MRNIP MRN complex interacting protein involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr11:1,834,148...1,859,601
Ensembl chr11:1,833,967...1,859,347
JBrowse link
G NBN nibrin acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:3805397|PMID:18614044)
(PMID:21873635)
MGI
InterPro
GO_Central
InterPro
GO_Central
PMID:18614044 PMID:21873635 GO_REF:0000002 MGI:3805397 NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:21741933) UniProt PMID:21741933 NCBI chr 1:108,307,039...108,315,732
Ensembl chr 1:108,307,042...108,316,495
JBrowse link
G PLK1 polo like kinase 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:22,165,338...22,176,847
Ensembl chr 6:22,165,338...22,176,441
JBrowse link
G RINT1 RAD50 interactor 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr18:14,843,820...14,877,334
Ensembl chr18:14,843,829...14,877,607
JBrowse link
G TAOK1 TAO kinase 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:43,501,752...43,660,077
Ensembl chr 9:43,559,708...43,651,377
JBrowse link
G TAOK2 TAO kinase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:18,014,685...18,029,188
Ensembl chr 6:18,000,138...18,029,185
JBrowse link
G TAOK3 TAO kinase 3 involved_in ISO (PMID:17396146) UniProt PMID:17396146 NCBI chr26:14,534,083...14,712,779
Ensembl chr26:14,534,901...14,631,899
JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 3:52,584,913...52,629,731
Ensembl chr 3:52,584,454...52,629,164
JBrowse link
G TMEM219 transmembrane protein 219 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:17,959,490...18,014,813
Ensembl chr 6:18,000,138...18,029,185
JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr23:30,517,172...30,578,664
Ensembl chr23:30,516,125...30,578,108
JBrowse link
G UIMC1 ubiquitin interaction motif containing 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 4:36,339,711...36,467,035
Ensembl chr 4:36,354,922...36,466,880
JBrowse link
mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr36:19,032,376...19,103,382
Ensembl chr36:19,010,717...19,103,292
JBrowse link
G CHEK2 checkpoint kinase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G EME1 essential meiotic structure-specific endonuclease 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 9:26,342,419...26,350,561
Ensembl chr 9:26,344,438...26,349,997
JBrowse link
G FANCD2 FA complementation group D2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr20:8,240,270...8,297,269
Ensembl chr20:8,240,311...8,297,568
JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr16:93,596...104,908
Ensembl chr16:93,626...125,597
JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within
IEA
IBA
ISO
(PMID:21873635)
(MGI:2683367|PMID:14690604), (MGI:3805397|PMID:18614044)
Ensembl
GO_Central
Ensembl
GO_Central
MGI
PMID:14690604 PMID:18614044 PMID:21873635 GO_REF:0000107 MGI:2683367 MGI:3805397 NCBI chr21:6,448,909...6,528,185
Ensembl chr21:6,449,822...6,527,119
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3512823|PMID:15533840) Ensembl
Ensembl
MGI
PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
G MUS81 MUS81 structure-specific endonuclease subunit involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr18:51,396,980...51,404,563
Ensembl chr18:51,396,980...51,402,534
JBrowse link
G NEK11 NIMA related kinase 11 involved_in ISO (PMID:15161910) UniProt PMID:15161910 NCBI chr23:28,244,116...28,496,595
Ensembl chr23:28,247,451...28,442,816
JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in ISO (PMID:15538388) UniProt PMID:15538388 NCBI chr 2:54,407,184...54,437,676
Ensembl chr 2:54,407,228...54,437,632
JBrowse link
G RAD9A RAD9 checkpoint clamp component A acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:1289930|PMID:9766521)
(PMID:21873635)
MGI
GO_Central
GO_Central
PMID:9766521 PMID:21873635 MGI:1289930 NCBI chr18:50,065,154...50,070,582
Ensembl chr18:50,065,685...50,070,710
JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr26:8,309,384...8,333,414
Ensembl chr26:8,309,592...8,343,424
JBrowse link
G TIPIN TIMELESS interacting protein involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr30:30,641,557...30,657,353
Ensembl chr30:30,641,555...30,657,260
JBrowse link
G TTC28 tetratricopeptide repeat domain 28 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr26:21,424,249...22,049,579
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3512823|PMID:15533840) Ensembl
Ensembl
MGI
PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr20:4,299,644...4,328,826
