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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA integrity checkpoint signaling
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Accession:GO:0031570 term browser browse the term
Definition:A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.
Synonyms:exact_synonym: DNA integrity checkpoint;   signal transduction involved in DNA integrity checkpoint
 alt_id: GO:0072401


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DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041 		JBrowse link
G ATR ATR serine/threonine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr 3:139,482,606...139,612,274
Ensembl chr 3:147,075,185...147,196,261 		JBrowse link
G ATRIP ATR interacting protein involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:48,368,775...48,387,698
Ensembl chr 3:49,450,991...49,469,351 		JBrowse link
G CDC5L cell division cycle 5 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:43,983,840...44,043,029
Ensembl chr 6:45,265,845...45,326,383 		JBrowse link
G CHEK1 checkpoint kinase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2449744|PMID:12529385)
(MGI:1860049|PMID:10859164)		 MGI
InterPro
Ensembl		 PMID:10859164 PMID:12529385 GO_REF:0000002 GO_REF:0000107 MGI:1860049 MGI:2449744 NCBI chr11:120,446,352...120,478,207
Ensembl chr11:124,359,218...124,390,981 		JBrowse link
G CHEK2 checkpoint kinase 2 ISO RGD PMID:10435585 RGD:633752 NCBI chr22:9,757,038...9,811,171 JBrowse link
G CLOCK clock circadian regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:68,391,310...68,509,813
Ensembl chr 4:75,018,898...75,066,726 		JBrowse link
G CLSPN claspin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:34,991,082...35,040,515
Ensembl chr 1:36,182,726...36,218,544 		JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:19,944,692...19,956,140
Ensembl chr21:33,317,841...33,328,132 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase involved_in IEA UniProt GO_REF:0000104 NCBI chr19:1,173,915...1,243,633
Ensembl chr19:2,147,031...2,210,039 		JBrowse link
G DTX3L deltex E3 ubiquitin ligase 3L involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:119,654,019...119,664,918
Ensembl chr 3:126,558,924...126,569,807 		JBrowse link
G E2F1 E2F transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:29,963,083...29,973,860
Ensembl chr20:31,103,764...31,110,604 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:18,871,867...18,973,380
Ensembl chr15:37,120,044...37,229,211 		JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:44,703,720...44,784,948 JBrowse link
G HINFP histone H4 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:113,959,670...113,973,781
Ensembl chr11:117,888,855...117,902,184 		JBrowse link
G HUS1 HUS1 checkpoint clamp component acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2449744|PMID:12529385) MGI
Ensembl
InterPro		 PMID:12529385 GO_REF:0000002 GO_REF:0000107 MGI:2449744 NCBI chr 7:48,606,848...48,622,194
Ensembl chr 7:48,714,668...48,731,005 		JBrowse link
G HUS1B HUS1 checkpoint clamp component B involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:466,508...469,590
Ensembl chr 6:601,288...602,124 		JBrowse link
G INTS7 integrator complex subunit 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:187,508,066...187,603,567
Ensembl chr 1:192,372,016...192,466,510 		JBrowse link
G LOC100994157 histone H2AX involved_in
NOT|acts_upstream_of_or_within		 ISO (PMID:17974976)
(MGI:2179182|PMID:11934988)		 UniProt
MGI		 PMID:11934988 PMID:17974976 MGI:2179182 NCBI chr11:113,932,078...113,933,679 JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:60,362,635...60,555,445
Ensembl chr2B:177,818,344...178,010,556 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114 		JBrowse link
G NBN nibrin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12529385) MGI
Ensembl		 PMID:12529385 GO_REF:0000107 NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307 		JBrowse link
G PARP9 poly(ADP-ribose) polymerase family member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:119,617,722...119,655,039
Ensembl chr 3:126,522,859...126,559,647 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:56,153,965...56,169,821
Ensembl chr11:59,595,120...59,607,828 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 acts_upstream_of_or_within ISO (MGI:2679752|PMID:12937170) MGI PMID:12937170 MGI:2679752 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762 		JBrowse link
G RAD1 RAD1 checkpoint DNA exonuclease involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 5:75,452,153...75,465,022
Ensembl chr 5:80,732,954...80,744,448 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:44,586,083...44,630,719
