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ONTOLOGY REPORT - ANNOTATIONS


Term:response to methotrexate
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Accession:GO:0031427 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.


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response to methotrexate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 IEP RGD PMID:16925582 RGD:1598604 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) IEP RGD PMID:6122150 RGD:2316003 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA PMID:20424322 BHF-UCL PMID:20424322 RGD:10054082 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Slc22a6 solute carrier family 22 member 6 IEP RGD PMID:16925582 RGD:1598604 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 IEP RGD PMID:16925582 RGD:1598604 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    response to stimulus 10358
      response to chemical 6187
        response to oxygen-containing compound 2363
          response to methotrexate 5
            cellular response to methotrexate 0
Path 2
Term Annotations click to browse term
  biological_process 19492
    response to stimulus 10358
      response to chemical 6187
        response to organic substance 3893
          response to organonitrogen compound 1476
            response to methotrexate 5
              cellular response to methotrexate 0
paths to the root