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ONTOLOGY REPORT - ANNOTATIONS

Term:retrograde protein transport, ER to cytosol
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Accession:GO:0030970 term browser browse the term
Definition:The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
Synonyms:exact_synonym: protein dislocation from ER;   protein retrotranslocation, ER to cytosol;   retrograde protein transport, endoplasmic reticulum to cytosol


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retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor involved_in ISO
IEA		 (PMID:25660456)
GO_REF:0000107		 RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346 		JBrowse link
G Derl1 derlin 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:15215856), (PMID:25660456)
(PMID:15215855)		 RGD PMID:15215855 PMID:15215856 PMID:25660456 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Derl2 derlin 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:16449189)
MGI:4947129 (PMID:21220515)		 RGD PMID:16449189 PMID:21220515 NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480 		JBrowse link
G Faf2 Fas associated factor family member 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:25660456)		 Ensembl
RGD		 PMID:25660456 GO_REF:0000107 NCBI chr17:9,947,211...9,989,474
Ensembl chr17:9,947,220...9,989,485 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 involved_in ISO
IEA		 (PMID:25660456)
GO_REF:0000107		 RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in ISS
ISO
IEA
EXP		 GO_REF:0000024
(PMID:25660456)
GO_REF:0000107
PMID:12847084
(MGI:5634892|PMID:12847084)
(PMID:12847084)		 ParkinsonsUK-UCL
RGD
Ensembl		 PMID:12847084 PMID:25660456 PMID:12847084 GO_REF:0000024 GO_REF:0000107 MGI:5634892, RGD:10047330 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745 		JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in ISO (PMID:17215517) RGD PMID:17215517 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804 		JBrowse link
G Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase involved_in ISO
IEA		 (PMID:25660456)
GO_REF:0000107		 RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA
IBA		 (PMID:15215856)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:15215856 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Syvn1 synoviolin 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase involved_in ISO (PMID:24807418) RGD PMID:24807418 NCBI chr14:77,065,391...77,070,871
Ensembl chr14:77,065,841...77,070,865 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO
EXP
IEA		 (PMID:25660456)
PMID:12847084
(MGI:5634892|PMID:12847084)
GO_REF:0000107
(PMID:12847084)		 RGD
Ensembl		 PMID:12847084 PMID:25660456 PMID:12847084 GO_REF:0000107 MGI:5634892, RGD:10047330 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
G Vcp valosin-containing protein involved_in ISO
EXP
IBA		 (PMID:15215856), (PMID:25660456)
(MGI:5634892|PMID:12847084)
GO_REF:0000033
(PMID:12847084)		 RGD
GO_Central		 PMID:12847084 PMID:15215856 PMID:25660456 PMID:12847084 GO_REF:0000033 MGI:5634892, RGD:10047330 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 3:141,145,792...141,183,557
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISO (MGI:5437551|PMID:22795130)
(PMID:22795130)		 RGD PMID:22795130 MGI:5437551 NCBI chr 9:83,630,037...83,748,690
Ensembl chr 9:83,630,063...83,748,689 		JBrowse link
negative regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Derl2 derlin 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Derl3 derlin 3 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745 		JBrowse link
G Svip small VCP interacting protein involved_in ISO
IBA
IEA		 (PMID:25660456)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25660456 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:101,587,128...101,592,818
Ensembl chr 1:101,587,128...101,593,116 		JBrowse link
G Ubac2 UBA domain containing 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr15:98,960,139...99,107,795
Ensembl chr15:98,960,139...99,107,787 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447 		JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 5:47,422,476...47,441,476
Ensembl chr 5:47,422,587...47,441,461 		JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO (PMID:24068323) RGD PMID:24068323 NCBI chr13:42,175,047...42,181,661
Ensembl chr13:42,174,820...42,177,205 		JBrowse link
positive regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO (PMID:18555783) RGD PMID:18555783 NCBI chr  X:151,397,567...151,429,666
Ensembl chr  X:151,397,576...151,428,506 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in ISO UniProtKB:Q9BV94 (PMID:24200403)
(MGI:5563002|PMID:24200403)		 RGD PMID:24200403 MGI:5563002 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in ISO UniProtKB:Q92611 (PMID:24200403)
(MGI:5563002|PMID:24200403)		 RGD PMID:24200403 MGI:5563002 NCBI chr 3:144,201,604...144,227,423
Ensembl chr 3:144,201,605...144,227,485 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    cellular process 19326
      cellular localization 3694
        intracellular transport 1404
          endoplasmic reticulum to cytosol transport 27
            retrograde protein transport, ER to cytosol 27
              membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
              negative regulation of retrograde protein transport, ER to cytosol 9
              positive regulation of retrograde protein transport, ER to cytosol 3
              regulation of retrograde protein transport, ER to cytosol + 12
Path 2
Term Annotations click to browse term
  biological_process 20134
    localization 5690
      cellular localization 3694
        cellular macromolecule localization 2715
          protein localization 2703
            establishment of protein localization 1768
              protein transport 1464
                intracellular protein transport 694
                  protein exit from endoplasmic reticulum 47
                    retrograde protein transport, ER to cytosol 27
                      membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
                      negative regulation of retrograde protein transport, ER to cytosol 9
                      positive regulation of retrograde protein transport, ER to cytosol 3
                      regulation of retrograde protein transport, ER to cytosol + 12
paths to the root