Ensembl chr20:4,300,386...4,328,768
JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD4 bromodomain containing 4 involved_in ISO (PMID:23728299) UniProt PMID:23728299 NCBI chr20:46,844,795...46,927,620
Ensembl chr20:46,891,514...46,927,608
JBrowse link
G CHEK2 checkpoint kinase 2 ISO RGD PMID:20637979 RGD:10401658 NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G DDX39B DExD-box helicase 39B involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr12:1,032,377...1,044,465
Ensembl chr12:1,032,368...1,044,492
JBrowse link
G THOC1 THO complex 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:67,082,100...67,136,592
Ensembl chr 7:67,082,231...67,136,525
JBrowse link
G THOC5 THO complex 5 involved_in ISO (PMID:22144908) UniProt PMID:22144908 NCBI chr26:22,748,857...22,785,288
Ensembl chr26:22,748,895...22,784,143
JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R10 protein phosphatase 1 regulatory subunit 10 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:416,533...434,777
Ensembl chr12:417,680...427,799
JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCAR2 cell cycle and apoptosis regulator 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr25:34,660,026...34,674,129
Ensembl chr25:34,660,553...34,674,037
JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:15342622) UniProt PMID:15342622 NCBI chr36:17,353,829...17,515,247
Ensembl chr36:17,341,300...17,514,869
JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRY1 cryptochrome circadian regulator 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr10:31,681,098...31,792,995
Ensembl chr10:31,681,288...31,780,306
JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3850765|PMID:19481525) Ensembl
Ensembl
MGI
PMID:19481525 GO_REF:0000107 MGI:3850765 NCBI chr22:60,624,215...60,667,844
Ensembl chr22:60,624,241...60,666,616
JBrowse link
G ETAA1 ETAA1 activator of ATR kinase involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr10:66,631,411...66,644,753
Ensembl chr10:66,631,544...66,643,728
JBrowse link
G FBXO4 F-box protein 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5299398|PMID:21911473) Ensembl
Ensembl
MGI
PMID:21911473 GO_REF:0000107 MGI:5299398 NCBI chr 4:67,620,947...67,664,862
Ensembl chr 4:67,651,275...67,664,915
JBrowse link
G FEM1B fem-1 homolog B involved_in ISO (PMID:19330022) UniProt PMID:19330022 NCBI chr30:32,297,847...32,315,823
Ensembl chr30:32,297,400...32,311,008
JBrowse link
G NEK1 NIMA related kinase 1 involved_in ISO (MGI:5619475|PMID:18843199) CACAO PMID:18843199 MGI:5619475 NCBI chr25:20,297,190...20,528,537
Ensembl chr25:20,299,079...20,518,483
JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in ISO (PMID:21504906) UniProt PMID:21504906 NCBI chr 5:75,960,909...76,001,088
Ensembl chr 5:75,960,955...76,000,467
JBrowse link
G RNASEH2B ribonuclease H2 subunit B acts_upstream_of_or_within ISO (MGI:5435090|PMID:22802351) MGI PMID:22802351 MGI:5435090 NCBI chr22:944,399...1,010,479
Ensembl chr22:931,751...991,223
JBrowse link
G RPA2 replication protein A2 involved_in ISO (PMID:21504906) UniProt PMID:21504906 NCBI chr 2:72,463,951...72,479,864
Ensembl chr 2:72,419,459...72,479,227
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16237
    cellular process 15517
      signal transduction 5651
        intracellular signal transduction 2557
          cell cycle checkpoint signaling 171
            DNA integrity checkpoint signaling 118
              DNA damage checkpoint signaling + 111
              DNA replication checkpoint signaling + 15
              meiotic DNA integrity checkpoint signaling + 1
              mitotic DNA integrity checkpoint signaling + 84
Path 2
Term Annotations click to browse term
  biological_process 16237
    biological regulation 11773
      regulation of biological process 11134
        regulation of cellular process 10657
          regulation of cell cycle 1047
            regulation of cell cycle process 686
              negative regulation of cell cycle process 287
                negative regulation of cell cycle phase transition 239
                  cell cycle checkpoint signaling 171
                    DNA integrity checkpoint signaling 118
                      DNA damage checkpoint signaling + 111
                      DNA replication checkpoint signaling + 15
                      meiotic DNA integrity checkpoint signaling + 1
                      mitotic DNA integrity checkpoint signaling + 84
paths to the root