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ONTOLOGY REPORT - ANNOTATIONS


Term:heterochromatin assembly
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Accession:GO:0031507 term browser browse the term
Definition:An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
Synonyms:exact_synonym: chromatin silencing;   chromatin-mediated silencing;   establishment of heterochromatin architecture;   heterochromatin formation;   transcriptional gene silencing
 narrow_synonym: establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region;   establishment of heterochromatin architecture involved in chromatin silencing at pericentric region;   heterochromatin assembly involved in chromatin silencing at centromere outer repeat region;   heterochromatin assembly involved in chromatin silencing at pericentric region;   heterochromatin formation involved in chromatin silencing at centromere outer repeat region;   heterochromatin formation involved in chromatin silencing at pericentric region
 broad_synonym: TGS;   heterochromatin maintenance
 related_synonym: establishment of chromatin silencing;   establishment of heterochromatic silencing;   heterochromatic silencing;   heterochromatin assembly involved in chromatin silencing;   heterochromatin formation involved in chromatin silencing
 alt_id: GO:0006342;   GO:0006343;   GO:0016440;   GO:0070869;   GO:1904497


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heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bahd1 bromo adjacent homology domain containing 1 involved_in ISO (PMID:19666599) UniProt PMID:19666599 NCBI chrNW_004955416:7,376,794...7,388,577
Ensembl chrNW_004955416:7,361,847...7,388,647
JBrowse link
G Baz2a bromodomain adjacent to zinc finger domain 2A acts_upstream_of_or_within ISO (MGI:3653583|PMID:16678107)
(MGI:4462332|PMID:20168299)
MGI PMID:16678107 PMID:20168299 MGI:3653583 MGI:4462332 NCBI chrNW_004955458:4,149,610...4,186,647
Ensembl chrNW_004955458:4,151,886...4,170,641
JBrowse link
G Ctbp1 C-terminal binding protein 1 involved_in ISO (PMID:21102443) BHF-UCL PMID:21102443 NCBI chrNW_004955514:630,168...652,817
Ensembl chrNW_004955514:626,645...652,817
JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in ISO (MGI:3820717|PMID:19026781) ARUK-UCL PMID:19026781 MGI:3820717 NCBI chrNW_004955451:16,548,898...16,563,449
Ensembl chrNW_004955451:16,548,858...16,564,310
JBrowse link
G Hells helicase, lymphoid specific acts_upstream_of_or_within ISO (MGI:3510059|PMID:15448183) MGI PMID:15448183 MGI:3510059 NCBI chrNW_004955507:995,389...1,034,852
Ensembl chrNW_004955507:990,429...1,034,852
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO (PMID:16901784) UniProt PMID:16901784 NCBI chrNW_004955458:12,493,790...12,624,805 JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (MGI:4461095|PMID:20123967) BHF-UCL PMID:20123967 MGI:4461095 NCBI chrNW_004955452:3,044,042...3,104,650
Ensembl chrNW_004955452:3,044,264...3,104,418
JBrowse link
G Kmt2d lysine methyltransferase 2D involved_in ISO (MGI:4849597|PMID:20808952) UniProt PMID:20808952 MGI:4849597 NCBI chrNW_004955500:7,850,782...7,891,703
Ensembl chrNW_004955500:7,853,292...7,886,067
JBrowse link
G Mecp2 methyl-CpG binding protein 2 acts_upstream_of_or_within ISO (MGI:3530434|PMID:15608638) MGI PMID:15608638 MGI:3530434 NCBI chrNW_004955580:674,014...737,586
Ensembl chrNW_004955580:679,109...735,288
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent 1D involved_in ISO (MGI:5551345|PMID:24135283) UniProt PMID:24135283 MGI:5551345 NCBI chrNW_004955451:1,878,110...1,915,794
Ensembl chrNW_004955451:1,878,629...1,915,654
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:15469825) BHF-UCL PMID:15469825 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663
JBrowse link