Ensembl chr 5:46,156,294...46,202,197 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr11:62,675,480...62,756,886
Ensembl chr11:66,061,208...66,068,214 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IEA InterPro GO_REF:0000002 NCBI chr12:108,072,061...108,103,338
Ensembl chr12:111,467,845...111,498,350 		JBrowse link
G RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr12:2,999,089...3,011,911
Ensembl chr12:2,930,957...2,943,419 		JBrowse link
G RPA4 replication protein A4 involved_in ISO (PMID:19942684) UniProt PMID:19942684 NCBI chr  X:86,114,330...86,116,687 JBrowse link
G TIPIN TIMELESS interacting protein acts_upstream_of_or_within ISO (MGI:3706226|PMID:17141802) MGI PMID:17141802 MGI:3706226 NCBI chr15:45,290,350...45,310,335
Ensembl chr15:63,566,463...63,585,717 		JBrowse link
G TIPRL TOR signaling pathway regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:143,666,013...143,689,490
Ensembl chr 1:147,391,890...147,415,425 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3818783|PMID:18045533) MGI
Ensembl		 PMID:18045533 GO_REF:0000107 MGI:3818783 NCBI chr 3:48,387,762...48,389,693
Ensembl chr 3:49,470,222...49,471,331 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:94,356,440...94,389,920
Ensembl chr 6:98,242,756...98,274,377 		JBrowse link
G USP28 ubiquitin specific peptidase 28 involved_in ISO (PMID:18662541) UniProt PMID:18662541 NCBI chr11:108,676,566...108,754,372
Ensembl chr11:112,517,693...112,595,585 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP2 caspase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:135,283,072...135,307,855
Ensembl chr 7:147,773,749...147,792,958 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain involved_in ISO (PMID:21726810) UniProt PMID:21726810 NCBI chr12:91,220,813...91,593,799 JBrowse link
G LOC100977427 60S ribosomal protein L26 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:56,616,749...56,617,299
Ensembl chr17:48,009,198...48,015,977 		JBrowse link
G MDM2 MDM2 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278 		JBrowse link
G MUC1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr 1:130,533,508...130,537,866
Ensembl chr 1:134,141,969...134,145,850 		JBrowse link
G PCBP4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chr 3:51,898,857...51,908,932
Ensembl chr 3:53,127,448...53,137,293 		JBrowse link
G PIDD1 p53-induced death domain protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:816,629...827,295
Ensembl chr11:860,899...867,436 		JBrowse link
G PML PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) UniProt PMID:15626733 MGI:3580934 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883 		JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430 NCBI chr14:82,383,086...82,549,822
Ensembl chr14:102,206,396...102,372,978 		JBrowse link
G PRAP1 proline rich acidic protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr10:134,248,728...134,268,442 JBrowse link
G RBM38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) UniProt PMID:17050675 NCBI chr20:53,731,641...53,749,688 JBrowse link
G RPL26 ribosomal protein L26 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,274,839...43,282,606
Ensembl chr17:48,009,198...48,015,977 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3589512|PMID:16107883) MGI
Ensembl		 PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:69,516,728...69,522,419
Ensembl chr16:89,174,071...89,177,823 		JBrowse link
G CLSPN claspin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12766152)
(PMID:16123041)		 MGI
UniProt
Ensembl		 PMID:12766152 PMID:16123041 GO_REF:0000107 NCBI chr 1:34,991,082...35,040,515
Ensembl chr 1:36,182,726...36,218,544 		JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:64,898,024...64,956,541
Ensembl chr10:67,207,261...67,264,257 		JBrowse link
G TIPIN TIMELESS interacting protein involved_in IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr15:45,290,350...45,310,335
Ensembl chr15:63,566,463...63,585,717 		JBrowse link
mitotic DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZNF830 zinc finger protein 830 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5428139|PMID:23213458) MGI
Ensembl		 PMID:23213458 GO_REF:0000107 MGI:5428139 NCBI chr17:21,823,998...21,825,632
Ensembl chr17:22,116,304...22,117,482 		JBrowse link
mitotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100986203 histone-lysine N-methyltransferase SETMAR involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:4,256,539...4,271,593
Ensembl chr 3:4,357,890...4,371,791 		JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLSPN claspin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:34,991,082...35,040,515
