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ONTOLOGY REPORT - ANNOTATIONS


Term:Mis6-Sim4 complex
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Accession:GO:0031511 term browser browse the term
Definition:A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
Synonyms:exact_synonym: Mis6-Mal2-Sim4 centromere complex;   Sim4 complex
 narrow_synonym: Mis6 centromere subcomplex


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Mis6-Sim4 complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpo centromere protein O IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:28,648,804...28,663,527
Ensembl chr 6:28,649,638...28,663,233
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Path 1
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  cellular_component 20609
    protein-containing complex 6092
      Mis6-Sim4 complex 1
Path 2
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  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        non-membrane-bounded organelle 5182
          intracellular non-membrane-bounded organelle 5171
            chromosome 1418
              chromosomal region 289
                chromosome, centromeric region 188
                  kinetochore 126
                    condensed chromosome kinetochore 73
                      condensed chromosome inner kinetochore 5
                        Mis6-Sim4 complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.