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ONTOLOGY REPORT - ANNOTATIONS


Term:Mis6-Sim4 complex
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Accession:GO:0031511 term browser browse the term
Definition:A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
Synonyms:exact_synonym: Mis6-Mal2-Sim4 centromere complex;   Sim4 complex
 narrow_synonym: Mis6 centromere subcomplex


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Mis6-Sim4 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07066944.1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Cenpo centromere protein O part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:27,203,642...27,218,394
Ensembl chr 6:27,188,537...27,218,314
JBrowse link
G Cenpq centromere protein Q part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:19,957,040...19,972,807 JBrowse link

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  cellular_component 20010
    protein-containing complex 6011
      Mis6-Sim4 complex 3
Path 2
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  cellular_component 20010
    cellular anatomical entity 19714
      organelle 13093
        non-membrane-bounded organelle 4903
          intracellular non-membrane-bounded organelle 4903
            chromosome 1168
              chromosomal region 277
                chromosome, centromeric region 183
                  condensed chromosome, centromeric region 133
                    kinetochore 122
                      inner kinetochore 5
                        Mis6-Sim4 complex 3
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