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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of histone modification
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Accession:GO:0031057 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone.
Synonyms:exact_synonym: down regulation of histone modification;   downregulation of histone modification
 narrow_synonym: inhibition of histone modification


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negative regulation of histone acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anp32a acidic nuclear phosphoprotein 32 family member A IMP RGD PMID:19136565 RGD:10401132 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in IEA
ISO
IBA
GO_REF:0000107
(MGI:5009779|PMID:20820192)
PMID:21873635
Ensembl
RGD
PMID:20820192, PMID:21873635 GO_REF:0000107 MGI:5009779, RGD:13792537 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Ctbp1 C-terminal binding protein 1 involved_in ISO (PMID:21102443) RGD PMID:21102443 NCBI chr14:82,762,109...82,789,350
Ensembl chr14:82,762,190...82,789,319
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (MGI:3697020|PMID:17028180) RGD PMID:17028180 MGI:3697020 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G L3mbtl2 L3MBTL histone methyl-lysine binding protein 2 acts_upstream_of_or_within ISO MGI:5810650 (MGI:5700289|PMID:22770845) RGD PMID:22770845 MGI:5700289 NCBI chr 7:122,896,860...122,918,025
Ensembl chr 7:122,896,871...122,918,036
JBrowse link
G Msx3 msh homeobox 3 acts_upstream_of_or_within ISO MGI:1098280|MGI:1276116 (MGI:3775414|PMID:11115394) RGD PMID:11115394 MGI:3775414 NCBI chr 1:212,514,223...212,517,151
Ensembl chr 1:212,514,223...212,517,151
JBrowse link
G Noc2l NOC2-like nucleolar associated transcriptional repressor involved_in IBA
ISO
PMID:21873635
(PMID:16322561)
RGD PMID:16322561, PMID:21873635 RGD:13792537 NCBI chr 5:173,659,796...173,672,699
Ensembl chr 5:173,660,921...173,672,459
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 involved_in ISO (PMID:16691198) RGD PMID:16691198 NCBI chr 5:16,904,926...16,930,111
Ensembl chr 5:16,904,926...16,930,075
JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:16959795) RGD PMID:16959795 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 involved_in ISO (PMID:11592977) RGD PMID:11592977 NCBI chr18:30,779,149...30,781,297
Ensembl chr18:30,779,150...30,781,292
JBrowse link
G Thap7 THAP domain containing 7 involved_in ISO (PMID:16195249) RGD PMID:16195249 NCBI chr11:87,399,430...87,403,381
Ensembl chr11:87,399,483...87,403,367
JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (MGI:3843109|PMID:19345188) RGD PMID:19345188 MGI:3843109 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
negative regulation of histone deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm5a lysine demethylase 5A involved_in ISO (MGI:5288521|PMID:21960634) RGD PMID:21960634 MGI:5288521 NCBI chr 4:152,892,388...152,972,196
Ensembl chr 4:152,892,388...152,972,201
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:19729656) RGD PMID:19729656 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
negative regulation of histone deacetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in ISO UniProtKB:P56524 (PMID:19276356) RGD PMID:19276356 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like involved_in ISO (PMID:21239494) RGD PMID:21239494 NCBI chr 1:169,720,247...169,721,788
Ensembl chr 1:169,720,253...169,721,758
JBrowse link
G Prmt6 protein arginine methyltransferase 6 involved_in ISO (PMID:30420520) RGD PMID:30420520 NCBI chr 2:213,173,403...213,180,721
Ensembl chr 2:213,173,403...213,178,632
Ensembl chr 2:213,173,403...213,178,632
JBrowse link
G Ski SKI proto-oncogene involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:172,556,196...172,623,878
Ensembl chr 5:172,559,135...172,623,899
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:19729656) RGD PMID:19729656 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Ucn urocortin involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