Ensembl chr 1:36,182,726...36,218,544 		JBrowse link
G NAE1 NEDD8 activating enzyme E1 subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:47,119,548...47,147,679
Ensembl chr16:66,221,829...66,246,865 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IEA InterPro GO_REF:0000002 NCBI chr15:68,270,029...68,322,201
Ensembl chr15:87,476,738...87,528,870 		JBrowse link
G ZNF830 zinc finger protein 830 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:21,823,998...21,825,632
Ensembl chr17:22,116,304...22,117,482 		JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 involved_in ISO (PMID:19412162) UniProt PMID:19412162 NCBI chr11:64,737,006...64,750,353 JBrowse link
G DGKZ diacylglycerol kinase zeta involved_in ISO (PMID:16286473) UniProt PMID:16286473 NCBI chr11:46,291,592...46,339,127
Ensembl chr11:46,841,605...46,889,763 		JBrowse link
G FBXO31 F-box protein 31 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:67,997,481...68,053,081
Ensembl chr16:87,322,364...87,377,104 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4366664|PMID:19744960) MGI
Ensembl		 PMID:19744960 GO_REF:0000107 MGI:4366664 NCBI chr2B:119,929,004...120,090,367
Ensembl chr2B:238,847,674...239,007,549 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:55,187,178...55,233,265
Ensembl chr16:74,541,450...74,586,951 		JBrowse link
G RPA2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:27,151,784...27,175,110
Ensembl chr 1:28,191,731...28,214,666 		JBrowse link
G RPS27L ribosomal protein S27 like involved_in ISO (PMID:18056458) UniProt PMID:18056458 NCBI chr15:42,101,137...42,105,019
Ensembl chr15:60,397,131...60,400,643 		JBrowse link
G SDE2 SDE2 telomere maintenance homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:201,443,945...201,460,668
Ensembl chr 1:206,441,517...206,457,679 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3589512|PMID:16107883) MGI
Ensembl		 PMID:16107883 GO_REF:0000107 MGI:3589512 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3818783|PMID:18045533)
(MGI:5562498|PMID:23993650)		 MGI
Ensembl		 PMID:18045533 PMID:23993650 GO_REF:0000107 MGI:3818783 MGI:5562498 NCBI chr 3:48,387,762...48,389,693
Ensembl chr 3:49,470,222...49,471,331 		JBrowse link
G WAC WW domain containing adaptor with coiled-coil involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:28,685,294...28,777,176
Ensembl chr10:29,042,331...29,130,591 		JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABRAXAS1 abraxas 1, BRCA1 A complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:40,711,139...40,736,763
Ensembl chr 4:46,556,892...46,581,573 		JBrowse link
G ATM ATM serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041 		JBrowse link
G BABAM1 BRISC and BRCA1 A complex member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:16,755,518...16,767,634
Ensembl chr19:17,729,568...17,742,447 		JBrowse link
G BABAM2 BRISC and BRCA1 A complex member 2 involved_in IEA Ensembl
UniProt		 GO_REF:0000104 GO_REF:0000107 NCBI chr2A:27,884,907...28,338,302
Ensembl chr2A:27,974,917...28,420,519 		JBrowse link
G BLM BLM RecQ like helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:69,407,248...69,508,070
Ensembl chr15:88,607,157...88,707,864 		JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,197,946...14,279,064
Ensembl chr17:14,428,526...14,506,815 		JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 involved_in IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr  X:144,550,320...144,592,795
Ensembl chr  X:154,389,283...154,428,669 		JBrowse link
G BRSK1 BR serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,326,538...52,355,060
Ensembl chr19:61,021,493...61,045,659 		JBrowse link
G C10H10orf90 chromosome 10 C10orf90 homolog involved_in ISO (MGI:4455105|PMID:20154723) UniProt PMID:20154723 MGI:4455105 NCBI chr10:122,987,122...123,243,653
Ensembl chr10:127,259,451...127,357,119 		JBrowse link
G CCNG1 cyclin G1 ISO RGD PMID:9464250 RGD:2316029 NCBI chr 5:158,814,563...158,822,019
Ensembl chr 5:165,592,971...165,598,728 		JBrowse link
G CDC14B cell division cycle 14B involved_in ISO (PMID:18662541) UniProt PMID:18662541 NCBI chr 9:67,596,037...67,715,668 JBrowse link
G CDK1 cyclin dependent kinase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679752|PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr10:57,314,692...57,331,261
Ensembl chr10:59,647,993...59,664,434 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in ISO (PMID:15790566) UniProt PMID:15790566 NCBI chr17:9,556,313...9,567,099
Ensembl chr17:9,738,141...9,749,302 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
