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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of histone methylation
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Accession:GO:0031062 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.
Synonyms:exact_synonym: up regulation of histone methylation;   upregulation of histone methylation
 narrow_synonym: activation of histone methylation;   stimulation of histone methylation



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positive regulation of histone methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baz2a bromodomain adjacent to zinc finger domain, 2A involved_in ISO (MGI:4462332|PMID:20168299) RGD PMID:20168299 MGI:4462332 NCBI chr 7:523,204...560,911
Ensembl chr 7:523,265...560,659
JBrowse link
G Chtop chromatin target of PRMT1 involved_in ISS
ISO
GO_REF:0000024
(PMID:25284789)
UniProt
RGD
PMID:25284789 GO_REF:0000024 NCBI chr 2:175,981,266...175,992,854
Ensembl chr 2:175,981,271...175,992,748
JBrowse link
G Fam47a family with sequence similarity 47, member A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:42,762,231...42,763,887
Ensembl chr  X:42,762,229...42,763,883
JBrowse link
G Fam47e family with sequence similarity 47, member E involved_in ISO (PMID:33376131) RGD PMID:33376131 NCBI chr14:15,485,537...15,521,599
Ensembl chr14:15,485,127...15,521,775
JBrowse link
G L3mbtl2 L3MBTL histone methyl-lysine binding protein 2 acts_upstream_of_or_within ISO MGI:5810650 (MGI:5700289|PMID:22770845) RGD PMID:22770845 MGI:5700289 NCBI chr 7:113,186,303...113,209,706
Ensembl chr 7:113,186,370...113,207,489
JBrowse link
G LOC102552474 protein FAM47E-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:13,775,705...13,777,481
Ensembl chr  X:13,776,114...13,777,409
JBrowse link
G Men1 menin 1 acts_upstream_of_or_within ISO MGI:3608952 (MGI:3607663|PMID:16195383) RGD PMID:16195383 MGI:3607663 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871
JBrowse link
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component involved_in ISO (PMID:22046413) RGD PMID:22046413 NCBI chr 1:83,683,654...83,689,233
Ensembl chr 1:83,668,813...83,689,237
JBrowse link
G Pax7 paired box 7 acts_upstream_of_or_within ISO MGI:1914617 (MGI:5447149|PMID:22862948) RGD PMID:22862948 MGI:5447149 NCBI chr 5:151,996,368...152,098,023
Ensembl chr 5:151,999,092...152,097,979
JBrowse link
G Paxbp1 PAX3 and PAX7 binding protein 1 acts_upstream_of_or_within ISO MGI:97491 (MGI:5447149|PMID:22862948) RGD PMID:22862948 MGI:5447149 NCBI chr11:30,272,037...30,301,504
Ensembl chr11:30,272,037...30,301,648
JBrowse link
G Rnf20 ring finger protein 20 acts_upstream_of_or_within ISO (MGI:5319125|PMID:22252316) RGD PMID:22252316 MGI:5319125 NCBI chr 5:63,976,063...64,001,754
Ensembl chr 5:63,976,045...64,001,754
JBrowse link
G Rrp8 ribosomal RNA processing 8 involved_in ISO (PMID:18485871) RGD PMID:18485871 NCBI chr 1:160,081,092...160,088,709
Ensembl chr 1:160,084,295...160,089,331
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:18485871) RGD PMID:18485871 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 involved_in ISO (MGI:4462332|PMID:20168299) RGD PMID:20168299 MGI:4462332 NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594
JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase involved_in ISO (PMID:18485871) RGD PMID:18485871 NCBI chr  X:14,421,028...14,434,216
Ensembl chr  X:14,421,109...14,433,982
JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 involved_in ISO (PMID:18485871) RGD PMID:18485871 NCBI chr  X:141,793,695...141,795,558 JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 involved_in ISO (PMID:25284789) RGD PMID:25284789 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25280941) RGD PMID:25280941 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
positive regulation of histone H3-K27 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eed embryonic ectoderm development acts_upstream_of_or_within ISO (MGI:4844067|PMID:17997413) RGD PMID:17997413 MGI:4844067 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
JBrowse link
