Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:heterochromatin formation
go back to main search page
Accession:GO:0031507 term browser browse the term
Definition:An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
Synonyms:exact_synonym: chromatin silencing;   chromatin-mediated silencing;   establishment of heterochromatin architecture;   heterochromatin assembly
 narrow_synonym: establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region;   establishment of heterochromatin architecture involved in chromatin silencing at pericentric region;   heterochromatin assembly involved in chromatin silencing at centromere outer repeat region;   heterochromatin assembly involved in chromatin silencing at pericentric region;   heterochromatin formation involved in chromatin silencing at centromere outer repeat region;   heterochromatin formation involved in chromatin silencing at pericentric region
 broad_synonym: TGS;   heterochromatin maintenance
 related_synonym: establishment of chromatin silencing;   establishment of heterochromatic silencing;   heterochromatic silencing;   heterochromatin assembly involved in chromatin silencing;   heterochromatin formation involved in chromatin silencing;   transcriptional gene silencing
 alt_id: GO:0006342;   GO:0006343;   GO:0016440;   GO:0070869;   GO:1904497

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bahd1 bromo adjacent homology domain containing 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936471:3,902,558...3,927,746
Ensembl chrNW_004936471:3,902,625...3,927,829 		JBrowse link
G Baz2a bromodomain adjacent to zinc finger domain 2A acts_upstream_of_or_within ISO (PMID:20168299)
(PMID:16678107)		 MGI PMID:16678107 PMID:20168299 NCBI chrNW_004936646:914,944...949,057
Ensembl chrNW_004936646:914,818...949,101 		JBrowse link
G Bcl6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23160044) Ensembl
MGI		 PMID:23160044 GO_REF:0000107 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071 		JBrowse link
G Cbx3 chromobox 3 involved_in ISO (PMID:17540172) ComplexPortal PMID:17540172 NCBI chrNW_004936478:2,981,218...2,989,329
Ensembl chrNW_004936478:2,981,228...2,989,324 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha acts_upstream_of_or_within ISO (PMID:22516971) MGI PMID:22516971 NCBI chrNW_004936493:6,963,406...7,013,256
Ensembl chrNW_004936493:6,935,386...7,007,610 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta acts_upstream_of_or_within ISO (PMID:22516971) MGI PMID:22516971 NCBI chrNW_004936485:19,547,836...19,570,716 JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936588:1,288,447...1,332,489
Ensembl chrNW_004936588:1,288,392...1,330,297 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936490:17,430,383...17,465,889
Ensembl chrNW_004936490:17,428,677...17,465,877 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936527:5,024,077...5,069,152
Ensembl chrNW_004936527:5,024,068...5,063,939 		JBrowse link
G Hdac2 histone deacetylase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936679:2,448,676...2,474,641
Ensembl chrNW_004936679:2,448,390...2,474,641 		JBrowse link
G Hells helicase, lymphoid specific involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15448183) Ensembl
MGI		 PMID:15448183 GO_REF:0000107 NCBI chrNW_004936601:626,354...662,477
Ensembl chrNW_004936601:626,823...662,465 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:3,944,419...3,958,289
Ensembl chrNW_004936545:3,944,419...4,064,193 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:19158276) GO_Central PMID:19158276 NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580 		JBrowse link
G Kmt2d lysine methyltransferase 2D involved_in ISO (MGI:4849597|PMID:20808952) UniProt PMID:20808952 MGI:4849597 NCBI chrNW_004936512:6,819,240...6,860,852
Ensembl chrNW_004936512:6,822,057...6,854,451 		JBrowse link
G L3mbtl1 L3MBTL histone methyl-lysine binding protein 1 involved_in ISO (PMID:17540172) ComplexPortal PMID:17540172 NCBI chrNW_004936530:3,038,873...3,069,724
Ensembl chrNW_004936530:3,038,847...3,069,494 		JBrowse link
G Lmna lamin A/C involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936580:5,374,208...5,395,442
