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ONTOLOGY REPORT - ANNOTATIONS

Term:lymphocyte costimulation
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Accession:GO:0031294 term browser browse the term
Definition:The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.
Synonyms:exact_synonym: lymphocyte co-stimulation

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lymphocyte costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 IEP RGD PMID:22417871 RGD:11252086 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
B cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd320 CD320 molecule involved_in ISO
ISS		 (PMID:10727470)
GO_REF:0000024		 RGD
UniProt		 PMID:10727470 GO_REF:0000024 NCBI chr 7:18,700,445...18,706,244
Ensembl chr 7:18,700,344...18,706,244 		JBrowse link
G Il4 interleukin 4 involved_in ISO
IBA		 (MGI:3817382|PMID:18762567)
PMID:21873635		 RGD PMID:18762567, PMID:21873635, PMID:21873635 MGI:3817382, RGD:13792537, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C involved_in ISO
IBA		 (MGI:3051152|PMID:15240667)
PMID:21873635		 RGD PMID:15240667, PMID:21873635, PMID:21873635 MGI:3051152, RGD:13792537, RGD:13792537 NCBI chr 7:123,453,799...123,456,289
Ensembl chr 7:123,453,788...123,456,268 		JBrowse link
G Tnfsf13b TNF superfamily member 13b ISO (MGI:3051152|PMID:15240667) RGD PMID:15240667 MGI:3051152 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366 		JBrowse link
CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
ISO		 GO_REF:0000024
(PMID:22307619)		 UniProt
RGD		 PMID:22307619 GO_REF:0000024 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311 		JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:4819294|PMID:20639485) RGD PMID:20639485 MGI:4819294 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd160 CD160 molecule involved_in ISO (PMID:18193050) RGD PMID:18193050 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732 		JBrowse link
negative regulation of T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lilrb2 leukocyte immunoglobulin like receptor B2 involved_in ISO (PMID:17163451) RGD PMID:17163451 NCBI chr 1:63,734,135...63,741,986
Ensembl chr 1:63,734,135...63,741,982 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:17163451) RGD PMID:17163451 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579 		JBrowse link
positive regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 ISO (MGI:4819294|PMID:20639485) RGD PMID:20639485 MGI:4819294 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778 		JBrowse link
positive regulation of T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456 		JBrowse link
G Ephb4 EPH receptor B4 ISO MGI:1096338 (MGI:3513714|PMID:15599401) RGD PMID:15599401 MGI:3513714 NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980 		JBrowse link
G Ephb6 Eph receptor B6 ISO MGI:104757 (MGI:3513714|PMID:15599401) RGD PMID:15599401 MGI:3513714 NCBI chr 4:70,903,253...70,918,514
Ensembl chr 4:70,903,253...70,918,514 		JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:4819294|PMID:20639485) RGD PMID:20639485 MGI:4819294 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778 		JBrowse link
T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 involved_in ISO (PMID:17287217) RGD PMID:17287217 NCBI chr12:15,700,600...15,844,512
Ensembl chr12:15,700,825...15,844,512 		JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:17287217)		 Ensembl
UniProt
RGD		 PMID:17287217 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782 		JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:11978774), (PMID:9973372) RGD PMID:9973372 PMID:11978774 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732 		JBrowse link
G Cd24 CD24 molecule involved_in ISO
ISS		 (PMID:11272271)
GO_REF:0000024		 RGD
UniProt		 PMID:11272271, PMID:11272271, PMID:11272271 GO_REF:0000024, RGD:8554145, RGD:8554145 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846 		JBrowse link
G Cd274 CD274 molecule involved_in ISO
IBA		 (PMID:10581077)
PMID:21873635		 RGD PMID:10581077, PMID:21873635 RGD:13792537 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943 		JBrowse link
G Cd28 Cd28 molecule involved_in IMP
IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
MGI:1857150|MGI:88332 (MGI:1340173|PMID:10429671), (MGI:2671029|PMID:12925852), (MGI:3051152|PMID:15240667), (MGI:3757614|PMID:9368605), (MGI:5544872|PMID:23793062), (MGI:62368|PMID:7688139), (MGI:65397|PMID:8125140)		 Ensembl
RGD		 PMID:7688139 PMID:8125140 PMID:9368605 PMID:10429671 PMID:12925852 PMID:15240667 PMID:23793062, PMID:7730618, PMID:21873635, PMID:21873635 GO_REF:0000107 MGI:1340173 MGI:2671029 MGI:3051152 MGI:3757614 MGI:5544872 MGI:62368 MGI:65397, RGD:2303155, RGD:13792537, RGD:13792537 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871 		JBrowse link