G Mtf2 metal response element binding transcription factor 2 involved_in ISO (MGI:4429983|PMID:20144788), (MGI:4946172|PMID:21059868) RGD PMID:20144788 PMID:21059868 MGI:4429983 MGI:4946172 NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:24474760)
Ensembl
UniProt
RGD
PMID:24474760 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Phf1 PHD finger protein 1 involved_in ISO (PMID:23273982) RGD PMID:23273982 NCBI chr20:5,017,765...5,022,872
Ensembl chr20:5,017,893...5,022,871
JBrowse link
G Phf19 PHD finger protein 19 involved_in ISO (PMID:23104054)
(MGI:5318799|PMID:22438827), (MGI:5487476|PMID:23104054)
RGD PMID:22438827 PMID:23104054 MGI:5318799 MGI:5487476 NCBI chr 3:18,175,281...18,197,289
Ensembl chr 3:18,175,282...18,196,405
JBrowse link
positive regulation of histone H3-K27 trimethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl2 ASXL transcriptional regulator 2 acts_upstream_of_or_within ISO MGI:3840841 (MGI:3840399|PMID:19270745) RGD PMID:19270745 MGI:3840399 NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477
JBrowse link
G Kpna7 karyopherin subunit alpha 7 acts_upstream_of_or_within ISO MGI:6108355 (MGI:5913752|PMID:20699224) RGD PMID:20699224 MGI:5913752 NCBI chr12:9,576,378...9,635,247
Ensembl chr12:9,576,378...9,612,833
JBrowse link
G Lcor ligand dependent nuclear receptor corepressor involved_in ISO (MGI:6159308|PMID:29628311) RGD PMID:29628311 MGI:6159308 NCBI chr 1:240,298,565...240,405,627
Ensembl chr 1:240,298,563...240,402,448
JBrowse link
positive regulation of histone H3-K36 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paxip1 PAX interacting protein 1 involved_in ISO (MGI:4821506|PMID:20671152) RGD PMID:20671152 MGI:4821506 NCBI chr 4:7,524,887...7,576,663
Ensembl chr 4:7,525,004...7,576,548
JBrowse link
positive regulation of histone H3-K36 trimethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 involved_in ISO (PMID:21555454) RGD PMID:21555454 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Nsd3 nuclear receptor binding SET domain protein 3 involved_in ISO (PMID:21555454) RGD PMID:21555454 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423
JBrowse link
G Prdm9 PR/SET domain 9 involved_in ISO (PMID:24634223) RGD PMID:24634223 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652
JBrowse link
positive regulation of histone H3-K4 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Auts2 activator of transcription and developmental regulator AUTS2 acts_upstream_of_or_within ISO (PMID:25519132) RGD PMID:25519132 NCBI chr12:24,104,187...25,194,123
Ensembl chr12:24,104,192...25,194,416
JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in IEA
ISO
GO_REF:0000107
(MGI:5009779|PMID:20820192)
(PMID:20820192)
Ensembl
RGD
PMID:20820192 GO_REF:0000107 MGI:5009779 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Ctnnb1 catenin beta 1 involved_in ISO
IEA
(MGI:5428344|PMID:22723415)
GO_REF:0000107
RGD
Ensembl
PMID:22723415 GO_REF:0000107 MGI:5428344 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in ISO (PMID:16024656)
(MGI:3849235|PMID:19345177)
RGD PMID:16024656 PMID:19345177 MGI:3849235 NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303
JBrowse link
G Dnmt1 DNA methyltransferase 1 involved_in ISO (PMID:18413740) RGD PMID:18413740 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta involved_in ISO (PMID:18413740) RGD PMID:18413740 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Gcg glucagon involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1344416|MGI:1918367|MGI:2155884 (MGI:5529403|PMID:24051374)
Ensembl
RGD
PMID:24051374 GO_REF:0000107 MGI:5529403 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Hcfc1 host cell factor C1 involved_in ISO (PMID:24244196) RGD PMID:24244196 NCBI chr  X:151,687,779...151,712,688
Ensembl chr  X:151,687,779...151,712,638
JBrowse link
G Kansl1 KAT8 regulatory NSL complex subunit 1 involved_in ISO (PMID:24244196) RGD PMID:24244196 NCBI chr10:89,237,667...89,368,735
Ensembl chr10:89,237,667...89,366,951
JBrowse link
G Kansl2 KAT8 regulatory NSL complex subunit 2 involved_in ISO (PMID:24244196) RGD PMID:24244196 NCBI chr 7:129,669,031...129,685,828
Ensembl chr 7:129,669,031...129,685,725
JBrowse link