Ensembl chrNW_004936580:5,373,974...5,395,468 		JBrowse link
G Lmnb1 lamin B1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936504:157,459...211,916
Ensembl chrNW_004936504:157,453...211,967 		JBrowse link
G Lmnb2 lamin B2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936588:1,448,195...1,465,332
Ensembl chrNW_004936588:1,448,277...1,465,376 		JBrowse link
G LOC101970440 histone H1.0 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:3,314,991...3,315,974
Ensembl chrNW_004936492:3,315,048...3,315,632 		JBrowse link
G Mecp2 methyl-CpG binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15608638) Ensembl
MGI		 PMID:15608638 GO_REF:0000107 NCBI chrNW_004936809:902,938...967,771
Ensembl chrNW_004936809:911,764...966,839 		JBrowse link
G Mis18a MIS18 kinetochore protein A acts_upstream_of_or_within ISO (PMID:22516971) MGI PMID:22516971 NCBI chrNW_004936500:9,822,366...9,832,732
Ensembl chrNW_004936500:9,822,381...9,832,561 		JBrowse link
G Pole3 DNA polymerase epsilon 3, accessory subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936559:220,941...222,783 JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent 1D involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:2,139,201...2,183,850
Ensembl chrNW_004936490:2,139,078...2,184,602 		JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936565:1,596,227...1,746,706
Ensembl chrNW_004936565:1,597,593...1,746,846 		JBrowse link
G Sin3a SIN3 transcription regulator family member A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:34,206,084...34,260,538
Ensembl chrNW_004936471:34,204,524...34,260,564 		JBrowse link
G Sirt1 sirtuin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23160044) Ensembl
MGI		 PMID:23160044 GO_REF:0000107 NCBI chrNW_004936521:10,296,097...10,316,673
Ensembl chrNW_004936521:10,296,097...10,322,215 		JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936535:4,857,816...4,890,266
Ensembl chrNW_004936535:4,856,672...4,890,225 		JBrowse link
G Spty2d1 SPT2 chromatin protein domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:667,453...689,291
Ensembl chrNW_004936528:667,348...689,291 		JBrowse link
G Tnp1 transition protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936586:504,864...505,447
Ensembl chrNW_004936586:504,864...505,447 		JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:17,178,981...17,322,600
Ensembl chrNW_004936476:17,181,214...17,322,163 		JBrowse link
G Uhrf1 ubiquitin like with PHD and ring finger domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:2,863,651...2,890,116
Ensembl chrNW_004936588:2,862,367...2,888,946 		JBrowse link
DNA methylation-dependent heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bend3 BEN domain containing 3 involved_in ISO (PMID:26100909) UniProt PMID:26100909 NCBI chrNW_004936564:3,495,020...3,513,684
Ensembl chrNW_004936564:3,496,392...3,513,671 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger acts_upstream_of_or_within ISO (PMID:24105743) MGI PMID:24105743 NCBI chrNW_004936520:5,707,542...5,716,966
Ensembl chrNW_004936520:5,707,778...5,717,024 		JBrowse link
G Ctcf CCCTC-binding factor acts_upstream_of_or_within ISO (PMID:24105743) MGI PMID:24105743 NCBI chrNW_004936475:17,987,137...18,031,733
Ensembl chrNW_004936475:17,987,156...18,031,760 		JBrowse link
G Dnmt1 DNA methyltransferase 1 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936659:520,181...565,496
Ensembl chrNW_004936659:520,493...565,416 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17938196)
(PMID:16322236)		 Ensembl
MGI		 PMID:16322236 PMID:17938196 GO_REF:0000107 NCBI chrNW_004936493:6,963,406...7,013,256
Ensembl chrNW_004936493:6,935,386...7,007,610 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta acts_upstream_of_or_within ISO (PMID:17938196) MGI PMID:17938196 NCBI chrNW_004936485:19,547,836...19,570,716 JBrowse link
G Dnmt3l DNA methyltransferase 3 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:143,078...160,318
Ensembl chrNW_004936500:143,078...160,212 		JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 involved_in ISO (MGI:3826717|PMID:18818694) UniProt PMID:18818694 MGI:3826717 NCBI chrNW_004936669:321,580...450,061
