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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA replication preinitiation complex
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Accession:GO:0031261 term browser browse the term
Definition:A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
Synonyms:exact_synonym: pre-IC


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DNA replication preinitiation complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc45 cell division cycle 45 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Orc3 origin recognition complex, subunit 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:50,019,159...50,075,533
Ensembl chr 5:50,020,815...50,075,454
JBrowse link
CMG complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gins4 GINS complex subunit 4 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr16:73,584,412...73,596,808
Ensembl chr16:73,584,521...73,596,793
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
GINS complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gins1 GINS complex subunit 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:146,695,366...146,716,787
Ensembl chr 3:146,695,344...146,716,816
JBrowse link
G Gins2 GINS complex subunit 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:54,151,048...54,163,701
Ensembl chr19:54,151,048...54,163,608
JBrowse link
G Gins4 GINS complex subunit 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:73,584,412...73,596,808
Ensembl chr16:73,584,521...73,596,793
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      nucleoplasm 3398
        DNA replication preinitiation complex 6
          CMG complex 2
          GINS complex 3
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        membrane-bounded organelle 11449
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              nuclear lumen 4262
                nucleoplasm 3398
                  DNA replication preinitiation complex 6
                    CMG complex 2
                    GINS complex 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.