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ONTOLOGY REPORT - ANNOTATIONS

Term:heterochromatin formation
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Accession:GO:0031507 term browser browse the term
Definition:An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
Synonyms:exact_synonym: chromatin silencing;   chromatin-mediated silencing;   establishment of heterochromatin architecture;   heterochromatin assembly
 narrow_synonym: establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region;   establishment of heterochromatin architecture involved in chromatin silencing at pericentric region;   heterochromatin assembly involved in chromatin silencing at centromere outer repeat region;   heterochromatin assembly involved in chromatin silencing at pericentric region;   heterochromatin formation involved in chromatin silencing at centromere outer repeat region;   heterochromatin formation involved in chromatin silencing at pericentric region
 broad_synonym: TGS;   heterochromatin maintenance
 related_synonym: establishment of chromatin silencing;   establishment of heterochromatic silencing;   heterochromatic silencing;   heterochromatin assembly involved in chromatin silencing;   heterochromatin formation involved in chromatin silencing;   transcriptional gene silencing
 alt_id: GO:0006342;   GO:0006343;   GO:0016440;   GO:0070869;   GO:1904497


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heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAHD1 bromo adjacent homology domain containing 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr30:7,609,087...7,638,880
Ensembl chr30:7,613,345...7,638,880 		JBrowse link
G BAZ2A bromodomain adjacent to zinc finger domain 2A acts_upstream_of_or_within ISO (PMID:16678107)
(PMID:20168299)		 MGI PMID:16678107 PMID:20168299 NCBI chr10:834,018...868,817
Ensembl chr10:836,465...863,874 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23160044) Ensembl
MGI		 PMID:23160044 GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G CBX3 chromobox 3 involved_in ISO (PMID:17540172) ComplexPortal PMID:17540172 NCBI chr14:39,510,694...39,520,796
Ensembl chr14:39,510,112...39,519,809 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha acts_upstream_of_or_within ISO (PMID:22516971) MGI PMID:22516971 NCBI chr17:19,489,524...19,563,074
Ensembl chr17:19,492,193...19,563,902 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta acts_upstream_of_or_within ISO (PMID:22516971) MGI PMID:22516971 NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase involved_in IEA InterPro GO_REF:0000002 NCBI chr20:56,805,030...56,868,771
Ensembl chr20:56,803,242...56,852,539 		JBrowse link
G EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:20,271,729...20,292,918
Ensembl chr 9:20,264,552...20,290,712 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838 		JBrowse link
G H1-0 H1.0 linker histone involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:26,827,748...26,829,909
Ensembl chr10:26,829,089...26,829,673 		JBrowse link
G H2AC15 H2A clustered histone 15 involved_in IBA GO_Central GO_REF:0000033 NCBI chr35:25,030,215...25,031,023
Ensembl chr35:25,030,551...25,030,940 		JBrowse link
G H2AC17 H2A clustered histone 17 involved_in IBA GO_Central GO_REF:0000033 NCBI chr35:25,060,505...25,061,332
Ensembl chr35:25,060,862...25,061,254 		JBrowse link
G H2AC5 H2A clustered histone 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr35:24,001,879...24,003,169
Ensembl chr35:24,001,900...24,002,292 		JBrowse link
G H2AC8 H2A clustered histone 8 involved_in IBA GO_Central GO_REF:0000033 NCBI chr35:24,131,647...24,132,475 JBrowse link
G HDAC2 histone deacetylase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:70,053,822...70,083,491
Ensembl chr12:70,053,297...70,103,578 		JBrowse link
G HELLS helicase, lymphoid specific involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15448183) Ensembl
MGI		 PMID:15448183 GO_REF:0000107 NCBI chr28:8,660,866...8,705,570
Ensembl chr28:8,661,008...8,705,580 		JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:8,348,101...8,491,435 JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:19158276) GO_Central PMID:19158276 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165 		JBrowse link
G HOTAIR HOX transcript antisense RNA involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24075995) RNAcentral