negative regulation of histone H2A K63-linked ubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:20725033)
UniProt
RGD
PMID:20725033, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:222,451,674...222,459,952
Ensembl chr 1:222,451,674...222,459,952
JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:127,282,445...127,301,086
Ensembl chr 6:127,282,466...127,301,083
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:22884692)
PMID:21873635
UniProt
RGD
PMID:22884692, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 9:92,305,059...92,435,388
Ensembl chr 9:92,305,051...92,435,365
JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 involved_in ISO
IEA
IBA
ISS
(PMID:22884692)
GO_REF:0000107
PMID:21873635
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:22884692, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 7:76,789,110...76,835,517
NCBI chr 7:76,839,661...76,907,441
Ensembl chr 7:76,789,531...76,853,840
JBrowse link
negative regulation of histone H3-K14 acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 involved_in ISO
IEA
(PMID:17916362)
GO_REF:0000107
RGD
Ensembl
PMID:17916362 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
negative regulation of histone H3-K27 acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sin3a SIN3 transcription regulator family member A involved_in ISO (PMID:22783022) RGD PMID:22783022 NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099
JBrowse link
negative regulation of histone H3-K27 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ezhip EZH inhibitory protein involved_in ISO (PMID:29909548), (PMID:30923826) RGD PMID:29909548 PMID:30923826 NCBI chr  X:17,250,334...17,253,582
Ensembl chr  X:17,250,687...17,252,877
JBrowse link
G Macroh2a1 macroH2A.1 histone involved_in ISO (PMID:25526730) RGD PMID:25526730 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678
JBrowse link
G Mtf2 metal response element binding transcription factor 2 involved_in ISO (MGI:4946172|PMID:21059868) RGD PMID:21059868 MGI:4946172 NCBI chr14:2,656,776...2,701,027
Ensembl chr14:2,658,267...2,700,977
JBrowse link
G Phf1 PHD finger protein 1 involved_in ISO (PMID:23142980) RGD PMID:23142980 NCBI chr20:5,526,926...5,531,940
Ensembl chr20:5,526,961...5,531,941
JBrowse link
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor involved_in ISO (PMID:23503590)
(MGI:5484727|PMID:23503590)
RGD PMID:23503590 MGI:5484727 NCBI chr10:65,470,470...65,507,581
Ensembl chr10:65,470,471...65,507,581
JBrowse link
negative regulation of histone H3-K27 trimethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ezhip EZH inhibitory protein acts_upstream_of_or_within ISO MGI:6404408 (MGI:6362099|PMID:31451685) RGD PMID:31451685 MGI:6362099 NCBI chr  X:17,250,334...17,253,582
Ensembl chr  X:17,250,687...17,252,877
JBrowse link
negative regulation of histone H3-K36 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcor BCL6 co-repressor involved_in ISO (PMID:19578371) RGD PMID:19578371 NCBI chr  X:11,570,155...11,692,022
Ensembl chr  X:11,648,989...11,691,099
JBrowse link
G Fh fumarate hydratase involved_in ISO
ISS
(PMID:26237645)
GO_REF:0000024
RGD
UniProt
PMID:26237645 GO_REF:0000024 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
negative regulation of histone H3-K4 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcor BCL6 co-repressor involved_in ISO (PMID:19578371) RGD PMID:19578371 NCBI chr  X:11,570,155...11,692,022
Ensembl chr  X:11,648,989...11,691,099
JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in IEA
ISO
GO_REF:0000107
(MGI:5009779|PMID:20820192)
Ensembl
RGD
PMID:20820192 GO_REF:0000107 MGI:5009779 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor involved_in ISO (MGI:5284774|PMID:17707228) RGD PMID:17707228 MGI:5284774 NCBI chr 3:7,190,721...7,203,444
Ensembl chr 3:7,190,722...7,203,420
JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (MGI:4461095|PMID:20123967) RGD PMID:20123967 MGI:4461095 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Macroh2a1 macroH2A.1 histone involved_in ISO (PMID:25526730) RGD PMID:25526730 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678
