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Term:chromosome breakage
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Accession:GO:0031052 term browser browse the term
Definition:Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.
Comment:Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences.
Synonyms:exact_synonym: establishment or maintenance of heterochromatin architecture

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chromosome breakage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmga2 high mobility group AT-hook 2 involved_in ISO
PMID:19549901 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
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G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (MGI:5917601|PMID:28691929) RGD PMID:28691929 MGI:5917601 NCBI chr19:39,235,883...39,268,536
Ensembl chr19:39,236,787...39,268,479
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Term paths to the root
Path 1
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  biological_process 19390
    cellular process 18252
      cellular component organization or biogenesis 6492
        cellular component organization 6250
          organelle organization 3788
            chromosome organization 900
              chromosome breakage 2
Path 2
Term Annotations click to browse term
  biological_process 19390
    metabolic process 11736
      cellular metabolic process 10656
        cellular nitrogen compound metabolic process 6503
          nucleobase-containing compound metabolic process 5360
            nucleic acid metabolic process 4874
              DNA metabolic process 878
                programmed DNA elimination 2
                  chromosome breakage 2
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