MGI		 PMID:24075995 GO_REF:0000115 NCBI chr27:1,296,506...1,300,023 JBrowse link
G KMT2D lysine methyltransferase 2D involved_in ISO (MGI:4849597|PMID:20808952) UniProt PMID:20808952 MGI:4849597 NCBI chr27:5,516,866...5,556,303
Ensembl chr27:5,521,804...5,553,490 		JBrowse link
G L3MBTL1 L3MBTL histone methyl-lysine binding protein 1 involved_in ISO (PMID:17540172) ComplexPortal PMID:17540172 NCBI chr24:31,238,787...31,266,062
Ensembl chr24:31,217,184...31,265,291 		JBrowse link
G LMNA lamin A/C involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:41,702,491...41,719,870
Ensembl chr 7:41,508,450...41,746,931 		JBrowse link
G LMNB1 lamin B1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:15,996,627...16,052,719
Ensembl chr11:15,930,436...16,052,127 		JBrowse link
G LMNB2 lamin B2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:56,652,183...56,663,476
Ensembl chr20:56,652,750...56,670,278 		JBrowse link
G LOC119867706 histone H2A type 1-E involved_in IBA GO_Central GO_REF:0000033
G MECP2 methyl-CpG binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15608638) Ensembl
MGI		 PMID:15608638 GO_REF:0000107 NCBI chr  X:121,866,721...121,876,088
Ensembl chr  X:121,873,218...121,932,994 		JBrowse link
G MECP2 methyl-CpG binding protein 2 involved_in IEA Ensembl GO_REF:0000107
G MIS18A MIS18 kinetochore protein A acts_upstream_of_or_within ISO (PMID:22516971) MGI PMID:22516971 NCBI chr31:27,025,657...27,039,001
Ensembl chr31:27,025,709...27,039,028 		JBrowse link
G POLE3 DNA polymerase epsilon 3, accessory subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:67,757,779...67,760,417
Ensembl chr11:67,758,918...67,760,374 		JBrowse link
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:35,856,277...35,914,096
Ensembl chr 9:35,856,765...35,913,884 		JBrowse link
G RB1 RB transcriptional corepressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726 		JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
G SIN3A SIN3 transcription regulator family member A involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:38,231,844...38,306,665
Ensembl chr30:38,232,680...38,382,635 		JBrowse link
G SIRT1 sirtuin 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:15469825)
(PMID:23160044)		 BHF-UCL
MGI		 PMID:15469825 PMID:23160044 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
G SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 involved_in ISO (MGI:3653583|PMID:16678107) ComplexPortal PMID:16678107 MGI:3653583 NCBI chr15:42,731,147...42,771,577
Ensembl chr15:42,731,426...42,770,624 		JBrowse link
G SPTY2D1 SPT2 chromatin protein domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:41,021,317...41,042,955
Ensembl chr21:41,023,629...41,042,492 		JBrowse link
G TIMM13 translocase of inner mitochondrial membrane 13 involved_in IEA TreeGrafter GO_REF:0000118
G TNP1 transition protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:23,742,875...23,743,417
Ensembl chr37:23,727,538...23,743,365 		JBrowse link
G TNP1 transition protein 1 involved_in IEA Ensembl GO_REF:0000107
G UBR2 ubiquitin protein ligase E3 component n-recognin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:11,167,286...11,296,817
Ensembl chr12:11,167,346...11,294,911 		JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:54,858,673...54,889,769
Ensembl chr20:54,859,947...54,889,907 		JBrowse link
G UTY tetratricopeptide repeat protein acts_upstream_of_or_within ISO (PMID:22192413) MGI PMID:22192413
DNA methylation-dependent heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BEND3 BEN domain containing 3 involved_in ISO (PMID:26100909) UniProt PMID:26100909 NCBI chr12:64,302,403...64,324,396
Ensembl chr12:64,306,140...64,322,725 		JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger acts_upstream_of_or_within ISO (PMID:24105743) MGI PMID:24105743 NCBI chr 2:10,818,232...10,828,473
Ensembl chr 2:10,818,232...10,833,613 		JBrowse link
G CTCF CCCTC-binding factor acts_upstream_of_or_within ISO (PMID:24105743) MGI PMID:24105743 NCBI chr 5:81,808,512...81,863,811
Ensembl chr 5:81,809,393...81,858,655 		JBrowse link
G DNMT1 DNA methyltransferase 1 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr20:50,872,213...50,928,352
Ensembl chr20:50,879,527...50,928,029 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17938196)