JBrowse link
G Prmt6 protein arginine methyltransferase 6 acts_upstream_of_or_within ISO (MGI:5504576|PMID:22904064) RGD PMID:22904064 MGI:5504576 NCBI chr 2:213,173,403...213,180,721
Ensembl chr 2:213,173,403...213,178,632
Ensembl chr 2:213,173,403...213,178,632
JBrowse link
G Wdr5 WD repeat domain 5 involved_in ISO (PMID:26324722) RGD PMID:26324722 NCBI chr 3:6,061,892...6,080,724
Ensembl chr 3:6,061,940...6,080,680
JBrowse link
negative regulation of histone H3-K79 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mllt6 MLLT6, PHD finger containing acts_upstream_of_or_within ISO MGI:3856248 (MGI:5644399|PMID:21546577) RGD PMID:21546577 MGI:5644399 NCBI chr10:85,607,988...85,628,171
Ensembl chr10:85,608,544...85,625,854
JBrowse link
negative regulation of histone H3-K9 acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac8 histone deacetylase 8 IMP RGD PMID:25019367 RGD:13208813 NCBI chr  X:72,163,777...72,370,058
Ensembl chr  X:72,163,777...72,370,044
JBrowse link
G Zfp451 zinc finger protein 451 involved_in ISO (PMID:24324267) RGD PMID:24324267 NCBI chr 9:38,395,464...38,451,585
Ensembl chr 9:38,396,449...38,451,656
JBrowse link
negative regulation of histone H3-K9 dimethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pih1d1 PIH1 domain containing 1 involved_in ISO (PMID:22368283) RGD PMID:22368283 NCBI chr 1:101,151,240...101,156,806
Ensembl chr 1:101,152,734...101,156,805
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 involved_in ISO (PMID:22368283) RGD PMID:22368283 NCBI chr20:13,679,955...13,702,821
Ensembl chr20:13,680,716...13,704,931
JBrowse link
negative regulation of histone H3-K9 methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated involved_in ISO
IEA
(PMID:20820192)
GO_REF:0000107
(MGI:5009779|PMID:20820192)
RGD
Ensembl
PMID:20820192 GO_REF:0000107 MGI:5009779 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Dnmt1 DNA methyltransferase 1 involved_in ISO
IEA
(PMID:18413740)
GO_REF:0000107
RGD
Ensembl
PMID:18413740 GO_REF:0000107 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta involved_in ISO (PMID:18413740) RGD PMID:18413740 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (MGI:4461095|PMID:20123967) RGD PMID:20123967 MGI:4461095 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Kdm3a lysine demethylase 3A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3764891 (MGI:3763001|PMID:17943087)
Ensembl
RGD
PMID:17943087 GO_REF:0000107 MGI:3763001 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Pax5 paired box 5 acts_upstream_of_or_within ISO (MGI:3050710|PMID:15258579) RGD PMID:15258579 MGI:3050710 NCBI chr 5:60,007,587...60,191,973
Ensembl chr 5:60,007,587...60,191,941
JBrowse link
negative regulation of histone H3-K9 trimethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm4a lysine demethylase 4A acts_upstream_of_or_within ISO (MGI:3629551|PMID:16738407) RGD PMID:16738407 MGI:3629551 NCBI chr 5:136,967,650...137,014,402
Ensembl chr 5:136,967,650...137,014,430
JBrowse link
G Kdm4b lysine demethylase 4B acts_upstream_of_or_within ISO (MGI:3629551|PMID:16738407) RGD PMID:16738407 MGI:3629551 NCBI chr 9:10,656,035...10,734,127
Ensembl chr 9:10,653,216...10,734,073
JBrowse link
G Kdm4c lysine demethylase 4C acts_upstream_of_or_within ISO (MGI:3629551|PMID:16738407) RGD PMID:16738407 MGI:3629551 NCBI chr 5:90,800,139...91,012,662
Ensembl chr 5:90,800,082...91,012,659
JBrowse link
G Kdm4d lysine demethylase 4D acts_upstream_of_or_within ISO (MGI:3629551|PMID:16738407) RGD PMID:16738407 MGI:3629551 NCBI chr 8:12,968,192...12,993,651
Ensembl chr 8:13,511,805...13,513,337
JBrowse link
G Pih1d1 PIH1 domain containing 1 involved_in ISO (PMID:22368283) RGD PMID:22368283 NCBI chr 1:101,151,240...101,156,806
Ensembl chr 1:101,152,734...101,156,805
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:5810254|PMID:25526086) RGD PMID:25526086 MGI:5810254 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 involved_in ISO (PMID:22368283) RGD PMID:22368283 NCBI chr20:13,679,955...13,702,821
Ensembl chr20:13,680,716...13,704,931
JBrowse link