G Kansl3 KAT8 regulatory NSL complex subunit 3 involved_in ISO
IEA
(PMID:24244196)
GO_REF:0000107
RGD
Ensembl
PMID:24244196 GO_REF:0000107 NCBI chr 9:38,562,170...38,605,757
Ensembl chr 9:38,562,177...38,605,692
JBrowse link
G Kat8 lysine acetyltransferase 8 involved_in ISO (PMID:24244196) RGD PMID:24244196 NCBI chr 1:182,524,355...182,536,638
Ensembl chr 1:182,515,327...182,536,633
JBrowse link
G Kmt2a lysine methyltransferase 2A involved_in ISO (MGI:5607228|PMID:21113167) RGD PMID:21113167 MGI:5607228 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Mcrs1 microspherule protein 1 involved_in ISO (PMID:24244196) RGD PMID:24244196 NCBI chr 7:130,383,853...130,392,667
Ensembl chr 7:130,383,853...130,392,685
JBrowse link
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Nelfa negative elongation factor complex member A IMP RGD PMID:21623364 RGD:9693718 NCBI chr14:76,808,920...76,832,998
Ensembl chr14:76,808,870...76,832,994
JBrowse link
G Nelfe negative elongation factor complex member E IMP RGD PMID:21623364 RGD:9693718 NCBI chr20:3,976,512...3,982,389
Ensembl chr20:3,976,518...3,982,355
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase involved_in ISO
IEA
(PMID:24244196)
GO_REF:0000107
RGD
Ensembl
PMID:24244196 GO_REF:0000107 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (MGI:4354659|PMID:19583951), (MGI:4821506|PMID:20671152) RGD PMID:19583951 PMID:20671152 MGI:4354659 MGI:4821506 NCBI chr 4:7,524,887...7,576,663
Ensembl chr 4:7,525,004...7,576,548
JBrowse link
G Phf20 PHD finger protein 20 involved_in ISO (PMID:24244196) RGD PMID:24244196 NCBI chr 3:144,710,253...144,816,696
Ensembl chr 3:144,710,353...144,814,439
JBrowse link
G Rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) involved_in ISO (MGI:3849235|PMID:19345177) RGD PMID:19345177 MGI:3849235 NCBI chr 3:106,659,363...106,718,970
Ensembl chr 3:106,659,308...106,718,970
JBrowse link
G Skic8 SKI8 subunit of superkiller complex involved_in ISO
IEA
ISS
(PMID:16024656)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:16024656 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:55,103,542...55,120,837
Ensembl chr 8:55,103,545...55,120,813
JBrowse link
G Smad4 SMAD family member 4 involved_in ISO
IEA
(MGI:3769957|PMID:16330325)
GO_REF:0000107
RGD
Ensembl
PMID:16330325 GO_REF:0000107 MGI:3769957 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Snw1 SNW domain containing 1 involved_in ISO (PMID:19818711) RGD PMID:19818711 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
JBrowse link
G Wdr5 WD repeat domain 5 involved_in ISO (PMID:24244196), (PMID:26324722) RGD PMID:24244196 PMID:26324722 NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671
JBrowse link
positive regulation of histone H3-K4 trimethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmt2e lysine methyltransferase 2E involved_in ISO (PMID:23629655) RGD PMID:23629655 NCBI chr 4:11,657,811...11,727,373
Ensembl chr 4:11,658,979...11,727,373
JBrowse link
G Prdm9 PR/SET domain 9 involved_in ISO (MGI:6355794|PMID:24095733) RGD PMID:24095733 MGI:6355794 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652
JBrowse link
positive regulation of histone H3-K79 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in ISO (PMID:16024656) RGD PMID:16024656 NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303
JBrowse link
G Skic8 SKI8 subunit of superkiller complex involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:16024656)
UniProt
Ensembl
RGD
PMID:16024656 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:55,103,542...55,120,837
Ensembl chr 8:55,103,545...55,120,813
JBrowse link
positive regulation of histone H3-K9 dimethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmrtc2 DMRT-like family C2 acts_upstream_of_or_within ISO MGI:3711104 (MGI:3710435|PMID:17447844) RGD PMID:17447844 MGI:3710435 NCBI chr 1:80,466,259...80,473,883
Ensembl chr 1:80,466,132...80,473,531
JBrowse link
G Prdm12 PR/SET domain 12 involved_in ISO
IBA
(PMID:26005867)
PMID:21873635
RGD PMID:26005867 PMID:21873635 RGD:13792537 NCBI chr 3:14,928,651...14,943,341
Ensembl chr 3:14,928,628...14,943,331
JBrowse link
