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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane protein intracellular domain proteolysis
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Accession:GO:0031293 term browser browse the term
Definition:The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.
Synonyms:related_synonym: membrane protein solubilization
 xref: Reactome:R-HSA-193692 "Regulated proteolysis of p75NTR"


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membrane protein intracellular domain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam9 ADAM metallopeptidase domain 9 acts_upstream_of_or_within ISO (PMID:23437250) RGD PMID:23437250 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO (PMID:12297508), (PMID:15274632) RGD PMID:12297508 PMID:15274632 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Hm13 histocompatibility minor 13 NOT|involved_in ISO (PMID:16829952) RGD PMID:16829952 NCBI chr 3:141,145,792...141,183,557
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Mbtps1 membrane-bound transcription factor peptidase, site 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q14703 (PMID:16417584)		 Ensembl
RGD		 PMID:16417584 GO_REF:0000107 NCBI chr19:47,561,598...47,612,769
Ensembl chr19:47,561,598...47,612,791 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 involved_in ISO UniProtKB:O54862 (PMID:11163209) RGD PMID:11163209 NCBI chr  X:37,410,914...37,461,130
Ensembl chr  X:37,410,811...37,464,430 		JBrowse link
G Mmp7 matrix metallopeptidase 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23437250)
GO_REF:0000107		 RGD
Ensembl		 PMID:23437250 GO_REF:0000107 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Ncstn nicastrin involved_in ISO (PMID:15274632) RGD PMID:15274632 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISO (PMID:15274632) RGD PMID:15274632 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22795130)		 UniProt
RGD		 PMID:22795130 GO_REF:0000024 NCBI chr 9:83,630,037...83,748,690
Ensembl chr 9:83,630,063...83,748,689 		JBrowse link
G Sppl2a signal peptide peptidase-like 2A involved_in ISO (PMID:16829951), (PMID:16829952), (PMID:17557115) RGD PMID:16829951 PMID:16829952 PMID:17557115 NCBI chr 3:114,149,337...114,193,408
Ensembl chr 3:114,151,069...114,193,264 		JBrowse link
G Sppl2b signal peptide peptidase-like 2B involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16829951), (PMID:16829952), (PMID:19114711), (PMID:22194595)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16829951 PMID:16829952 PMID:19114711 PMID:22194595 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:8,843,918...8,856,642
Ensembl chr 7:8,843,918...8,856,608 		JBrowse link
G Sppl2c signal peptide peptidase like 2C NOT|involved_in ISO (PMID:16829952)
(PMID:30733281)		 RGD PMID:16829952 PMID:30733281 NCBI chr10:89,095,279...89,097,487
Ensembl chr10:89,095,261...89,098,580 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS		 (PMID:25310401)
GO_REF:0000024		 RGD
UniProt		 PMID:25310401 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
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  biological_process 20536
    cellular process 19526
      metabolic process 12168
        primary metabolic process 10755
          protein metabolic process 5241
            proteolysis 1701
              membrane protein proteolysis 64
                membrane protein intracellular domain proteolysis 13
                  Notch receptor processing, ligand-dependent 0
paths to the root