negative regulation of histone H4 acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctbp1 C-terminal binding protein 1 involved_in ISO
IEA
(PMID:21102443)
GO_REF:0000107
RGD
Ensembl
PMID:21102443 GO_REF:0000107 NCBI chr14:82,762,109...82,789,350
Ensembl chr14:82,762,190...82,789,319
JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (PMID:20139074) RGD PMID:20139074 NCBI chr 3:79,918,127...79,937,708
Ensembl chr 3:79,918,969...79,938,301
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 involved_in ISO (PMID:20937824) RGD PMID:20937824 NCBI chr18:30,779,149...30,781,297
Ensembl chr18:30,779,150...30,781,292
JBrowse link
negative regulation of histone H4-K16 acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5543312|PMID:23863932)
Ensembl
RGD
PMID:23863932 GO_REF:0000107 MGI:5543312 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO (MGI:5543312|PMID:23863932) RGD PMID:23863932 MGI:5543312 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Pih1d1 PIH1 domain containing 1 involved_in ISO (PMID:22368283) RGD PMID:22368283 NCBI chr 1:101,151,240...101,156,806
Ensembl chr 1:101,152,734...101,156,805
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA
(PMID:17916362)
GO_REF:0000107
RGD
Ensembl
PMID:17916362 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
negative regulation of histone methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fendrr FOXF1 adjacent non-coding developmental regulatory RNA acts_upstream_of_or_within ISO MGI:5470087 (MGI:5462100|PMID:23369715) RGD PMID:23369715 MGI:5462100 NCBI chr19:52,991,283...53,010,509 JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 involved_in ISO (MGI:4431292|PMID:20064375), (MGI:4436818|PMID:20064376) RGD PMID:20064375 PMID:20064376 MGI:4431292 MGI:4436818 NCBI chr17:20,183,440...20,365,219
Ensembl chr17:20,184,245...20,364,714
JBrowse link
negative regulation of histone phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Macroh2a1 macroH2A.1 histone involved_in ISO (PMID:22194607) RGD PMID:22194607 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678
JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B acts_upstream_of_or_within ISO MGI:2183933 (MGI:3720437|PMID:17488778) RGD PMID:17488778 MGI:3720437 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19599
    cellular process 18451
      negative regulation of cellular process 5096
        negative regulation of cellular component organization 796
          negative regulation of chromatin organization 70
            negative regulation of histone modification 53
              negative regulation of histone acetylation + 20
              negative regulation of histone deacetylation + 7
              negative regulation of histone demethylase activity (H3-K4 specific) 0
              negative regulation of histone deubiquitination 0
              negative regulation of histone methylation + 26
              negative regulation of histone phosphorylation + 3
              negative regulation of histone ubiquitination + 4
Path 2
Term Annotations click to browse term
  biological_process 19599
    cellular process 18451
      cellular component organization or biogenesis 6720
        cellular component organization 6475
          organelle organization 4054
            chromosome organization 1223
              chromatin organization 808
                covalent chromatin modification 519
                  histone modification 504
                    regulation of histone modification 180
                      negative regulation of histone modification 53
                        negative regulation of histone acetylation + 20
                        negative regulation of histone deacetylation + 7
                        negative regulation of histone demethylase activity (H3-K4 specific) 0
                        negative regulation of histone deubiquitination 0
                        negative regulation of histone methylation + 26
                        negative regulation of histone phosphorylation + 3
                        negative regulation of histone ubiquitination + 4
paths to the root