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ONTOLOGY REPORT - ANNOTATIONS


Term:lymphocyte costimulation
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Accession:GO:0031294 term browser browse the term
Definition:The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.
Synonyms:exact_synonym: lymphocyte co-stimulation



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lymphocyte costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 IEP RGD PMID:22417871 RGD:11252086 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
B cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd320 CD320 molecule involved_in ISO
ISS
(PMID:10727470)
GO_REF:0000024
RGD
UniProt
PMID:10727470 GO_REF:0000024 NCBI chr 7:14,626,171...14,631,976
Ensembl chr 7:14,609,146...14,631,976
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3817382|PMID:18762567)
RGD PMID:18762567 PMID:21873635 MGI:3817382, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3051152|PMID:15240667)
RGD PMID:15240667 PMID:21873635 MGI:3051152, RGD:13792537 NCBI chr 7:113,736,046...113,738,523
Ensembl chr 7:113,736,055...113,738,517
JBrowse link
G Tnfsf13b TNF superfamily member 13b acts_upstream_of_or_within ISO (MGI:3051152|PMID:15240667) RGD PMID:15240667 MGI:3051152 NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693
JBrowse link
CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISO
IEA
ISS
(PMID:22307619)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:22307619 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4819294|PMID:20639485) RGD PMID:20639485 MGI:4819294 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
negative regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd160 CD160 molecule involved_in ISO (PMID:18193050) RGD PMID:18193050 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834
JBrowse link
negative regulation of T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lilrb2 leukocyte immunoglobulin like receptor B2 involved_in ISO (PMID:17163451) RGD PMID:17163451 NCBI chr 1:65,326,832...65,334,683
Ensembl chr 1:65,326,832...65,334,679
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:17163451) RGD PMID:17163451 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
positive regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4819294|PMID:20639485) RGD PMID:20639485 MGI:4819294 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
positive regulation of T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Ephb4 EPH receptor B4 acts_upstream_of_or_within ISO MGI:1096338 (MGI:3513714|PMID:15599401) RGD PMID:15599401 MGI:3513714 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
JBrowse link
G Ephb6 Eph receptor B6 acts_upstream_of_or_within ISO MGI:104757 (MGI:3513714|PMID:15599401) RGD PMID:15599401 MGI:3513714 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4819294|PMID:20639485) RGD PMID:20639485 MGI:4819294 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 involved_in ISO (PMID:17287217) RGD PMID:17287217 NCBI chr12:13,620,979...13,758,115
Ensembl chr12:13,621,087...13,758,112
JBrowse link
G Cav1 caveolin 1 involved_in ISO
ISS
IEA
(PMID:17287217)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:17287217 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:11978774), (PMID:9973372) RGD PMID:9973372 PMID:11978774 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834
JBrowse link
G Cd24 CD24 molecule involved_in ISS
ISO
PMID:11272271
(PMID:11272271)
GO_REF:0000024
RGD
UniProt
PMID:11272271 PMID:11272271 GO_REF:0000024, RGD:8554145 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd274 CD274 molecule involved_in ISO
IBA
(PMID:10581077)
PMID:21873635
RGD PMID:10581077 PMID:21873635 RGD:13792537 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
IBA
MGI:1857150|MGI:88332 (MGI:1340173|PMID:10429671), (MGI:2671029|PMID:12925852), (MGI:3051152|PMID:15240667), (MGI:3757614|PMID:9368605), (MGI:5544872|PMID:23793062), (MGI:62368|PMID:7688139), (MGI:65397|PMID:8125140)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:7688139 PMID:8125140 PMID:9368605 PMID:10429671 PMID:12925852 More... GO_REF:0000107 MGI:1340173 MGI:2671029 MGI:3051152 MGI:3757614 MGI:5544872 MGI:62368 MGI:65397, RGD:2303155, RGD:13792537 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd3e CD3e molecule acts_upstream_of_or_within ISO MGI:88327 (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd5 Cd5 molecule involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:1340173|PMID:10429671)