G Tnp1 transition protein 1 involved_in ISO (PMID:11315969) UniProt PMID:11315969 NCBI chrNW_004955453:16,387,897...16,388,513
Ensembl chrNW_004955453:16,387,527...16,388,890
JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 involved_in ISO (MGI:4431162|PMID:20080676) UniProt PMID:20080676 MGI:4431162 NCBI chrNW_004955437:8,678,212...8,780,700
Ensembl chrNW_004955437:8,677,801...8,782,120
JBrowse link
DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt3a DNA methyltransferase 3 alpha acts_upstream_of_or_within ISO (MGI:3611125|PMID:16322236)
(MGI:3768461|PMID:17938196)
MGI PMID:16322236 PMID:17938196 MGI:3611125 MGI:3768461 NCBI chrNW_004955469:7,264,431...7,367,059
Ensembl chrNW_004955469:7,269,952...7,367,059
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta acts_upstream_of_or_within ISO (MGI:3768461|PMID:17938196) MGI PMID:17938196 MGI:3768461 NCBI chrNW_004955422:28,380,595...28,427,012
Ensembl chrNW_004955422:28,380,591...28,421,301
JBrowse link
G Hdac1 histone deacetylase 1 involved_in ISO (PMID:23770133) BHF-UCL PMID:23770133 NCBI chrNW_004955452:10,636,366...10,668,873
Ensembl chrNW_004955452:10,636,366...10,670,864
JBrowse link
G Hells helicase, lymphoid specific involved_in ISO (MGI:3573964|PMID:15647320) UniProt PMID:15647320 MGI:3573964 NCBI chrNW_004955507:995,389...1,034,852
Ensembl chrNW_004955507:990,429...1,034,852
JBrowse link
G Kmt2b lysine methyltransferase 2B acts_upstream_of_or_within ISO (MGI:4849597|PMID:20808952) MGI PMID:20808952 MGI:4849597 NCBI chrNW_004955468:2,813,183...2,834,326
Ensembl chrNW_004955468:2,813,496...2,834,326
JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 involved_in ISO (PMID:23770133) BHF-UCL PMID:23770133 NCBI chrNW_004955402:38,761,668...38,829,830
Ensembl chrNW_004955402:38,767,419...38,830,204
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 acts_upstream_of_or_within ISO (MGI:3611125|PMID:16322236) MGI PMID:16322236 MGI:3611125 NCBI chrNW_004955495:6,385,449...6,388,911
Ensembl chrNW_004955495:6,336,367...6,389,056
JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 acts_upstream_of_or_within ISO (MGI:3611125|PMID:16322236) MGI PMID:16322236 MGI:3611125 NCBI chrNW_004955495:2,021,671...2,105,155
Ensembl chrNW_004955495:2,021,566...2,105,397
JBrowse link
inactivation of X chromosome by heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in ISO (MGI:5532809|PMID:23754746) UniProt PMID:23754746 MGI:5532809 NCBI chrNW_004955402:7,544,265...7,661,191
Ensembl chrNW_004955402:7,544,265...7,649,067
JBrowse link
negative regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apobec1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 involved_in ISO (MGI:5285126|PMID:21496894) UniProt PMID:21496894 MGI:5285126 NCBI chrNW_004955413:6,471,933...6,480,475
Ensembl chrNW_004955413:6,471,953...6,480,469
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 involved_in ISO (PMID:21496894) UniProt PMID:21496894 NCBI chrNW_004955425:20,767,406...20,857,165 JBrowse link
negative regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phf2 PHD finger protein 2 involved_in ISO (PMID:20129925) UniProt PMID:20129925 NCBI chrNW_004955515:4,428,068...4,471,642
Ensembl chrNW_004955515:4,429,957...4,471,641
JBrowse link
G Phf8 PHD finger protein 8 involved_in ISO (PMID:20208542) UniProt PMID:20208542 NCBI chrNW_004955475:1,105,619...1,230,758
Ensembl chrNW_004955475:1,105,619...1,230,756
JBrowse link
positive regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf7ip activating transcription factor 7 interacting protein involved_in ISO (PMID:27732843) UniProt PMID:27732843 NCBI chrNW_004955413:11,117,369...11,261,787
Ensembl chrNW_004955413:11,117,223...11,261,606
JBrowse link
G Dnmt1 DNA methyltransferase 1 involved_in ISO (PMID:24623306) UniProt PMID:24623306 NCBI chrNW_004955495:1,465,529...1,505,379
