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ONTOLOGY REPORT - ANNOTATIONS


Term:death-inducing signaling complex
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Accession:GO:0031264 term browser browse the term
Definition:A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
Comment:Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
Synonyms:exact_synonym: DISC;   DISC protein complex;   death receptor-induced signaling complex;   death receptor-induced signalling complex;   death-inducing signalling complex
 xref: Wikipedia:Death-inducing_signaling_complex


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death-inducing signaling complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 IDA RGD PMID:17518537 RGD:2290177 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 part_of IDA
ISO
(PMID:11101870), (PMID:21803845) RGD PMID:11101870 PMID:21803845, PMID:17518537 RGD:2290177 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator part_of IDA
ISO
(PMID:21803845) RGD PMID:21803845, PMID:17518537 RGD:2290177 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Fadd Fas associated via death domain part_of IDA
ISO
(PMID:11101870), (PMID:21803845) RGD PMID:11101870 PMID:21803845, PMID:17518537 RGD:2290177 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor part_of IDA
ISO
(PMID:11101870), (PMID:21803845) RGD PMID:11101870 PMID:21803845, PMID:17518537 RGD:2290177 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 part_of ISO (PMID:11101870) RGD PMID:11101870 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
CD95 death-inducing signaling complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8 caspase 8 part_of IDA
ISO
(PMID:11717445) RGD PMID:11717445, PMID:16493077 RGD:4143200 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator IDA RGD PMID:16493077 RGD:4143200 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Fadd Fas associated via death domain part_of IDA
IBA
ISO
PMID:21873635
(PMID:20935634)
RGD PMID:20935634, PMID:16493077, PMID:21873635 RGD:4143200, RGD:13792537 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor part_of IDA
ISO
IBA
(MGI:5294527|PMID:20935634)
(PMID:20935634)
PMID:21873635
RGD PMID:20935634, PMID:16493077, PMID:21873635 MGI:5294527, RGD:4143200, RGD:13792537 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20137
    protein-containing complex 5955
      membrane protein complex 1240
        plasma membrane protein complex 562
          death-inducing signaling complex 6
            CD95 death-inducing signaling complex 4
            TRAIL death-inducing signaling complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20137
    cellular anatomical entity 19833
      membrane 10004
        plasma membrane 6224
          plasma membrane protein complex 562
            death-inducing signaling complex 6
              CD95 death-inducing signaling complex 4
              TRAIL death-inducing signaling complex 0
paths to the root