Ensembl chrNW_004936669:321,249...423,018 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 involved_in ISO (MGI:3826717|PMID:18818694) UniProt PMID:18818694 MGI:3826717 NCBI chrNW_004936727:1,648,451...1,663,294
Ensembl chrNW_004936727:1,648,448...1,663,455 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO (PMID:24105743) MGI PMID:24105743 NCBI chrNW_004936527:5,024,077...5,069,152
Ensembl chrNW_004936527:5,024,068...5,063,939 		JBrowse link
G Hdac1 histone deacetylase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:15,320,635...15,351,418
Ensembl chrNW_004936474:15,320,729...15,350,860 		JBrowse link
G Hells helicase, lymphoid specific involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936601:626,354...662,477
Ensembl chrNW_004936601:626,823...662,465 		JBrowse link
G Kmt2b lysine methyltransferase 2B acts_upstream_of_or_within ISO (PMID:20808952) MGI PMID:20808952 NCBI chrNW_004936570:583,616...605,846
Ensembl chrNW_004936570:583,616...605,603 		JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936497:12,848,918...12,868,504
Ensembl chrNW_004936497:12,848,874...12,871,639 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936497:9,512,350...9,619,250
Ensembl chrNW_004936497:9,545,907...9,619,267 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16322236) TreeGrafter
MGI		 PMID:16322236 GO_REF:0000118 NCBI chrNW_004936588:865,046...873,821
Ensembl chrNW_004936588:864,867...874,923 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent 1D involved_in ISO (MGI:5551345|PMID:24135283) UniProt PMID:24135283 MGI:5551345 NCBI chrNW_004936490:2,139,201...2,183,850
Ensembl chrNW_004936490:2,139,078...2,184,602 		JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 acts_upstream_of_or_within ISO (PMID:16322236) MGI PMID:16322236 NCBI chrNW_004936659:1,152,846...1,246,718
Ensembl chrNW_004936659:1,169,792...1,249,213 		JBrowse link
G Tex15 testis expressed 15, meiosis and synapsis associated acts_upstream_of_or_within_positive_effect ISO (MGI:6434559|PMID:32381626) UniProt PMID:32381626 MGI:6434559 NCBI chrNW_004936792:668,290...727,197
Ensembl chrNW_004936792:668,290...686,241 		JBrowse link
dosage compensation by inactivation of X chromosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1 DNA repair associated involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936526:6,014,745...6,022,213 JBrowse link
G Lrif1 ligand dependent nuclear receptor interacting factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936704:2,313,923...2,334,839
Ensembl chrNW_004936704:2,319,145...2,333,400 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936880:646,835...661,312
Ensembl chrNW_004936880:644,079...661,544 		JBrowse link
G Rbm15 RNA binding motif protein 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936704:1,779,981...1,787,339
Ensembl chrNW_004936704:1,779,482...1,788,710 		JBrowse link
G Rbm15b RNA binding motif protein 15B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:2,780,110...2,782,775
Ensembl chrNW_004936529:2,780,110...2,782,455 		JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936672:1,686,070...1,838,315
Ensembl chrNW_004936672:1,685,734...1,838,315 		JBrowse link
G Ythdc1 YTH N6-methyladenosine RNA binding protein C1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936582:130,593...161,275
Ensembl chrNW_004936582:126,736...161,586 		JBrowse link
facultative heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eed embryonic ectoderm development involved_in ISO (MGI:4431292|PMID:20064375), (MGI:4436818|PMID:20064376) GO_Central PMID:20064375 PMID:20064376 MGI:4431292 MGI:4436818 NCBI chrNW_004936498:14,050,731...14,082,410
Ensembl chrNW_004936498:14,051,045...14,083,570 		JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:321,580...450,061
Ensembl chrNW_004936669:321,249...423,018 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in ISO (MGI:4436818|PMID:20064376) GO_Central PMID:20064376 MGI:4436818 NCBI chrNW_004936490:17,430,383...17,465,889
Ensembl chrNW_004936490:17,428,677...17,465,877 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:5,024,077...5,069,152
Ensembl chrNW_004936527:5,024,068...5,063,939 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936552:1,566,382...1,786,837
