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ONTOLOGY REPORT - ANNOTATIONS

Term:Cul2-RING ubiquitin ligase complex
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Accession:GO:0031462 term browser browse the term
Definition:A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
Synonyms:exact_synonym: CDL2 complex;   CRL2 complex;   cullin-RING ligase 2
 narrow_synonym: VBC complex
 broad_synonym: CBC complex;   EC2S complex;   ECS complex
 related_synonym: SCF2 complex


show annotations for term's descendants           Sort by:
Cul2-RING ubiquitin ligase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appbp2 amyloid beta precursor protein binding protein 2 part_of ISS
ISO
IBA		 GO_REF:0000024
(PMID:26138980)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:26138980 GO_REF:0000024 GO_REF:0000033 NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835 		JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 NOT|located_in ISO (PMID:27565346)
(PMID:24076655)		 RGD PMID:24076655 PMID:27565346 NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245 		JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 part_of ISO (PMID:17636018)
(MGI:3723573|PMID:17636018)		 RGD PMID:17636018 MGI:3723573 NCBI chr 4:33,506,992...33,544,630
Ensembl chr 4:33,506,992...33,544,630 		JBrowse link
G Commd1 copper metabolism domain containing 1 part_of ISO (PMID:17183367) RGD PMID:17183367 NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501 		JBrowse link
G Cul2 cullin 2 part_of ISO
IBA		 (PMID:17636018)
GO_REF:0000033
(PMID:16129783)		 RGD
GO_Central		 PMID:16129783 PMID:17636018 GO_REF:0000033 NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968 		JBrowse link
G Elob elongin B part_of ISO (PMID:17636018) RGD PMID:17636018 NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635 		JBrowse link
G ENSRNOG00000065810 part_of IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr  X:30,456,351...30,456,728 JBrowse link
G Fem1a fem-1 homolog A part_of ISS
ISO		 GO_REF:0000024
(PMID:29779948)		 UniProt
RGD		 PMID:29779948 GO_REF:0000024 NCBI chr 9:1,091,695...1,093,901
Ensembl chr 9:1,090,527...1,100,628 		JBrowse link
G Fem1b fem-1 homolog B part_of ISS
ISO		 GO_REF:0000024
(PMID:29779948)		 UniProt
RGD		 PMID:29779948 GO_REF:0000024 NCBI chr 8:63,265,301...63,278,577
Ensembl chr 8:63,265,301...63,278,577 		JBrowse link
G Fem1c fem-1 homolog C part_of ISO (PMID:26138980), (PMID:29775578), (PMID:29779948) RGD PMID:26138980 PMID:29775578 PMID:29779948 NCBI chr18:39,232,900...39,258,692
Ensembl chr18:39,232,900...39,258,692 		JBrowse link
G Glmn glomulin, FKBP associated protein part_of ISO UniProtKB:Q13617 (PMID:22405651) RGD PMID:22405651 NCBI chr14:2,187,144...2,231,295
Ensembl chr14:2,187,642...2,230,420 		JBrowse link
G Klhdc10 kelch domain containing 10 is_active_in
part_of		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:29779948), (PMID:33909987)		 UniProt
Ensembl
RGD		 PMID:29779948 PMID:33909987 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:59,021,300...59,079,118
Ensembl chr 4:59,021,310...59,074,941 		JBrowse link
G Klhdc2 kelch domain containing 2 is_active_in ISO
ISS		 (PMID:26138980), (PMID:29775578), (PMID:29779948), (PMID:30526872)
GO_REF:0000024		 RGD
UniProt		 PMID:26138980 PMID:29775578 PMID:29779948 PMID:30526872 GO_REF:0000024 NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187 		JBrowse link
G Klhdc3 kelch domain containing 3 is_active_in
part_of		 ISO
ISS
IEA		 (PMID:26138980), (PMID:29779948)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:26138980 PMID:29779948 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:14,302,345...14,308,736
Ensembl chr 9:14,302,354...14,308,736 		JBrowse link
G LOC100909936 putative PRAME family member 24-like is_active_in ISO (PMID:26138980) RGD PMID:26138980 NCBI chr14:14,420,434...14,423,091
Ensembl chr14:14,420,441...14,423,091
Ensembl chr14:14,420,441...14,423,091 		JBrowse link
G Pramef27 PRAME family member 27 part_of ISO (PMID:26138980) RGD PMID:26138980 NCBI chr 5:155,752,765...155,759,663
Ensembl chr 5:155,756,015...155,759,663 		JBrowse link
G Pramex1 PRAME like, X-linked 1 part_of ISO (PMID:21822215), (PMID:26138980) RGD PMID:21822215 PMID:26138980 NCBI chr  X:98,567,994...98,574,654
Ensembl chr  X:98,569,415...98,572,096 		JBrowse link
G Rbx1 ring-box 1 part_of ISO (PMID:17636018) RGD PMID:17636018 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor part_of ISO (PMID:16129783) RGD PMID:16129783 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
G Zer1 zyg-11 related, cell cycle regulator part_of ISO
IBA		 (PMID:17304241), (PMID:31273098)
GO_REF:0000033		 RGD
GO_Central		 PMID:17304241 PMID:31273098 GO_REF:0000033 NCBI chr 3:13,369,688...13,397,524
Ensembl chr 3:13,369,688...13,397,420 		JBrowse link
G Zswim5 zinc finger, SWIM-type containing 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:130,346,733...130,463,791
Ensembl chr 5:130,343,034...130,463,784 		JBrowse link
G Zswim6 zinc finger, SWIM-type containing 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:39,211,131...39,378,877
Ensembl chr 2:39,212,949...39,378,924 		JBrowse link
G Zswim8 zinc finger, SWIM-type containing 8 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:3,573,780...3,589,501
Ensembl chr15:3,573,780...3,589,487 		JBrowse link
G Zyg11a zyg-11 family member A, cell cycle regulator part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:122,935,439...122,973,766
Ensembl chr 5:122,937,136...122,973,649 		JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator part_of ISO
IBA		 (PMID:31273098)
GO_REF:0000033		 RGD
GO_Central		 PMID:31273098 GO_REF:0000033 NCBI chr 5:122,985,548...123,042,735
Ensembl chr 5:122,992,147...123,042,736 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21254
    protein-containing complex 6911
      intracellular protein-containing complex 985
        ubiquitin ligase complex 346
          cullin-RING ubiquitin ligase complex 196
            Cul2-RING ubiquitin ligase complex 25
Path 2
Term Annotations click to browse term
  cellular_component 21254
    protein-containing complex 6911
      catalytic complex 1930
        transferase complex 902
          ubiquitin ligase complex 346
            cullin-RING ubiquitin ligase complex 196
              Cul2-RING ubiquitin ligase complex 25
paths to the root