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ONTOLOGY REPORT - ANNOTATIONS

Term:stress-activated protein kinase signaling cascade
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Accession:GO:0031098 term browser browse the term
Definition:The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.
Synonyms:exact_synonym: SAPK signaling pathway;   SAPK signalling pathway;   stress-activated protein kinase signaling pathway;   stress-activated protein kinase signalling pathway
 narrow_synonym: JNK signaling pathway;   JNK signalling pathway

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stress-activated protein kinase signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B ISO RGD PMID:16669970 RGD:1626090 NCBI chrNW_004936579:1,312,175...1,328,397 JBrowse link
G Gfral GDNF family receptor alpha like involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16086688) Ensembl
MGI		 PMID:16086688 GO_REF:0000107 NCBI chrNW_004936476:5,759,739...5,817,766
Ensembl chrNW_004936476:5,759,739...5,817,766 		JBrowse link
G Kat7 lysine acetyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:11,775,224...11,805,489
Ensembl chrNW_004936490:11,772,046...11,805,759 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936741:362,682...386,633
Ensembl chrNW_004936741:362,387...386,678 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:3,029,942...3,203,319
Ensembl chrNW_004936509:3,029,979...3,202,796 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936629:542,143...549,861
Ensembl chrNW_004936629:545,755...549,837 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:23,237,762...23,310,211
Ensembl chrNW_004936476:23,237,277...23,310,232 		JBrowse link
G Rhoa ras homolog family member A ISO RGD PMID:17369826 RGD:1642964 NCBI chrNW_004936529:1,000,050...1,045,655
Ensembl chrNW_004936529:999,935...1,045,681 		JBrowse link
G Usp25 ubiquitin specific peptidase 25 involved_in ISO (PMID:23042150) MGI PMID:23042150 NCBI chrNW_004936505:8,613,588...8,683,560
Ensembl chrNW_004936505:8,548,677...8,681,232 		JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19696743) Ensembl
MGI		 PMID:19696743 GO_REF:0000107 NCBI chrNW_004936650:679,650...718,867
Ensembl chrNW_004936650:679,647...720,038 		JBrowse link
G Foxm1 forkhead box M1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936606:3,185,289...3,198,427
Ensembl chrNW_004936606:3,185,982...3,198,378 		JBrowse link
G Foxo1 forkhead box O1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936565:5,210,014...5,299,213
Ensembl chrNW_004936565:5,210,014...5,302,436 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISO (MGI:5009411|PMID:16023107) BHF-UCL PMID:16023107 MGI:5009411 NCBI chrNW_004936599:2,197,681...2,200,642
Ensembl chrNW_004936599:2,197,634...2,201,050 		JBrowse link
G Igbp1 immunoglobulin binding protein 1 involved_in ISO (PMID:17438131) UniProt PMID:17438131 NCBI chrNW_004936762:1,292,572...1,319,145 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO (PMID:19545562) UniProt PMID:19545562 NCBI chrNW_004936470:20,480,844...20,485,955
Ensembl chrNW_004936470:20,480,829...20,485,965 		JBrowse link
G Pbk PDZ binding kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21715333) Ensembl
MGI		 PMID:21715333 GO_REF:0000107 NCBI chrNW_004936675:704,001...722,769
Ensembl chrNW_004936675:704,516...722,755 		JBrowse link
G Ppia peptidylprolyl isomerase A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:19,669,727...19,673,355 JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:802,753...810,270
Ensembl chrNW_004936529:802,759...810,265 		JBrowse link
negative regulation of stress-activated protein kinase signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:35857590) UniProt PMID:35857590 NCBI chrNW_004936509:3,029,942...3,203,319
Ensembl chrNW_004936509:3,029,979...3,202,796 		JBrowse link
positive regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl6ip5 ADP ribosylation factor like GTPase 6 interacting protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936603:1,524,959...1,549,923
Ensembl chrNW_004936603:1,524,625...1,549,923 		JBrowse link
G Card9 caspase recruitment domain family member 9 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17187069) MGI
Ensembl		 PMID:17187069 GO_REF:0000107 NCBI chrNW_004936669:1,428,208...1,438,012
Ensembl chrNW_004936669:1,429,594...1,438,005 		JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (MGI:5803730|PMID:27288407) UniProt PMID:27288407 MGI:5803730 NCBI chrNW_004936902:436,224...446,435 JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:19211730 RGD:5130956 NCBI chrNW_004936478:6,901,098...6,947,719
Ensembl chrNW_004936478:6,899,017...6,947,790 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936663:1,127,047...1,157,263
Ensembl chrNW_004936663:1,126,977...1,157,137 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:17161379 RGD:5508698 NCBI chrNW_004936549:1,378,536...1,400,501