Ensembl chrNW_004936552:1,566,788...1,785,490 		JBrowse link
G Kdm5a lysine demethylase 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936606:486,424...570,546
Ensembl chrNW_004936606:485,655...570,739 		JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:2,921,987...2,971,521
Ensembl chrNW_004936538:2,921,719...2,971,552 		JBrowse link
gene silencing by piRNA-directed DNA methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt3b DNA methyltransferase 3 beta acts_upstream_of_or_within ISO (PMID:27856912) MGI PMID:27856912 NCBI chrNW_004936485:19,547,836...19,570,716 JBrowse link
heterochromatin boundary formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trip12 thyroid hormone receptor interactor 12 involved_in ISO (PMID:22884692) UniProt PMID:22884692 NCBI chrNW_004936525:6,539,234...6,690,457
Ensembl chrNW_004936525:6,539,191...6,690,457 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:41,222,782...41,345,755
Ensembl chrNW_004936470:41,252,951...41,344,134 		JBrowse link
inactivation of paternal X chromosome by genomic imprinting term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prdm14 PR/SET domain 14 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24268575) Ensembl
MGI		 PMID:24268575 GO_REF:0000107 NCBI chrNW_004936496:14,789,443...14,820,967
Ensembl chrNW_004936496:14,806,928...14,820,967 		JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18425126), (PMID:23754746) Ensembl
MGI		 PMID:18425126 PMID:23754746 GO_REF:0000107 NCBI chrNW_004936672:1,686,070...1,838,315
Ensembl chrNW_004936672:1,685,734...1,838,315 		JBrowse link
negative regulation of DNA methylation-dependent heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt3l DNA methyltransferase 3 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:143,078...160,318
Ensembl chrNW_004936500:143,078...160,212 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:5,317,109...5,423,593
Ensembl chrNW_004936500:5,316,164...5,404,353 		JBrowse link
G Kmt2a lysine methyltransferase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:3,480,071...3,566,823
Ensembl chrNW_004936542:3,391,774...3,562,147 		JBrowse link
negative regulation of heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101970296 RLF zinc finger acts_upstream_of_or_within ISO (PMID:25857663) MGI PMID:25857663 NCBI chrNW_004936474:21,943,329...22,014,738 JBrowse link
negative regulation of rDNA heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phf2 PHD finger protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:2,912,114...2,956,429
Ensembl chrNW_004936487:2,912,112...2,954,525 		JBrowse link
G Phf8 PHD finger protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936751:850,630...935,382
Ensembl chrNW_004936751:850,237...934,586 		JBrowse link
pericentric heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpv centromere protein V involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936821:267,137...276,969
Ensembl chrNW_004936821:267,178...276,401 		JBrowse link
G Dicer1 dicer 1, ribonuclease III acts_upstream_of_or_within ISO (PMID:15713842) MGI PMID:15713842 NCBI chrNW_004936846:528,768...584,599
Ensembl chrNW_004936846:532,972...575,689 		JBrowse link
G Hells helicase, lymphoid specific involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936601:626,354...662,477
Ensembl chrNW_004936601:626,823...662,465 		JBrowse link
G LOC101963041 histone H3.3A acts_upstream_of_or_within ISO (PMID:26159997) MGI PMID:26159997 NCBI chrNW_004936526:2,835,002...2,842,328 JBrowse link
G LOC101963257 histone H3.3A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26159997) Ensembl
MGI		 PMID:26159997 GO_REF:0000107 NCBI chrNW_004936594:959,493...961,703
Ensembl chrNW_004936594:958,049...961,708 		JBrowse link
G Sirt6 sirtuin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:2,387,162...2,394,066
Ensembl chrNW_004936588:2,386,977...2,394,096 		JBrowse link
pericentric heterochromatin organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mis18a MIS18 kinetochore protein A acts_upstream_of_or_within ISO (PMID:22516971) MGI PMID:22516971 NCBI chrNW_004936500:9,822,366...9,832,732