positive regulation of histone H3-K9 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated involved_in IEA
ISO
GO_REF:0000107
(MGI:5009779|PMID:20820192)
Ensembl
RGD
PMID:20820192 GO_REF:0000107 MGI:5009779 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor involved_in ISO (MGI:5284774|PMID:17707228) RGD PMID:17707228 MGI:5284774 NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942
JBrowse link
G H1f5 H1.5 linker histone, cluster member involved_in ISO (PMID:22956909) RGD PMID:22956909 NCBI chr17:42,726,189...42,726,857
Ensembl chr17:42,726,127...42,769,160
JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 involved_in ISO (MGI:4441247|PMID:19010785) RGD PMID:19010785 MGI:4441247 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690
JBrowse link
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Prdm12 PR/SET domain 12 acts_upstream_of_or_within ISO (MGI:5774920|PMID:26005867)
(PMID:26005867)
RGD PMID:26005867 MGI:5774920 NCBI chr 3:14,928,651...14,943,341
Ensembl chr 3:14,928,628...14,943,331
JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (MGI:5584328|PMID:24735877) RGD PMID:24735877 MGI:5584328 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:22956909) RGD PMID:22956909 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
positive regulation of histone H3-K9 trimethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmrtc2 DMRT-like family C2 acts_upstream_of_or_within ISO MGI:3711104 (MGI:3710435|PMID:17447844) RGD PMID:17447844 MGI:3710435 NCBI chr 1:80,466,259...80,473,883
Ensembl chr 1:80,466,132...80,473,531
JBrowse link
G Lmna lamin A/C involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5913114|PMID:23695662)
Ensembl
RGD
PMID:23695662 GO_REF:0000107 MGI:5913114 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Mecp2 methyl CpG binding protein 2 involved_in ISO (MGI:5811980|PMID:25722434) RGD PMID:25722434 MGI:5811980 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO MGI:2445449 (MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:5913114 NCBI chr  X:14,421,028...14,434,216
Ensembl chr  X:14,421,109...14,433,982
JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 acts_upstream_of_or_within ISO MGI:2445449 (MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:5913114 NCBI chr  X:141,793,695...141,795,558 JBrowse link
positive regulation of histone H4-K20 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated involved_in IEA
ISO
GO_REF:0000107
(PMID:20820192)
(MGI:5009779|PMID:20820192)
Ensembl
RGD
PMID:20820192 GO_REF:0000107 MGI:5009779 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    positive regulation of biological process 6782
      positive regulation of cellular process 6111
        positive regulation of cellular metabolic process 3264
          positive regulation of histone methylation 62
            positive regulation of histone H3-K27 methylation + 8
            positive regulation of histone H3-K36 methylation + 4
            positive regulation of histone H3-K4 methylation + 27
            positive regulation of histone H3-K79 methylation + 2
            positive regulation of histone H3-K9 methylation + 13
            positive regulation of histone H4-K20 methylation 1
Path 2
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      organic substance metabolic process 11873
        macromolecule metabolic process 10218
          protein metabolic process 6233
            protein modification process 3757
              protein alkylation 232
                protein methylation 232
                  histone methylation 184
                    regulation of histone methylation 96
                      positive regulation of histone methylation 62
                        positive regulation of histone H3-K27 methylation + 8
                        positive regulation of histone H3-K36 methylation + 4
                        positive regulation of histone H3-K4 methylation + 27
                        positive regulation of histone H3-K79 methylation + 2
                        positive regulation of histone H3-K9 methylation + 13
                        positive regulation of histone H4-K20 methylation 1
paths to the root