RGD PMID:10429671 PMID:21873635 MGI:1340173, RGD:13792537 NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
JBrowse link
G Cd80 Cd80 molecule involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3521631|PMID:15568026), (MGI:3757624|PMID:1385153)
RGD PMID:1385153 PMID:15568026 PMID:21873635 MGI:3521631 MGI:3757624, RGD:13792537 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd86 CD86 molecule involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Dpp4 dipeptidylpeptidase 4 involved_in ISO
ISS
(PMID:10900005), (PMID:17287217)
GO_REF:0000024
RGD
UniProt
PMID:10900005 PMID:17287217 GO_REF:0000024 NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Efnb1 ephrin B1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3513714|PMID:15599401)
Ensembl
RGD
PMID:15599401 GO_REF:0000107 MGI:3513714 NCBI chr  X:64,257,351...64,270,158
Ensembl chr  X:64,257,351...64,270,157
JBrowse link
G Efnb2 ephrin B2 acts_upstream_of_or_within ISO (MGI:3513714|PMID:15599401) RGD PMID:15599401 MGI:3513714 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391
JBrowse link
G Efnb3 ephrin B3 acts_upstream_of_or_within ISO (MGI:3513714|PMID:15599401) RGD PMID:15599401 MGI:3513714 NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471
JBrowse link
G Hhla2 HERV-H LTR-associating 2 involved_in ISO (PMID:23784006) RGD PMID:23784006 NCBI chr11:51,257,681...51,271,408 JBrowse link
G Icos inducible T-cell co-stimulator involved_in IDA
IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro
RGD
PMID:11006126 PMID:21873635 GO_REF:0000002, RGD:631942, RGD:13792537 NCBI chr 9:62,368,075...62,406,900
Ensembl chr 9:62,383,832...62,405,672
JBrowse link
G Lgals1 galectin 1 acts_upstream_of_or_within ISO (MGI:5317492|PMID:22357632) RGD PMID:22357632 MGI:5317492 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G Lgals8 galectin 8 acts_upstream_of_or_within ISO (MGI:5317492|PMID:22357632) RGD PMID:22357632 MGI:5317492 NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938
JBrowse link
G Spn sialophorin acts_upstream_of_or_within ISO (MGI:1340173|PMID:10429671), (MGI:3029936|PMID:11380685), (MGI:73884|PMID:7790813) RGD PMID:7790813 PMID:10429671 PMID:11380685 MGI:1340173 MGI:3029936 MGI:73884 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2389403 (MGI:3051152|PMID:15240667), (MGI:3052401|PMID:15368291)
RGD PMID:15240667 PMID:15368291 PMID:21873635 MGI:3051152 MGI:3052401, RGD:13792537 NCBI chr 7:113,736,046...113,738,523
Ensembl chr 7:113,736,055...113,738,517
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 involved_in ISO (PMID:10754304) RGD PMID:10754304 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
JBrowse link
G Tnfsf13b TNF superfamily member 13b acts_upstream_of_or_within ISO (MGI:3051152|PMID:15240667), (MGI:3052401|PMID:15368291) RGD PMID:15240667 PMID:15368291 MGI:3051152 MGI:3052401 NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693
JBrowse link
G Tnfsf14 TNF superfamily member 14 involved_in
acts_upstream_of_or_within
ISO (PMID:10754304)
(MGI:3521631|PMID:15568026)
RGD PMID:10754304 PMID:15568026 MGI:3521631 NCBI chr 9:2,069,075...2,073,128
Ensembl chr 9:2,069,104...2,073,216
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    immune system process 2829
      lymphocyte costimulation 36
        B cell costimulation 4
        T cell costimulation + 33
Path 2
Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of biological process 12866
        positive regulation of biological process 6686
          positive regulation of cellular process 6170
            positive regulation of cell activation 497
              positive regulation of leukocyte activation 477
                positive regulation of lymphocyte activation 411
                  lymphocyte costimulation 36
                    B cell costimulation 4
                    T cell costimulation + 33
paths to the root