(PMID:16322236)		 Ensembl
MGI		 PMID:16322236 PMID:17938196 GO_REF:0000107 NCBI chr17:19,489,524...19,563,074
Ensembl chr17:19,492,193...19,563,902 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta acts_upstream_of_or_within ISO (PMID:17938196) MGI PMID:17938196 NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900 		JBrowse link
G DNMT3L DNA methyltransferase 3 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:38,099,100...38,111,432 JBrowse link
G EHMT1 euchromatic histone lysine methyltransferase 1 involved_in ISO (MGI:3826717|PMID:18818694) UniProt PMID:18818694 MGI:3826717 NCBI chr 9:48,031,593...48,110,954
Ensembl chr 9:48,032,709...48,175,828 		JBrowse link
G EHMT2 euchromatic histone lysine methyltransferase 2 involved_in ISO (MGI:3826717|PMID:18818694) UniProt PMID:18818694 MGI:3826717 NCBI chr12:1,341,202...1,354,602
Ensembl chr12:1,341,191...1,354,584 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO (PMID:24105743) MGI PMID:24105743 NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838 		JBrowse link
G HDAC1 histone deacetylase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:68,901,339...68,936,473
Ensembl chr 2:68,901,651...68,936,186 		JBrowse link
G HELLS helicase, lymphoid specific involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr28:8,660,866...8,705,570
Ensembl chr28:8,661,008...8,705,580 		JBrowse link
G KMT2B lysine methyltransferase 2B acts_upstream_of_or_within ISO (PMID:20808952) MGI PMID:20808952 NCBI chr 1:116,894,024...116,913,464
Ensembl chr 1:116,893,074...116,913,472 		JBrowse link
G MBD1 methyl-CpG binding domain protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:78,597,688...78,611,303
Ensembl chr 7:78,597,746...78,651,472 		JBrowse link
G MBD2 methyl-CpG binding domain protein 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:21,232,260...21,283,687
Ensembl chr 1:21,235,967...21,283,346 		JBrowse link
G MBD3 methyl-CpG binding domain protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16322236) TreeGrafter
MGI		 PMID:16322236 GO_REF:0000118 NCBI chr20:57,296,713...57,312,988
Ensembl chr20:57,296,713...57,307,110 		JBrowse link
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D involved_in ISO (MGI:5551345|PMID:24135283) UniProt PMID:24135283 MGI:5551345 NCBI chr 9:35,856,277...35,914,096
Ensembl chr 9:35,856,765...35,913,884 		JBrowse link
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 acts_upstream_of_or_within ISO (PMID:16322236) MGI PMID:16322236 NCBI chr20:50,175,489...50,268,865
Ensembl chr20:50,175,687...50,268,836 		JBrowse link
G TEX15 testis expressed 15, meiosis and synapsis associated acts_upstream_of_or_within_positive_effect ISO (MGI:6434559|PMID:32381626) UniProt PMID:32381626 MGI:6434559 NCBI chr16:33,423,546...33,517,458
Ensembl chr16:33,423,876...33,515,452 		JBrowse link
dosage compensation by inactivation of X chromosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRCA1 BRCA1 DNA repair associated involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494 		JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:35,832,956...35,842,898
Ensembl chr 7:35,833,988...35,843,754 		JBrowse link
G LRIF1 ligand dependent nuclear receptor interacting factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:41,023,383...41,041,776
Ensembl chr 6:41,023,787...41,039,844 		JBrowse link
G METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:18,528,755...18,546,303
Ensembl chr15:18,528,772...18,546,531 		JBrowse link
G RBM15 RNA binding motif protein 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:41,645,765...41,653,621
Ensembl chr 6:41,645,769...41,653,799 		JBrowse link
G RBM15B RNA binding motif protein 15B involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:38,191,079...38,194,150
Ensembl chr20:38,191,439...38,192,730 		JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:69,359,286...69,505,067
Ensembl chr 7:69,358,447...69,621,067 		JBrowse link
G YTHDC1 YTH N6-methyladenosine RNA binding protein C1 involved_in ISO (PMID:27602518) UniProt PMID:27602518 NCBI chr13:58,818,424...58,858,241
Ensembl chr13:58,818,796...58,857,571 		JBrowse link
facultative heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EED embryonic ectoderm development involved_in ISO (MGI:4431292|PMID:20064375), (MGI:4436818|PMID:20064376) GO_Central PMID:20064375 PMID:20064376 MGI:4431292 MGI:4436818 NCBI chr21:13,260,062...13,289,511