G CHEK1 checkpoint kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:120,446,352...120,478,207
Ensembl chr11:124,359,218...124,390,981 		JBrowse link
G CLSPN claspin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:34,991,082...35,040,515
Ensembl chr 1:36,182,726...36,218,544 		JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:19,944,692...19,956,140
Ensembl chr21:33,317,841...33,328,132 		JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:187,603,600...187,672,006
Ensembl chr 1:192,466,408...192,535,071 		JBrowse link
G FOXN3 forkhead box N3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:69,778,191...70,238,813
Ensembl chr14:89,140,892...89,387,807 		JBrowse link
G FOXO4 forkhead box O4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2183145|PMID:12048180) MGI
Ensembl		 PMID:12048180 GO_REF:0000107 MGI:2183145 NCBI chr  X:60,364,466...60,372,147
Ensembl chr  X:70,422,504...70,429,971 		JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:2,533,172...2,564,301
Ensembl chr19:3,500,117...3,510,867 		JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in ISO (PMID:16061642) UniProt PMID:16061642 NCBI chr12:22,954,946...23,096,623 JBrowse link
G IER3 immediate early response 3 acts_upstream_of_or_within ISO (MGI:5432078|PMID:20467439) MGI PMID:20467439 MGI:5432078 NCBI chr 6:30,488,162...30,489,784 JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase acts_upstream_of_or_within ISO (MGI:2682526|PMID:14614141) MGI PMID:14614141 MGI:2682526 NCBI chr 3:126,489,125...126,498,034
Ensembl chr 3:133,839,643...133,851,450 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease acts_upstream_of_or_within ISO (MGI:2683367|PMID:14690604) MGI PMID:14690604 MGI:2683367 NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966 		JBrowse link
G MRNIP MRN complex interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:174,989,967...175,020,550
Ensembl chr 5:182,299,016...182,340,632 		JBrowse link
G NBN nibrin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3805397|PMID:18614044) MGI
InterPro
Ensembl		 PMID:18614044 GO_REF:0000002 GO_REF:0000107 MGI:3805397 NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307 		JBrowse link
G NOP53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:21741933) UniProt PMID:21741933 NCBI chr19:44,739,739...44,751,303 JBrowse link
G PLK1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779 		JBrowse link
G RINT1 RAD50 interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:97,522,208...97,567,897
Ensembl chr 7:110,252,776...110,287,702 		JBrowse link
G SYF2 SYF2 pre-mRNA splicing factor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5435138|PMID:22448250) MGI
Ensembl		 PMID:22448250 GO_REF:0000107 MGI:5435138 NCBI chr 1:24,422,931...24,432,870
Ensembl chr 1:25,397,241...25,406,806 		JBrowse link
G TAOK1 TAO kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:27,222,725...27,385,713
Ensembl chr17:27,746,797...27,840,623 		JBrowse link
G TAOK2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:30,347,229...30,366,743 JBrowse link
G TAOK3 TAO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:115,730,619...115,954,149
Ensembl chr12:119,109,642...119,226,502 		JBrowse link
G TRIM39 tripartite motif containing 39 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:30,104,381...30,121,649
Ensembl chr 6:30,975,260...30,995,764 		JBrowse link
G UIMC1 ubiquitin interaction motif containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:172,205,958...172,321,758
Ensembl chr 5:179,271,577...179,374,229 		JBrowse link
mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:62,348,245...62,444,428
Ensembl chr2B:179,799,365...179,895,007 		JBrowse link
G CHEK2 checkpoint kinase 2 involved_in ISO (PMID:11298456) UniProt PMID:11298456 NCBI chr22:9,757,038...9,811,171 JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease acts_upstream_of_or_within ISO (MGI:2683367|PMID:14690604), (MGI:3805397|PMID:18614044) MGI PMID:14690604 PMID:18614044 MGI:2683367 MGI:3805397 NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966 		JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3512823|PMID:15533840) MGI
Ensembl		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
G NEK11 NIMA related kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:128,111,202...128,434,781
Ensembl chr 3:135,433,828...135,757,221 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:44,586,083...44,630,719
Ensembl chr 5:46,156,294...46,202,197 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1289930|PMID:9766521) MGI
Ensembl		 PMID:9766521 GO_REF:0000107 MGI:1289930 NCBI chr11:62,675,480...62,756,886
Ensembl chr11:66,061,208...66,068,214 		JBrowse link
