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ONTOLOGY REPORT - ANNOTATIONS


Term:response to methotrexate
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Accession:GO:0031427 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.


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response to methotrexate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 IEP RGD PMID:16925582 RGD:1598604 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) IEP RGD PMID:6122150 RGD:2316003 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Dhfr dihydrofolate reductase IDA PMID:20424322 BHF-UCL PMID:20424322 RGD:10054082 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Slc22a6 solute carrier family 22 member 6 IEP RGD PMID:16925582 RGD:1598604 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 IEP RGD PMID:16925582 RGD:1598604 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    response to stimulus 10583
      response to chemical 6342
        response to oxygen-containing compound 2344
          response to methotrexate 5
            cellular response to methotrexate 0
Path 2
Term Annotations click to browse term
  biological_process 20028
    response to stimulus 10583
      response to chemical 6342
        response to organic substance 3865
          response to organonitrogen compound 1458
            response to methotrexate 5
              cellular response to methotrexate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.