Ensembl chr21:13,260,002...13,289,337 		JBrowse link
G EHMT1 euchromatic histone lysine methyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,031,593...48,110,954
Ensembl chr 9:48,032,709...48,175,828 		JBrowse link
G EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in ISO (MGI:4436818|PMID:20064376) GO_Central PMID:20064376 MGI:4436818 NCBI chr 9:20,271,729...20,292,918
Ensembl chr 9:20,264,552...20,290,712 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838 		JBrowse link
G JARID2 jumonji and AT-rich interaction domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:14,476,656...14,737,535
Ensembl chr35:14,445,914...14,736,158 		JBrowse link
G KDM5A lysine demethylase 5A involved_in ISO (MGI:4431292|PMID:20064375) GO_Central PMID:20064375 MGI:4431292 NCBI chr27:42,364,606...42,447,839
Ensembl chr27:42,360,456...42,447,821 		JBrowse link
G SUZ12 SUZ12 polycomb repressive complex 2 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:40,992,797...41,038,729
Ensembl chr 9:40,994,825...41,038,645 		JBrowse link
gene silencing by piRNA-directed DNA methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNMT3B DNA methyltransferase 3 beta acts_upstream_of_or_within ISO (PMID:27856912) MGI PMID:27856912 NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900 		JBrowse link
heterochromatin boundary formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRIP12 thyroid hormone receptor interactor 12 involved_in ISO (PMID:22884692) UniProt PMID:22884692 NCBI chr25:42,060,103...42,208,326
Ensembl chr25:42,060,991...42,208,054 		JBrowse link
G UBR5 ubiquitin protein ligase E3 component n-recognin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:3,887,408...4,023,364
Ensembl chr13:3,879,220...4,023,955 		JBrowse link
inactivation of paternal X chromosome by genomic imprinting term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRDM14 PR/SET domain 14 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24268575) Ensembl
MGI		 PMID:24268575 GO_REF:0000107 NCBI chr29:19,203,798...19,220,149
Ensembl chr29:19,203,807...19,220,518 		JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18425126), (PMID:23754746) Ensembl
MGI		 PMID:18425126 PMID:23754746 GO_REF:0000107 NCBI chr 7:69,359,286...69,505,067
Ensembl chr 7:69,358,447...69,621,067 		JBrowse link
negative regulation of DNA methylation-dependent heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNMT3L DNA methyltransferase 3 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:38,099,100...38,111,432 JBrowse link
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:32,564,970...32,655,232
Ensembl chr31:32,511,502...32,652,572 		JBrowse link
G KMT2A lysine methyltransferase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:15,212,559...15,302,825
Ensembl chr 5:15,217,348...15,270,971 		JBrowse link
negative regulation of heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RLF RLF zinc finger acts_upstream_of_or_within ISO (PMID:25857663) MGI PMID:25857663 NCBI chr15:2,723,511...2,815,305
Ensembl chr15:2,723,272...2,815,540 		JBrowse link
negative regulation of rDNA heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PHF2 PHD finger protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:98,188,014...98,253,930
Ensembl chr 1:98,188,826...98,254,411 		JBrowse link
G PHF8 PHD finger protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:45,635,204...45,741,850
Ensembl chr  X:45,571,840...46,081,994 		JBrowse link
pericentric heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CENPV centromere protein V involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:39,568,115...39,582,900
Ensembl chr 5:39,567,790...39,582,897 		JBrowse link
G DICER1 dicer 1, ribonuclease III acts_upstream_of_or_within ISO (PMID:15713842) MGI PMID:15713842 NCBI chr 8:63,970,245...64,029,438
Ensembl chr 8:63,972,027...64,019,879 		JBrowse link
G H3-3A H3.3 histone A acts_upstream_of_or_within ISO (PMID:26159997) MGI PMID:26159997 NCBI chr 7:38,797,168...38,805,417
Ensembl chr 7:38,797,448...38,805,416 		JBrowse link
G HELLS helicase, lymphoid specific involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr28:8,660,866...8,705,570
Ensembl chr28:8,661,008...8,705,580 		JBrowse link