Ensembl chrNW_004936500:9,822,381...9,832,561 		JBrowse link
G Wdhd1 WD repeat and HMG-box DNA binding protein 1 acts_upstream_of_or_within ISO (PMID:21266480) MGI PMID:21266480 NCBI chrNW_004936697:129,821...184,238
Ensembl chrNW_004936697:130,105...183,576 		JBrowse link
piRNA-mediated retrotransposon silencing by heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx4 DEAD-box helicase 4 acts_upstream_of_positive_effect ISO (MGI:5908740|PMID:28633017) UniProt PMID:28633017 MGI:5908740 NCBI chrNW_004936480:12,027,117...12,078,716
Ensembl chrNW_004936480:12,027,357...12,077,689 		JBrowse link
G LOC101963659 SPOC domain-containing protein 1 involved_in ISO (MGI:6453929|PMID:32674113) UniProt PMID:32674113 MGI:6453929 NCBI chrNW_004936474:14,894,564...14,918,088 JBrowse link
G Piwil1 piwi like RNA-mediated gene silencing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936660:1,398,640...1,418,865
Ensembl chrNW_004936660:1,400,212...1,418,744 		JBrowse link
G Piwil2 piwi like RNA-mediated gene silencing 2 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (MGI:5501381|PMID:23706823) Ensembl
UniProt		 PMID:23706823 GO_REF:0000107 MGI:5501381 NCBI chrNW_004936555:6,078,681...6,133,184
Ensembl chrNW_004936555:6,078,681...6,133,020 		JBrowse link
G Tdrd9 tudor domain containing 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:1,186,643...1,283,213
Ensembl chrNW_004936621:1,185,920...1,283,303 		JBrowse link
G Tex15 testis expressed 15, meiosis and synapsis associated involved_in ISO (MGI:6447460|PMID:32719317) UniProt PMID:32719317 MGI:6447460 NCBI chrNW_004936792:668,290...727,197
Ensembl chrNW_004936792:668,290...686,241 		JBrowse link
positive regulation of DNA methylation-dependent heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf7ip activating transcription factor 7 interacting protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936587:2,922,855...3,026,773
Ensembl chrNW_004936587:2,919,666...3,026,837 		JBrowse link
G Atf7ip2 activating transcription factor 7 interacting protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936530:8,795,303...8,832,683
Ensembl chrNW_004936530:8,796,077...8,830,847 		JBrowse link
G LOC101978403 histone-lysine N-methyltransferase SETDB2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936565:2,536,623...2,607,824
Ensembl chrNW_004936565:2,591,305...2,606,130
Ensembl chrNW_004936565:2,591,305...2,606,130 		JBrowse link
G Morc2 MORC family CW-type zinc finger 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936755:133,315...171,507
Ensembl chrNW_004936755:130,983...171,492 		JBrowse link
G Mphosph8 M-phase phosphoprotein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936720:1,972,063...2,025,283
Ensembl chrNW_004936720:1,972,119...2,025,332 		JBrowse link
G Pphln1 periphilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:1,001,733...1,158,647
Ensembl chrNW_004936512:1,057,128...1,158,650 		JBrowse link
G Resf1 retroelement silencing factor 1 involved_in ISO (MGI:6271895|PMID:29728365) UniProt PMID:29728365 MGI:6271895 NCBI chrNW_004936607:4,247,824...4,274,410 JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936580:1,146,286...1,192,842
Ensembl chrNW_004936580:1,146,277...1,192,842 		JBrowse link
G Tasor transcription activation suppressor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936473:7,053,797...7,098,608
Ensembl chrNW_004936473:7,055,462...7,098,358 		JBrowse link
G Trim28 tripartite motif containing 28 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004937062:126,832...132,938
Ensembl chrNW_004937062:126,708...134,366 		JBrowse link
G Znf304 zinc finger protein 304 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936897:244,051...253,580
Ensembl chrNW_004936897:243,884...254,033 		JBrowse link
positive regulation of heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk2 cyclin dependent kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:379,849...385,648
Ensembl chrNW_004936646:379,842...385,877 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:4,050,693...4,111,682
Ensembl chrNW_004936481:4,050,794...4,111,682 		JBrowse link