Ensembl chrNW_004936549:1,378,736...1,400,532 		JBrowse link
G Igfbp6 insulin like growth factor binding protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:10,415,004...10,419,698
Ensembl chrNW_004936512:10,414,807...10,419,741 		JBrowse link
G Il1a interleukin 1 alpha ISO RGD PMID:15671867 RGD:1358666 NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:12629164 PMID:15671867 RGD:1358666 RGD:1626685 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il26 interleukin 26 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:6,143,665...6,207,430
Ensembl chrNW_004936545:6,191,368...6,207,597 		JBrowse link
G Inava innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936567:3,443,053...3,458,184
Ensembl chrNW_004936567:3,443,042...3,464,506 		JBrowse link
G Kiss1 KiSS-1 metastasis suppressor NOT ISO RGD PMID:16222076 RGD:1599289 NCBI chrNW_004936567:584,443...595,045
Ensembl chrNW_004936567:584,443...586,837 		JBrowse link
G Klhdc10 kelch domain containing 10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936579:5,082,221...5,143,004
Ensembl chrNW_004936579:5,087,028...5,142,253 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:12024021 RGD:2302280 NCBI chrNW_004936629:201,269...211,058
Ensembl chrNW_004936629:200,534...211,064 		JBrowse link
G Mid1 midline 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:414,420...576,717
Ensembl chrNW_004936470:414,409...576,669 		JBrowse link
G Nod1 nucleotide binding oligomerization domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936478:6,717,354...6,768,293
Ensembl chrNW_004936478:6,715,245...6,768,372 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17187069)
(PMID:18261938)		 MGI
Ensembl		 PMID:17187069 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936475:3,708,069...3,742,845
Ensembl chrNW_004936475:3,713,362...3,745,982 		JBrowse link
G Pdcd10 programmed cell death 10 involved_in ISO (PMID:22652780) UniProt PMID:22652780 NCBI chrNW_004936593:4,650,624...4,693,387
Ensembl chrNW_004936593:4,651,114...4,692,534 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894097)
(PMID:11894098), (PMID:18261938)		 Ensembl
MGI		 PMID:11894097 PMID:11894098 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936544:3,606,925...3,653,248
Ensembl chrNW_004936544:3,606,879...3,655,532 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,575,255...2,585,969
Ensembl chrNW_004936677:2,579,010...2,586,002 		JBrowse link
G Sema4c semaphorin 4C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936744:794,127...804,618
Ensembl chrNW_004936744:793,898...804,642 		JBrowse link
G Stk25 serine/threonine kinase 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936745:420,591...426,890
Ensembl chrNW_004936745:420,073...426,393 		JBrowse link
G Taok1 TAO kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:5,531,639...5,668,119
Ensembl chrNW_004936538:5,531,633...5,659,239 		JBrowse link
G Taok2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:12,477,032...12,495,298
Ensembl chrNW_004936501:12,477,032...12,495,501 		JBrowse link
G Taok3 TAO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:2,116,804...2,305,331
Ensembl chrNW_004936668:2,222,866...2,304,151 		JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISS
IEA		 AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chrNW_004936628:310,720...394,002
Ensembl chrNW_004936628:308,691...394,007 		JBrowse link
G Tlr4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fas Fas cell surface death receptor involved_in ISO (PMID:11096076) CAFA PMID:11096076 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist NOT|involved_in ISO (MGI:5318033|PMID:12135612) BHF-UCL PMID:12135612 MGI:5318033 NCBI chrNW_004936673:1,394,743...1,399,726
Ensembl chrNW_004936673:1,395,757...1,396,311 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISO (MGI:5009198|PMID:10945608) BHF-UCL PMID:10945608 MGI:5009198 NCBI chrNW_004936599:2,197,681...2,200,642
Ensembl chrNW_004936599:2,197,634...2,201,050 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936471:26,589,251...26,628,302
Ensembl chrNW_004936471:26,589,161...26,628,302 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936588:2,338,127...2,377,090
Ensembl chrNW_004936588:2,336,858...2,377,090 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180 		JBrowse link
G Nbr1 NBR1 autophagy cargo receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,803,074...17,832,349
Ensembl chrNW_004936490:17,803,006...17,832,945 		JBrowse link
G Prdx1 peroxiredoxin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16880205) Ensembl
MGI		 PMID:16880205 GO_REF:0000107 NCBI chrNW_004936474:26,641,776...26,653,291
Ensembl chrNW_004936474:26,639,259...26,653,328 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936572:5,926,193...5,938,621