G SIRT6 sirtuin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:55,412,989...55,424,944
Ensembl chr20:55,412,646...55,424,944 		JBrowse link
pericentric heterochromatin organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIS18A MIS18 kinetochore protein A acts_upstream_of_or_within ISO (PMID:22516971) MGI PMID:22516971 NCBI chr31:27,025,657...27,039,001
Ensembl chr31:27,025,709...27,039,028 		JBrowse link
G WDHD1 WD repeat and HMG-box DNA binding protein 1 acts_upstream_of_or_within ISO (PMID:21266480) MGI PMID:21266480 NCBI chr 8:30,820,488...30,872,515
Ensembl chr 8:30,821,096...30,872,512 		JBrowse link
piRNA-mediated retrotransposon silencing by heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX4 DEAD-box helicase 4 acts_upstream_of_positive_effect ISO (MGI:5908740|PMID:28633017) UniProt PMID:28633017 MGI:5908740 NCBI chr 2:43,026,367...43,109,546
Ensembl chr 2:43,027,296...43,109,526 		JBrowse link
G PIWIL1 piwi like RNA-mediated gene silencing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:1,760,544...1,791,204
Ensembl chr26:1,761,149...1,791,185 		JBrowse link
G PIWIL2 piwi like RNA-mediated gene silencing 2 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (MGI:5501381|PMID:23706823) Ensembl
UniProt		 PMID:23706823 GO_REF:0000107 MGI:5501381 NCBI chr25:34,911,120...34,987,287
Ensembl chr25:34,912,358...34,987,339 		JBrowse link
G SPOCD1 SPOC domain containing 1 involved_in ISO (MGI:6453929|PMID:32674113) UniProt PMID:32674113 MGI:6453929 NCBI chr 2:69,254,343...69,326,588
Ensembl chr 2:69,289,328...69,326,595 		JBrowse link
G TDRD9 tudor domain containing 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:71,610,653...71,717,772
Ensembl chr 8:71,610,711...71,717,199 		JBrowse link
G TEX15 testis expressed 15, meiosis and synapsis associated involved_in ISO (MGI:6447460|PMID:32719317) UniProt PMID:32719317 MGI:6447460 NCBI chr16:33,423,546...33,517,458
Ensembl chr16:33,423,876...33,515,452 		JBrowse link
positive regulation of DNA methylation-dependent heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF7IP activating transcription factor 7 interacting protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr27:32,082,615...32,194,954
Ensembl chr27:32,086,675...32,177,364 		JBrowse link
G ATF7IP2 activating transcription factor 7 interacting protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:32,078,700...32,128,491
Ensembl chr 6:32,079,186...32,118,658 		JBrowse link
G MORC2 MORC family CW-type zinc finger 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:23,951,704...23,993,620
Ensembl chr26:23,953,130...23,992,431 		JBrowse link
G MPHOSPH8 M-phase phosphoprotein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:18,392,706...18,443,241
Ensembl chr25:18,392,409...18,443,241 		JBrowse link
G PPHLN1 periphilin 1 involved_in ISO (PMID:28581500) UniProt PMID:28581500 NCBI chr27:11,445,893...11,590,168
Ensembl chr27:11,443,394...11,590,107 		JBrowse link
G RESF1 retroelement silencing factor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:16,829,611...16,856,960
Ensembl chr27:16,829,968...16,839,166 		JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:60,035,819...60,069,721
Ensembl chr17:60,037,379...60,069,551 		JBrowse link
G SETDB2 SET domain bifurcated histone lysine methyltransferase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:2,263,990...2,319,249
Ensembl chr22:2,244,507...2,319,158 		JBrowse link
G TASOR transcription activation suppressor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:33,665,231...33,713,264
Ensembl chr20:33,646,000...33,712,936 		JBrowse link
G TRIM28 tripartite motif containing 28 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:99,408,920...99,415,432
Ensembl chr 1:99,408,925...99,415,146 		JBrowse link
G ZNF304 zinc finger protein 304 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:100,739,792...100,748,656
Ensembl chr 1:100,740,374...100,768,032 		JBrowse link
positive regulation of heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK2 cyclin dependent kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:300,863...306,546
Ensembl chr10:300,903...305,438 		JBrowse link
G TPR translocated promoter region, nuclear basket protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:19,376,951...19,442,368
