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ONTOLOGY REPORT - ANNOTATIONS


Term:ruffle organization
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Accession:GO:0031529 term browser browse the term
Definition:A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
Synonyms:exact_synonym: ruffle organisation
 related_synonym: ruffle organization and biogenesis



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ruffle organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in ISO (PMID:19846667) RGD PMID:19846667 NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15569314) RGD PMID:15569314 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Coro1b coronin 1B involved_in IEA
ISO
GO_REF:0000107
(PMID:16027158)
Ensembl
RGD
PMID:16027158 GO_REF:0000107 NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5294513|PMID:21610095)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:21610095 GO_REF:0000024 GO_REF:0000107 MGI:5294513 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Lima1 LIM domain and actin binding 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3768577|PMID:17875928)
(PMID:12566430)
UniProt
RGD
PMID:12566430 PMID:17875928 GO_REF:0000024 MGI:3768577 NCBI chr 7:130,901,717...131,001,573
Ensembl chr 7:130,901,717...131,001,473
JBrowse link
G Lpin1 lipin 1 acts_upstream_of_or_within ISO MGI:1856603 (MGI:1095561|PMID:10438476) RGD PMID:10438476 MGI:1095561 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within ISO (MGI:3510095|PMID:15467718) RGD PMID:15467718 MGI:3510095 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Palld palladin, cytoskeletal associated protein IMP RGD PMID:16868024 RGD:2325783 NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
JBrowse link
G Plek pleckstrin involved_in ISO (PMID:10497244) RGD PMID:10497244 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131
JBrowse link
G Plekha1 pleckstrin homology domain containing A1 involved_in ISO (PMID:15485858) RGD PMID:15485858 NCBI chr 1:185,427,982...185,479,157
Ensembl chr 1:185,428,048...185,479,156
JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:15467718) RGD PMID:15467718 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO (MGI:6296816|PMID:23908015) RGD PMID:23908015 MGI:6296816 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link
G Tpm1 tropomyosin 1 involved_in IGI PMID:15897890 BHF-UCL PMID:15897890 RGD:8656006 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
negative regulation of ruffle assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap24 Rho GTPase activating protein 24 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5297730|PMID:21911940)
RGD PMID:21911940 PMID:21873635 MGI:5297730, RGD:13792537 NCBI chr14:6,800,631...7,184,001
Ensembl chr14:6,800,631...7,183,823
JBrowse link
G Evl Enah/Vasp-like involved_in ISO (PMID:23153535) RGD PMID:23153535 NCBI chr 6:127,473,119...127,594,342
Ensembl chr 6:127,474,543...127,594,344
JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 involved_in ISO (PMID:19171758) RGD PMID:19171758 NCBI chr 1:222,877,962...223,074,514
Ensembl chr 1:222,877,622...223,074,514
JBrowse link
G Pfn2 profilin 2 involved_in ISO
IEA
(PMID:23153535)
GO_REF:0000107
(MGI:5545940|PMID:23153535)
RGD
Ensembl
PMID:23153535 GO_REF:0000107 MGI:5545940 NCBI chr 2:142,067,102...142,072,938
Ensembl chr 2:142,067,104...142,072,938
JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (MGI:3831067|PMID:19100238) RGD PMID:19100238 MGI:3831067 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:5315060|PMID:22194864)
Ensembl
UniProt
RGD
PMID:22194864 GO_REF:0000024 GO_REF:0000107 MGI:5315060 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650
JBrowse link
positive regulation of ruffle assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil2 capping protein regulator and myosin 1 linker 2 involved_in ISO (PMID:26466680), (PMID:26578515) RGD PMID:26466680 PMID:26578515 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965
JBrowse link
G Cobl cordon-bleu WH2 repeat protein involved_in ISO (MGI:3765263|PMID:17956734) RGD PMID:17956734 MGI:3765263 NCBI chr14:86,828,137...87,060,682
Ensembl chr14:86,828,139...87,060,800
JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 IMP RGD PMID:16260607 RGD:11557987 NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386
JBrowse link
G Def8 differentially expressed in FDCP 8 homolog involved_in ISS
ISO
GO_REF:0000024
(MGI:5806241|PMID:27777970)
UniProt
RGD
PMID:27777970 GO_REF:0000024 MGI:5806241 NCBI chr19:51,474,783...51,495,638
Ensembl chr19:51,474,878...51,495,638
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
JBrowse link
G Eps8l1 EPS8-like 1 involved_in ISO
IBA
UniProtKB:Q08509|UniProtKB:Q8R5F8|UniProtKB:Q91WL0|UniProtKB:Q99K30 (PMID:14565974)
PMID:21873635
RGD PMID:14565974 PMID:21873635 RGD:13792537 NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524
JBrowse link
G Eps8l2 EPS8-like 2 involved_in IBA
ISO
PMID:21873635
UniProtKB:Q08509|UniProtKB:Q8R5F8|UniProtKB:Q91WL0|UniProtKB:Q99K30 (PMID:14565974)
RGD PMID:14565974 PMID:21873635 RGD:13792537 NCBI chr 1:196,446,067...196,471,542
Ensembl chr 1:196,446,287...196,471,541
JBrowse link
G Eps8l3 EPS8 like 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 2:195,514,692...195,528,085 JBrowse link
G Fam98a family with sequence similarity 98, member A involved_in ISS
ISO
GO_REF:0000024
(MGI:5806241|PMID:27777970)
UniProt
RGD
PMID:27777970 GO_REF:0000024 MGI:5806241 NCBI chr 6:19,874,082...19,888,744
Ensembl chr 6:19,874,071...19,888,742
JBrowse link