Ensembl chrNW_004955495:1,465,480...1,505,462
JBrowse link
G Morc2 MORC family CW-type zinc finger 2 involved_in ISO (PMID:28581500), (PMID:29211708)
(MGI:6271895|PMID:29728365)
UniProt PMID:28581500 PMID:29211708 PMID:29728365 MGI:6271895 NCBI chrNW_004955455:5,124,737...5,164,495
Ensembl chrNW_004955455:5,124,737...5,164,495
JBrowse link
G Mphosph8 M-phase phosphoprotein 8 involved_in ISO (PMID:28581500), (PMID:29211708) UniProt PMID:28581500 PMID:29211708 NCBI chrNW_004955497:518,462...546,748 JBrowse link
G Pphln1 periphilin 1 involved_in ISO (PMID:28581500) UniProt PMID:28581500 NCBI chrNW_004955500:1,744,968...1,892,056
Ensembl chrNW_004955500:1,806,658...1,892,056
JBrowse link
G Resf1 retroelement silencing factor 1 involved_in ISO (MGI:6271895|PMID:29728365) UniProt PMID:29728365 MGI:6271895 NCBI chrNW_004955505:3,684,848...3,709,624 JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 involved_in ISO (PMID:24623306), (PMID:27732843)
(MGI:5440670|PMID:20164836), (MGI:6271895|PMID:29728365)
UniProt PMID:20164836 PMID:24623306 PMID:27732843 PMID:29728365 MGI:5440670 MGI:6271895 NCBI chrNW_004955588:290,497...338,438
Ensembl chrNW_004955588:290,168...338,426
JBrowse link
G Tasor transcription activation suppressor involved_in ISO (PMID:28581500), (PMID:29211708) UniProt PMID:28581500 PMID:29211708 NCBI chrNW_004955430:6,440,655...6,480,956
Ensembl chrNW_004955430:6,442,084...6,480,802
JBrowse link
G Trim28 tripartite motif containing 28 involved_in ISO (PMID:24623306)
(MGI:5440670|PMID:20164836)
UniProt PMID:20164836 PMID:24623306 MGI:5440670 NCBI chrNW_004955584:1,148,903...1,156,001 JBrowse link
positive regulation of heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpr translocated promoter region, nuclear basket protein involved_in ISO (PMID:20407419) UniProt PMID:20407419 NCBI chrNW_004955406:24,742,525...24,805,989
Ensembl chrNW_004955406:24,742,525...24,805,989
JBrowse link
rDNA heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baz2a bromodomain adjacent to zinc finger domain 2A acts_upstream_of_or_within
involved_in
ISO (MGI:4462332|PMID:20168299)
(MGI:3653583|PMID:16678107)
(MGI:3587127|PMID:16085498), (MGI:3852313|PMID:12198165), (MGI:3852588|PMID:19578370)
MGI
UniProt
PMID:12198165 PMID:16085498 PMID:16678107 PMID:19578370 PMID:20168299 MGI:3587127 MGI:3653583 MGI:3852313 MGI:3852588 MGI:4462332 NCBI chrNW_004955458:4,149,610...4,186,647
Ensembl chrNW_004955458:4,151,886...4,170,641
JBrowse link
G Bend3 BEN domain containing 3 involved_in ISO (PMID:26100909) UniProt PMID:26100909 NCBI chrNW_004955411:32,346,573...32,384,796
Ensembl chrNW_004955411:32,345,577...32,384,796
JBrowse link
G Rrp8 ribosomal RNA processing 8 involved_in ISO (PMID:18485871) UniProt PMID:18485871 NCBI chrNW_004955414:22,311,038...22,316,144
Ensembl chrNW_004955414:22,311,038...22,316,144
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:18485871) UniProt PMID:18485871 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 involved_in ISO (MGI:3587127|PMID:16085498) UniProt PMID:16085498 MGI:3587127 NCBI chrNW_004955471:12,206,462...12,240,219
Ensembl chrNW_004955471:12,203,318...12,237,333
JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase involved_in ISO (PMID:18485871) UniProt PMID:18485871 NCBI chrNW_004955543:258,479...271,128
Ensembl chrNW_004955543:258,479...272,473
JBrowse link
G Ubtf upstream binding transcription factor acts_upstream_of_or_within ISO (MGI:3836497|PMID:19103806) MGI PMID:19103806 MGI:3836497 NCBI chrNW_004955451:17,294,163...17,302,807
Ensembl chrNW_004955451:17,294,251...17,302,746
JBrowse link
regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) BHF-UCL PMID:19736317 NCBI chrNW_004955583:995,707...1,003,202 JBrowse link
regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102008188 core histone macro-H2A.1 NOT|involved_in ISO (PMID:24071584) UniProt PMID:24071584 NCBI chrNW_004955408:30,497,531...30,550,095
Ensembl chrNW_004955408:30,497,531...30,550,118
JBrowse link
subtelomeric heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in ISO (MGI:892875|PMID:9214638) ARUK-UCL PMID:9214638 MGI:892875 NCBI chrNW_004955451:16,548,898...16,563,449
Ensembl chrNW_004955451:16,548,858...16,564,310
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in ISO (PMID:9214638) ARUK-UCL PMID:9214638 NCBI chrNW_004955491:4,215,353...4,292,229
Ensembl chrNW_004955491:4,215,298...4,292,235
JBrowse link
G H3f3a H3 histone, family 3A acts_upstream_of_or_within ISO (MGI:5694896|PMID:26159997) MGI PMID:26159997 MGI:5694896 NCBI chrNW_004955489:269,900...278,398
Ensembl chrNW_004955489:269,900...278,398
JBrowse link
G H3f3b H3 histone, family 3B acts_upstream_of_or_within ISO (MGI:5694896|PMID:26159997) MGI PMID:26159997 MGI:5694896 NCBI chrNW_004955506:6,475,336...6,478,781
Ensembl chrNW_004955506:6,474,727...6,482,244
JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (MGI:5584328|PMID:24735877) BHF-UCL PMID:24735877 MGI:5584328 NCBI chrNW_004955440:16,977,710...17,047,809
Ensembl chrNW_004955440:16,979,042...17,041,748
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11982
    metabolic process 7566
      negative regulation of metabolic process 2473
        negative regulation of macromolecule metabolic process 2265
          negative regulation of gene expression 856
            negative regulation of gene expression, epigenetic 54
              heterochromatin assembly 46
                DNA methylation-dependent heterochromatin assembly + 20
                heterochromatin assembly by small RNA + 0
                heterochromatin boundary formation 0
                heterochromatin domain assembly + 0
                heterochromatin island assembly + 0
                inactivation of X chromosome by heterochromatin assembly 1
                negative regulation of heterochromatin assembly + 4
                positive regulation of heterochromatin assembly + 10
                pre-transcriptional gene silencing by RNA + 0
                rDNA heterochromatin assembly + 10
                regulation of heterochromatin assembly + 16
                silent mating-type cassette heterochromatin assembly + 0
                subtelomeric heterochromatin assembly 5
Path 2
Term Annotations click to browse term
  biological_process 11982
    cellular process 11219
      cellular component organization or biogenesis 4794
        cellular component organization 4710
          organelle organization 2804
            chromosome organization 589
              chromatin organization 248
                regulation of gene expression, epigenetic 102
                  negative regulation of gene expression, epigenetic 54
                    heterochromatin assembly 46
                      DNA methylation-dependent heterochromatin assembly + 20
                      heterochromatin assembly by small RNA + 0
                      heterochromatin boundary formation 0
                      heterochromatin domain assembly + 0
                      heterochromatin island assembly + 0
                      inactivation of X chromosome by heterochromatin assembly 1
                      negative regulation of heterochromatin assembly + 4
                      positive regulation of heterochromatin assembly + 10
                      pre-transcriptional gene silencing by RNA + 0
                      rDNA heterochromatin assembly + 10
                      regulation of heterochromatin assembly + 16
                      silent mating-type cassette heterochromatin assembly + 0
                      subtelomeric heterochromatin assembly 5
paths to the root