Ensembl chr 7:19,376,975...19,442,303 		JBrowse link
random inactivation of X chromosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRCA1 BRCA1 DNA repair associated involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12419249) Ensembl
MGI		 PMID:12419249 GO_REF:0000107 NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494 		JBrowse link
G CDYL chromodomain Y like involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:4,844,757...5,074,967
Ensembl chr35:4,844,779...5,073,670 		JBrowse link
G JARID2 jumonji and AT-rich interaction domain containing 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27892467) Ensembl
MGI		 PMID:27892467 GO_REF:0000107 NCBI chr35:14,476,656...14,737,535
Ensembl chr35:14,445,914...14,736,158 		JBrowse link
G LOC491808 E3 ubiquitin-protein ligase RLIM-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:29,455,208...29,459,188 JBrowse link
G PCGF3 polycomb group ring finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:91,673,424...91,708,751
Ensembl chr 3:91,676,496...91,708,754 		JBrowse link
G PCGF5 polycomb group ring finger 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:5,821,278...5,889,382
Ensembl chr28:5,821,307...5,883,795 		JBrowse link
G RLIM ring finger protein, LIM domain interacting involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24613346) Ensembl
MGI
TreeGrafter		 PMID:24613346 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:57,879,749...57,905,805
Ensembl chr  X:57,885,123...57,889,253 		JBrowse link
G SUZ12 SUZ12 polycomb repressive complex 2 subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27892467) Ensembl
MGI		 PMID:27892467 GO_REF:0000107 NCBI chr 9:40,992,797...41,038,729
Ensembl chr 9:40,994,825...41,038,645 		JBrowse link
rDNA heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAZ2A bromodomain adjacent to zinc finger domain 2A involved_in
acts_upstream_of_or_within		 ISO (MGI:3587127|PMID:16085498), (MGI:3852313|PMID:12198165), (MGI:3852588|PMID:19578370)
(PMID:16678107)
(PMID:20168299)		 UniProt
MGI		 PMID:12198165 PMID:16085498 PMID:16678107 PMID:19578370 PMID:20168299 MGI:3587127 MGI:3852313 MGI:3852588 NCBI chr10:834,018...868,817
Ensembl chr10:836,465...863,874 		JBrowse link
G BEND3 BEN domain containing 3 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr12:64,302,403...64,324,396
Ensembl chr12:64,306,140...64,322,725 		JBrowse link
G RRP8 ribosomal RNA processing 8 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr21:29,907,555...29,917,142
Ensembl chr21:29,907,361...29,918,408 		JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (PMID:18485871) UniProt PMID:18485871 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
G SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 involved_in ISO (MGI:3587127|PMID:16085498), (MGI:3852313|PMID:12198165) UniProt PMID:12198165 PMID:16085498 MGI:3587127 MGI:3852313 NCBI chr15:42,731,147...42,771,577
Ensembl chr15:42,731,426...42,770,624 		JBrowse link
G SUV39H1 SUV39H1 histone lysine methyltransferase involved_in ISO (PMID:18485871) UniProt PMID:18485871 NCBI chr  X:41,894,623...41,907,854
Ensembl chr  X:41,893,045...41,906,403 		JBrowse link
regulation of DNA methylation-dependent heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KDM1A lysine demethylase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:76,313,742...76,375,716
Ensembl chr 2:76,156,434...76,375,632 		JBrowse link
G L3MBTL3 L3MBTL histone methyl-lysine binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:68,538,014...68,655,173
Ensembl chr 1:68,540,051...68,654,414 		JBrowse link
G SAMD1 sterile alpha motif domain containing 1 involved_in ISO (PMID:33980486) UniProt PMID:33980486 NCBI chr20:48,427,935...48,430,703 JBrowse link
regulation of heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAZ1A bromodomain adjacent to zinc finger domain 1A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:13,604,694...13,694,508
Ensembl chr 8:13,605,182...13,693,847 		JBrowse link
regulation of rDNA heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MACROH2A1 macroH2A.1 histone NOT|involved_in ISO (PMID:24071584) UniProt PMID:24071584 NCBI chr11:23,369,957...23,448,235
Ensembl chr11:23,370,300...23,438,219 		JBrowse link