G Hras HRas proto-oncogene, GTPase involved_in ISO (PMID:23027131) RGD PMID:23027131 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5806241|PMID:27777970)
UniProt
RGD
PMID:27777970 GO_REF:0000024 MGI:5806241 NCBI chr10:53,505,628...53,582,025
Ensembl chr10:53,516,491...53,570,907
JBrowse link
G Nlgn1 neuroligin 1 involved_in IDA PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464
JBrowse link
G P2ry12 purinergic receptor P2Y12 involved_in IMP PMID:17299767 ARUK-UCL PMID:17299767 RGD:13673751 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
JBrowse link
G Pfn1 profilin 1 involved_in ISO (PMID:23153535) RGD PMID:23153535 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5806241|PMID:27777970)
UniProt
RGD
PMID:27777970 GO_REF:0000024 MGI:5806241 NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412
JBrowse link
regulation of ruffle assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in ISO (PMID:24625804) RGD PMID:24625804 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Coro1c coronin 1C involved_in ISO UniProtKB:Q8BK67 (MGI:5621257|PMID:25074804) RGD PMID:25074804 MGI:5621257 NCBI chr12:42,712,960...42,785,179
Ensembl chr12:42,712,991...42,785,179
JBrowse link
G Icam1 intercellular adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:5486234|PMID:23372835) RGD PMID:23372835 MGI:5486234 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like involved_in ISO (PMID:21448158) RGD PMID:21448158 NCBI chr 1:159,151,417...159,155,192
Ensembl chr 1:159,151,432...159,155,192
JBrowse link
G P2rx4 purinergic receptor P2X 4 NOT|involved_in IMP PMID:17299767 ARUK-UCL PMID:17299767 RGD:13673751 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO UniProtKB:Q9WUM4 (MGI:5621257|PMID:25074804) RGD PMID:25074804 MGI:5621257 NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205
JBrowse link
G Rdx radixin involved_in ISO (PMID:22467863) RGD PMID:22467863 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678
JBrowse link
G Rhog ras homolog family member G acts_upstream_of_or_within ISO (MGI:5486234|PMID:23372835) RGD PMID:23372835 MGI:5486234 NCBI chr 1:156,618,713...156,630,710
Ensembl chr 1:156,615,349...156,631,257
JBrowse link
G Sh3yl1 SH3 and SYLF domain containing 1 acts_upstream_of_or_within ISO (MGI:5008671|PMID:21624956) RGD PMID:21624956 MGI:5008671 NCBI chr 6:47,522,098...47,565,858
Ensembl chr 6:47,522,091...47,565,858
JBrowse link
G Wdpcp WD repeat containing planar cell polarity effector acts_upstream_of_or_within ISO MGI:5558098 (MGI:5544506|PMID:24302887) RGD PMID:24302887 MGI:5544506 NCBI chr14:95,645,955...95,977,120
Ensembl chr14:95,646,038...95,977,113
JBrowse link
ruffle assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5315376|PMID:10934045)
GO_REF:0000024
RGD
UniProt
PMID:10934045 PMID:21873635 GO_REF:0000024 MGI:5315376, RGD:13792537 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Aif1l allograft inflammatory factor 1-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:15,229,476...15,254,033
Ensembl chr 3:15,229,524...15,254,023
JBrowse link
G Arf6 ADP-ribosylation factor 6 involved_in ISO (PMID:10036235) RGD PMID:10036235 NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114
JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 acts_upstream_of_or_within ISO MGI:5500046 (MGI:5486234|PMID:23372835) RGD PMID:23372835 MGI:5486234 NCBI chr 2:146,740,336...146,850,918
Ensembl chr 2:146,739,631...146,850,819
JBrowse link
G Bag4 BAG cochaperone 4 involved_in ISO (MGI:5292318|PMID:21712384) RGD PMID:21712384 MGI:5292318 NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5699914|PMID:26437238)
Ensembl
RGD
PMID:26437238 GO_REF:0000107 MGI:5699914 NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010
JBrowse link
G Dbnl drebrin-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K involved_in ISO (PMID:12556481) RGD PMID:12556481 NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5008671|PMID:21624956)
GO_REF:0000107
RGD
Ensembl
PMID:21624956 GO_REF:0000107 MGI:5008671 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Mtss2 MTSS I-BAR domain containing 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:38,692,793...38,714,575
Ensembl chr19:38,693,194...38,713,507
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta acts_upstream_of_or_within ISO (MGI:5699914|PMID:26437238) RGD PMID:26437238 MGI:5699914 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha involved_in ISO (PMID:20660631) RGD PMID:20660631 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO
IEA
(PMID:10036235)
GO_REF:0000107
(MGI:5315376|PMID:10934045)
RGD
Ensembl
PMID:10036235 PMID:10934045 GO_REF:0000107 MGI:5315376 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Sh3bp1 SH3-domain binding protein 1 involved_in ISO (MGI:74310|PMID:7621827) RGD PMID:7621827 MGI:74310 NCBI chr 7:110,457,626...110,470,201
Ensembl chr 7:110,457,710...110,470,201
JBrowse link
G Snx10 sorting nexin 10 acts_upstream_of_or_within ISO MGI:5690193 (MGI:5688814|PMID:25811986) RGD PMID:25811986 MGI:5688814 NCBI chr 4:80,612,648...80,677,005
Ensembl chr 4:80,612,669...80,676,996
JBrowse link
G Ston1 stonin 1 acts_upstream_of_or_within ISO MGI:5788726 (MGI:5699914|PMID:26437238) RGD PMID:26437238 MGI:5699914 NCBI chr 6:5,843,186...5,892,557
Ensembl chr 6:5,843,185...5,892,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    cellular process 17431
      cellular component organization or biogenesis 6532
        cellular component organization 6307
          cell projection organization 1771
            plasma membrane bounded cell projection organization 1735
              ruffle organization 59
                ruffle assembly + 47
paths to the root