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ONTOLOGY REPORT - ANNOTATIONS


Term:retrograde protein transport, ER to cytosol
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Accession:GO:0030970 term browser browse the term
Definition:The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
Synonyms:exact_synonym: protein dislocation from ER;   protein retrotranslocation, ER to cytosol;   retrograde protein transport, endoplasmic reticulum to cytosol


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retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346
JBrowse link
G Derl1 derlin 1 involved_in
acts_upstream_of_or_within
ISO (PMID:15215856), (PMID:25660456)
(PMID:15215855)
RGD PMID:15215855 PMID:15215856 PMID:25660456 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145
JBrowse link
G Derl2 derlin 2 involved_in
acts_upstream_of_or_within
ISO (PMID:16449189)
MGI:4947129 (MGI:4947015|PMID:21220515)
RGD PMID:16449189 PMID:21220515 MGI:4947015 NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518
JBrowse link
G Faf2 Fas associated factor family member 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:25660456)
Ensembl
RGD
PMID:25660456 GO_REF:0000107 NCBI chr17:9,947,216...9,989,474
Ensembl chr17:9,947,220...9,989,485
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 involved_in ISO
IEA
(PMID:25660456)
GO_REF:0000107
RGD
Ensembl
PMID:25660456 GO_REF:0000107 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:25660456)
ParkinsonsUK-UCL
Ensembl
RGD
PMID:25660456 GO_REF:0000024 GO_REF:0000107 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913
JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745
JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in ISO (PMID:17215517) RGD PMID:17215517 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase involved_in IEA
ISO
GO_REF:0000107
(PMID:25660456)
Ensembl
RGD
PMID:25660456 GO_REF:0000107 NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648
JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA
IBA
(PMID:15215856)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:15215856 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833
JBrowse link
G Syvn1 synoviolin 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152
JBrowse link
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase involved_in ISO (PMID:24807418) RGD PMID:24807418 NCBI chr14:77,065,391...77,070,871
Ensembl chr14:77,065,841...77,070,865
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087
JBrowse link
G Vcp valosin-containing protein involved_in IBA
ISO
PMID:21873635
(MGI:5634892|PMID:12847084)
(PMID:15215856), (PMID:25660456)
RGD PMID:12847084 PMID:15215856 PMID:25660456 PMID:21873635 MGI:5634892, RGD:13792537 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 3:141,145,769...141,184,703
Ensembl chr 3:141,145,782...141,184,703
JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISO (MGI:5437551|PMID:22795130) RGD PMID:22795130 MGI:5437551 NCBI chr 9:83,630,037...83,748,690
Ensembl chr 9:83,630,063...83,748,689
JBrowse link
negative regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Derl2 derlin 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518
JBrowse link
G Derl3 derlin 3 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027
JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480
JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745
JBrowse link
G Svip small VCP interacting protein involved_in IBA
ISO
PMID:21873635
(PMID:25660456)
RGD PMID:25660456 PMID:21873635 RGD:13792537 NCBI chr 1:101,587,128...101,592,818
Ensembl chr 1:101,587,128...101,593,116
JBrowse link
G Ubac2 UBA domain containing 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr15:98,960,139...99,107,795
Ensembl chr15:98,960,139...99,107,787
JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447
JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 5:47,422,513...47,441,476
Ensembl chr 5:47,422,587...47,441,461
JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO (PMID:24068323) RGD PMID:24068323 NCBI chr13:42,175,313...42,177,030
Ensembl chr13:42,174,820...42,177,205
JBrowse link
positive regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO (PMID:18555783) RGD PMID:18555783 NCBI chr  X:151,397,567...151,429,666
Ensembl chr  X:151,397,576...151,428,506
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in ISO UniProtKB:Q9BV94 (PMID:24200403)
(MGI:5563002|PMID:24200403)
RGD PMID:24200403 MGI:5563002 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in ISO UniProtKB:Q92611 (PMID:24200403)
(MGI:5563002|PMID:24200403)
RGD PMID:24200403 MGI:5563002 NCBI chr 3:144,201,604...144,227,423
Ensembl chr 3:144,201,605...144,227,485
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    localization 6447
      cellular localization 2965
        intracellular transport 1518
          endoplasmic reticulum to cytosol transport 27
            retrograde protein transport, ER to cytosol 27
              membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
              negative regulation of retrograde protein transport, ER to cytosol 9
              positive regulation of retrograde protein transport, ER to cytosol 3
              regulation of retrograde protein transport, ER to cytosol + 12
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      nitrogen compound metabolic process 9982
        organonitrogen compound metabolic process 6802
          organonitrogen compound catabolic process 1332
            protein catabolic process 1007
              cellular protein catabolic process 839
                proteolysis involved in cellular protein catabolic process 783
                  proteasomal protein catabolic process 513
                    ERAD pathway 105
                      retrograde protein transport, ER to cytosol 27
                        membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
                        negative regulation of retrograde protein transport, ER to cytosol 9
                        positive regulation of retrograde protein transport, ER to cytosol 3
                        regulation of retrograde protein transport, ER to cytosol + 12
paths to the root