G Cd3e CD3e molecule ISO MGI:88327 (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806 		JBrowse link
G Cd5 Cd5 molecule involved_in ISO
IBA		 (MGI:1340173|PMID:10429671)
PMID:21873635		 RGD PMID:10429671, PMID:21873635, PMID:21873635 MGI:1340173, RGD:13792537, RGD:13792537 NCBI chr 1:226,770,912...226,791,861
Ensembl chr 1:226,770,744...226,791,879 		JBrowse link
G Cd80 Cd80 molecule involved_in ISO
IBA		 (MGI:3521631|PMID:15568026), (MGI:3757624|PMID:1385153)
PMID:21873635		 RGD PMID:1385153 PMID:15568026, PMID:21873635, PMID:21873635 MGI:3521631 MGI:3757624, RGD:13792537, RGD:13792537 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353 		JBrowse link
G Cd86 CD86 molecule involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10900005), (PMID:17287217)		 UniProt
RGD		 PMID:10900005 PMID:17287217 GO_REF:0000024 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672 		JBrowse link
G Efnb1 ephrin B1 IEA
ISO		 GO_REF:0000107
(MGI:3513714|PMID:15599401)		 Ensembl
RGD		 PMID:15599401 GO_REF:0000107 MGI:3513714 NCBI chr  X:68,891,227...68,904,034
Ensembl chr  X:68,891,227...68,904,038 		JBrowse link
G Efnb2 ephrin B2 ISO (MGI:3513714|PMID:15599401) RGD PMID:15599401 MGI:3513714 NCBI chr16:86,631,151...86,672,050
Ensembl chr16:86,631,064...86,675,049 		JBrowse link
G Efnb3 ephrin B3 ISO (MGI:3513714|PMID:15599401) RGD PMID:15599401 MGI:3513714 NCBI chr10:56,161,431...56,168,819
Ensembl chr10:56,161,432...56,167,426 		JBrowse link
G Hhla2 HERV-H LTR-associating 2 involved_in ISO (PMID:23784006) RGD PMID:23784006 NCBI chr11:53,866,424...53,875,343 JBrowse link
G Icos inducible T-cell co-stimulator involved_in IDA
IBA
IEA		 PMID:21873635
GO_REF:0000002		 InterPro PMID:11006126, PMID:21873635, PMID:21873635 GO_REF:0000002, RGD:631942, RGD:13792537, RGD:13792537 NCBI chr 9:67,748,157...67,786,808
Ensembl chr 9:67,763,897...67,785,580 		JBrowse link
G Lgals1 galectin 1 ISO (MGI:5317492|PMID:22357632) RGD PMID:22357632 MGI:5317492 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289 		JBrowse link
G Lgals8 galectin 8 ISO (MGI:5317492|PMID:22357632) RGD PMID:22357632 MGI:5317492 NCBI chr17:66,487,451...66,515,316
Ensembl chr17:66,487,457...66,511,870 		JBrowse link
G LOC100911215 T-cell surface glycoprotein CD5-like involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537
G Pdcd1lg2 programmed cell death 1 ligand 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 1:247,562,202...247,629,279
Ensembl chr 1:247,562,202...247,627,193 		JBrowse link
G Spn sialophorin ISO (MGI:1340173|PMID:10429671), (MGI:3029936|PMID:11380685), (MGI:73884|PMID:7790813) RGD PMID:7790813 PMID:10429671 PMID:11380685 MGI:1340173 MGI:3029936 MGI:73884 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226 		JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C involved_in ISO
IBA		 MGI:2389403 (MGI:3051152|PMID:15240667), (MGI:3052401|PMID:15368291)
PMID:21873635		 RGD PMID:15240667 PMID:15368291, PMID:21873635, PMID:21873635 MGI:3051152 MGI:3052401, RGD:13792537, RGD:13792537 NCBI chr 7:123,453,799...123,456,289
Ensembl chr 7:123,453,788...123,456,268 		JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 involved_in ISO (PMID:10754304) RGD PMID:10754304 NCBI chr 5:172,328,259...172,337,221
Ensembl chr 5:172,328,262...172,335,892 		JBrowse link
G Tnfsf13b TNF superfamily member 13b ISO (MGI:3051152|PMID:15240667), (MGI:3052401|PMID:15368291) RGD PMID:15240667 PMID:15368291 MGI:3051152 MGI:3052401 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366 		JBrowse link
G Tnfsf14 TNF superfamily member 14 involved_in ISO (PMID:10754304)
(MGI:3521631|PMID:15568026)		 RGD PMID:10754304 PMID:15568026 MGI:3521631 NCBI chr 9:9,761,363...9,765,461
Ensembl chr 9:9,761,536...9,765,186 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    immune system process 2843
      lymphocyte costimulation 37
        B cell costimulation 4
        T cell costimulation + 34
Path 2
Term Annotations click to browse term
  biological_process 20078
    biological regulation 13898
      regulation of biological process 13140
        positive regulation of biological process 6624
          positive regulation of cellular process 6106
            positive regulation of cell activation 492
              positive regulation of leukocyte activation 477
                positive regulation of lymphocyte activation 409
                  lymphocyte costimulation 37
                    B cell costimulation 4
                    T cell costimulation + 34
paths to the root