random inactivation of X chromosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1 DNA repair associated acts_upstream_of_or_within ISO (PMID:12419249) MGI PMID:12419249 NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Cdyl chromodomain Y like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936534:7,525,618...7,601,184
Ensembl chrNW_004936534:7,525,612...7,594,813 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27892467) Ensembl
MGI		 PMID:27892467 GO_REF:0000107 NCBI chrNW_004936552:1,566,382...1,786,837
Ensembl chrNW_004936552:1,566,788...1,785,490 		JBrowse link
G Pcgf3 polycomb group ring finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:22,349,166...22,373,256
Ensembl chrNW_004936477:22,349,171...22,373,393 		JBrowse link
G Pcgf5 polycomb group ring finger 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936601:3,201,589...3,268,990
Ensembl chrNW_004936601:3,207,250...3,267,372 		JBrowse link
G Rlim ring finger protein, LIM domain interacting involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24613346) Ensembl
MGI
TreeGrafter		 PMID:24613346 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936683:930,537...961,792
Ensembl chrNW_004936683:934,338...961,863 		JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27892467) Ensembl
MGI		 PMID:27892467 GO_REF:0000107 NCBI chrNW_004936538:2,921,987...2,971,521
Ensembl chrNW_004936538:2,921,719...2,971,552 		JBrowse link
rDNA heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baz2a bromodomain adjacent to zinc finger domain 2A involved_in
acts_upstream_of_or_within		 ISO (MGI:3587127|PMID:16085498), (MGI:3852313|PMID:12198165), (MGI:3852588|PMID:19578370)
(PMID:20168299)
(PMID:16678107)		 UniProt
MGI		 PMID:12198165 PMID:16085498 PMID:16678107 PMID:19578370 PMID:20168299 MGI:3587127 MGI:3852313 MGI:3852588 NCBI chrNW_004936646:914,944...949,057
Ensembl chrNW_004936646:914,818...949,101 		JBrowse link
G Bend3 BEN domain containing 3 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936564:3,495,020...3,513,684
Ensembl chrNW_004936564:3,496,392...3,513,671 		JBrowse link
G Rrp8 ribosomal RNA processing 8 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936842:656,508...661,894
Ensembl chrNW_004936842:657,727...661,757 		JBrowse link
G Sirt1 sirtuin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:10,296,097...10,316,673
Ensembl chrNW_004936521:10,296,097...10,322,215 		JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936535:4,857,816...4,890,266
Ensembl chrNW_004936535:4,856,672...4,890,225 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936721:646,778...661,144
Ensembl chrNW_004936721:646,772...661,091 		JBrowse link
regulation of DNA methylation-dependent heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:8,262,913...8,319,089
Ensembl chrNW_004936474:8,262,885...8,319,092 		JBrowse link
G L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936790:1,210,842...1,298,577
Ensembl chrNW_004936790:1,212,536...1,298,566 		JBrowse link
G Samd1 sterile alpha motif domain containing 1 involved_in ISO (PMID:33980486) UniProt PMID:33980486 NCBI chrNW_004936659:2,744,967...2,750,135 JBrowse link
regulation of heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baz1a bromodomain adjacent to zinc finger domain 1A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936494:8,968,704...9,080,620
Ensembl chrNW_004936494:8,968,704...9,080,620 		JBrowse link
regulation of rDNA heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101971629 core histone macro-H2A.1 NOT|involved_in ISO (PMID:24071584) UniProt PMID:24071584 NCBI chrNW_004936597:2,496,489...2,556,352
Ensembl chrNW_004936597:2,495,862...2,556,603 		JBrowse link
regulatory ncRNA-mediated heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arb2a ARB2 cotranscriptional regulator A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936523:9,037,516...9,485,257
Ensembl chrNW_004936523:9,037,490...9,486,495 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha involved_in ISO (PMID:23435381) FlyBase PMID:23435381 NCBI chrNW_004936493:6,963,406...7,013,256
Ensembl chrNW_004936493:6,935,386...7,007,610 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in ISO (PMID:23435381) FlyBase PMID:23435381 NCBI chrNW_004936527:5,024,077...5,069,152