G TIPIN TIMELESS interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:45,290,350...45,310,335
Ensembl chr15:63,566,463...63,585,717 		JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3512823|PMID:15533840) MGI
Ensembl		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr 3:14,063,499...14,097,023
Ensembl chr 3:14,403,958...14,437,377 		JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD4 bromodomain containing 4 involved_in ISO (PMID:23728299) UniProt PMID:23728299 NCBI chr19:14,768,239...14,805,770
Ensembl chr19:15,754,930...15,789,600 		JBrowse link
G CHEK2 checkpoint kinase 2 ISO RGD PMID:20637979 RGD:10401658 NCBI chr22:9,757,038...9,811,171 JBrowse link
G DDX39B DExD-box helicase 39B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,191,333...31,203,246
Ensembl chr 6:32,081,210...32,092,569 		JBrowse link
G THOC1 THO complex 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:14,052,858...14,102,559
Ensembl chr18:17,692,797...17,742,570 		JBrowse link
G THOC5 THO complex subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:10,553,665...10,599,948
Ensembl chr22:28,357,644...28,404,346 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R10 protein phosphatase 1 regulatory subunit 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:30,342,669...30,359,644
Ensembl chr 6:31,212,522...31,229,697 		JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCAR2 cell cycle and apoptosis regulator 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:21,854,803...21,870,556
Ensembl chr 8:18,794,027...18,808,571 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:60,362,635...60,555,445
Ensembl chr2B:177,818,344...178,010,556 		JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRY1 cryptochrome circadian regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:104,558,874...104,658,833
Ensembl chr12:107,954,262...108,052,484 		JBrowse link
G CUL4A cullin 4A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3850765|PMID:19481525) MGI
Ensembl		 PMID:19481525 GO_REF:0000107 MGI:3850765 NCBI chr13:94,350,484...94,409,183
Ensembl chr13:113,428,271...113,472,701 		JBrowse link
G ETAA1 ETAA1 activator of ATR kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:67,455,668...67,470,509
Ensembl chr2A:68,578,554...68,591,534 		JBrowse link
G FBXO4 F-box protein 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5299398|PMID:21911473) MGI
Ensembl		 PMID:21911473 GO_REF:0000107 MGI:5299398 NCBI chr 5:68,336,673...68,474,481
Ensembl chr 5:73,500,850...73,517,051 		JBrowse link
G FEM1B fem-1 homolog B involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:47,236,920...47,254,878
Ensembl chr15:66,005,614...66,024,007 		JBrowse link
G NEK1 NIMA related kinase 1 involved_in ISO (MGI:5619475|PMID:18843199) CACAO PMID:18843199 MGI:5619475 NCBI chr 4:161,618,181...161,830,332
Ensembl chr 4:173,690,074...173,902,100 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:55,187,178...55,233,265
Ensembl chr16:74,541,450...74,586,951 		JBrowse link
G RNASEH2B ribonuclease H2 subunit B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5435090|PMID:22802351) MGI
Ensembl		 PMID:22802351 GO_REF:0000107 MGI:5435090 NCBI chr13:32,047,830...32,108,573
Ensembl chr13:50,795,701...50,852,909 		JBrowse link
G RPA2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:27,151,784...27,175,110
Ensembl chr 1:28,191,731...28,214,666 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15348
    cellular process 14054
      signal transduction 5001
        intracellular signal transduction 2405
          cell cycle checkpoint signaling 159
            DNA integrity checkpoint signaling 113
              DNA damage checkpoint signaling + 108
              DNA replication checkpoint signaling + 7
              meiotic DNA integrity checkpoint signaling + 0
              mitotic DNA integrity checkpoint signaling + 74
Path 2
Term Annotations click to browse term
  biological_process 15348
    biological regulation 10759
      regulation of biological process 10418
        negative regulation of biological process 5272
          negative regulation of cellular process 4576
            negative regulation of cell cycle 340
              negative regulation of cell cycle process 268
                negative regulation of cell cycle phase transition 223
                  cell cycle checkpoint signaling 159
                    DNA integrity checkpoint signaling 113
                      DNA damage checkpoint signaling + 108
                      DNA replication checkpoint signaling + 7
                      meiotic DNA integrity checkpoint signaling + 0
                      mitotic DNA integrity checkpoint signaling + 74
paths to the root