Ensembl chrNW_004936572:5,924,158...5,938,658 		JBrowse link
regulation of stress-activated protein kinase signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zmpste24 zinc metallopeptidase STE24 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16079796) Ensembl
MGI		 PMID:16079796 GO_REF:0000107 NCBI chrNW_004936474:22,035,059...22,077,846
Ensembl chrNW_004936474:22,034,801...22,077,986 		JBrowse link
stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:21367774 RGD:5129174 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Card9 caspase recruitment domain family member 9 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:17187069) Ensembl
MGI		 PMID:17187069 GO_REF:0000107 NCBI chrNW_004936669:1,428,208...1,438,012
Ensembl chrNW_004936669:1,429,594...1,438,005 		JBrowse link
G Cd2ap CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15213232) Ensembl
MGI		 PMID:15213232 GO_REF:0000107 NCBI chrNW_004936476:12,890,595...12,989,046
Ensembl chrNW_004936476:12,890,468...12,987,843 		JBrowse link
G Cryab crystallin alpha B ISO RGD PMID:18420382 RGD:2303631 NCBI chrNW_004936612:2,532,851...2,536,473
Ensembl chrNW_004936612:2,532,812...2,537,495 		JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:19696743) Ensembl
MGI		 PMID:19696743 GO_REF:0000107 NCBI chrNW_004936650:679,650...718,867
Ensembl chrNW_004936650:679,647...720,038 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:4,882,191...4,891,807
Ensembl chrNW_004936588:4,882,184...4,892,071 		JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:4,363,361...4,461,133
Ensembl chrNW_004936578:4,368,900...4,532,966 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:3,029,942...3,203,319
Ensembl chrNW_004936509:3,029,979...3,202,796 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936560:3,988,696...4,197,953
Ensembl chrNW_004936560:3,989,420...4,197,501 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936510:1,772,971...1,836,075
Ensembl chrNW_004936510:1,772,971...1,837,765 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936629:542,143...549,861
Ensembl chrNW_004936629:545,755...549,837 		JBrowse link
G Mapk13 mitogen-activated protein kinase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:23,212,116...23,218,726
Ensembl chrNW_004936476:23,212,074...23,218,775 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 involved_in ISO
IEA		 RGD
Ensembl		 PMID:16407200 GO_REF:0000107 RGD:1580544 NCBI chrNW_004936476:23,237,762...23,310,211
Ensembl chrNW_004936476:23,237,277...23,310,232 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936728:1,775,746...1,893,895
Ensembl chrNW_004936728:1,775,641...1,893,907 		JBrowse link
G Nod1 nucleotide binding oligomerization domain containing 1 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936478:6,717,354...6,768,293
Ensembl chrNW_004936478:6,715,245...6,768,372 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936475:3,708,069...3,742,845
Ensembl chrNW_004936475:3,713,362...3,745,982 		JBrowse link
G Pbk PDZ binding kinase involved_in
acts_upstream_of		 IEA
ISO		 (PMID:21715333) Ensembl
MGI		 PMID:21715333 GO_REF:0000107 NCBI chrNW_004936675:704,001...722,769
Ensembl chrNW_004936675:704,516...722,755 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:11894097)
(PMID:11894098), (PMID:18261938)		 Ensembl
MGI		 PMID:11894097 PMID:11894098 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936544:3,606,925...3,653,248
Ensembl chrNW_004936544:3,606,879...3,655,532 		JBrowse link
G Taok2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:12,477,032...12,495,298
Ensembl chrNW_004936501:12,477,032...12,495,501 		JBrowse link
G Tlr4 toll like receptor 4 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    cellular process 15075
      cellular response to stimulus 7239
        cellular response to stress 1840
          stress-activated protein kinase signaling cascade 64
            negative regulation of stress-activated protein kinase signaling cascade + 10
            positive regulation of stress-activated protein kinase signaling cascade + 27
            regulation of stress-activated protein kinase signaling cascade + 47
            stress-activated MAPK cascade + 57
Path 2
Term Annotations click to browse term
  biological_process 15969
    biological regulation 11154
      regulation of biological process 10818
        regulation of cellular process 10346
          signal transduction 5702
            intracellular signal transduction 2551
              stress-activated protein kinase signaling cascade 64
                negative regulation of stress-activated protein kinase signaling cascade + 10
                positive regulation of stress-activated protein kinase signaling cascade + 27
                regulation of stress-activated protein kinase signaling cascade + 47
                stress-activated MAPK cascade + 57
paths to the root