regulatory ncRNA-mediated heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARB2A ARB2 cotranscriptional regulator A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:15,281,442...15,695,303
Ensembl chr 3:15,281,448...15,694,715 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha involved_in ISO (PMID:23435381) FlyBase PMID:23435381 NCBI chr17:19,489,524...19,563,074
Ensembl chr17:19,492,193...19,563,902 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in ISO (PMID:23435381) FlyBase PMID:23435381 NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838 		JBrowse link
G LOC119867316 putative protein FAM172B involved_in IEA TreeGrafter GO_REF:0000118
G NRDE2 NRDE-2, necessary for RNA interference, domain containing involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:61,285,998...61,332,518
Ensembl chr 8:61,286,950...61,332,431 		JBrowse link
G ZNFX1 zinc finger NFX1-type containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr24:35,932,037...35,954,170
Ensembl chr24:35,932,523...35,954,170 		JBrowse link
subtelomeric heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATRX ATRX chromatin remodeler involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:59,772,067...60,107,016
Ensembl chr  X:59,774,585...60,106,980 		JBrowse link
G EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in ISO (MGI:892875|PMID:9214638) ARUK-UCL PMID:9214638 MGI:892875 NCBI chr 9:20,271,729...20,292,918
Ensembl chr 9:20,264,552...20,290,712 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838 		JBrowse link
G H3-3A H3.3 histone A acts_upstream_of_or_within ISO (PMID:26159997) MGI PMID:26159997 NCBI chr 7:38,797,168...38,805,417
Ensembl chr 7:38,797,448...38,805,416 		JBrowse link
G HAT1 histone acetyltransferase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr36:16,310,269...16,378,029
Ensembl chr36:16,310,710...16,378,017 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,661,278...52,711,969
Ensembl chr19:52,661,155...52,709,279 		JBrowse link
G SIRT6 sirtuin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:55,412,989...55,424,944
Ensembl chr20:55,412,646...55,424,944 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      negative regulation of metabolic process 3119
        negative regulation of macromolecule metabolic process 2889
          negative regulation of macromolecule biosynthetic process 2509
            negative regulation of gene expression 1416
              negative regulation of gene expression, epigenetic 150
                heterochromatin formation 118
                  constitutive heterochromatin formation + 10
                  dosage compensation by inactivation of X chromosome + 16
                  facultative heterochromatin formation + 48
                  heterochromatin boundary formation 2
                  negative regulation of heterochromatin formation + 6
                  pericentric heterochromatin organization 2
                  positive regulation of heterochromatin formation + 13
                  regulation of heterochromatin formation + 24
                  regulatory ncRNA-mediated heterochromatin formation + 13
Path 2
Term Annotations click to browse term
  biological_process 17917
    biological regulation 12438
      regulation of biological process 12078
        regulation of metabolic process 6412
          regulation of biosynthetic process 5261
            regulation of cellular biosynthetic process 5175
              regulation of macromolecule biosynthetic process 5079
                regulation of gene expression 4962
                  negative regulation of gene expression 1416
                    negative regulation of gene expression, epigenetic 150
                      heterochromatin formation 118
                        constitutive heterochromatin formation + 10
                        dosage compensation by inactivation of X chromosome + 16
                        facultative heterochromatin formation + 48
                        heterochromatin boundary formation 2
                        negative regulation of heterochromatin formation + 6
                        pericentric heterochromatin organization 2
                        positive regulation of heterochromatin formation + 13
                        regulation of heterochromatin formation + 24
                        regulatory ncRNA-mediated heterochromatin formation + 13
paths to the root