Ensembl chrNW_004936527:5,024,068...5,063,939 		JBrowse link
G Nrde2 NRDE-2, necessary for RNA interference, domain containing involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936488:17,473,787...17,519,278
Ensembl chrNW_004936488:17,473,607...17,519,536 		JBrowse link
G Znfx1 zinc finger NFX1-type containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936514:4,964,844...4,992,004
Ensembl chrNW_004936514:4,966,172...4,988,922 		JBrowse link
subtelomeric heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrx ATRX chromatin remodeler involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936683:2,496,307...2,718,539
Ensembl chrNW_004936683:2,495,959...2,718,620 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in ISO (MGI:892875|PMID:9214638) ARUK-UCL PMID:9214638 MGI:892875 NCBI chrNW_004936490:17,430,383...17,465,889
Ensembl chrNW_004936490:17,428,677...17,465,877 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:5,024,077...5,069,152
Ensembl chrNW_004936527:5,024,068...5,063,939 		JBrowse link
G Hat1 histone acetyltransferase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936509:2,105,866...2,153,089
Ensembl chrNW_004936509:2,105,845...2,153,198 		JBrowse link
G LOC101963041 histone H3.3A acts_upstream_of_or_within ISO (PMID:26159997) MGI PMID:26159997 NCBI chrNW_004936526:2,835,002...2,842,328 JBrowse link
G LOC101963257 histone H3.3A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26159997) Ensembl
MGI		 PMID:26159997 GO_REF:0000107 NCBI chrNW_004936594:959,493...961,703
Ensembl chrNW_004936594:958,049...961,708 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:26,045,500...26,105,980
Ensembl chrNW_004936469:26,048,953...26,105,997 		JBrowse link
G Sirt6 sirtuin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:2,387,162...2,394,066
Ensembl chrNW_004936588:2,386,977...2,394,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      negative regulation of metabolic process 2630
        negative regulation of macromolecule metabolic process 2404
          negative regulation of macromolecule biosynthetic process 2047
            negative regulation of gene expression 1055
              negative regulation of gene expression, epigenetic 136
                heterochromatin formation 106
                  constitutive heterochromatin formation + 11
                  dosage compensation by inactivation of X chromosome + 15
                  facultative heterochromatin formation + 48
                  heterochromatin boundary formation 2
                  negative regulation of heterochromatin formation + 6
                  pericentric heterochromatin organization 2
                  positive regulation of heterochromatin formation + 13
                  regulation of heterochromatin formation + 24
                  regulatory ncRNA-mediated heterochromatin formation + 12
Path 2
Term Annotations click to browse term
  biological_process 15969
    biological regulation 11154
      regulation of biological process 10818
        regulation of metabolic process 5604
          regulation of biosynthetic process 4525
            regulation of cellular biosynthetic process 4439
              regulation of macromolecule biosynthetic process 4344
                regulation of gene expression 4232
                  negative regulation of gene expression 1055
                    negative regulation of gene expression, epigenetic 136
                      heterochromatin formation 106
                        constitutive heterochromatin formation + 11
                        dosage compensation by inactivation of X chromosome + 15
                        facultative heterochromatin formation + 48
                        heterochromatin boundary formation 2
                        negative regulation of heterochromatin formation + 6
                        pericentric heterochromatin organization 2
                        positive regulation of heterochromatin formation + 13
                        regulation of heterochromatin formation + 24
                        regulatory ncRNA-mediated heterochromatin formation + 12
paths to the root